Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q451_LEIMA

TriTrypDb:

LmjF.33.1360 , LMJLV39_330022100 , LMJSD75_330021800

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q451

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q451

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	257	261	PF00656	0.639
CLV_C14_Caspase3-7	51	55	PF00656	0.768
CLV_NRD_NRD_1	137	139	PF00675	0.604
CLV_NRD_NRD_1	221	223	PF00675	0.635
CLV_NRD_NRD_1	286	288	PF00675	0.497
CLV_PCSK_KEX2_1	137	139	PF00082	0.604
CLV_PCSK_KEX2_1	219	221	PF00082	0.658
CLV_PCSK_KEX2_1	286	288	PF00082	0.497
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.658
CLV_PCSK_PC7_1	216	222	PF00082	0.665
CLV_PCSK_SKI1_1	252	256	PF00082	0.450
CLV_PCSK_SKI1_1	289	293	PF00082	0.445
CLV_PCSK_SKI1_1	341	345	PF00082	0.713
CLV_PCSK_SKI1_1	421	425	PF00082	0.660
CLV_PCSK_SKI1_1	455	459	PF00082	0.503
DEG_APCC_DBOX_1	249	257	PF00400	0.576
DEG_APCC_DBOX_1	434	442	PF00400	0.500
DEG_SCF_FBW7_1	20	26	PF00400	0.617
DEG_SCF_FBW7_1	396	402	PF00400	0.737
DEG_SPOP_SBC_1	227	231	PF00917	0.667
DOC_CKS1_1	20	25	PF01111	0.615
DOC_CKS1_1	305	310	PF01111	0.677
DOC_CKS1_1	396	401	PF01111	0.637
DOC_CYCLIN_RxL_1	247	260	PF00134	0.484
DOC_CYCLIN_yCln2_LP_2	385	391	PF00134	0.585
DOC_MAPK_gen_1	247	256	PF00069	0.587
DOC_MAPK_gen_1	286	293	PF00069	0.515
DOC_PP2B_LxvP_1	107	110	PF13499	0.628
DOC_PP2B_LxvP_1	86	89	PF13499	0.535
DOC_USP7_MATH_1	110	114	PF00917	0.661
DOC_USP7_MATH_1	184	188	PF00917	0.623
DOC_USP7_MATH_1	227	231	PF00917	0.729
DOC_USP7_MATH_1	300	304	PF00917	0.597
DOC_USP7_MATH_1	368	372	PF00917	0.740
DOC_USP7_MATH_1	397	401	PF00917	0.663
DOC_USP7_MATH_1	407	411	PF00917	0.604
DOC_USP7_MATH_1	91	95	PF00917	0.593
DOC_WW_Pin1_4	153	158	PF00397	0.470
DOC_WW_Pin1_4	19	24	PF00397	0.612
DOC_WW_Pin1_4	220	225	PF00397	0.837
DOC_WW_Pin1_4	232	237	PF00397	0.480
DOC_WW_Pin1_4	304	309	PF00397	0.685
DOC_WW_Pin1_4	313	318	PF00397	0.673
DOC_WW_Pin1_4	395	400	PF00397	0.648
DOC_WW_Pin1_4	56	61	PF00397	0.660
DOC_WW_Pin1_4	89	94	PF00397	0.748
LIG_14-3-3_CanoR_1	225	234	PF00244	0.646
LIG_14-3-3_CanoR_1	24	30	PF00244	0.678
LIG_14-3-3_CanoR_1	295	299	PF00244	0.565
LIG_14-3-3_CanoR_1	408	416	PF00244	0.662
LIG_14-3-3_CanoR_1	417	423	PF00244	0.707
LIG_BIR_III_2	183	187	PF00653	0.616
LIG_Clathr_ClatBox_1	253	257	PF01394	0.452
LIG_FHA_1	243	249	PF00498	0.668
LIG_FHA_1	362	368	PF00498	0.746
LIG_FHA_1	380	386	PF00498	0.539
LIG_FHA_1	422	428	PF00498	0.587
LIG_FHA_1	449	455	PF00498	0.607
LIG_FHA_1	81	87	PF00498	0.758
LIG_FHA_2	26	32	PF00498	0.656
LIG_FHA_2	456	462	PF00498	0.509
LIG_FHA_2	49	55	PF00498	0.685
LIG_FHA_2	60	66	PF00498	0.533
LIG_GSK3_LRP6_1	89	94	PF00069	0.507
LIG_LIR_Apic_2	260	266	PF02991	0.482
LIG_LIR_Apic_2	400	406	PF02991	0.705
LIG_LIR_Gen_1	325	332	PF02991	0.518
LIG_LIR_Gen_1	68	77	PF02991	0.472
LIG_LIR_Nem_3	325	330	PF02991	0.519
LIG_LIR_Nem_3	65	70	PF02991	0.492
LIG_SH2_CRK	327	331	PF00017	0.590
LIG_SH2_NCK_1	310	314	PF00017	0.643
LIG_SH2_PTP2	403	406	PF00017	0.671
LIG_SH2_PTP2	70	73	PF00017	0.450
LIG_SH2_SRC	403	406	PF00017	0.528
LIG_SH2_STAP1	29	33	PF00017	0.677
LIG_SH2_STAP1	310	314	PF00017	0.654
LIG_SH2_STAP1	327	331	PF00017	0.455
LIG_SH2_STAT3	144	147	PF00017	0.657
LIG_SH2_STAT5	403	406	PF00017	0.745
LIG_SH2_STAT5	70	73	PF00017	0.450
LIG_SH3_3	122	128	PF00018	0.706
LIG_SH3_3	151	157	PF00018	0.576
