Complex1_LYR_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

iron-sulfur cluster assembly protein, putative

Species:

Leishmania major

UniProt:

Q4Q452_LEIMA

TriTrypDb:

LmjF.33.1355 , LMJLV39_330021600 , LMJSD75_330021300

Length:

162

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	2
GO:1990221	L-cysteine desulfurase complex	3	2

Expansion

Sequence features

Q4Q452

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q452

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006399	tRNA metabolic process	7	2
GO:0006400	tRNA modification	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006790	sulfur compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008033	tRNA processing	8	2
GO:0008152	metabolic process	1	6
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	6
GO:0016043	cellular component organization	3	6
GO:0016070	RNA metabolic process	5	2
GO:0016226	iron-sulfur cluster assembly	4	6
GO:0022607	cellular component assembly	4	6
GO:0031163	metallo-sulfur cluster assembly	5	6
GO:0034227	tRNA thio-modification	7	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	6
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0051536	iron-sulfur cluster binding	3	2
GO:0051540	metal cluster binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.530
CLV_NRD_NRD_1	150	152	PF00675	0.680
CLV_NRD_NRD_1	20	22	PF00675	0.505
CLV_NRD_NRD_1	46	48	PF00675	0.547
CLV_NRD_NRD_1	79	81	PF00675	0.452
CLV_PCSK_KEX2_1	136	138	PF00082	0.665
CLV_PCSK_KEX2_1	150	152	PF00082	0.565
CLV_PCSK_KEX2_1	20	22	PF00082	0.505
CLV_PCSK_KEX2_1	79	81	PF00082	0.452
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.578
CLV_PCSK_SKI1_1	110	114	PF00082	0.379
CLV_PCSK_SKI1_1	126	130	PF00082	0.454
DEG_APCC_DBOX_1	117	125	PF00400	0.530
DEG_APCC_DBOX_1	19	27	PF00400	0.492
DEG_APCC_DBOX_1	4	12	PF00400	0.489
DOC_CYCLIN_RxL_1	134	143	PF00134	0.450
DOC_MAPK_gen_1	120	129	PF00069	0.627
DOC_MAPK_gen_1	20	28	PF00069	0.502
DOC_MAPK_RevD_3	6	21	PF00069	0.491
DOC_PP1_RVXF_1	135	142	PF00149	0.653
DOC_USP7_MATH_1	31	35	PF00917	0.495
LIG_14-3-3_CanoR_1	20	24	PF00244	0.427
LIG_14-3-3_CanoR_1	5	9	PF00244	0.488
LIG_Actin_WH2_2	4	22	PF00022	0.492
LIG_APCC_ABBAyCdc20_2	136	142	PF00400	0.690
LIG_BRCT_BRCA1_1	38	42	PF00533	0.454
LIG_FHA_1	12	18	PF00498	0.493
LIG_FHA_1	38	44	PF00498	0.454
LIG_FHA_2	60	66	PF00498	0.420
LIG_LIR_Gen_1	96	104	PF02991	0.530
LIG_LIR_Nem_3	83	89	PF02991	0.530
LIG_LIR_Nem_3	96	101	PF02991	0.249
LIG_Pex14_2	86	90	PF04695	0.530
LIG_PTB_Apo_2	128	135	PF02174	0.629
LIG_PTB_Phospho_1	128	134	PF10480	0.629
LIG_SH2_STAT3	89	92	PF00017	0.407
LIG_SH2_STAT5	140	143	PF00017	0.681
LIG_SH2_STAT5	89	92	PF00017	0.436
LIG_TRAF2_1	105	108	PF00917	0.530
LIG_TRAF2_1	62	65	PF00917	0.501
MOD_CK1_1	27	33	PF00069	0.501
MOD_CK1_1	54	60	PF00069	0.458
MOD_CK2_1	102	108	PF00069	0.452
MOD_CK2_1	59	65	PF00069	0.439
MOD_GlcNHglycan	33	36	PF01048	0.492
MOD_GlcNHglycan	56	59	PF01048	0.600
MOD_GSK3_1	27	34	PF00069	0.499
MOD_GSK3_1	59	66	PF00069	0.668
MOD_NEK2_1	11	16	PF00069	0.459
MOD_NEK2_1	19	24	PF00069	0.425
MOD_NEK2_1	36	41	PF00069	0.443
MOD_NEK2_1	4	9	PF00069	0.487
MOD_NEK2_1	74	79	PF00069	0.530
MOD_NEK2_2	37	42	PF00069	0.452
MOD_PKA_2	19	25	PF00069	0.426
MOD_PKA_2	4	10	PF00069	0.487
MOD_PKA_2	46	52	PF00069	0.463
MOD_Plk_4	37	43	PF00069	0.524
TRG_DiLeu_BaEn_3	107	113	PF01217	0.530
TRG_ER_diArg_1	19	21	PF00400	0.499
TRG_ER_diArg_1	79	81	PF00400	0.452
TRG_NES_CRM1_1	119	132	PF08389	0.627
TRG_Pf-PMV_PEXEL_1	137	142	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6M0	Leishmania donovani	95%	99%
A4HLJ7	Leishmania braziliensis	80%	100%
A4I907	Leishmania infantum	95%	99%
E9B3X2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%