LeishMANIAdb
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Amino acid permease-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Amino acid permease-like protein
Gene product:
amino acid permease-like protein
Species:
Leishmania major
UniProt:
Q4Q445_LEIMA
TriTrypDb:
LmjF.33.1420 , LMJLV39_330022700 * , LMJSD75_330022400
Length:
487

Annotations

LeishMANIAdb annotations

An enormously expanded group of various amino acid transporters.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 36
NetGPI no yes: 0, no: 36
Cellular components
Term Name Level Count
GO:0016020 membrane 2 32
GO:0110165 cellular anatomical entity 1 32

Expansion

Sequence features

Q4Q445
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q445

Function

Biological processes
Term Name Level Count
GO:0003333 amino acid transmembrane transport 5 7
GO:0006810 transport 3 7
GO:0006865 amino acid transport 5 7
GO:0009987 cellular process 1 7
GO:0015849 organic acid transport 5 7
GO:0051179 localization 1 7
GO:0051234 establishment of localization 2 7
GO:0055085 transmembrane transport 2 7
GO:0071702 organic substance transport 4 7
GO:0071705 nitrogen compound transport 4 7
GO:1903825 organic acid transmembrane transport 3 7
GO:1905039 carboxylic acid transmembrane transport 4 7
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 7
GO:0005342 organic acid transmembrane transporter activity 3 7
GO:0015171 amino acid transmembrane transporter activity 5 7
GO:0015179 L-amino acid transmembrane transporter activity 6 7
GO:0022857 transmembrane transporter activity 2 7
GO:0046943 carboxylic acid transmembrane transporter activity 4 7
GO:0003824 catalytic activity 1 9
GO:0016787 hydrolase activity 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 236 238 PF00675 0.238
CLV_PCSK_KEX2_1 236 238 PF00082 0.214
CLV_PCSK_SKI1_1 332 336 PF00082 0.182
CLV_PCSK_SKI1_1 80 84 PF00082 0.266
CLV_PCSK_SKI1_1 92 96 PF00082 0.291
CLV_Separin_Metazoa 89 93 PF03568 0.304
DEG_Nend_Nbox_1 1 3 PF02207 0.545
DEG_SCF_FBW7_1 128 134 PF00400 0.371
DEG_SPOP_SBC_1 162 166 PF00917 0.160
DOC_ANK_TNKS_1 175 182 PF00023 0.368
DOC_CDC14_PxL_1 146 154 PF14671 0.368
DOC_CKS1_1 128 133 PF01111 0.382
DOC_CYCLIN_yCln2_LP_2 113 119 PF00134 0.227
DOC_CYCLIN_yCln2_LP_2 210 216 PF00134 0.284
DOC_CYCLIN_yCln2_LP_2 264 270 PF00134 0.262
DOC_MAPK_gen_1 236 243 PF00069 0.413
DOC_MAPK_gen_1 336 346 PF00069 0.461
DOC_MAPK_MEF2A_6 206 214 PF00069 0.252
DOC_MAPK_MEF2A_6 236 245 PF00069 0.452
DOC_MAPK_MEF2A_6 339 348 PF00069 0.356
DOC_MAPK_MEF2A_6 394 403 PF00069 0.426
DOC_PP2B_LxvP_1 113 116 PF13499 0.326
DOC_PP2B_LxvP_1 210 213 PF13499 0.284
DOC_PP2B_LxvP_1 31 34 PF13499 0.282
DOC_PP2B_LxvP_1 412 415 PF13499 0.305
DOC_PP4_FxxP_1 142 145 PF00568 0.254
DOC_PP4_FxxP_1 434 437 PF00568 0.306
DOC_USP7_MATH_1 131 135 PF00917 0.357
DOC_USP7_MATH_1 162 166 PF00917 0.284
DOC_USP7_MATH_1 5 9 PF00917 0.498
DOC_WW_Pin1_4 127 132 PF00397 0.333
LIG_14-3-3_CanoR_1 236 240 PF00244 0.533
LIG_14-3-3_CanoR_1 451 456 PF00244 0.407
LIG_14-3-3_CanoR_1 72 76 PF00244 0.540
LIG_BRCT_BRCA1_1 164 168 PF00533 0.269
LIG_BRCT_BRCA1_1 222 226 PF00533 0.311
LIG_BRCT_BRCA1_1 330 334 PF00533 0.509
LIG_Clathr_ClatBox_1 107 111 PF01394 0.368
LIG_FHA_1 120 126 PF00498 0.340
LIG_FHA_1 164 170 PF00498 0.290
LIG_FHA_1 188 194 PF00498 0.294
LIG_FHA_1 249 255 PF00498 0.345
LIG_FHA_1 333 339 PF00498 0.512
LIG_FHA_1 403 409 PF00498 0.311
LIG_FHA_1 44 50 PF00498 0.334
LIG_FHA_1 77 83 PF00498 0.479
LIG_FHA_2 452 458 PF00498 0.391
LIG_GBD_Chelix_1 224 232 PF00786 0.368
LIG_IRF3_LxIS_1 152 158 PF10401 0.480
LIG_IRF3_LxIS_1 393 400 PF10401 0.489
LIG_LIR_Apic_2 431 437 PF02991 0.283
LIG_LIR_Gen_1 137 146 PF02991 0.348
LIG_LIR_Gen_1 158 168 PF02991 0.241
LIG_LIR_Gen_1 331 338 PF02991 0.481
LIG_LIR_Gen_1 59 70 PF02991 0.271
LIG_LIR_Gen_1 74 83 PF02991 0.462
LIG_LIR_Nem_3 137 142 PF02991 0.305
LIG_LIR_Nem_3 158 163 PF02991 0.271
LIG_LIR_Nem_3 165 171 PF02991 0.282
LIG_LIR_Nem_3 223 229 PF02991 0.282
LIG_LIR_Nem_3 331 337 PF02991 0.491
LIG_LIR_Nem_3 367 371 PF02991 0.435
LIG_LIR_Nem_3 454 458 PF02991 0.486
LIG_LIR_Nem_3 59 65 PF02991 0.295
LIG_LIR_Nem_3 74 78 PF02991 0.515
LIG_LYPXL_yS_3 207 210 PF13949 0.185
LIG_PCNA_PIPBox_1 118 127 PF02747 0.277
LIG_PCNA_yPIPBox_3 118 132 PF02747 0.309
LIG_Pex14_1 203 207 PF04695 0.173
LIG_Pex14_2 138 142 PF04695 0.264
LIG_SH2_CRK 293 297 PF00017 0.299
LIG_SH2_CRK 368 372 PF00017 0.369
LIG_SH2_NCK_1 319 323 PF00017 0.421
LIG_SH2_NCK_1 37 41 PF00017 0.302
LIG_SH2_PTP2 62 65 PF00017 0.202
LIG_SH2_SRC 124 127 PF00017 0.173
LIG_SH2_SRC 37 40 PF00017 0.301
LIG_SH2_STAT3 440 443 PF00017 0.505
LIG_SH2_STAT5 106 109 PF00017 0.310
LIG_SH2_STAT5 124 127 PF00017 0.278
LIG_SH2_STAT5 177 180 PF00017 0.245
LIG_SH2_STAT5 263 266 PF00017 0.294
LIG_SH2_STAT5 290 293 PF00017 0.331
LIG_SH2_STAT5 62 65 PF00017 0.370
LIG_SH3_3 113 119 PF00018 0.253
LIG_SH3_3 176 182 PF00018 0.266
LIG_SUMO_SIM_anti_2 341 348 PF11976 0.505
LIG_SUMO_SIM_anti_2 419 425 PF11976 0.320
LIG_SUMO_SIM_anti_2 457 462 PF11976 0.494
LIG_SUMO_SIM_anti_2 46 51 PF11976 0.357
LIG_SUMO_SIM_par_1 106 112 PF11976 0.294
LIG_SUMO_SIM_par_1 265 272 PF11976 0.182
