Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q437_LEIMA

TriTrypDb:

LmjF.33.1510 , LMJLV39_330023600 , LMJSD75_330023300

Length:

631

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q437

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q437

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	422	426	PF00656	0.585
CLV_NRD_NRD_1	215	217	PF00675	0.685
CLV_NRD_NRD_1	310	312	PF00675	0.670
CLV_NRD_NRD_1	334	336	PF00675	0.541
CLV_NRD_NRD_1	393	395	PF00675	0.485
CLV_NRD_NRD_1	439	441	PF00675	0.537
CLV_PCSK_FUR_1	391	395	PF00082	0.481
CLV_PCSK_KEX2_1	214	216	PF00082	0.671
CLV_PCSK_KEX2_1	310	312	PF00082	0.670
CLV_PCSK_KEX2_1	334	336	PF00082	0.541
CLV_PCSK_KEX2_1	393	395	PF00082	0.485
CLV_PCSK_SKI1_1	132	136	PF00082	0.691
CLV_PCSK_SKI1_1	327	331	PF00082	0.525
CLV_PCSK_SKI1_1	504	508	PF00082	0.522
CLV_Separin_Metazoa	211	215	PF03568	0.647
CLV_Separin_Metazoa	437	441	PF03568	0.579
DEG_Nend_UBRbox_1	1	4	PF02207	0.537
DEG_SPOP_SBC_1	187	191	PF00917	0.698
DEG_SPOP_SBC_1	482	486	PF00917	0.756
DOC_CDC14_PxL_1	157	165	PF14671	0.676
DOC_CYCLIN_RxL_1	340	351	PF00134	0.568
DOC_MAPK_MEF2A_6	2	9	PF00069	0.561
DOC_MAPK_MEF2A_6	376	384	PF00069	0.481
DOC_PP2B_LxvP_1	25	28	PF13499	0.599
DOC_USP7_MATH_1	108	112	PF00917	0.647
DOC_USP7_MATH_1	127	131	PF00917	0.511
DOC_USP7_MATH_1	270	274	PF00917	0.637
DOC_USP7_MATH_1	28	32	PF00917	0.680
DOC_USP7_MATH_1	293	297	PF00917	0.681
DOC_USP7_MATH_1	370	374	PF00917	0.436
DOC_USP7_MATH_1	428	432	PF00917	0.532
DOC_USP7_MATH_1	43	47	PF00917	0.464
DOC_USP7_MATH_1	482	486	PF00917	0.754
DOC_USP7_MATH_1	597	601	PF00917	0.647
DOC_USP7_MATH_2	313	319	PF00917	0.550
DOC_WW_Pin1_4	166	171	PF00397	0.679
DOC_WW_Pin1_4	356	361	PF00397	0.787
DOC_WW_Pin1_4	362	367	PF00397	0.620
DOC_WW_Pin1_4	409	414	PF00397	0.497
DOC_WW_Pin1_4	557	562	PF00397	0.717
DOC_WW_Pin1_4	613	618	PF00397	0.573
LIG_14-3-3_CanoR_1	126	134	PF00244	0.708
LIG_14-3-3_CanoR_1	214	221	PF00244	0.710
LIG_14-3-3_CanoR_1	235	242	PF00244	0.575
LIG_14-3-3_CanoR_1	243	251	PF00244	0.627
LIG_14-3-3_CanoR_1	369	375	PF00244	0.663
LIG_14-3-3_CanoR_1	391	401	PF00244	0.584
LIG_14-3-3_CanoR_1	492	499	PF00244	0.556
LIG_14-3-3_CanoR_1	57	63	PF00244	0.527
LIG_Actin_WH2_2	227	245	PF00022	0.542
LIG_Actin_WH2_2	377	395	PF00022	0.541
LIG_Actin_WH2_2	453	468	PF00022	0.475
LIG_Actin_WH2_2	518	534	PF00022	0.496
LIG_APCC_ABBA_1	5	10	PF00400	0.548
LIG_APCC_ABBA_1	507	512	PF00400	0.480
LIG_BRCT_BRCA1_1	304	308	PF00533	0.614
LIG_BRCT_BRCA1_1	52	56	PF00533	0.630
LIG_deltaCOP1_diTrp_1	300	308	PF00928	0.539
