RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q443_LEIMA

TriTrypDb:

LmjF.33.1440 , LMJLV39_330022900 , LMJSD75_330022600

Length:

682

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q443

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q443

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.719
CLV_C14_Caspase3-7	383	387	PF00656	0.735
CLV_C14_Caspase3-7	631	635	PF00656	0.632
CLV_NRD_NRD_1	517	519	PF00675	0.595
CLV_NRD_NRD_1	534	536	PF00675	0.678
CLV_NRD_NRD_1	595	597	PF00675	0.743
CLV_PCSK_KEX2_1	517	519	PF00082	0.605
CLV_PCSK_KEX2_1	534	536	PF00082	0.678
CLV_PCSK_KEX2_1	80	82	PF00082	0.678
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.678
CLV_PCSK_PC7_1	530	536	PF00082	0.709
CLV_PCSK_SKI1_1	261	265	PF00082	0.690
CLV_PCSK_SKI1_1	524	528	PF00082	0.789
CLV_PCSK_SKI1_1	539	543	PF00082	0.526
DEG_APCC_DBOX_1	164	172	PF00400	0.576
DEG_Nend_Nbox_1	1	3	PF02207	0.707
DEG_SPOP_SBC_1	235	239	PF00917	0.732
DOC_CKS1_1	11	16	PF01111	0.701
DOC_CKS1_1	353	358	PF01111	0.722
DOC_CKS1_1	413	418	PF01111	0.654
DOC_CYCLIN_yCln2_LP_2	219	225	PF00134	0.695
DOC_MAPK_DCC_7	665	674	PF00069	0.558
DOC_MAPK_gen_1	534	544	PF00069	0.477
DOC_MAPK_MEF2A_6	665	674	PF00069	0.558
DOC_PP1_RVXF_1	537	544	PF00149	0.615
DOC_PP2B_LxvP_1	219	222	PF13499	0.612
DOC_USP7_MATH_1	175	179	PF00917	0.735
DOC_USP7_MATH_1	235	239	PF00917	0.732
DOC_USP7_MATH_1	256	260	PF00917	0.651
DOC_USP7_MATH_1	290	294	PF00917	0.743
DOC_USP7_MATH_1	298	302	PF00917	0.715
DOC_USP7_MATH_1	327	331	PF00917	0.704
DOC_USP7_MATH_1	35	39	PF00917	0.710
DOC_USP7_MATH_1	397	401	PF00917	0.748
DOC_USP7_MATH_1	431	435	PF00917	0.588
DOC_USP7_MATH_1	480	484	PF00917	0.786
DOC_USP7_MATH_1	554	558	PF00917	0.635
DOC_USP7_UBL2_3	573	577	PF12436	0.635
DOC_WW_Pin1_4	10	15	PF00397	0.695
DOC_WW_Pin1_4	134	139	PF00397	0.780
DOC_WW_Pin1_4	171	176	PF00397	0.710
DOC_WW_Pin1_4	221	226	PF00397	0.715
DOC_WW_Pin1_4	242	247	PF00397	0.745
DOC_WW_Pin1_4	318	323	PF00397	0.697
DOC_WW_Pin1_4	352	357	PF00397	0.719
DOC_WW_Pin1_4	412	417	PF00397	0.685
LIG_14-3-3_CanoR_1	216	220	PF00244	0.674
LIG_14-3-3_CanoR_1	233	241	PF00244	0.503
LIG_14-3-3_CanoR_1	302	308	PF00244	0.608
LIG_14-3-3_CanoR_1	517	526	PF00244	0.776
LIG_14-3-3_CanoR_1	59	64	PF00244	0.599
LIG_14-3-3_CanoR_1	81	91	PF00244	0.681
LIG_BRCT_BRCA1_1	556	560	PF00533	0.635
LIG_FHA_1	121	127	PF00498	0.761
LIG_FHA_1	216	222	PF00498	0.749
LIG_FHA_1	304	310	PF00498	0.709
LIG_FHA_1	326	332	PF00498	0.623
LIG_FHA_1	340	346	PF00498	0.633
LIG_FHA_1	370	376	PF00498	0.812
LIG_FHA_1	527	533	PF00498	0.678
LIG_FHA_1	645	651	PF00498	0.443
LIG_FHA_2	550	556	PF00498	0.521
LIG_FHA_2	606	612	PF00498	0.438
LIG_LIR_Apic_2	483	489	PF02991	0.745
LIG_LIR_Apic_2	561	566	PF02991	0.635
LIG_LIR_Gen_1	128	136	PF02991	0.595
LIG_LIR_Gen_1	153	164	PF02991	0.591
LIG_LIR_Gen_1	305	314	PF02991	0.737
LIG_LIR_Gen_1	371	378	PF02991	0.589
