Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q444_LEIMA

TriTrypDb:

LmjF.33.1430 , LMJLV39_330022800 , LMJSD75_330022500

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q444

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q444

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	24	26	PF00675	0.726
CLV_NRD_NRD_1	284	286	PF00675	0.600
CLV_NRD_NRD_1	299	301	PF00675	0.610
CLV_NRD_NRD_1	314	316	PF00675	0.603
CLV_NRD_NRD_1	463	465	PF00675	0.609
CLV_NRD_NRD_1	5	7	PF00675	0.769
CLV_PCSK_FUR_1	3	7	PF00082	0.767
CLV_PCSK_FUR_1	74	78	PF00082	0.597
CLV_PCSK_KEX2_1	231	233	PF00082	0.676
CLV_PCSK_KEX2_1	24	26	PF00082	0.726
CLV_PCSK_KEX2_1	299	301	PF00082	0.670
CLV_PCSK_KEX2_1	314	316	PF00082	0.603
CLV_PCSK_KEX2_1	463	465	PF00082	0.600
CLV_PCSK_KEX2_1	5	7	PF00082	0.769
CLV_PCSK_KEX2_1	76	78	PF00082	0.590
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.641
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.598
CLV_PCSK_SKI1_1	203	207	PF00082	0.607
DEG_Nend_Nbox_1	1	3	PF02207	0.616
DEG_SCF_FBW7_2	331	337	PF00400	0.733
DEG_SPOP_SBC_1	224	228	PF00917	0.733
DEG_SPOP_SBC_1	82	86	PF00917	0.622
DOC_CDC14_PxL_1	260	268	PF14671	0.510
DOC_CDC14_PxL_1	554	562	PF14671	0.511
DOC_CKS1_1	331	336	PF01111	0.724
DOC_CKS1_1	446	451	PF01111	0.549
DOC_MAPK_DCC_7	511	519	PF00069	0.651
DOC_PP2B_LxvP_1	358	361	PF13499	0.731
DOC_PP4_FxxP_1	180	183	PF00568	0.643
DOC_USP7_MATH_1	155	159	PF00917	0.640
DOC_USP7_MATH_1	224	228	PF00917	0.682
DOC_USP7_MATH_1	429	433	PF00917	0.734
DOC_USP7_MATH_1	447	451	PF00917	0.510
DOC_USP7_MATH_1	83	87	PF00917	0.715
DOC_WW_Pin1_4	120	125	PF00397	0.745
DOC_WW_Pin1_4	187	192	PF00397	0.547
DOC_WW_Pin1_4	205	210	PF00397	0.385
DOC_WW_Pin1_4	330	335	PF00397	0.640
DOC_WW_Pin1_4	339	344	PF00397	0.819
DOC_WW_Pin1_4	385	390	PF00397	0.622
DOC_WW_Pin1_4	445	450	PF00397	0.706
DOC_WW_Pin1_4	453	458	PF00397	0.507
LIG_14-3-3_CanoR_1	171	181	PF00244	0.689
LIG_14-3-3_CanoR_1	299	303	PF00244	0.590
LIG_14-3-3_CanoR_1	408	417	PF00244	0.521
LIG_14-3-3_CanoR_1	44	49	PF00244	0.711
LIG_14-3-3_CanoR_1	540	545	PF00244	0.535
LIG_BIR_III_4	102	106	PF00653	0.614
LIG_BRCT_BRCA1_1	189	193	PF00533	0.525
LIG_deltaCOP1_diTrp_1	194	202	PF00928	0.510
LIG_FHA_1	187	193	PF00498	0.674
LIG_FHA_1	220	226	PF00498	0.713
LIG_FHA_1	268	274	PF00498	0.543
LIG_FHA_1	456	462	PF00498	0.747
LIG_FHA_1	572	578	PF00498	0.637
LIG_FHA_2	316	322	PF00498	0.654
LIG_FHA_2	344	350	PF00498	0.693
LIG_FHA_2	354	360	PF00498	0.738
LIG_FHA_2	497	503	PF00498	0.470
LIG_Integrin_RGD_1	487	489	PF01839	0.521
LIG_LIR_Gen_1	257	267	PF02991	0.551
LIG_LIR_Gen_1	362	371	PF02991	0.646
LIG_LIR_Gen_1	479	486	PF02991	0.457
LIG_LIR_LC3C_4	33	37	PF02991	0.486
LIG_LIR_Nem_3	257	263	PF02991	0.531
LIG_LIR_Nem_3	362	366	PF02991	0.787
LIG_LIR_Nem_3	479	484	PF02991	0.456
LIG_LIR_Nem_3	503	509	PF02991	0.453
LIG_LIR_Nem_3	556	560	PF02991	0.496
LIG_LYPXL_yS_3	557	560	PF13949	0.499
LIG_Pex14_2	559	563	PF04695	0.532
LIG_SH2_CRK	106	110	PF00017	0.577
LIG_SH2_CRK	181	185	PF00017	0.539
LIG_SH2_CRK	260	264	PF00017	0.548
LIG_SH2_CRK	481	485	PF00017	0.465
LIG_SH2_CRK	555	559	PF00017	0.652
LIG_SH2_PTP2	419	422	PF00017	0.570
LIG_SH2_SRC	419	422	PF00017	0.707
LIG_SH2_SRC	555	558	PF00017	0.549
LIG_SH2_STAP1	481	485	PF00017	0.465
LIG_SH2_STAT5	419	422	PF00017	0.570
LIG_SH3_3	149	155	PF00018	0.585
LIG_SH3_3	218	224	PF00018	0.727
LIG_SH3_3	386	392	PF00018	0.649
LIG_SH3_3	451	457	PF00018	0.702