LIG_deltaCOP1_diTrp_1	502	510	PF00928	0.603
LIG_EVH1_1	179	183	PF00568	0.590
LIG_FHA_1	196	202	PF00498	0.577
LIG_FHA_1	287	293	PF00498	0.617
LIG_FHA_1	321	327	PF00498	0.495
LIG_FHA_1	342	348	PF00498	0.620
LIG_FHA_1	369	375	PF00498	0.495
LIG_FHA_1	4	10	PF00498	0.527
LIG_FHA_2	167	173	PF00498	0.773
LIG_FHA_2	197	203	PF00498	0.556
LIG_FHA_2	256	262	PF00498	0.697
LIG_FHA_2	420	426	PF00498	0.581
LIG_FHA_2	579	585	PF00498	0.829
LIG_LIR_Apic_2	584	590	PF02991	0.702
LIG_LIR_Gen_1	152	161	PF02991	0.607
LIG_LIR_Gen_1	271	281	PF02991	0.590
LIG_LIR_Nem_3	152	157	PF02991	0.564
LIG_LIR_Nem_3	271	277	PF02991	0.608
LIG_LYPXL_yS_3	448	451	PF13949	0.493
LIG_NRBOX	287	293	PF00104	0.577
LIG_NRBOX	325	331	PF00104	0.531
LIG_PCNA_PIPBox_1	1	10	PF02747	0.668
LIG_SH2_CRK	274	278	PF00017	0.606
LIG_SH2_CRK	429	433	PF00017	0.470
LIG_SH2_NCK_1	274	278	PF00017	0.688
LIG_SH2_NCK_1	90	94	PF00017	0.520
LIG_SH2_SRC	102	105	PF00017	0.608
LIG_SH2_STAP1	274	278	PF00017	0.688
LIG_SH2_STAP1	429	433	PF00017	0.470
LIG_SH2_STAP1	90	94	PF00017	0.520
LIG_SH2_STAT5	459	462	PF00017	0.430
LIG_SH2_STAT5	94	97	PF00017	0.506
LIG_SH3_3	121	127	PF00018	0.672
LIG_SH3_3	177	183	PF00018	0.650
LIG_SH3_3	247	253	PF00018	0.613
LIG_Sin3_3	71	78	PF02671	0.628
LIG_SUMO_SIM_anti_2	344	349	PF11976	0.559
LIG_SUMO_SIM_par_1	182	191	PF11976	0.593
LIG_TRAF2_1	170	173	PF00917	0.787
LIG_TYR_ITIM	446	451	PF00017	0.508
MOD_CDK_SPxxK_3	362	369	PF00069	0.722
MOD_CK1_1	111	117	PF00069	0.685
MOD_CK1_1	296	302	PF00069	0.704
MOD_CK1_1	31	37	PF00069	0.655
MOD_CK1_1	351	357	PF00069	0.767
MOD_CK1_1	368	374	PF00069	0.363
MOD_CK1_1	38	44	PF00069	0.613
MOD_CK1_1	557	563	PF00069	0.754
MOD_CK1_1	60	66	PF00069	0.573
MOD_CK1_1	89	95	PF00069	0.534
MOD_CK2_1	166	172	PF00069	0.777
MOD_CK2_1	187	193	PF00069	0.798
MOD_CK2_1	196	202	PF00069	0.562
MOD_CK2_1	255	261	PF00069	0.657
MOD_CK2_1	43	49	PF00069	0.604
MOD_CK2_1	578	584	PF00069	0.810
MOD_GlcNHglycan	110	113	PF01048	0.583
MOD_GlcNHglycan	129	132	PF01048	0.548
MOD_GlcNHglycan	158	161	PF01048	0.691
MOD_GlcNHglycan	190	193	PF01048	0.579
MOD_GlcNHglycan	22	25	PF01048	0.565
MOD_GlcNHglycan	317	320	PF01048	0.620
MOD_GlcNHglycan	350	353	PF01048	0.749
MOD_GlcNHglycan	41	44	PF01048	0.440
MOD_GlcNHglycan	413	416	PF01048	0.489
MOD_GlcNHglycan	485	488	PF01048	0.667
MOD_GlcNHglycan	494	497	PF01048	0.547
MOD_GlcNHglycan	504	507	PF01048	0.434
MOD_GlcNHglycan	595	598	PF01048	0.664
MOD_GlcNHglycan	599	602	PF01048	0.583
MOD_GlcNHglycan	91	94	PF01048	0.519
MOD_GSK3_1	104	111	PF00069	0.567
MOD_GSK3_1	135	142	PF00069	0.741
MOD_GSK3_1	216	223	PF00069	0.680