LIG_LIR_Gen_1	636	643	PF02991	0.562
LIG_LIR_Gen_1	85	96	PF02991	0.738
LIG_LIR_Nem_3	128	132	PF02991	0.592
LIG_LIR_Nem_3	153	159	PF02991	0.602
LIG_LIR_Nem_3	266	271	PF02991	0.668
LIG_LIR_Nem_3	371	377	PF02991	0.589
LIG_LIR_Nem_3	557	563	PF02991	0.524
LIG_LIR_Nem_3	601	606	PF02991	0.437
LIG_LIR_Nem_3	636	641	PF02991	0.586
LIG_LIR_Nem_3	85	91	PF02991	0.746
LIG_MYND_1	23	27	PF01753	0.700
LIG_PCNA_PIPBox_1	404	413	PF02747	0.651
LIG_PCNA_yPIPBox_3	401	411	PF02747	0.641
LIG_Pex14_2	87	91	PF04695	0.745
LIG_PTB_Apo_2	262	269	PF02174	0.565
LIG_PTB_Apo_2	632	639	PF02174	0.554
LIG_PTB_Phospho_1	262	268	PF10480	0.569
LIG_PTB_Phospho_1	632	638	PF10480	0.567
LIG_SH2_CRK	563	567	PF00017	0.635
LIG_SH2_NCK_1	129	133	PF00017	0.593
LIG_SH2_SRC	129	132	PF00017	0.594
LIG_SH2_SRC	374	377	PF00017	0.819
LIG_SH2_SRC	63	66	PF00017	0.613
LIG_SH2_STAP1	271	275	PF00017	0.724
LIG_SH2_STAT3	410	413	PF00017	0.776
LIG_SH2_STAT3	497	500	PF00017	0.716
LIG_SH2_STAT3	643	646	PF00017	0.595
LIG_SH2_STAT5	291	294	PF00017	0.716
LIG_SH2_STAT5	374	377	PF00017	0.819
LIG_SH2_STAT5	411	414	PF00017	0.693
LIG_SH2_STAT5	528	531	PF00017	0.560
LIG_SH2_STAT5	638	641	PF00017	0.539
LIG_SH3_3	169	175	PF00018	0.755
LIG_SH3_3	20	26	PF00018	0.616
LIG_SH3_3	219	225	PF00018	0.613
LIG_SH3_3	278	284	PF00018	0.739
LIG_SH3_3	308	314	PF00018	0.739
LIG_SH3_3	316	322	PF00018	0.656
LIG_SH3_3	350	356	PF00018	0.679
LIG_SH3_3	400	406	PF00018	0.679
LIG_SH3_3	5	11	PF00018	0.785
LIG_SH3_3	663	669	PF00018	0.518
LIG_SUMO_SIM_anti_2	330	335	PF11976	0.735
LIG_SUMO_SIM_anti_2	568	574	PF11976	0.635
LIG_SUMO_SIM_par_1	568	574	PF11976	0.521
LIG_SUMO_SIM_par_1	670	676	PF11976	0.476
LIG_SxIP_EBH_1	389	402	PF03271	0.743
LIG_TRAF2_1	147	150	PF00917	0.688
LIG_TRAF2_1	76	79	PF00917	0.760
LIG_TRFH_1	410	414	PF08558	0.773
LIG_TYR_ITSM	370	377	PF00017	0.586
MOD_CDK_SPxxK_3	10	17	PF00069	0.702
MOD_CK1_1	182	188	PF00069	0.782
MOD_CK1_1	208	214	PF00069	0.737
MOD_CK1_1	239	245	PF00069	0.579
MOD_CK1_1	300	306	PF00069	0.737
MOD_CK1_1	366	372	PF00069	0.787
MOD_CK1_1	388	394	PF00069	0.736
MOD_CK1_1	462	468	PF00069	0.730
MOD_CK1_1	469	475	PF00069	0.734
MOD_CK1_1	591	597	PF00069	0.697
MOD_CK2_1	605	611	PF00069	0.442
MOD_CK2_1	661	667	PF00069	0.584
MOD_GlcNHglycan	100	103	PF01048	0.802
MOD_GlcNHglycan	134	137	PF01048	0.744
MOD_GlcNHglycan	181	184	PF01048	0.647
MOD_GlcNHglycan	207	210	PF01048	0.791
MOD_GlcNHglycan	27	30	PF01048	0.693
MOD_GlcNHglycan	274	278	PF01048	0.801
MOD_GlcNHglycan	292	295	PF01048	0.506
MOD_GlcNHglycan	315	318	PF01048	0.746
MOD_GlcNHglycan	348	351	PF01048	0.600
MOD_GlcNHglycan	367	371	PF01048	0.701
MOD_GlcNHglycan	482	485	PF01048	0.715
MOD_GlcNHglycan	520	523	PF01048	0.759
MOD_GlcNHglycan	590	593	PF01048	0.667
MOD_GlcNHglycan	600	603	PF01048	0.371
MOD_GlcNHglycan	65	68	PF01048	0.737
MOD_GlcNHglycan	650	653	PF01048	0.487
MOD_GSK3_1	121	128	PF00069	0.735
