LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q433_LEIMA
TriTrypDb:
LmjF.33.1550 , LMJLV39_330024000 , LMJSD75_330023700 *
Length:
327

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q433
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q433

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 209 211 PF00675 0.430
CLV_NRD_NRD_1 47 49 PF00675 0.451
CLV_PCSK_KEX2_1 46 48 PF00082 0.448
CLV_PCSK_SKI1_1 301 305 PF00082 0.438
CLV_PCSK_SKI1_1 38 42 PF00082 0.495
DEG_Nend_UBRbox_1 1 4 PF02207 0.562
DEG_SCF_FBW7_1 168 175 PF00400 0.551
DEG_SPOP_SBC_1 167 171 PF00917 0.613
DEG_SPOP_SBC_1 172 176 PF00917 0.542
DEG_SPOP_SBC_1 84 88 PF00917 0.726
DOC_MAPK_gen_1 210 217 PF00069 0.513
DOC_MAPK_gen_1 246 256 PF00069 0.600
DOC_USP7_MATH_1 167 171 PF00917 0.572
DOC_USP7_MATH_1 172 176 PF00917 0.536
DOC_USP7_MATH_1 179 183 PF00917 0.480
DOC_USP7_MATH_1 258 262 PF00917 0.596
DOC_USP7_MATH_1 79 83 PF00917 0.710
DOC_WW_Pin1_4 152 157 PF00397 0.514
DOC_WW_Pin1_4 168 173 PF00397 0.609
DOC_WW_Pin1_4 272 277 PF00397 0.594
DOC_WW_Pin1_4 85 90 PF00397 0.595
LIG_14-3-3_CanoR_1 126 132 PF00244 0.400
LIG_14-3-3_CanoR_1 148 156 PF00244 0.588
LIG_14-3-3_CanoR_1 214 218 PF00244 0.445
LIG_14-3-3_CanoR_1 249 257 PF00244 0.537
LIG_14-3-3_CanoR_1 307 316 PF00244 0.491
LIG_Actin_WH2_2 181 199 PF00022 0.453
LIG_BIR_III_4 295 299 PF00653 0.503
LIG_BRCT_BRCA1_1 174 178 PF00533 0.511
LIG_BRCT_BRCA1_1 273 277 PF00533 0.638
LIG_FHA_1 85 91 PF00498 0.561
LIG_FHA_2 11 17 PF00498 0.389
LIG_FHA_2 178 184 PF00498 0.513
LIG_FHA_2 230 236 PF00498 0.553
LIG_FHA_2 64 70 PF00498 0.725
LIG_LIR_Apic_2 313 318 PF02991 0.512
LIG_LIR_Gen_1 23 31 PF02991 0.467
LIG_LIR_Gen_1 59 65 PF02991 0.624
LIG_LIR_Nem_3 23 28 PF02991 0.502
LIG_MLH1_MIPbox_1 174 178 PF16413 0.576
LIG_PCNA_yPIPBox_3 114 126 PF02747 0.469
LIG_SH2_STAT5 177 180 PF00017 0.586
LIG_SH2_STAT5 25 28 PF00017 0.611
LIG_SH2_STAT5 315 318 PF00017 0.467
LIG_SH3_2 287 292 PF14604 0.586
LIG_SH3_3 153 159 PF00018 0.607
LIG_SH3_3 284 290 PF00018 0.723
LIG_SUMO_SIM_par_1 164 171 PF11976 0.510
LIG_UBA3_1 206 211 PF00899 0.488
LIG_WRC_WIRS_1 11 16 PF05994 0.394
LIG_WRC_WIRS_1 300 305 PF05994 0.479
MOD_CK1_1 102 108 PF00069 0.447
MOD_CK1_1 125 131 PF00069 0.403
MOD_CK1_1 182 188 PF00069 0.434
MOD_CK1_1 233 239 PF00069 0.528
MOD_CK1_1 272 278 PF00069 0.597
MOD_CK2_1 10 16 PF00069 0.392
MOD_CK2_1 177 183 PF00069 0.528
MOD_CK2_1 26 32 PF00069 0.407
MOD_CK2_1 263 269 PF00069 0.608
MOD_CK2_1 299 305 PF00069 0.485
MOD_CK2_1 63 69 PF00069 0.722
MOD_GlcNHglycan 101 104 PF01048 0.479
MOD_GlcNHglycan 160 163 PF01048 0.654
MOD_GlcNHglycan 224 227 PF01048 0.531
MOD_GlcNHglycan 232 235 PF01048 0.501
MOD_GlcNHglycan 271 274 PF01048 0.718
MOD_GlcNHglycan 277 280 PF01048 0.540
MOD_GlcNHglycan 28 31 PF01048 0.381
MOD_GSK3_1 167 174 PF00069 0.640
MOD_GSK3_1 229 236 PF00069 0.559
MOD_GSK3_1 248 255 PF00069 0.475
MOD_GSK3_1 259 266 PF00069 0.698
MOD_GSK3_1 268 275 PF00069 0.717
MOD_GSK3_1 307 314 PF00069 0.459
MOD_GSK3_1 65 72 PF00069 0.704
MOD_GSK3_1 75 82 PF00069 0.675
MOD_GSK3_1 85 92 PF00069 0.571
MOD_NEK2_1 101 106 PF00069 0.420
MOD_NEK2_1 202 207 PF00069 0.515
MOD_NEK2_1 228 233 PF00069 0.580
MOD_NEK2_1 259 264 PF00069 0.711
MOD_NEK2_2 10 15 PF00069 0.390
MOD_PIKK_1 125 131 PF00454 0.403
MOD_PIKK_1 33 39 PF00454 0.405
MOD_PKA_2 125 131 PF00069 0.403
MOD_PKA_2 147 153 PF00069 0.559
MOD_PKA_2 213 219 PF00069 0.494
MOD_PKA_2 248 254 PF00069 0.557
MOD_Plk_1 182 188 PF00069 0.571
MOD_Plk_1 69 75 PF00069 0.529
MOD_Plk_2-3 65 71 PF00069 0.592
MOD_Plk_4 173 179 PF00069 0.545
MOD_Plk_4 20 26 PF00069 0.540
MOD_Plk_4 202 208 PF00069 0.419
MOD_Plk_4 213 219 PF00069 0.520
MOD_Plk_4 252 258 PF00069 0.639
MOD_Plk_4 299 305 PF00069 0.485
MOD_Plk_4 311 317 PF00069 0.379
MOD_ProDKin_1 152 158 PF00069 0.516
MOD_ProDKin_1 168 174 PF00069 0.608
MOD_ProDKin_1 272 278 PF00069 0.597
MOD_ProDKin_1 85 91 PF00069 0.594
TRG_DiLeu_BaEn_1 16 21 PF01217 0.396
TRG_DiLeu_BaEn_1 252 257 PF01217 0.560
TRG_DiLeu_BaEn_1 319 324 PF01217 0.436
TRG_ENDOCYTIC_2 25 28 PF00928 0.593
TRG_ER_diArg_1 46 48 PF00400 0.452
TRG_Pf-PMV_PEXEL_1 71 75 PF00026 0.534

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2U9 Leptomonas seymouri 45% 99%
A0A3S7X6T2 Leishmania donovani 93% 100%
A4HLL5 Leishmania braziliensis 79% 100%
A4I926 Leishmania infantum 93% 100%
E9B3Z1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS