NIPA-like protein 3

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

NIPA-like protein 3

Gene product:

sulfite exporter TauE/SafE, putative

Species:

Leishmania major

UniProt:

Q4Q432_LEIMA

TriTrypDb:

LmjF.33.1560 , LMJLV39_330024100 , LMJSD75_330023800

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q432

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q432

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	144	146	PF00675	0.356
CLV_NRD_NRD_1	499	501	PF00675	0.522
CLV_NRD_NRD_1	570	572	PF00675	0.545
CLV_PCSK_FUR_1	145	149	PF00082	0.365
CLV_PCSK_KEX2_1	147	149	PF00082	0.378
CLV_PCSK_KEX2_1	461	463	PF00082	0.474
CLV_PCSK_KEX2_1	479	481	PF00082	0.320
CLV_PCSK_KEX2_1	499	501	PF00082	0.524
CLV_PCSK_KEX2_1	570	572	PF00082	0.529
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.406
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.474
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.313
CLV_PCSK_SKI1_1	121	125	PF00082	0.491
CLV_PCSK_SKI1_1	156	160	PF00082	0.378
CLV_PCSK_SKI1_1	297	301	PF00082	0.447
CLV_PCSK_SKI1_1	539	543	PF00082	0.530
CLV_PCSK_SKI1_1	71	75	PF00082	0.382
CLV_PCSK_SKI1_1	91	95	PF00082	0.313
DEG_SPOP_SBC_1	634	638	PF00917	0.787
DOC_ANK_TNKS_1	198	205	PF00023	0.665
DOC_CKS1_1	215	220	PF01111	0.725
DOC_CKS1_1	618	623	PF01111	0.732
DOC_CYCLIN_RxL_1	119	127	PF00134	0.317
DOC_CYCLIN_RxL_1	68	76	PF00134	0.360
DOC_MAPK_gen_1	154	162	PF00069	0.549
DOC_MAPK_gen_1	469	477	PF00069	0.595
DOC_MAPK_MEF2A_6	154	162	PF00069	0.578
DOC_MAPK_RevD_3	131	147	PF00069	0.363
DOC_PP1_RVXF_1	120	127	PF00149	0.317
DOC_PP1_RVXF_1	358	364	PF00149	0.263
DOC_PP1_RVXF_1	69	75	PF00149	0.328
DOC_PP4_FxxP_1	352	355	PF00568	0.317
DOC_PP4_FxxP_1	495	498	PF00568	0.636
DOC_PP4_FxxP_1	74	77	PF00568	0.300
DOC_PP4_MxPP_1	198	201	PF00568	0.709
DOC_USP7_MATH_1	191	195	PF00917	0.680
DOC_USP7_MATH_1	220	224	PF00917	0.700
DOC_USP7_MATH_1	498	502	PF00917	0.617
DOC_USP7_MATH_1	634	638	PF00917	0.787
DOC_USP7_MATH_1	98	102	PF00917	0.303
DOC_USP7_UBL2_3	317	321	PF12436	0.463
DOC_WW_Pin1_4	214	219	PF00397	0.713
DOC_WW_Pin1_4	286	291	PF00397	0.651
DOC_WW_Pin1_4	51	56	PF00397	0.320
DOC_WW_Pin1_4	571	576	PF00397	0.678
DOC_WW_Pin1_4	588	593	PF00397	0.700
DOC_WW_Pin1_4	610	615	PF00397	0.702
DOC_WW_Pin1_4	617	622	PF00397	0.731
DOC_WW_Pin1_4	657	662	PF00397	0.746
DOC_WW_Pin1_4	73	78	PF00397	0.360
LIG_14-3-3_CanoR_1	212	218	PF00244	0.614
LIG_14-3-3_CanoR_1	297	302	PF00244	0.649
LIG_14-3-3_CanoR_1	360	369	PF00244	0.263
LIG_14-3-3_CanoR_1	471	477	PF00244	0.618
LIG_14-3-3_CanoR_1	490	496	PF00244	0.633
LIG_14-3-3_CanoR_1	499	509	PF00244	0.691
LIG_14-3-3_CanoR_1	570	575	PF00244	0.671
LIG_Actin_WH2_2	108	123	PF00022	0.429
LIG_BIR_III_4	311	315	PF00653	0.604
LIG_BRCT_BRCA1_1	47	51	PF00533	0.364
LIG_FHA_1	115	121	PF00498	0.385
LIG_FHA_1	12	18	PF00498	0.320
LIG_FHA_1	125	131	PF00498	0.307
LIG_FHA_1	175	181	PF00498	0.694
