RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania major

UniProt:

Q4Q441_LEIMA

TriTrypDb:

LmjF.33.1460 , LMJLV39_330023200 , LMJSD75_330022900

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q441

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q441

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003723	RNA binding	4	4
GO:0005488	binding	1	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_SPOP_SBC_1	285	289	PF00917	0.728
DOC_CKS1_1	135	140	PF01111	0.790
DOC_USP7_MATH_1	146	150	PF00917	0.820
DOC_USP7_MATH_1	152	156	PF00917	0.719
DOC_USP7_MATH_1	187	191	PF00917	0.818
DOC_USP7_MATH_1	221	225	PF00917	0.794
DOC_USP7_MATH_1	25	29	PF00917	0.561
DOC_USP7_MATH_1	286	290	PF00917	0.704
DOC_USP7_MATH_1	302	306	PF00917	0.469
DOC_USP7_MATH_1	57	61	PF00917	0.630
DOC_WW_Pin1_4	134	139	PF00397	0.786
DOC_WW_Pin1_4	229	234	PF00397	0.801
DOC_WW_Pin1_4	241	246	PF00397	0.617
DOC_WW_Pin1_4	257	262	PF00397	0.523
DOC_WW_Pin1_4	322	327	PF00397	0.727
LIG_14-3-3_CanoR_1	222	226	PF00244	0.774
LIG_14-3-3_CanoR_1	80	87	PF00244	0.643
LIG_BIR_II_1	1	5	PF00653	0.586
LIG_BRCT_BRCA1_1	11	15	PF00533	0.630
LIG_BRCT_BRCA1_1	190	194	PF00533	0.816
LIG_FHA_1	233	239	PF00498	0.777
LIG_FHA_1	77	83	PF00498	0.653
LIG_FHA_2	112	118	PF00498	0.800
LIG_FHA_2	45	51	PF00498	0.630
LIG_LIR_Gen_1	154	163	PF02991	0.796
LIG_LIR_Gen_1	263	268	PF02991	0.790
LIG_LIR_Nem_3	154	159	PF02991	0.800
LIG_LIR_Nem_3	161	166	PF02991	0.681
LIG_LIR_Nem_3	21	26	PF02991	0.520
LIG_MLH1_MIPbox_1	11	15	PF16413	0.630
LIG_Pex14_2	11	15	PF04695	0.630
LIG_Pex14_2	156	160	PF04695	0.792
LIG_PTAP_UEV_1	251	256	PF05743	0.774
LIG_SH2_CRK	26	30	PF00017	0.630
LIG_SH2_CRK	282	286	PF00017	0.735
LIG_SH2_NCK_1	282	286	PF00017	0.735
LIG_SH2_SRC	321	324	PF00017	0.757
LIG_SH2_STAP1	212	216	PF00017	0.771
LIG_SH2_STAT5	264	267	PF00017	0.788
LIG_SH2_STAT5	321	324	PF00017	0.757
LIG_SH3_3	198	204	PF00018	0.804
LIG_SH3_3	249	255	PF00018	0.793
LIG_SH3_3	262	268	PF00018	0.595
LIG_SH3_3	320	326	PF00018	0.752
LIG_TRAF2_1	173	176	PF00917	0.845
LIG_TYR_ITIM	319	324	PF00017	0.754
LIG_WRPW_2	23	26	PF00400	0.630
LIG_WW_1	200	203	PF00397	0.795
MOD_CK1_1	128	134	PF00069	0.777
MOD_CK1_1	155	161	PF00069	0.793
MOD_CK1_1	167	173	PF00069	0.633
MOD_CK1_1	228	234	PF00069	0.803
MOD_CK1_1	236	242	PF00069	0.698
MOD_CK1_1	270	276	PF00069	0.728
MOD_CK1_1	60	66	PF00069	0.615
MOD_CK1_1	76	82	PF00069	0.473
MOD_CK2_1	170	176	PF00069	0.842
MOD_CK2_1	44	50	PF00069	0.523
MOD_GlcNHglycan	105	109	PF01048	0.769
MOD_GlcNHglycan	165	169	PF01048	0.804
MOD_GlcNHglycan	171	175	PF01048	0.748
MOD_GlcNHglycan	181	184	PF01048	0.567
MOD_GlcNHglycan	213	216	PF01048	0.768
MOD_GlcNHglycan	252	255	PF01048	0.800
MOD_GlcNHglycan	269	272	PF01048	0.484
MOD_GlcNHglycan	288	291	PF01048	0.415
MOD_GlcNHglycan	304	307	PF01048	0.453
MOD_GlcNHglycan	82	85	PF01048	0.510
MOD_GSK3_1	100	107	PF00069	0.583
MOD_GSK3_1	111	118	PF00069	0.624
MOD_GSK3_1	121	128	PF00069	0.734
MOD_GSK3_1	151	158	PF00069	0.784
MOD_GSK3_1	221	228	PF00069	0.800
MOD_GSK3_1	229	236	PF00069	0.677
MOD_GSK3_1	240	247	PF00069	0.507
MOD_GSK3_1	302	309	PF00069	0.708
MOD_GSK3_1	41	48	PF00069	0.556
MOD_GSK3_1	76	83	PF00069	0.491
MOD_GSK3_1	88	95	PF00069	0.500
MOD_N-GLC_1	126	131	PF02516	0.782
MOD_N-GLC_1	152	157	PF02516	0.805
MOD_NEK2_1	126	131	PF00069	0.782
MOD_NEK2_1	139	144	PF00069	0.570
MOD_NEK2_1	159	164	PF00069	0.790
MOD_NEK2_1	210	215	PF00069	0.778
MOD_NEK2_1	225	230	PF00069	0.567
MOD_PIKK_1	65	71	PF00454	0.693
MOD_PKA_2	221	227	PF00069	0.771
MOD_Plk_1	115	121	PF00069	0.615
MOD_Plk_1	152	158	PF00069	0.803
MOD_Plk_4	115	121	PF00069	0.615
MOD_Plk_4	155	161	PF00069	0.793
MOD_Plk_4	221	227	PF00069	0.798
MOD_Plk_4	233	239	PF00069	0.621
MOD_Plk_4	25	31	PF00069	0.515
MOD_Plk_4	260	266	PF00069	0.791
MOD_ProDKin_1	134	140	PF00069	0.789
MOD_ProDKin_1	229	235	PF00069	0.805
MOD_ProDKin_1	241	247	PF00069	0.617
MOD_ProDKin_1	257	263	PF00069	0.526
TRG_DiLeu_BaEn_1	115	120	PF01217	0.667
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.661
TRG_ENDOCYTIC_2	163	166	PF00928	0.797
TRG_ENDOCYTIC_2	26	29	PF00928	0.541
TRG_ENDOCYTIC_2	264	267	PF00928	0.788
TRG_ENDOCYTIC_2	281	284	PF00928	0.469
TRG_ENDOCYTIC_2	321	324	PF00928	0.757

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7U5	Leishmania donovani	98%	100%
A4I918	Leishmania infantum	97%	99%