MOD_GSK3_1	151	158	PF00069	0.727
MOD_GSK3_1	171	178	PF00069	0.579
MOD_GSK3_1	207	214	PF00069	0.814
MOD_GSK3_1	21	28	PF00069	0.748
MOD_GSK3_1	235	242	PF00069	0.714
MOD_GSK3_1	250	257	PF00069	0.652
MOD_GSK3_1	269	276	PF00069	0.504
MOD_GSK3_1	298	305	PF00069	0.656
MOD_GSK3_1	388	395	PF00069	0.738
MOD_GSK3_1	431	438	PF00069	0.739
MOD_GSK3_1	458	465	PF00069	0.651
MOD_GSK3_1	53	60	PF00069	0.690
MOD_GSK3_1	554	561	PF00069	0.625
MOD_GSK3_1	598	605	PF00069	0.454
MOD_GSK3_1	644	651	PF00069	0.439
MOD_GSK3_1	82	89	PF00069	0.825
MOD_GSK3_1	98	105	PF00069	0.562
MOD_LATS_1	203	209	PF00433	0.742
MOD_N-GLC_1	179	184	PF02516	0.830
MOD_N-GLC_1	264	269	PF02516	0.564
MOD_N-GLC_1	441	446	PF02516	0.726
MOD_N-GLC_1	447	452	PF02516	0.665
MOD_N-GLC_1	46	51	PF02516	0.613
MOD_N-GLC_1	53	58	PF02516	0.559
MOD_NEK2_1	121	126	PF00069	0.742
MOD_NEK2_1	142	147	PF00069	0.772
MOD_NEK2_1	176	181	PF00069	0.747
MOD_NEK2_1	254	259	PF00069	0.727
MOD_NEK2_1	263	268	PF00069	0.603
MOD_NEK2_1	4	9	PF00069	0.647
MOD_NEK2_1	53	58	PF00069	0.577
MOD_NEK2_1	639	644	PF00069	0.574
MOD_NEK2_1	661	666	PF00069	0.551
MOD_NEK2_1	87	92	PF00069	0.738
MOD_NEK2_2	102	107	PF00069	0.729
MOD_NEK2_2	256	261	PF00069	0.621
MOD_NEK2_2	431	436	PF00069	0.590
MOD_PIKK_1	182	188	PF00454	0.799
MOD_PIKK_1	300	306	PF00454	0.792
MOD_PIKK_1	53	59	PF00454	0.570
MOD_PIKK_1	554	560	PF00454	0.635
MOD_PIKK_1	82	88	PF00454	0.600
MOD_PK_1	565	571	PF00069	0.635
MOD_PKA_2	215	221	PF00069	0.694
MOD_PKA_2	339	345	PF00069	0.768
MOD_Plk_1	264	270	PF00069	0.565
MOD_Plk_1	441	447	PF00069	0.685
MOD_Plk_1	46	52	PF00069	0.612
MOD_Plk_1	554	560	PF00069	0.635
MOD_Plk_2-3	493	499	PF00069	0.711
MOD_Plk_4	121	127	PF00069	0.736
MOD_Plk_4	152	158	PF00069	0.587
MOD_Plk_4	236	242	PF00069	0.741
MOD_Plk_4	250	256	PF00069	0.642
MOD_Plk_4	305	311	PF00069	0.792
MOD_Plk_4	327	333	PF00069	0.737
MOD_Plk_4	35	41	PF00069	0.808
MOD_Plk_4	459	465	PF00069	0.788
MOD_Plk_4	46	52	PF00069	0.616
MOD_Plk_4	565	571	PF00069	0.635
MOD_ProDKin_1	10	16	PF00069	0.700
MOD_ProDKin_1	134	140	PF00069	0.779
MOD_ProDKin_1	171	177	PF00069	0.713
MOD_ProDKin_1	221	227	PF00069	0.717
MOD_ProDKin_1	242	248	PF00069	0.745
MOD_ProDKin_1	318	324	PF00069	0.697
MOD_ProDKin_1	352	358	PF00069	0.721
MOD_ProDKin_1	412	418	PF00069	0.684
TRG_DiLeu_BaLyEn_6	668	673	PF01217	0.546
TRG_ENDOCYTIC_2	129	132	PF00928	0.594
TRG_ENDOCYTIC_2	173	176	PF00928	0.801
TRG_ENDOCYTIC_2	2	5	PF00928	0.704
TRG_ENDOCYTIC_2	307	310	PF00928	0.766
TRG_ENDOCYTIC_2	374	377	PF00928	0.601
TRG_ENDOCYTIC_2	638	641	PF00928	0.559
TRG_ENDOCYTIC_2	88	91	PF00928	0.746
TRG_ER_diArg_1	517	519	PF00400	0.595
TRG_ER_diArg_1	533	535	PF00400	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6N3	Leishmania donovani	86%	100%
A4HLK5	Leishmania braziliensis	58%	100%
A4I916	Leishmania infantum	86%	100%
E9B3Y1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%