Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q446_LEIMA

TriTrypDb:

LmjF.33.1410 , LMJLV39_330022600 , LMJSD75_330022300

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000421	autophagosome membrane	6	2
GO:0005774	vacuolar membrane	5	2
GO:0005840	ribosome	5	11
GO:0016020	membrane	2	2
GO:0031090	organelle membrane	3	2
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

Q4Q446

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q446

Function

Biological processes
Term	Name	Level	Count
GO:0000045	autophagosome assembly	6	11
GO:0006996	organelle organization	4	11
GO:0007033	vacuole organization	5	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0070925	organelle assembly	5	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:1905037	autophagosome organization	6	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	466	470	PF00656	0.473
CLV_C14_Caspase3-7	527	531	PF00656	0.750
CLV_NRD_NRD_1	207	209	PF00675	0.500
CLV_NRD_NRD_1	391	393	PF00675	0.460
CLV_NRD_NRD_1	428	430	PF00675	0.463
CLV_PCSK_KEX2_1	207	209	PF00082	0.505
CLV_PCSK_KEX2_1	226	228	PF00082	0.574
CLV_PCSK_KEX2_1	293	295	PF00082	0.196
CLV_PCSK_KEX2_1	390	392	PF00082	0.494
CLV_PCSK_KEX2_1	428	430	PF00082	0.463
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.726
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.196
CLV_PCSK_SKI1_1	130	134	PF00082	0.404
CLV_PCSK_SKI1_1	180	184	PF00082	0.491
CLV_PCSK_SKI1_1	195	199	PF00082	0.506
CLV_PCSK_SKI1_1	293	297	PF00082	0.312
CLV_PCSK_SKI1_1	396	400	PF00082	0.439
CLV_PCSK_SKI1_1	429	433	PF00082	0.564
CLV_PCSK_SKI1_1	442	446	PF00082	0.291
CLV_PCSK_SKI1_1	471	475	PF00082	0.484
CLV_PCSK_SKI1_1	539	543	PF00082	0.535
CLV_PCSK_SKI1_1	99	103	PF00082	0.591
DEG_APCC_DBOX_1	391	399	PF00400	0.511
DEG_SPOP_SBC_1	277	281	PF00917	0.396
DOC_CYCLIN_RxL_1	471	479	PF00134	0.531
DOC_MAPK_DCC_7	475	485	PF00069	0.429
DOC_MAPK_gen_1	183	192	PF00069	0.491
DOC_MAPK_MEF2A_6	509	518	PF00069	0.462
DOC_USP7_MATH_1	265	269	PF00917	0.594
DOC_USP7_MATH_1	277	281	PF00917	0.530
DOC_USP7_MATH_1	36	40	PF00917	0.571
DOC_USP7_MATH_1	431	435	PF00917	0.543
DOC_USP7_MATH_1	504	508	PF00917	0.507
DOC_USP7_MATH_1	528	532	PF00917	0.744
DOC_USP7_MATH_1	543	547	PF00917	0.583
DOC_USP7_MATH_1	575	579	PF00917	0.484
DOC_USP7_MATH_1	82	86	PF00917	0.602
DOC_WW_Pin1_4	239	244	PF00397	0.777
DOC_WW_Pin1_4	246	251	PF00397	0.737
DOC_WW_Pin1_4	256	261	PF00397	0.499
DOC_WW_Pin1_4	308	313	PF00397	0.351
DOC_WW_Pin1_4	531	536	PF00397	0.710
DOC_WW_Pin1_4	8	13	PF00397	0.671
LIG_14-3-3_CanoR_1	167	173	PF00244	0.591
LIG_14-3-3_CanoR_1	195	200	PF00244	0.540
LIG_14-3-3_CanoR_1	442	449	PF00244	0.437
LIG_14-3-3_CanoR_1	509	516	PF00244	0.537
LIG_14-3-3_CanoR_1	68	78	PF00244	0.583
LIG_Actin_WH2_2	165	182	PF00022	0.557
LIG_Actin_WH2_2	19	37	PF00022	0.600
