RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania major

UniProt:

Q4Q442_LEIMA

TriTrypDb:

LmjF.33.1450 , LMJLV39_330023000 , LMJSD75_330022800

Length:

209

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q442

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q442

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	66	68	PF00675	0.569
CLV_PCSK_KEX2_1	110	112	PF00082	0.257
CLV_PCSK_KEX2_1	66	68	PF00082	0.569
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.257
CLV_PCSK_SKI1_1	179	183	PF00082	0.381
CLV_PCSK_SKI1_1	91	95	PF00082	0.282
DEG_Nend_Nbox_1	1	3	PF02207	0.535
DEG_SCF_FBW7_1	194	201	PF00400	0.483
DEG_SCF_FBW7_1	54	61	PF00400	0.576
DOC_CYCLIN_yCln2_LP_2	14	17	PF00134	0.525
DOC_MAPK_gen_1	69	78	PF00069	0.401
DOC_PP2B_LxvP_1	14	17	PF13499	0.525
DOC_USP7_MATH_1	145	149	PF00917	0.371
DOC_USP7_MATH_1	192	196	PF00917	0.424
DOC_USP7_MATH_1	198	202	PF00917	0.474
DOC_WW_Pin1_4	194	199	PF00397	0.438
DOC_WW_Pin1_4	54	59	PF00397	0.571
LIG_APCC_ABBA_1	182	187	PF00400	0.402
LIG_BRCT_BRCA1_1	129	133	PF00533	0.379
LIG_FHA_1	168	174	PF00498	0.396
LIG_FHA_1	197	203	PF00498	0.502
LIG_FHA_1	26	32	PF00498	0.449
LIG_FHA_2	136	142	PF00498	0.420
LIG_FHA_2	84	90	PF00498	0.457
LIG_LIR_Nem_3	130	136	PF02991	0.353
LIG_LIR_Nem_3	92	97	PF02991	0.503
LIG_SH2_NCK_1	60	64	PF00017	0.540
LIG_SH2_STAP1	204	208	PF00017	0.511
LIG_SH2_STAT3	38	41	PF00017	0.518
LIG_SH2_STAT5	153	156	PF00017	0.416
LIG_SH2_STAT5	166	169	PF00017	0.376
LIG_SH2_STAT5	38	41	PF00017	0.556
LIG_SH3_3	10	16	PF00018	0.534
LIG_SH3_3	131	137	PF00018	0.502
LIG_SH3_3	186	192	PF00018	0.483
LIG_SH3_3	59	65	PF00018	0.759
LIG_SUMO_SIM_anti_2	143	148	PF11976	0.353
LIG_SUMO_SIM_par_1	102	109	PF11976	0.457
LIG_WW_3	63	67	PF00397	0.575
MOD_CK1_1	118	124	PF00069	0.581
MOD_CK2_1	135	141	PF00069	0.423
MOD_GlcNHglycan	117	120	PF01048	0.600
MOD_GlcNHglycan	130	133	PF01048	0.359
MOD_GlcNHglycan	20	23	PF01048	0.564
MOD_GSK3_1	128	135	PF00069	0.409
MOD_GSK3_1	167	174	PF00069	0.430
MOD_GSK3_1	192	199	PF00069	0.447
MOD_GSK3_1	54	61	PF00069	0.561
MOD_NEK2_1	106	111	PF00069	0.457
MOD_NEK2_1	36	41	PF00069	0.573
MOD_NEK2_2	145	150	PF00069	0.396
MOD_Plk_4	15	21	PF00069	0.654
MOD_ProDKin_1	194	200	PF00069	0.447
MOD_ProDKin_1	54	60	PF00069	0.576
TRG_ENDOCYTIC_2	97	100	PF00928	0.508
TRG_ER_diArg_1	65	67	PF00400	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P505	Leptomonas seymouri	72%	100%
A0A3Q8IC83	Leishmania donovani	37%	95%
A0A3S7X6S0	Leishmania donovani	98%	100%
A4HLK6	Leishmania braziliensis	84%	100%
A4I287	Leishmania infantum	37%	95%
A4I917	Leishmania infantum	98%	100%
E9B3Y2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%