PRA1 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

PRA1 family protein

Gene product:

PRA1 family protein, putative

Species:

Leishmania major

UniProt:

Q4Q436_LEIMA

TriTrypDb:

LmjF.33.1520 , LMJLV39_330023700 , LMJSD75_330023400

Length:

207

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005794	Golgi apparatus	5	3
GO:0016020	membrane	2	14
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	14

Expansion

Sequence features

Q4Q436

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q436

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	85	89	PF00656	0.499
CLV_NRD_NRD_1	140	142	PF00675	0.303
CLV_NRD_NRD_1	186	188	PF00675	0.392
CLV_NRD_NRD_1	192	194	PF00675	0.347
CLV_NRD_NRD_1	202	204	PF00675	0.298
CLV_NRD_NRD_1	22	24	PF00675	0.299
CLV_NRD_NRD_1	95	97	PF00675	0.298
CLV_PCSK_KEX2_1	186	188	PF00082	0.392
CLV_PCSK_KEX2_1	194	196	PF00082	0.326
CLV_PCSK_KEX2_1	202	204	PF00082	0.298
CLV_PCSK_KEX2_1	95	97	PF00082	0.302
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.385
CLV_PCSK_SKI1_1	121	125	PF00082	0.281
CLV_PCSK_SKI1_1	203	207	PF00082	0.366
CLV_PCSK_SKI1_1	23	27	PF00082	0.357
CLV_Separin_Metazoa	20	24	PF03568	0.469
DEG_APCC_DBOX_1	120	128	PF00400	0.281
DEG_Nend_Nbox_1	1	3	PF02207	0.615
DOC_MAPK_gen_1	118	128	PF00069	0.169
DOC_MAPK_gen_1	98	107	PF00069	0.586
DOC_MAPK_MEF2A_6	121	128	PF00069	0.366
DOC_PP1_RVXF_1	119	126	PF00149	0.299
DOC_PP1_RVXF_1	24	31	PF00149	0.469
DOC_PP2B_LxvP_1	34	37	PF13499	0.503
DOC_USP7_UBL2_3	153	157	PF12436	0.577
DOC_USP7_UBL2_3	78	82	PF12436	0.550
DOC_WW_Pin1_4	57	62	PF00397	0.269
LIG_Actin_RPEL_3	93	112	PF02755	0.469
LIG_EH1_1	61	69	PF00400	0.487
LIG_FHA_1	49	55	PF00498	0.347
LIG_FHA_2	142	148	PF00498	0.577
LIG_GBD_Chelix_1	106	114	PF00786	0.348
LIG_LIR_Gen_1	11	21	PF02991	0.499
LIG_LIR_Gen_1	122	133	PF02991	0.396
LIG_LIR_Gen_1	40	50	PF02991	0.532
LIG_LIR_Nem_3	11	16	PF02991	0.533
LIG_LIR_Nem_3	122	128	PF02991	0.400
LIG_LIR_Nem_3	40	46	PF02991	0.529
LIG_LIR_Nem_3	60	65	PF02991	0.274
LIG_NRBOX	101	107	PF00104	0.440
LIG_NRBOX	109	115	PF00104	0.366
LIG_NRBOX	119	125	PF00104	0.213
LIG_Pex14_1	9	13	PF04695	0.480
LIG_PTB_Apo_2	56	63	PF02174	0.380
LIG_REV1ctd_RIR_1	114	122	PF16727	0.197
LIG_SH2_CRK	99	103	PF00017	0.486
LIG_SH2_PTP2	43	46	PF00017	0.345
LIG_SH2_SRC	172	175	PF00017	0.629
LIG_SH2_SRC	43	46	PF00017	0.351
LIG_SH2_STAP1	161	165	PF00017	0.573
LIG_SH2_STAP1	39	43	PF00017	0.509
LIG_SH2_STAT5	145	148	PF00017	0.603
LIG_SH2_STAT5	172	175	PF00017	0.608
LIG_SH2_STAT5	43	46	PF00017	0.349
LIG_SH2_STAT5	48	51	PF00017	0.339
LIG_SH3_3	47	53	PF00018	0.383
LIG_SUMO_SIM_anti_2	66	72	PF11976	0.424
LIG_SUMO_SIM_anti_2	88	94	PF11976	0.540
LIG_SUMO_SIM_par_1	69	75	PF11976	0.415
LIG_TYR_ITIM	97	102	PF00017	0.485
LIG_UBA3_1	112	118	PF00899	0.197
LIG_UBA3_1	70	78	PF00899	0.351
MOD_CK2_1	175	181	PF00069	0.615
MOD_Cter_Amidation	93	96	PF01082	0.209
MOD_GlcNHglycan	176	180	PF01048	0.286
MOD_N-GLC_2	130	132	PF02516	0.351
MOD_NEK2_1	63	68	PF00069	0.327
MOD_PKA_1	141	147	PF00069	0.563
MOD_Plk_4	141	147	PF00069	0.594
MOD_Plk_4	63	69	PF00069	0.424
MOD_Plk_4	86	92	PF00069	0.575
MOD_ProDKin_1	57	63	PF00069	0.269
MOD_SUMO_rev_2	190	196	PF00179	0.584
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.351
TRG_ENDOCYTIC_2	43	46	PF00928	0.336
TRG_ENDOCYTIC_2	99	102	PF00928	0.500
TRG_ER_diArg_1	193	196	PF00400	0.587
TRG_ER_diArg_1	95	98	PF00400	0.502
TRG_NLS_MonoExtC_3	79	85	PF00514	0.469
TRG_NLS_MonoExtN_4	78	84	PF00514	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JEM7	Bodo saltans	26%	99%
A0A1X0P100	Trypanosomatidae	44%	78%
A0A3Q8IK58	Leishmania donovani	91%	100%
A0A3S7X6T0	Leishmania donovani	26%	100%
A0A422NG43	Trypanosoma rangeli	40%	70%
A4HLL2	Leishmania braziliensis	80%	100%
A4I924	Leishmania infantum	26%	100%
D0A526	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	91%
E9AHN5	Leishmania infantum	91%	100%
E9B3Y8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9B3Y9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q4Q435	Leishmania major	26%	100%