LeishMANIAdb
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PRA1 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
PRA1 family protein
Gene product:
PRA1 family protein, putative
Species:
Leishmania major
UniProt:
Q4Q436_LEIMA
TriTrypDb:
LmjF.33.1520 * , LMJLV39_330023700 * , LMJSD75_330023400 *
Length:
207

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 2
GO:0005794 Golgi apparatus 5 3
GO:0016020 membrane 2 14
GO:0043226 organelle 2 3
GO:0043227 membrane-bounded organelle 3 3
GO:0043229 intracellular organelle 3 3
GO:0043231 intracellular membrane-bounded organelle 4 3
GO:0110165 cellular anatomical entity 1 14
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Expansion

Sequence features

Q4Q436
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q436

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 85 89 PF00656 0.499
CLV_NRD_NRD_1 140 142 PF00675 0.303
CLV_NRD_NRD_1 186 188 PF00675 0.392
CLV_NRD_NRD_1 192 194 PF00675 0.347
CLV_NRD_NRD_1 202 204 PF00675 0.298
CLV_NRD_NRD_1 22 24 PF00675 0.299
CLV_NRD_NRD_1 95 97 PF00675 0.298
CLV_PCSK_KEX2_1 186 188 PF00082 0.392
CLV_PCSK_KEX2_1 194 196 PF00082 0.326
CLV_PCSK_KEX2_1 202 204 PF00082 0.298
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0S4JEM7 Bodo saltans 26% 99%
A0A1X0P100 Trypanosomatidae 44% 78%
A0A3Q8IK58 Leishmania donovani 91% 100%
A0A3S7X6T0 Leishmania donovani 26% 100%
A0A422NG43 Trypanosoma rangeli 40% 70%
A4HLL2 Leishmania braziliensis 80% 100%
A4I924 Leishmania infantum 26% 100%
D0A526 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 91%
E9AHN5 Leishmania infantum 91% 100%
E9B3Y8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS