Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania major

UniProt:

Q4Q440_LEIMA

TriTrypDb:

LmjF.33.1470 , LMJLV39_330023300 , LMJSD75_330023000

Length:

130

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q440

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q440

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	18
GO:0003723	RNA binding	4	18
GO:0005488	binding	1	18
GO:0097159	organic cyclic compound binding	2	18
GO:1901363	heterocyclic compound binding	2	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	98	100	PF00675	0.540
CLV_PCSK_KEX2_1	98	100	PF00082	0.540
CLV_PCSK_SKI1_1	37	41	PF00082	0.251
DOC_USP7_MATH_1	76	80	PF00917	0.489
DOC_USP7_UBL2_3	113	117	PF12436	0.567
DOC_WW_Pin1_4	101	106	PF00397	0.437
LIG_14-3-3_CanoR_1	37	43	PF00244	0.490
LIG_14-3-3_CanoR_1	68	75	PF00244	0.515
LIG_14-3-3_CanoR_1	98	106	PF00244	0.511
LIG_Actin_WH2_2	39	55	PF00022	0.515
LIG_BIR_III_4	54	58	PF00653	0.515
LIG_FHA_1	17	23	PF00498	0.468
LIG_FHA_1	47	53	PF00498	0.515
LIG_FHA_1	64	70	PF00498	0.515
LIG_FHA_2	30	36	PF00498	0.408
LIG_LIR_Gen_1	62	69	PF02991	0.450
LIG_LIR_Gen_1	72	80	PF02991	0.407
LIG_LIR_Nem_3	41	46	PF02991	0.423
LIG_LIR_Nem_3	62	67	PF02991	0.404
LIG_SH2_SRC	108	111	PF00017	0.471
LIG_SH2_STAP1	108	112	PF00017	0.513
LIG_SH2_STAT5	96	99	PF00017	0.370
LIG_SH3_3	119	125	PF00018	0.455
LIG_WRC_WIRS_1	39	44	PF05994	0.515
LIG_WRC_WIRS_1	64	69	PF05994	0.489
MOD_CK1_1	59	65	PF00069	0.412
MOD_GlcNHglycan	16	19	PF01048	0.542
MOD_GlcNHglycan	61	64	PF01048	0.208
MOD_GSK3_1	59	66	PF00069	0.448
MOD_GSK3_1	97	104	PF00069	0.347
MOD_N-GLC_1	117	122	PF02516	0.601
MOD_N-GLC_1	3	8	PF02516	0.567
MOD_NEK2_1	92	97	PF00069	0.366
MOD_NEK2_2	63	68	PF00069	0.488
MOD_NEK2_2	76	81	PF00069	0.398
MOD_PKA_2	67	73	PF00069	0.489
MOD_PKA_2	97	103	PF00069	0.516
MOD_ProDKin_1	101	107	PF00069	0.431
MOD_SUMO_rev_2	54	60	PF00179	0.515
TRG_ENDOCYTIC_2	43	46	PF00928	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Z2	Leptomonas seymouri	29%	97%
A0A0N1I2T7	Leptomonas seymouri	87%	100%
A0A0S4J311	Bodo saltans	59%	100%
A0A0S4JKJ5	Bodo saltans	38%	70%
A0A1X0NTL2	Trypanosomatidae	45%	71%
A0A1X0P0Y7	Trypanosomatidae	59%	100%
A0A1X0P102	Trypanosomatidae	60%	100%
A0A1X0P2H6	Trypanosomatidae	32%	92%
A0A3Q8IMA7	Leishmania donovani	96%	100%
A0A3R7KDP6	Trypanosoma rangeli	59%	100%
A0A422NG57	Trypanosoma rangeli	61%	100%
A4HIQ2	Leishmania braziliensis	28%	92%
A4HLK8	Leishmania braziliensis	96%	100%
A4I919	Leishmania infantum	97%	100%
C9ZRC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	85%
C9ZRQ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	72%
D0A516	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
D0A517	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9B3Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	75%
E9B3Y4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q9FFZ6	Arabidopsis thaliana	36%	89%
Q9LIS2	Arabidopsis thaliana	34%	96%