Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q448_LEIMA

TriTrypDb:

LmjF.33.1390 , LMJLV39_330022400 , LMJSD75_330022100

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0020023	kinetoplast	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q448

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q448

PDB structure(s): 7aih_Y , 7ane_Y

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.457
CLV_NRD_NRD_1	161	163	PF00675	0.508
CLV_NRD_NRD_1	224	226	PF00675	0.404
CLV_NRD_NRD_1	260	262	PF00675	0.433
CLV_NRD_NRD_1	57	59	PF00675	0.449
CLV_PCSK_KEX2_1	128	130	PF00082	0.457
CLV_PCSK_KEX2_1	161	163	PF00082	0.508
CLV_PCSK_KEX2_1	260	262	PF00082	0.483
CLV_PCSK_KEX2_1	59	61	PF00082	0.430
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.430
CLV_PCSK_SKI1_1	225	229	PF00082	0.342
DEG_APCC_DBOX_1	5	13	PF00400	0.557
DEG_Nend_Nbox_1	1	3	PF02207	0.667
DOC_MAPK_gen_1	161	169	PF00069	0.539
DOC_MAPK_gen_1	260	268	PF00069	0.519
DOC_MAPK_RevD_3	7	21	PF00069	0.444
DOC_PP2B_LxvP_1	132	135	PF13499	0.445
DOC_PP2B_LxvP_1	145	148	PF13499	0.407
DOC_USP7_MATH_1	288	292	PF00917	0.534
DOC_USP7_MATH_1	94	98	PF00917	0.490
DOC_WW_Pin1_4	130	135	PF00397	0.439
LIG_14-3-3_CanoR_1	95	103	PF00244	0.392
LIG_APCC_ABBA_1	235	240	PF00400	0.516
LIG_deltaCOP1_diTrp_1	165	169	PF00928	0.450
LIG_FHA_1	12	18	PF00498	0.663
LIG_FHA_1	131	137	PF00498	0.446
LIG_FHA_1	162	168	PF00498	0.427
LIG_FHA_1	180	186	PF00498	0.330
LIG_FHA_2	208	214	PF00498	0.394
LIG_LIR_Gen_1	164	174	PF02991	0.485
LIG_LIR_Gen_1	218	228	PF02991	0.344
LIG_LIR_Gen_1	277	288	PF02991	0.519
LIG_LIR_Gen_1	75	85	PF02991	0.420
LIG_LIR_Nem_3	156	160	PF02991	0.455
LIG_LIR_Nem_3	164	169	PF02991	0.433
LIG_LIR_Nem_3	175	180	PF02991	0.355
LIG_LIR_Nem_3	215	220	PF02991	0.365
LIG_LIR_Nem_3	277	283	PF02991	0.447
LIG_LIR_Nem_3	75	80	PF02991	0.424
LIG_LYPXL_yS_3	157	160	PF13949	0.437
LIG_MYND_1	130	134	PF01753	0.442
LIG_SH2_CRK	127	131	PF00017	0.510
LIG_SH2_CRK	280	284	PF00017	0.556
LIG_SH2_CRK	77	81	PF00017	0.451
LIG_SH2_NCK_1	280	284	PF00017	0.536
LIG_SH2_NCK_1	77	81	PF00017	0.523
LIG_SH2_PTP2	220	223	PF00017	0.367
LIG_SH2_SRC	139	142	PF00017	0.401
LIG_SH2_STAT5	179	182	PF00017	0.461
LIG_SH2_STAT5	220	223	PF00017	0.352
LIG_SH2_STAT5	47	50	PF00017	0.458
LIG_TRAF2_1	111	114	PF00917	0.349
LIG_TRAF2_1	99	102	PF00917	0.522
LIG_TYR_ITIM	278	283	PF00017	0.416
MOD_CK1_1	78	84	PF00069	0.495
MOD_CK2_1	207	213	PF00069	0.407
MOD_GlcNHglycan	29	32	PF01048	0.565
MOD_GlcNHglycan	77	80	PF01048	0.517
MOD_LATS_1	126	132	PF00433	0.515
MOD_PIKK_1	149	155	PF00454	0.488
MOD_PKA_1	128	134	PF00069	0.446
MOD_PKA_1	161	167	PF00069	0.486
MOD_PKA_1	20	26	PF00069	0.495
MOD_PKA_2	128	134	PF00069	0.446
MOD_PKA_2	161	167	PF00069	0.392
MOD_PKA_2	75	81	PF00069	0.465
MOD_PKA_2	87	93	PF00069	0.333
MOD_PKA_2	94	100	PF00069	0.269
MOD_Plk_1	66	72	PF00069	0.602
MOD_ProDKin_1	130	136	PF00069	0.435
MOD_SUMO_for_1	190	193	PF00179	0.542
MOD_SUMO_rev_2	78	85	PF00179	0.518
TRG_DiLeu_BaEn_1	113	118	PF01217	0.453
TRG_DiLeu_BaEn_4	101	107	PF01217	0.497
TRG_DiLeu_BaEn_4	113	119	PF01217	0.363
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.446
TRG_ENDOCYTIC_2	157	160	PF00928	0.462
TRG_ENDOCYTIC_2	220	223	PF00928	0.352
TRG_ENDOCYTIC_2	280	283	PF00928	0.425
TRG_ENDOCYTIC_2	286	289	PF00928	0.348
TRG_ENDOCYTIC_2	77	80	PF00928	0.430
TRG_ER_diArg_1	127	129	PF00400	0.452
TRG_ER_diArg_1	160	162	PF00400	0.498
TRG_NES_CRM1_1	98	110	PF08389	0.424
TRG_NLS_MonoExtC_3	57	63	PF00514	0.437
TRG_Pf-PMV_PEXEL_1	104	109	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4Q5	Leptomonas seymouri	83%	100%
A0A0S4JF52	Bodo saltans	52%	100%
A0A1X0P198	Trypanosomatidae	67%	100%
A0A3Q8IDR8	Leishmania donovani	98%	100%
A0A3R7MCA1	Trypanosoma rangeli	68%	100%
A4HLK0	Leishmania braziliensis	90%	100%
A4I911	Leishmania infantum	99%	100%
D0A511	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9B3X6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
V5BHC0	Trypanosoma cruzi	67%	100%