PRA1 family protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

PRA1 family protein

Gene product:

PRA1 family protein, putative

Species:

Leishmania major

UniProt:

Q4Q435_LEIMA

TriTrypDb:

LmjF.33.1530 , LMJLV39_330023800 , LMJSD75_330023500

Length:

181

Annotations

LeishMANIAdb annotations

A small protein consisting of 2+2 helical bundles, very conserved in Eukaryota. Might have an N-terminal transit signal.. Localization: Mitochondrial (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	2
GO:0016020	membrane	2	11
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q435

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q435

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.263
CLV_PCSK_KEX2_1	169	171	PF00082	0.316
CLV_PCSK_SKI1_1	123	127	PF00082	0.269
DOC_CKS1_1	40	45	PF01111	0.366
DOC_PP4_FxxP_1	40	43	PF00568	0.413
DOC_WW_Pin1_4	39	44	PF00397	0.444
LIG_14-3-3_CanoR_1	97	106	PF00244	0.459
LIG_BIR_II_1	1	5	PF00653	0.526
LIG_BRCT_BRCA1_1	148	152	PF00533	0.255
LIG_BRCT_BRCA1_1	31	35	PF00533	0.462
LIG_EH1_1	63	71	PF00400	0.244
LIG_eIF4E_1	64	70	PF01652	0.268
LIG_FHA_1	45	51	PF00498	0.508
LIG_FHA_1	89	95	PF00498	0.283
LIG_LIR_Apic_2	37	43	PF02991	0.447
LIG_LIR_Gen_1	128	139	PF02991	0.426
LIG_LIR_Gen_1	175	181	PF02991	0.616
LIG_LIR_Gen_1	72	82	PF02991	0.267
LIG_LIR_Gen_1	91	101	PF02991	0.407
LIG_LIR_Nem_3	128	134	PF02991	0.424
LIG_LIR_Nem_3	149	155	PF02991	0.302
LIG_LIR_Nem_3	175	181	PF02991	0.596
LIG_LIR_Nem_3	72	77	PF02991	0.267
LIG_LIR_Nem_3	91	96	PF02991	0.407
LIG_MLH1_MIPbox_1	31	35	PF16413	0.462
LIG_PCNA_yPIPBox_3	18	26	PF02747	0.558
LIG_Pex14_1	31	35	PF04695	0.413
LIG_Pex14_2	35	39	PF04695	0.508
LIG_PTB_Apo_2	119	126	PF02174	0.459
LIG_PTB_Apo_2	76	83	PF02174	0.248
LIG_SH2_CRK	85	89	PF00017	0.269
LIG_SH2_GRB2like	61	64	PF00017	0.416
LIG_SH2_PTP2	74	77	PF00017	0.266
LIG_SH2_STAP1	61	65	PF00017	0.480
LIG_SH2_STAP1	85	89	PF00017	0.313
LIG_SH2_STAT5	119	122	PF00017	0.463
LIG_SH2_STAT5	131	134	PF00017	0.190
LIG_SH2_STAT5	143	146	PF00017	0.257
LIG_SH2_STAT5	59	62	PF00017	0.458
LIG_SH2_STAT5	64	67	PF00017	0.280
LIG_SH2_STAT5	74	77	PF00017	0.266
LIG_SH2_STAT5	93	96	PF00017	0.266
LIG_SUMO_SIM_anti_2	72	79	PF11976	0.266
LIG_SUMO_SIM_par_1	86	91	PF11976	0.261
LIG_TRAF2_1	111	114	PF00917	0.508
LIG_TYR_ITSM	89	96	PF00017	0.269
MOD_CK1_1	146	152	PF00069	0.247
MOD_CK1_1	2	8	PF00069	0.572
MOD_CK1_1	44	50	PF00069	0.516
MOD_CK2_1	109	115	PF00069	0.508
MOD_GlcNHglycan	145	148	PF01048	0.494
MOD_GlcNHglycan	175	178	PF01048	0.451
MOD_GlcNHglycan	43	46	PF01048	0.271
MOD_GlcNHglycan	99	102	PF01048	0.294
MOD_GSK3_1	142	149	PF00069	0.280
MOD_GSK3_1	155	162	PF00069	0.315
MOD_GSK3_1	35	42	PF00069	0.466
MOD_GSK3_1	65	72	PF00069	0.350
MOD_NEK2_1	125	130	PF00069	0.471
MOD_NEK2_1	142	147	PF00069	0.162
MOD_NEK2_1	154	159	PF00069	0.224
MOD_NEK2_1	34	39	PF00069	0.506
MOD_NEK2_1	65	70	PF00069	0.377
MOD_NEK2_1	88	93	PF00069	0.287
MOD_NEK2_1	95	100	PF00069	0.300
MOD_NEK2_2	164	169	PF00069	0.511
MOD_PIKK_1	125	131	PF00454	0.444
MOD_Plk_1	2	8	PF00069	0.590
MOD_Plk_1	35	41	PF00069	0.521
MOD_Plk_4	146	152	PF00069	0.272
MOD_Plk_4	35	41	PF00069	0.508
MOD_Plk_4	65	71	PF00069	0.381
MOD_Plk_4	88	94	PF00069	0.429
MOD_ProDKin_1	39	45	PF00069	0.444
TRG_ENDOCYTIC_2	131	134	PF00928	0.275
TRG_ENDOCYTIC_2	64	67	PF00928	0.286
TRG_ENDOCYTIC_2	74	77	PF00928	0.266
TRG_ENDOCYTIC_2	85	88	PF00928	0.266
TRG_ENDOCYTIC_2	93	96	PF00928	0.291
TRG_ER_diArg_1	168	170	PF00400	0.516
TRG_ER_diArg_1	96	99	PF00400	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1K1	Leptomonas seymouri	75%	76%
A0A0S4JEM7	Bodo saltans	36%	87%
A0A1X0P0Z7	Trypanosomatidae	41%	86%
A0A3Q8IK58	Leishmania donovani	26%	100%
A0A3R7ML24	Trypanosoma rangeli	39%	88%
A0A3S7X6T0	Leishmania donovani	97%	100%
A4HLL3	Leishmania braziliensis	89%	79%
A4I924	Leishmania infantum	97%	100%
D0A528	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	85%
E9AHN5	Leishmania infantum	26%	100%
E9B3Y9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O80915	Arabidopsis thaliana	23%	82%
P93829	Arabidopsis thaliana	30%	99%
Q4Q436	Leishmania major	26%	100%
Q9C889	Arabidopsis thaliana	30%	96%
Q9SIY7	Arabidopsis thaliana	27%	85%