LIG_SUMO_SIM_par_1 29 35 PF11976 0.340
LIG_SUMO_SIM_par_1 397 402 PF11976 0.223
LIG_SUMO_SIM_par_1 416 422 PF11976 0.186
LIG_SUMO_SIM_par_1 53 59 PF11976 0.296
LIG_TRAF2_1 74 77 PF00917 0.445
LIG_TYR_ITIM 104 109 PF00017 0.287
LIG_TYR_ITIM 60 65 PF00017 0.271
LIG_Vh1_VBS_1 239 257 PF01044 0.373
LIG_WRC_WIRS_1 135 140 PF05994 0.267
LIG_WRC_WIRS_1 157 162 PF05994 0.371
LIG_WRC_WIRS_1 216 221 PF05994 0.278
MOD_CDK_SPK_2 127 132 PF00069 0.305
MOD_CK1_1 134 140 PF00069 0.196
MOD_CK1_1 164 170 PF00069 0.318
MOD_CK1_1 186 192 PF00069 0.235
MOD_CK1_1 320 326 PF00069 0.437
MOD_CK1_1 364 370 PF00069 0.454
MOD_CK1_1 419 425 PF00069 0.353
MOD_CK1_1 8 14 PF00069 0.597
MOD_CK2_1 367 373 PF00069 0.478
MOD_CK2_1 451 457 PF00069 0.496
MOD_CK2_1 71 77 PF00069 0.441
MOD_Cter_Amidation 83 86 PF01082 0.258
MOD_GlcNHglycan 10 13 PF01048 0.348
MOD_GlcNHglycan 101 104 PF01048 0.251
MOD_GlcNHglycan 184 188 PF01048 0.485
MOD_GlcNHglycan 198 201 PF01048 0.430
MOD_GlcNHglycan 320 323 PF01048 0.240
MOD_GlcNHglycan 34 37 PF01048 0.377
MOD_GlcNHglycan 351 354 PF01048 0.291
MOD_GSK3_1 127 134 PF00069 0.222
MOD_GSK3_1 144 151 PF00069 0.321
MOD_GSK3_1 17 24 PF00069 0.303
MOD_GSK3_1 183 190 PF00069 0.336
MOD_GSK3_1 244 251 PF00069 0.287
MOD_GSK3_1 328 335 PF00069 0.514
MOD_GSK3_1 397 404 PF00069 0.275
MOD_N-GLC_1 194 199 PF02516 0.425
MOD_N-GLC_2 357 359 PF02516 0.160
MOD_NEK2_1 155 160 PF00069 0.436
MOD_NEK2_1 161 166 PF00069 0.282
MOD_NEK2_1 21 26 PF00069 0.307
MOD_NEK2_1 235 240 PF00069 0.551
MOD_NEK2_1 248 253 PF00069 0.348
MOD_NEK2_1 291 296 PF00069 0.355
MOD_NEK2_1 397 402 PF00069 0.294
MOD_NEK2_1 427 432 PF00069 0.301
MOD_NEK2_1 7 12 PF00069 0.700
MOD_NEK2_2 53 58 PF00069 0.360
MOD_PKA_2 235 241 PF00069 0.508
MOD_PKA_2 308 314 PF00069 0.491
MOD_PKA_2 71 77 PF00069 0.514
MOD_Plk_1 183 189 PF00069 0.292
MOD_Plk_1 332 338 PF00069 0.540
MOD_Plk_4 10 16 PF00069 0.503
MOD_Plk_4 131 137 PF00069 0.267
MOD_Plk_4 156 162 PF00069 0.427
MOD_Plk_4 164 170 PF00069 0.281
MOD_Plk_4 220 226 PF00069 0.308
MOD_Plk_4 308 314 PF00069 0.493
MOD_Plk_4 416 422 PF00069 0.263
MOD_Plk_4 43 49 PF00069 0.322
MOD_Plk_4 451 457 PF00069 0.511
MOD_Plk_4 53 59 PF00069 0.301
MOD_ProDKin_1 127 133 PF00069 0.333
MOD_SUMO_for_1 371 374 PF00179 0.373
TRG_DiLeu_BaEn_1 342 347 PF01217 0.505
TRG_DiLeu_BaLyEn_6 205 210 PF01217 0.222
TRG_ENDOCYTIC_2 106 109 PF00928 0.302
TRG_ENDOCYTIC_2 207 210 PF00928 0.469
TRG_ENDOCYTIC_2 229 232 PF00928 0.451
TRG_ENDOCYTIC_2 368 371 PF00928 0.496
TRG_ENDOCYTIC_2 62 65 PF00928 0.293
TRG_ENDOCYTIC_2 75 78 PF00928 0.453
TRG_ER_diArg_1 235 237 PF00400 0.516

