PRA1 family protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

PRA1 family protein

Gene product:

PRA1 family protein, putative

Species:

Leishmania major

UniProt:

Q4Q435_LEIMA

TriTrypDb:

LmjF.33.1530 , LMJLV39_330023800 , LMJSD75_330023500

Length:

181

Annotations

LeishMANIAdb annotations

A small protein consisting of 2+2 helical bundles, very conserved in Eukaryota. Might have an N-terminal transit signal.. Localization: Mitochondrial (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Show entries

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	2
GO:0016020	membrane	2	11
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

Q4Q435

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q435

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.263
CLV_PCSK_KEX2_1	169	171	PF00082	0.316
CLV_PCSK_SKI1_1	123	127	PF00082	0.269
DOC_CKS1_1	40	45	PF01111	0.366
DOC_PP4_FxxP_1	40	43	PF00568	0.413
DOC_WW_Pin1_4	39	44	PF00397	0.444
LIG_14-3-3_CanoR_1	97	106	PF00244	0.459
LIG_BIR_II_1	1	5	PF00653	0.526
LIG_BRCT_BRCA1_1	148	152	PF00533	0.255
LIG_BRCT_BRCA1_1	31	35	PF00533	0.462

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1K1	Leptomonas seymouri	75%	76%
A0A0S4JEM7	Bodo saltans	36%	87%
A0A1X0P0Z7	Trypanosomatidae	41%	86%
A0A3Q8IK58	Leishmania donovani	26%	100%
A0A3R7ML24	Trypanosoma rangeli	39%	88%
A0A3S7X6T0	Leishmania donovani	97%	100%
A4HLL3	Leishmania braziliensis	89%	79%
A4I924	Leishmania infantum	97%	100%
D0A528	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	85%
E9AHN5	Leishmania infantum	26%	100%

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