LIG_CaM_IQ_9	148	164	PF13499	0.554
LIG_DLG_GKlike_1	391	398	PF00625	0.507
LIG_FHA_1	146	152	PF00498	0.604
LIG_FHA_1	187	193	PF00498	0.467
LIG_FHA_1	358	364	PF00498	0.501
LIG_FHA_1	381	387	PF00498	0.473
LIG_FHA_1	44	50	PF00498	0.420
LIG_FHA_1	472	478	PF00498	0.560
LIG_FHA_1	508	514	PF00498	0.494
LIG_FHA_1	70	76	PF00498	0.510
LIG_FHA_2	169	175	PF00498	0.591
LIG_FHA_2	182	188	PF00498	0.519
LIG_FHA_2	196	202	PF00498	0.445
LIG_FHA_2	401	407	PF00498	0.410
LIG_FHA_2	422	428	PF00498	0.486
LIG_FHA_2	54	60	PF00498	0.576
LIG_FHA_2	87	93	PF00498	0.550
LIG_LIR_Gen_1	157	165	PF02991	0.458
LIG_LIR_Gen_1	42	52	PF02991	0.557
LIG_LIR_Nem_3	114	120	PF02991	0.455
LIG_LIR_Nem_3	157	161	PF02991	0.456
LIG_LIR_Nem_3	163	168	PF02991	0.462
LIG_LIR_Nem_3	39	44	PF02991	0.579
LIG_NRBOX	394	400	PF00104	0.501
LIG_Pex14_2	564	568	PF04695	0.494
LIG_SH2_CRK	117	121	PF00017	0.458
LIG_SH2_CRK	158	162	PF00017	0.455
LIG_SH2_CRK	165	169	PF00017	0.467
LIG_SH2_CRK	44	48	PF00017	0.555
LIG_SH2_STAP1	91	95	PF00017	0.403
LIG_SH2_STAT3	551	554	PF00017	0.580
LIG_SH2_STAT5	158	161	PF00017	0.546
LIG_SH2_STAT5	178	181	PF00017	0.604
LIG_SH2_STAT5	317	320	PF00017	0.501
LIG_SH2_STAT5	333	336	PF00017	0.392
LIG_SH2_STAT5	44	47	PF00017	0.557
LIG_SH3_3	6	12	PF00018	0.670
LIG_SUMO_SIM_anti_2	510	517	PF11976	0.458
LIG_SUMO_SIM_par_1	195	202	PF11976	0.432
LIG_SUMO_SIM_par_1	462	469	PF11976	0.478
LIG_SUMO_SIM_par_1	575	580	PF11976	0.473
LIG_TRAF2_1	125	128	PF00917	0.510
LIG_UBA3_1	132	139	PF00899	0.605
MOD_CK1_1	11	17	PF00069	0.639
MOD_CK1_1	249	255	PF00069	0.678
MOD_CK1_1	268	274	PF00069	0.563
MOD_CK1_1	319	325	PF00069	0.444
MOD_CK1_1	379	385	PF00069	0.330
MOD_CK1_1	394	400	PF00069	0.377
MOD_CK1_1	43	49	PF00069	0.592
MOD_CK1_1	507	513	PF00069	0.462
MOD_CK1_1	531	537	PF00069	0.662
MOD_CK1_1	546	552	PF00069	0.596
MOD_CK1_1	556	562	PF00069	0.590
MOD_CK1_1	69	75	PF00069	0.614
MOD_CK1_1	86	92	PF00069	0.486
MOD_CK2_1	168	174	PF00069	0.558
MOD_CK2_1	181	187	PF00069	0.525
MOD_CK2_1	86	92	PF00069	0.554
MOD_Cter_Amidation	291	294	PF01082	0.224
MOD_GlcNHglycan	297	300	PF01048	0.359
MOD_GlcNHglycan	370	373	PF01048	0.314
MOD_GlcNHglycan	415	418	PF01048	0.327
MOD_GlcNHglycan	433	436	PF01048	0.426
MOD_GlcNHglycan	449	452	PF01048	0.286
MOD_GlcNHglycan	498	501	PF01048	0.499
MOD_GlcNHglycan	506	509	PF01048	0.510
MOD_GlcNHglycan	530	533	PF01048	0.657
MOD_GlcNHglycan	555	558	PF01048	0.654
MOD_GSK3_1	239	246	PF00069	0.722
MOD_GSK3_1	249	256	PF00069	0.669
MOD_GSK3_1	268	275	PF00069	0.546
MOD_GSK3_1	36	43	PF00069	0.591
MOD_GSK3_1	376	383	PF00069	0.312
MOD_GSK3_1	427	434	PF00069	0.529
MOD_GSK3_1	492	499	PF00069	0.462
MOD_GSK3_1	504	511	PF00069	0.457
MOD_GSK3_1	526	533	PF00069	0.747
MOD_GSK3_1	543	550	PF00069	0.506
MOD_GSK3_1	82	89	PF00069	0.634
MOD_LATS_1	440	446	PF00433	0.421
MOD_N-GLC_1	546	551	PF02516	0.632
MOD_N-GLC_1	83	88	PF02516	0.604
MOD_NEK2_1	244	249	PF00069	0.689
MOD_NEK2_1	295	300	PF00069	0.345
MOD_NEK2_1	318	323	PF00069	0.469
MOD_NEK2_1	327	332	PF00069	0.344
MOD_NEK2_1	354	359	PF00069	0.382
MOD_NEK2_1	368	373	PF00069	0.275
MOD_NEK2_1	399	404	PF00069	0.410
MOD_NEK2_1	455	460	PF00069	0.420
MOD_NEK2_1	47	52	PF00069	0.503
MOD_NEK2_1	473	478	PF00069	0.353
MOD_NEK2_1	66	71	PF00069	0.623
MOD_NEK2_2	36	41	PF00069	0.570
MOD_NEK2_2	410	415	PF00069	0.443
MOD_PIKK_1	34	40	PF00454	0.544
MOD_PKA_1	391	397	PF00069	0.476
MOD_PKA_2	111	117	PF00069	0.506
MOD_PKA_2	168	174	PF00069	0.558
MOD_PKA_2	391	397	PF00069	0.477
MOD_PKA_2	427	433	PF00069	0.451
MOD_PKA_2	447	453	PF00069	0.494
MOD_PKA_2	492	498	PF00069	0.393
MOD_PKA_2	508	514	PF00069	0.430
MOD_PKA_2	69	75	PF00069	0.628
MOD_Plk_1	156	162	PF00069	0.542
MOD_Plk_1	186	192	PF00069	0.380
MOD_Plk_1	380	386	PF00069	0.312
MOD_Plk_1	405	411	PF00069	0.475
MOD_Plk_1	546	552	PF00069	0.518
MOD_Plk_1	66	72	PF00069	0.593
MOD_Plk_1	83	89	PF00069	0.497
MOD_Plk_4	268	274	PF00069	0.515
MOD_Plk_4	36	42	PF00069	0.544
MOD_Plk_4	410	416	PF00069	0.390
MOD_Plk_4	47	53	PF00069	0.516
MOD_Plk_4	473	479	PF00069	0.519
MOD_ProDKin_1	239	245	PF00069	0.779
MOD_ProDKin_1	246	252	PF00069	0.738
MOD_ProDKin_1	256	262	PF00069	0.495
MOD_ProDKin_1	308	314	PF00069	0.343
MOD_ProDKin_1	531	537	PF00069	0.693
MOD_ProDKin_1	8	14	PF00069	0.670
MOD_SUMO_for_1	214	217	PF00179	0.594
MOD_SUMO_rev_2	121	126	PF00179	0.460
MOD_SUMO_rev_2	176	185	PF00179	0.565
MOD_SUMO_rev_2	290	295	PF00179	0.387
TRG_DiLeu_BaEn_1	23	28	PF01217	0.596
TRG_DiLeu_BaEn_4	128	134	PF01217	0.450
TRG_ENDOCYTIC_2	117	120	PF00928	0.456
TRG_ENDOCYTIC_2	158	161	PF00928	0.434
TRG_ENDOCYTIC_2	165	168	PF00928	0.446
TRG_ENDOCYTIC_2	44	47	PF00928	0.544
TRG_ER_diArg_1	133	136	PF00400	0.363
TRG_ER_diArg_1	167	170	PF00400	0.563
TRG_ER_diArg_1	206	208	PF00400	0.549
TRG_ER_diArg_1	389	392	PF00400	0.477
TRG_ER_diArg_1	61	64	PF00400	0.574
TRG_ER_diArg_1	68	71	PF00400	0.572
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	396	401	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAK2	Leptomonas seymouri	68%	100%
A0A0S4IUZ3	Bodo saltans	24%	100%
A0A0S4JA64	Bodo saltans	21%	99%
A0A1X0NWL7	Trypanosomatidae	36%	100%
A0A3R7NP23	Trypanosoma rangeli	21%	99%
A0A3S7X6T5	Leishmania donovani	93%	100%
A0A422NYX2	Trypanosoma rangeli	35%	100%
A4HLK2	Leishmania braziliensis	81%	100%
A4I913	Leishmania infantum	93%	100%
D0A054	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
D0A7L8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B3X8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O15736	Dictyostelium discoideum	23%	96%
Q5RAC9	Pongo abelii	26%	97%
Q676U5	Homo sapiens	26%	97%
Q6NNP0	Arabidopsis thaliana	27%	100%
Q8C0J2	Mus musculus	25%	97%
V5BW76	Trypanosoma cruzi	39%	100%