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5D2 Leptomonas seymouri 25% 100%
A0A0N0P613 Leptomonas seymouri 44% 100%
A0A0N1I3H4 Leptomonas seymouri 24% 89%
A0A0N1IAJ0 Leptomonas seymouri 29% 100%
A0A0N1IJ81 Leptomonas seymouri 76% 100%
A0A0N1PA98 Leptomonas seymouri 20% 79%
A0A0S4IV32 Bodo saltans 30% 99%
A0A0S4JQ87 Bodo saltans 26% 100%
A0A1X0P1N2 Trypanosomatidae 48% 100%
A0A1X0P4S1 Trypanosomatidae 39% 100%
A0A3Q8ID74 Leishmania donovani 23% 91%
A0A3Q8IHH7 Leishmania donovani 95% 100%
A0A3R7MWF1 Trypanosoma rangeli 50% 100%
A0A3S7X443 Leishmania donovani 26% 100%
A0A3S7XA86 Leishmania donovani 37% 100%
A0A3S7XCE3 Leishmania donovani 27% 100%
A1YG32 Pan paniscus 25% 96%
A2VE31 Bos taurus 24% 96%
A4HFT5 Leishmania braziliensis 27% 100%
A4HJ35 Leishmania braziliensis 26% 100%
A4HJF8 Leishmania braziliensis 21% 79%
A4HJF9 Leishmania braziliensis 21% 83%
A4HJG1 Leishmania braziliensis 21% 83%
A4HJG3 Leishmania braziliensis 22% 79%
A4HJG5 Leishmania braziliensis 22% 79%
A4HLK3 Leishmania braziliensis 84% 100%
A4HNJ6 Leishmania braziliensis 39% 100%
A4HNJ7 Leishmania braziliensis 44% 100%
A4I6J8 Leishmania infantum 23% 91%
A4I6J9 Leishmania infantum 26% 100%
A4I914 Leishmania infantum 95% 100%
A4IC53 Leishmania infantum 37% 100%
A4IC66 Leishmania infantum 38% 100%
A4ICC3 Leishmania infantum 26% 100%
C9ZMB9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
C9ZWR7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E8NHF9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E8NHS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 20% 84%
E9AD45 Leishmania major 23% 91%
E9ADD7 Leishmania major 26% 100%
E9AG08 Leishmania major 36% 87%
E9AG09 Leishmania major 38% 87%
E9AHD9 Leishmania infantum 23% 91%
E9AHL2 Leishmania infantum 21% 100%
E9AUB8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AZ62 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B1I4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B1Y0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 21% 80%
E9B3X9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9B761 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9B762 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
F4KBM7 Arabidopsis thaliana 23% 100%
G3UVW3 Mus musculus 24% 100%
P38176 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22% 100%
P40074 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 100%
P40501 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 99%
Q28HE5 Xenopus tropicalis 26% 100%
Q4Q072 Leishmania major 26% 100%
Q4Q6M9 Leishmania major 27% 100%
Q4Q6N1 Leishmania major 22% 91%
Q503G8 Danio rerio 25% 100%
Q5E9S9 Bos taurus 23% 100%
Q5F468 Gallus gallus 24% 97%
Q5R9F5 Pongo abelii 22% 100%
Q5SPB1 Danio rerio 25% 97%
Q6DEL1 Danio rerio 22% 100%
Q6DFE7 Xenopus laevis 22% 100%
Q6JWR2 Rattus norvegicus 22% 100%
Q6WWW3 Rattus norvegicus 24% 100%
Q8BWH0 Mus musculus 23% 100%
Q8CFE6 Mus musculus 25% 97%
Q8R1S9 Mus musculus 23% 89%
Q8WUX1 Homo sapiens 23% 100%
Q96QD8 Homo sapiens 25% 96%
Q99624 Homo sapiens 23% 97%
Q9DCP2 Mus musculus 25% 96%
Q9JHE5 Rattus norvegicus 26% 97%
Q9JHZ9 Rattus norvegicus 25% 97%
Q9LI61 Arabidopsis thaliana 22% 100%
Q9LYM2 Arabidopsis thaliana 24% 100%
Q9M8L9 Arabidopsis thaliana 21% 100%
Q9NVC3 Homo sapiens 22% 100%
V5AXD0 Trypanosoma cruzi 50% 100%
V5BQ72 Trypanosoma cruzi 23% 87%
V5BTX5 Trypanosoma cruzi 40% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS