Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q450_LEIMA

TriTrypDb:

LmjF.33.1370 , LMJLV39_330022200 , LMJSD75_330021900

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q450

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q450

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	298	302	PF00656	0.691
CLV_C14_Caspase3-7	420	424	PF00656	0.600
CLV_NRD_NRD_1	171	173	PF00675	0.623
CLV_NRD_NRD_1	204	206	PF00675	0.829
CLV_NRD_NRD_1	294	296	PF00675	0.825
CLV_NRD_NRD_1	347	349	PF00675	0.619
CLV_NRD_NRD_1	409	411	PF00675	0.622
CLV_NRD_NRD_1	414	416	PF00675	0.599
CLV_PCSK_KEX2_1	204	206	PF00082	0.685
CLV_PCSK_KEX2_1	275	277	PF00082	0.594
CLV_PCSK_KEX2_1	294	296	PF00082	0.690
CLV_PCSK_KEX2_1	346	348	PF00082	0.627
CLV_PCSK_KEX2_1	409	411	PF00082	0.622
CLV_PCSK_KEX2_1	414	416	PF00082	0.599
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.641
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.594
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.627
CLV_PCSK_PC7_1	271	277	PF00082	0.627
CLV_PCSK_PC7_1	410	416	PF00082	0.541
CLV_PCSK_SKI1_1	119	123	PF00082	0.648
CLV_PCSK_SKI1_1	276	280	PF00082	0.562
DEG_COP1_1	320	330	PF00400	0.618
DEG_COP1_1	366	374	PF00400	0.553
DOC_CKS1_1	69	74	PF01111	0.513
DOC_MAPK_gen_1	280	288	PF00069	0.595
DOC_USP7_MATH_1	175	179	PF00917	0.637
DOC_USP7_MATH_1	190	194	PF00917	0.614
DOC_USP7_MATH_1	245	249	PF00917	0.800
DOC_USP7_MATH_1	26	30	PF00917	0.583
DOC_USP7_MATH_1	278	282	PF00917	0.704
DOC_USP7_MATH_1	64	68	PF00917	0.532
DOC_USP7_UBL2_3	169	173	PF12436	0.625
DOC_WW_Pin1_4	222	227	PF00397	0.648
DOC_WW_Pin1_4	255	260	PF00397	0.679
DOC_WW_Pin1_4	346	351	PF00397	0.704
DOC_WW_Pin1_4	370	375	PF00397	0.649
DOC_WW_Pin1_4	393	398	PF00397	0.729
DOC_WW_Pin1_4	68	73	PF00397	0.509
LIG_14-3-3_CanoR_1	18	22	PF00244	0.526
LIG_14-3-3_CanoR_1	221	226	PF00244	0.651
LIG_14-3-3_CanoR_1	271	279	PF00244	0.596
LIG_14-3-3_CanoR_1	294	303	PF00244	0.692
LIG_14-3-3_CanoR_1	391	400	PF00244	0.784
LIG_14-3-3_CanoR_1	409	414	PF00244	0.522
LIG_14-3-3_CanoR_1	42	46	PF00244	0.629
LIG_14-3-3_CanoR_1	75	79	PF00244	0.597
LIG_BIR_II_1	1	5	PF00653	0.470
LIG_BIR_III_4	63	67	PF00653	0.518
LIG_Clathr_ClatBox_1	59	63	PF01394	0.476
LIG_FHA_1	255	261	PF00498	0.738
LIG_FHA_1	385	391	PF00498	0.661
LIG_FHA_1	75	81	PF00498	0.656
LIG_FHA_2	418	424	PF00498	0.602
LIG_LIR_Nem_3	20	24	PF02991	0.589
LIG_SH2_CRK	76	80	PF00017	0.486
LIG_SH2_STAP1	76	80	PF00017	0.486
LIG_SH2_STAT3	316	319	PF00017	0.655
LIG_SH2_STAT5	5	8	PF00017	0.488
LIG_SH2_STAT5	76	79	PF00017	0.546
LIG_SH3_2	289	294	PF14604	0.604
LIG_SH3_3	123	129	PF00018	0.646
LIG_SH3_3	136	142	PF00018	0.690
LIG_SH3_3	154	160	PF00018	0.666
LIG_SH3_3	257	263	PF00018	0.676
LIG_SH3_3	284	290	PF00018	0.601
LIG_SH3_3	322	328	PF00018	0.643
LIG_SH3_3	366	372	PF00018	0.667
LIG_SH3_3	399	405	PF00018	0.587
LIG_SH3_3	55	61	PF00018	0.518
LIG_SH3_3	66	72	PF00018	0.473
LIG_SUMO_SIM_anti_2	77	84	PF11976	0.569
LIG_SUMO_SIM_par_1	77	84	PF11976	0.504
LIG_TRAF2_1	179	182	PF00917	0.725
LIG_TRAF2_1	333	336	PF00917	0.694
MOD_CDC14_SPxK_1	396	399	PF00782	0.675
MOD_CDK_SPxK_1	393	399	PF00069	0.681
MOD_CDK_SPxxK_3	346	353	PF00069	0.675
MOD_CDK_SPxxK_3	68	75	PF00069	0.580
MOD_CK1_1	103	109	PF00069	0.693
MOD_CK1_1	191	197	PF00069	0.634
