Putative QA-SNARE protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

QA-SNARE protein putative

Species:

Leishmania major

UniProt:

Q4Q454_LEIMA

TriTrypDb:

LmjF.33.1340 , LMJLV39_330021400 , LMJSD75_330021100

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0012505	endomembrane system	2	2
GO:0016020	membrane	2	2
GO:0031201	SNARE complex	3	13
GO:0032991	protein-containing complex	1	13
GO:0098796	membrane protein complex	2	13
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q454

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q454

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	13
GO:0006886	intracellular protein transport	4	13
GO:0006906	vesicle fusion	6	2
GO:0006996	organelle organization	4	2
GO:0008104	protein localization	4	13
GO:0009987	cellular process	1	13
GO:0015031	protein transport	4	13
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0022406	membrane docking	2	2
GO:0033036	macromolecule localization	2	13
GO:0045184	establishment of protein localization	3	13
GO:0046907	intracellular transport	3	13
GO:0048278	vesicle docking	4	2
GO:0048284	organelle fusion	5	2
GO:0051179	localization	1	13
GO:0051234	establishment of localization	2	13
GO:0051640	organelle localization	2	2
GO:0051641	cellular localization	2	13
GO:0051649	establishment of localization in cell	3	13
GO:0061024	membrane organization	4	2
GO:0061025	membrane fusion	5	2
GO:0070727	cellular macromolecule localization	3	13
GO:0071702	organic substance transport	4	13
GO:0071705	nitrogen compound transport	4	13
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090174	organelle membrane fusion	6	2
GO:0140056	organelle localization by membrane tethering	3	2
GO:0016192	vesicle-mediated transport	4	11