LIG_SUMO_SIM_par_1	356	362	PF11976	0.807
LIG_SUMO_SIM_par_1	473	479	PF11976	0.446
LIG_TRFH_1	260	264	PF08558	0.526
LIG_TRFH_1	265	269	PF08558	0.522
LIG_TYR_ITIM	417	422	PF00017	0.710
LIG_WRC_WIRS_1	360	365	PF05994	0.786
LIG_WRC_WIRS_1	50	55	PF05994	0.669
LIG_WW_1	178	181	PF00397	0.576
MOD_CK1_1	120	126	PF00069	0.752
MOD_CK1_1	172	178	PF00069	0.749
MOD_CK1_1	30	36	PF00069	0.560
MOD_CK1_1	425	431	PF00069	0.674
MOD_CK1_1	434	440	PF00069	0.615
MOD_CK1_1	455	461	PF00069	0.600
MOD_CK1_1	49	55	PF00069	0.755
MOD_CK1_1	539	545	PF00069	0.597
MOD_CK2_1	120	126	PF00069	0.675
MOD_CK2_1	224	230	PF00069	0.729
MOD_CK2_1	298	304	PF00069	0.531
MOD_CK2_1	315	321	PF00069	0.752
MOD_GlcNHglycan	11	14	PF01048	0.728
MOD_GlcNHglycan	167	170	PF01048	0.680
MOD_GlcNHglycan	171	174	PF01048	0.752
MOD_GlcNHglycan	20	23	PF01048	0.571
MOD_GlcNHglycan	227	230	PF01048	0.819
MOD_GlcNHglycan	32	35	PF01048	0.605
MOD_GlcNHglycan	410	413	PF01048	0.642
MOD_GlcNHglycan	426	430	PF01048	0.556
MOD_GlcNHglycan	492	495	PF01048	0.461
MOD_GlcNHglycan	78	81	PF01048	0.821
MOD_GSK3_1	116	123	PF00069	0.752
MOD_GSK3_1	165	172	PF00069	0.692
MOD_GSK3_1	210	217	PF00069	0.670
MOD_GSK3_1	219	226	PF00069	0.690
MOD_GSK3_1	317	324	PF00069	0.711
MOD_GSK3_1	339	346	PF00069	0.660
MOD_GSK3_1	425	432	PF00069	0.688
MOD_GSK3_1	441	448	PF00069	0.520
MOD_GSK3_1	455	462	PF00069	0.694
MOD_GSK3_1	496	503	PF00069	0.473
MOD_GSK3_1	536	543	PF00069	0.648
MOD_GSK3_1	83	90	PF00069	0.630
MOD_N-GLC_1	540	545	PF02516	0.535
MOD_N-GLC_2	293	295	PF02516	0.490
MOD_NEK2_1	219	224	PF00069	0.728
MOD_NEK2_1	253	258	PF00069	0.673
MOD_NEK2_1	280	285	PF00069	0.704
MOD_NEK2_1	298	303	PF00069	0.473
MOD_NEK2_1	310	315	PF00069	0.618
MOD_NEK2_1	338	343	PF00069	0.726
MOD_NEK2_1	436	441	PF00069	0.648
MOD_NEK2_1	490	495	PF00069	0.474
MOD_NEK2_1	500	505	PF00069	0.491
MOD_PIKK_1	254	260	PF00454	0.641
MOD_PIKK_1	273	279	PF00454	0.423
MOD_PIKK_1	434	440	PF00454	0.659
MOD_PK_1	325	331	PF00069	0.657
MOD_PKA_1	61	67	PF00069	0.597
MOD_PKA_1	76	82	PF00069	0.599
MOD_PKA_2	298	304	PF00069	0.580
MOD_PKA_2	407	413	PF00069	0.526
MOD_PKA_2	539	545	PF00069	0.597
MOD_PKA_2	76	82	PF00069	0.641
MOD_Plk_1	147	153	PF00069	0.628
MOD_Plk_1	254	260	PF00069	0.606
MOD_Plk_1	540	546	PF00069	0.538
MOD_Plk_2-3	393	399	PF00069	0.781
MOD_Plk_4	353	359	PF00069	0.640
MOD_Plk_4	431	437	PF00069	0.652
MOD_Plk_4	502	508	PF00069	0.391
MOD_Plk_4	540	546	PF00069	0.605
MOD_ProDKin_1	120	126	PF00069	0.747
MOD_ProDKin_1	187	193	PF00069	0.541
MOD_ProDKin_1	205	211	PF00069	0.400
MOD_ProDKin_1	330	336	PF00069	0.645
MOD_ProDKin_1	339	345	PF00069	0.819
MOD_ProDKin_1	385	391	PF00069	0.622
MOD_ProDKin_1	445	451	PF00069	0.706
MOD_ProDKin_1	453	459	PF00069	0.507
MOD_SUMO_rev_2	56	63	PF00179	0.779
TRG_ENDOCYTIC_2	181	184	PF00928	0.546
TRG_ENDOCYTIC_2	260	263	PF00928	0.519
TRG_ENDOCYTIC_2	419	422	PF00928	0.570
TRG_ENDOCYTIC_2	481	484	PF00928	0.467
TRG_ENDOCYTIC_2	557	560	PF00928	0.499
TRG_ER_diArg_1	2	5	PF00400	0.770
TRG_ER_diArg_1	23	25	PF00400	0.564
TRG_ER_diArg_1	298	300	PF00400	0.677
TRG_ER_diArg_1	511	514	PF00400	0.519
TRG_Pf-PMV_PEXEL_1	197	201	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.717

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4L4	Leptomonas seymouri	40%	100%
A0A3Q8IEV6	Leishmania donovani	88%	100%
A4HLK4	Leishmania braziliensis	66%	100%
A4I915	Leishmania infantum	88%	96%
E9B3Y0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%