MOD_CK1_1	224	230	PF00069	0.632
MOD_CK1_1	234	240	PF00069	0.583
MOD_CK1_1	248	254	PF00069	0.579
MOD_CK1_1	255	261	PF00069	0.600
MOD_CK1_1	266	272	PF00069	0.571
MOD_CK1_1	296	302	PF00069	0.642
MOD_CK1_1	30	36	PF00069	0.574
MOD_CK1_1	317	323	PF00069	0.660
MOD_CK1_1	351	357	PF00069	0.668
MOD_CK1_1	359	365	PF00069	0.591
MOD_CK1_1	408	414	PF00069	0.685
MOD_CK1_1	88	94	PF00069	0.551
MOD_CK2_1	146	152	PF00069	0.692
MOD_CK2_1	165	171	PF00069	0.695
MOD_CK2_1	175	181	PF00069	0.610
MOD_CK2_1	278	284	PF00069	0.625
MOD_CK2_1	346	352	PF00069	0.650
MOD_DYRK1A_RPxSP_1	370	374	PF00069	0.619
MOD_GlcNHglycan	102	105	PF01048	0.657
MOD_GlcNHglycan	111	114	PF01048	0.581
MOD_GlcNHglycan	147	151	PF01048	0.753
MOD_GlcNHglycan	177	180	PF01048	0.640
MOD_GlcNHglycan	190	193	PF01048	0.501
MOD_GlcNHglycan	228	231	PF01048	0.636
MOD_GlcNHglycan	233	236	PF01048	0.629
MOD_GlcNHglycan	265	268	PF01048	0.695
MOD_GlcNHglycan	316	319	PF01048	0.604
MOD_GlcNHglycan	33	36	PF01048	0.553
MOD_GlcNHglycan	358	361	PF01048	0.649
MOD_GlcNHglycan	393	396	PF01048	0.688
MOD_GlcNHglycan	43	46	PF01048	0.591
MOD_GlcNHglycan	54	57	PF01048	0.441
MOD_GlcNHglycan	90	93	PF01048	0.775
MOD_GSK3_1	222	229	PF00069	0.572
MOD_GSK3_1	246	253	PF00069	0.633
MOD_GSK3_1	26	33	PF00069	0.578
MOD_GSK3_1	266	273	PF00069	0.508
MOD_GSK3_1	293	300	PF00069	0.605
MOD_GSK3_1	348	355	PF00069	0.642
MOD_GSK3_1	359	366	PF00069	0.719
MOD_GSK3_1	382	389	PF00069	0.587
MOD_GSK3_1	400	407	PF00069	0.612
MOD_GSK3_1	417	424	PF00069	0.545
MOD_GSK3_1	64	71	PF00069	0.516
MOD_GSK3_1	81	88	PF00069	0.546
MOD_GSK3_1	99	106	PF00069	0.684
MOD_LATS_1	138	144	PF00433	0.569
MOD_N-GLC_1	165	170	PF02516	0.686
MOD_N-GLC_1	30	35	PF02516	0.543
MOD_N-GLC_2	41	43	PF02516	0.614
MOD_NEK2_1	120	125	PF00069	0.565
MOD_NEK2_1	27	32	PF00069	0.580
MOD_NEK2_2	386	391	PF00069	0.662
MOD_PIKK_1	246	252	PF00454	0.676
MOD_PIKK_1	320	326	PF00454	0.669
MOD_PK_1	85	91	PF00069	0.515
MOD_PKA_1	140	146	PF00069	0.590
MOD_PKA_1	409	415	PF00069	0.545
MOD_PKA_2	17	23	PF00069	0.522
MOD_PKA_2	246	252	PF00069	0.653
MOD_PKA_2	270	276	PF00069	0.696
MOD_PKA_2	293	299	PF00069	0.647
MOD_PKA_2	338	344	PF00069	0.693
MOD_PKA_2	408	414	PF00069	0.609
MOD_PKA_2	41	47	PF00069	0.622
MOD_PKA_2	74	80	PF00069	0.554
MOD_PKA_2	81	87	PF00069	0.525
MOD_Plk_1	335	341	PF00069	0.651
MOD_Plk_2-3	419	425	PF00069	0.607
MOD_Plk_4	64	70	PF00069	0.522
MOD_Plk_4	74	80	PF00069	0.532
MOD_ProDKin_1	222	228	PF00069	0.650
MOD_ProDKin_1	255	261	PF00069	0.681
MOD_ProDKin_1	346	352	PF00069	0.705
MOD_ProDKin_1	370	376	PF00069	0.650
MOD_ProDKin_1	393	399	PF00069	0.730
MOD_ProDKin_1	68	74	PF00069	0.515
MOD_SUMO_rev_2	168	175	PF00179	0.605
MOD_SUMO_rev_2	323	333	PF00179	0.650
TRG_ENDOCYTIC_2	76	79	PF00928	0.481
TRG_ER_diArg_1	413	415	PF00400	0.611
TRG_NLS_MonoCore_2	202	207	PF00514	0.637
TRG_NLS_MonoCore_2	344	349	PF00514	0.692
TRG_NLS_MonoExtC_3	202	207	PF00514	0.637
TRG_NLS_MonoExtC_3	345	350	PF00514	0.632
TRG_NLS_MonoExtN_4	201	208	PF00514	0.630
TRG_NLS_MonoExtN_4	345	350	PF00514	0.717

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWS2	Leptomonas seymouri	42%	100%
A0A3S7X6S8	Leishmania donovani	90%	100%
A4I909	Leishmania infantum	90%	100%
E9AIV5	Leishmania braziliensis	66%	100%
E9B3X4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%