LIG_SH3_3	17	23	PF00018	0.638
LIG_SH3_3	187	193	PF00018	0.724
LIG_SH3_3	288	294	PF00018	0.539
LIG_SH3_3	302	308	PF00018	0.524
LIG_SH3_3	314	320	PF00018	0.716
LIG_SH3_3	385	391	PF00018	0.574
LIG_SH3_3	87	93	PF00018	0.808
LIG_SUMO_SIM_anti_2	436	443	PF11976	0.714
LIG_SUMO_SIM_par_1	252	257	PF11976	0.452
LIG_SUMO_SIM_par_1	392	398	PF11976	0.728
LIG_TRAF2_1	63	66	PF00917	0.647
LIG_TYR_ITSM	323	330	PF00017	0.557
MOD_CDK_SPK_2	19	24	PF00069	0.612
MOD_CDK_SPK_2	220	225	PF00069	0.657
MOD_CDK_SPxxK_3	94	101	PF00069	0.671
MOD_CK1_1	113	119	PF00069	0.700
MOD_CK1_1	207	213	PF00069	0.803
MOD_CK1_1	223	229	PF00069	0.598
MOD_CK1_1	230	236	PF00069	0.663
MOD_CK1_1	25	31	PF00069	0.603
MOD_CK1_1	309	315	PF00069	0.607
MOD_CK1_1	316	322	PF00069	0.550
MOD_CK1_1	395	401	PF00069	0.665
MOD_CK1_1	434	440	PF00069	0.716
MOD_CK1_1	59	65	PF00069	0.755
MOD_CK1_1	94	100	PF00069	0.660
MOD_CK2_1	153	159	PF00069	0.459
MOD_CK2_1	455	461	PF00069	0.507
MOD_CK2_1	59	65	PF00069	0.688
MOD_CK2_1	99	105	PF00069	0.610
MOD_GlcNHglycan	175	178	PF01048	0.605
MOD_GlcNHglycan	302	305	PF01048	0.556
MOD_GlcNHglycan	370	373	PF01048	0.671
MOD_GlcNHglycan	54	57	PF01048	0.705
MOD_GlcNHglycan	74	77	PF01048	0.465
MOD_GlcNHglycan	80	83	PF01048	0.670
MOD_GSK3_1	19	26	PF00069	0.585
MOD_GSK3_1	200	207	PF00069	0.760
MOD_GSK3_1	223	230	PF00069	0.731
MOD_GSK3_1	294	301	PF00069	0.648
MOD_GSK3_1	309	316	PF00069	0.618
MOD_GSK3_1	322	329	PF00069	0.468
MOD_GSK3_1	395	402	PF00069	0.664
MOD_GSK3_1	427	434	PF00069	0.733
MOD_GSK3_1	48	55	PF00069	0.636
MOD_GSK3_1	80	87	PF00069	0.668
MOD_N-GLC_1	336	341	PF02516	0.581
MOD_N-GLC_2	270	272	PF02516	0.533
MOD_N-GLC_2	334	336	PF02516	0.661
MOD_NEK2_1	111	116	PF00069	0.730
MOD_NEK2_1	194	199	PF00069	0.655
MOD_NEK2_1	204	209	PF00069	0.558
MOD_NEK2_1	326	331	PF00069	0.618
MOD_NEK2_1	416	421	PF00069	0.699
MOD_NEK2_2	322	327	PF00069	0.567
MOD_PIKK_1	194	200	PF00454	0.702
MOD_PKA_2	13	19	PF00069	0.651
MOD_PKA_2	207	213	PF00069	0.609
MOD_PKA_2	23	29	PF00069	0.675
MOD_PKA_2	294	300	PF00069	0.530
MOD_PKA_2	368	374	PF00069	0.756
MOD_PKA_2	407	413	PF00069	0.702
MOD_PKA_2	416	422	PF00069	0.678
MOD_PKA_2	434	440	PF00069	0.547
MOD_Plk_2-3	99	105	PF00069	0.568
MOD_Plk_4	184	190	PF00069	0.693
MOD_Plk_4	322	328	PF00069	0.543
MOD_Plk_4	399	405	PF00069	0.720
MOD_Plk_4	434	440	PF00069	0.631
MOD_Plk_4	448	454	PF00069	0.562
MOD_Plk_4	91	97	PF00069	0.706
MOD_ProDKin_1	153	159	PF00069	0.470
MOD_ProDKin_1	19	25	PF00069	0.613
MOD_ProDKin_1	220	226	PF00069	0.836
MOD_ProDKin_1	232	238	PF00069	0.478
MOD_ProDKin_1	304	310	PF00069	0.687
MOD_ProDKin_1	313	319	PF00069	0.671
MOD_ProDKin_1	395	401	PF00069	0.649
MOD_ProDKin_1	56	62	PF00069	0.656
MOD_ProDKin_1	89	95	PF00069	0.745
TRG_DiLeu_BaEn_2	158	164	PF01217	0.448
TRG_DiLeu_BaLyEn_6	249	254	PF01217	0.474
TRG_ENDOCYTIC_2	327	330	PF00928	0.594
TRG_ENDOCYTIC_2	70	73	PF00928	0.450
TRG_ER_diArg_1	220	222	PF00400	0.667
TRG_ER_diArg_1	250	253	PF00400	0.652
TRG_ER_diArg_1	286	289	PF00400	0.507
TRG_NLS_MonoCore_2	218	223	PF00514	0.662
TRG_NLS_MonoExtN_4	216	223	PF00514	0.640
TRG_Pf-PMV_PEXEL_1	252	257	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4L8	Leptomonas seymouri	36%	81%
A0A3S7X6N2	Leishmania donovani	90%	100%
A4HLJ8	Leishmania braziliensis	70%	81%
A4I908	Leishmania infantum	90%	100%
E9B3X3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%