MOD_GSK3_1	28	35	PF00069	0.691
MOD_GSK3_1	356	363	PF00069	0.735
MOD_GSK3_1	38	45	PF00069	0.752
MOD_GSK3_1	455	462	PF00069	0.403
MOD_GSK3_1	553	560	PF00069	0.565
MOD_GSK3_1	56	63	PF00069	0.538
MOD_GSK3_1	593	600	PF00069	0.563
MOD_LATS_1	453	459	PF00433	0.470
MOD_N-GLC_1	261	266	PF02516	0.840
MOD_N-GLC_1	466	471	PF02516	0.566
MOD_NEK2_1	186	191	PF00069	0.594
MOD_NEK2_1	341	346	PF00069	0.507
MOD_NEK2_1	419	424	PF00069	0.526
MOD_NEK2_1	465	470	PF00069	0.502
MOD_NEK2_1	547	552	PF00069	0.614
MOD_NEK2_1	554	559	PF00069	0.685
MOD_NEK2_1	56	61	PF00069	0.632
MOD_PIKK_1	28	34	PF00454	0.735
MOD_PIKK_1	293	299	PF00454	0.597
MOD_PIKK_1	603	609	PF00454	0.593
MOD_PK_1	376	382	PF00069	0.596
MOD_PKA_1	214	220	PF00069	0.704
MOD_PKA_2	125	131	PF00069	0.808
MOD_PKA_2	214	220	PF00069	0.704
MOD_PKA_2	368	374	PF00069	0.676
MOD_PKA_2	392	398	PF00069	0.548
MOD_PKA_2	465	471	PF00069	0.537
MOD_PKA_2	497	503	PF00069	0.541
MOD_PKA_2	56	62	PF00069	0.614
MOD_PKA_2	593	599	PF00069	0.620
MOD_PKB_1	214	222	PF00069	0.705
MOD_Plk_1	139	145	PF00069	0.595
MOD_Plk_1	270	276	PF00069	0.711
MOD_Plk_1	286	292	PF00069	0.406
MOD_Plk_1	9	15	PF00069	0.541
MOD_Plk_2-3	139	145	PF00069	0.662
MOD_Plk_4	3	9	PF00069	0.556
MOD_Plk_4	304	310	PF00069	0.521
MOD_Plk_4	370	376	PF00069	0.537
MOD_Plk_4	428	434	PF00069	0.472
MOD_Plk_4	455	461	PF00069	0.385
MOD_ProDKin_1	166	172	PF00069	0.682
MOD_ProDKin_1	356	362	PF00069	0.772
MOD_ProDKin_1	409	415	PF00069	0.493
MOD_ProDKin_1	557	563	PF00069	0.721
MOD_ProDKin_1	613	619	PF00069	0.566
MOD_SUMO_for_1	14	17	PF00179	0.568
MOD_SUMO_rev_2	257	265	PF00179	0.704
TRG_DiLeu_BaEn_1	337	342	PF01217	0.600
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.472
TRG_DiLeu_BaLyEn_6	446	451	PF01217	0.508
TRG_DiLeu_BaLyEn_6	526	531	PF01217	0.469
TRG_ENDOCYTIC_2	102	105	PF00928	0.507
TRG_ENDOCYTIC_2	274	277	PF00928	0.610
TRG_ENDOCYTIC_2	429	432	PF00928	0.474
TRG_ENDOCYTIC_2	448	451	PF00928	0.265
TRG_ER_diArg_1	213	216	PF00400	0.670
TRG_ER_diArg_1	309	311	PF00400	0.666
TRG_ER_diArg_1	391	394	PF00400	0.469
TRG_ER_diArg_1	491	494	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.663
TRG_Pf-PMV_PEXEL_1	310	315	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	327	331	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	529	533	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P490	Leptomonas seymouri	37%	100%
A0A3Q8IGM0	Leishmania donovani	88%	100%
A4HLL1	Leishmania braziliensis	71%	100%
A4I923	Leishmania infantum	87%	100%
E9B3Y7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%