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005484	SNAP receptor activity	3	4
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030674	protein-macromolecule adaptor activity	2	4
GO:0060090	molecular adaptor activity	1	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.338
CLV_C14_Caspase3-7	215	219	PF00656	0.402
CLV_NRD_NRD_1	15	17	PF00675	0.436
CLV_NRD_NRD_1	157	159	PF00675	0.306
CLV_PCSK_KEX2_1	15	17	PF00082	0.424
CLV_PCSK_KEX2_1	157	159	PF00082	0.324
CLV_PCSK_SKI1_1	124	128	PF00082	0.450
CLV_PCSK_SKI1_1	15	19	PF00082	0.552
CLV_PCSK_SKI1_1	164	168	PF00082	0.344
CLV_PCSK_SKI1_1	211	215	PF00082	0.353
CLV_PCSK_SKI1_1	68	72	PF00082	0.356
CLV_PCSK_SKI1_1	98	102	PF00082	0.232
DEG_APCC_DBOX_1	97	105	PF00400	0.292
DEG_Nend_UBRbox_2	1	3	PF02207	0.620
DOC_CYCLIN_RxL_1	132	146	PF00134	0.389
DOC_MAPK_gen_1	136	144	PF00069	0.399
DOC_MAPK_gen_1	157	168	PF00069	0.293
DOC_MAPK_gen_1	66	73	PF00069	0.288
DOC_MAPK_MEF2A_6	136	144	PF00069	0.399
DOC_PP1_RVXF_1	180	187	PF00149	0.293
DOC_PP1_RVXF_1	66	73	PF00149	0.480
DOC_PP4_FxxP_1	39	42	PF00568	0.546
DOC_PP4_FxxP_1	72	75	PF00568	0.264
DOC_USP7_MATH_1	251	255	PF00917	0.435
DOC_USP7_UBL2_3	76	80	PF12436	0.357
LIG_14-3-3_CanoR_1	124	130	PF00244	0.310
LIG_14-3-3_CanoR_1	132	140	PF00244	0.240
LIG_14-3-3_CanoR_1	15	20	PF00244	0.652
LIG_Actin_WH2_2	101	117	PF00022	0.357
LIG_BRCT_BRCA1_1	8	12	PF00533	0.518
LIG_FHA_1	105	111	PF00498	0.468
LIG_FHA_1	230	236	PF00498	0.397
LIG_FHA_1	33	39	PF00498	0.703
LIG_FHA_2	115	121	PF00498	0.344
LIG_FHA_2	19	25	PF00498	0.477
LIG_FHA_2	190	196	PF00498	0.316
LIG_FHA_2	207	213	PF00498	0.219
LIG_FHA_2	237	243	PF00498	0.305
LIG_LIR_Apic_2	36	42	PF02991	0.571
LIG_LIR_Gen_1	162	173	PF02991	0.357
LIG_LIR_Gen_1	183	191	PF02991	0.342
LIG_LIR_LC3C_4	232	235	PF02991	0.317
LIG_LIR_Nem_3	134	140	PF02991	0.404
LIG_LIR_Nem_3	162	168	PF02991	0.324
LIG_LIR_Nem_3	171	177	PF02991	0.324
LIG_SH2_CRK	165	169	PF00017	0.280
LIG_SH2_NCK_1	174	178	PF00017	0.423
LIG_SH3_3	28	34	PF00018	0.633
LIG_SH3_4	33	40	PF00018	0.438
LIG_SUMO_SIM_par_1	105	112	PF11976	0.431
LIG_SUMO_SIM_par_1	231	236	PF11976	0.305
LIG_TRAF2_1	119	122	PF00917	0.404
LIG_TRAF2_1	146	149	PF00917	0.384
LIG_TRAF2_1	219	222	PF00917	0.404
LIG_UBA3_1	70	76	PF00899	0.241
MOD_CAAXbox	272	275	PF01239	0.514
MOD_CK1_1	116	122	PF00069	0.415
MOD_CK1_1	26	32	PF00069	0.572
MOD_CK2_1	114	120	PF00069	0.361
MOD_CK2_1	143	149	PF00069	0.344
MOD_CK2_1	206	212	PF00069	0.324
MOD_CK2_1	216	222	PF00069	0.232
MOD_CK2_1	26	32	PF00069	0.651
MOD_CK2_1	46	52	PF00069	0.498
MOD_CK2_1	76	82	PF00069	0.238
MOD_GlcNHglycan	145	148	PF01048	0.415
MOD_GlcNHglycan	253	256	PF01048	0.388
MOD_GlcNHglycan	7	11	PF01048	0.563
MOD_GSK3_1	109	116	PF00069	0.435
MOD_GSK3_1	42	49	PF00069	0.515
MOD_N-GLC_1	267	272	PF02516	0.387
MOD_NEK2_1	104	109	PF00069	0.313
MOD_NEK2_1	114	119	PF00069	0.278
MOD_NEK2_1	56	61	PF00069	0.408
MOD_PIKK_1	109	115	PF00454	0.384
MOD_PKA_1	15	21	PF00069	0.455
MOD_PKA_2	131	137	PF00069	0.207
MOD_PKA_2	15	21	PF00069	0.539
MOD_Plk_1	104	110	PF00069	0.465
MOD_Plk_1	180	186	PF00069	0.293
MOD_Plk_1	26	32	PF00069	0.686
MOD_Plk_2-3	236	242	PF00069	0.287
MOD_Plk_4	104	110	PF00069	0.394
MOD_Plk_4	195	201	PF00069	0.267
MOD_Plk_4	229	235	PF00069	0.287
MOD_Plk_4	236	242	PF00069	0.269
MOD_SUMO_rev_2	154	163	PF00179	0.293
MOD_SUMO_rev_2	207	216	PF00179	0.403
TRG_DiLeu_BaEn_1	85	90	PF01217	0.448
TRG_DiLeu_BaEn_3	120	126	PF01217	0.404
TRG_ENDOCYTIC_2	165	168	PF00928	0.280
TRG_ENDOCYTIC_2	174	177	PF00928	0.280
TRG_ER_diArg_1	65	68	PF00400	0.295
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I246	Leptomonas seymouri	62%	99%
A0A0N1IMN0	Leptomonas seymouri	26%	91%
A0A0S4J7F1	Bodo saltans	34%	93%
A0A0S4JKJ1	Bodo saltans	28%	92%
A0A1X0P0Y0	Trypanosomatidae	36%	93%
A0A1X0P5S4	Trypanosomatidae	25%	91%
A0A3Q8IK46	Leishmania donovani	92%	100%
A0A3R7MIN3	Trypanosoma rangeli	33%	92%
A0A3S7X9G5	Leishmania donovani	28%	91%
A0A422P2Q8	Trypanosoma rangeli	25%	91%
A4HLJ5	Leishmania braziliensis	77%	100%
A4HMT8	Leishmania braziliensis	27%	91%
A4HN16	Leishmania braziliensis	75%	88%
A4I905	Leishmania infantum	92%	100%
A4IBD9	Leishmania infantum	28%	91%
A8WVD0	Caenorhabditis briggsae	28%	94%
C9ZZ78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	90%
D0A501	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	96%
E9AF95	Leishmania major	28%	100%
E9B3X0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B6F0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	91%
O16000	Caenorhabditis elegans	28%	95%
P61264	Mus musculus	27%	95%
P61265	Rattus norvegicus	27%	95%
P61266	Homo sapiens	27%	95%
P61267	Bos taurus	27%	95%
P61268	Ovis aries	27%	95%
Q08849	Rattus norvegicus	29%	95%
Q13277	Homo sapiens	29%	95%
Q16932	Aplysia californica	27%	95%
Q64704	Mus musculus	29%	95%
Q8BVI5	Mus musculus	26%	84%
Q9P6P1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	91%
V5BLU5	Trypanosoma cruzi	34%	93%
V5C306	Trypanosoma cruzi	25%	91%