LIG_FHA_1	446	452	PF00498	0.356
LIG_FHA_1	5	11	PF00498	0.588
LIG_FHA_1	504	510	PF00498	0.691
LIG_FHA_1	578	584	PF00498	0.733
LIG_FHA_2	111	117	PF00498	0.450
LIG_FHA_2	241	247	PF00498	0.630
LIG_FHA_2	548	554	PF00498	0.743
LIG_GBD_Chelix_1	326	334	PF00786	0.360
LIG_LIR_Apic_2	213	218	PF02991	0.680
LIG_LIR_Apic_2	494	498	PF02991	0.626
LIG_LIR_Gen_1	298	306	PF02991	0.575
LIG_LIR_Gen_1	383	393	PF02991	0.289
LIG_LIR_Gen_1	417	426	PF02991	0.300
LIG_LIR_Gen_1	439	447	PF02991	0.309
LIG_LIR_Gen_1	503	511	PF02991	0.700
LIG_LIR_LC3C_4	76	80	PF02991	0.360
LIG_LIR_Nem_3	298	304	PF02991	0.579
LIG_LIR_Nem_3	383	389	PF02991	0.275
LIG_LIR_Nem_3	417	421	PF02991	0.355
LIG_LIR_Nem_3	439	443	PF02991	0.309
LIG_LIR_Nem_3	503	508	PF02991	0.698
LIG_LIR_Nem_3	6	12	PF02991	0.466
LIG_MYND_1	286	290	PF01753	0.651
LIG_NRBOX	422	428	PF00104	0.300
LIG_PDZ_Class_1	665	670	PF00595	0.741
LIG_Pex14_2	348	352	PF04695	0.317
LIG_Pex14_2	400	404	PF04695	0.360
LIG_PTB_Apo_2	378	385	PF02174	0.317
LIG_SH2_CRK	215	219	PF00017	0.672
LIG_SH2_CRK	618	622	PF00017	0.749
LIG_SH2_NCK_1	215	219	PF00017	0.603
LIG_SH2_PTP2	12	15	PF00017	0.328
LIG_SH2_PTP2	135	138	PF00017	0.300
LIG_SH2_PTP2	69	72	PF00017	0.360
LIG_SH2_STAT5	112	115	PF00017	0.370
LIG_SH2_STAT5	12	15	PF00017	0.376
LIG_SH2_STAT5	135	138	PF00017	0.334
LIG_SH2_STAT5	215	218	PF00017	0.609
LIG_SH2_STAT5	357	360	PF00017	0.263
LIG_SH2_STAT5	457	460	PF00017	0.447
LIG_SH2_STAT5	69	72	PF00017	0.300
LIG_SH2_STAT5	81	84	PF00017	0.379
LIG_SH3_3	197	203	PF00018	0.700
LIG_SH3_3	337	343	PF00018	0.336
LIG_SH3_3	572	578	PF00018	0.705
LIG_SUMO_SIM_anti_2	101	108	PF11976	0.336
LIG_TRAF2_1	166	169	PF00917	0.558
LIG_TYR_ITIM	10	15	PF00017	0.376
LIG_TYR_ITIM	110	115	PF00017	0.451
LIG_TYR_ITIM	133	138	PF00017	0.360
LIG_TYR_ITIM	67	72	PF00017	0.300
LIG_TYR_ITIM	79	84	PF00017	0.300
LIG_UBA3_1	427	436	PF00899	0.376
LIG_WRC_WIRS_1	502	507	PF05994	0.695
MOD_CDC14_SPxK_1	294	297	PF00782	0.658
MOD_CDC14_SPxK_1	59	62	PF00782	0.356
MOD_CDK_SPK_2	610	615	PF00069	0.642
MOD_CDK_SPxK_1	286	292	PF00069	0.648
MOD_CDK_SPxK_1	56	62	PF00069	0.363
MOD_CDK_SPxxK_3	657	664	PF00069	0.690
MOD_CK1_1	174	180	PF00069	0.610
MOD_CK1_1	291	297	PF00069	0.623
MOD_CK1_1	364	370	PF00069	0.290
MOD_CK1_1	491	497	PF00069	0.660
MOD_CK1_1	501	507	PF00069	0.628
MOD_CK1_1	562	568	PF00069	0.697
MOD_CK1_1	623	629	PF00069	0.748
MOD_CK1_1	635	641	PF00069	0.779
MOD_CK1_1	646	652	PF00069	0.830
MOD_CK1_1	662	668	PF00069	0.713
MOD_CK1_1	87	93	PF00069	0.573
MOD_CK2_1	240	246	PF00069	0.640
MOD_CK2_1	470	476	PF00069	0.585
MOD_CK2_1	547	553	PF00069	0.742
MOD_GlcNHglycan	227	230	PF01048	0.527
MOD_GlcNHglycan	322	325	PF01048	0.494
MOD_GlcNHglycan	363	366	PF01048	0.504
MOD_GlcNHglycan	544	547	PF01048	0.540
MOD_GlcNHglycan	564	567	PF01048	0.469
MOD_GlcNHglycan	601	604	PF01048	0.601
MOD_GlcNHglycan	644	648	PF01048	0.545
MOD_GSK3_1	110	117	PF00069	0.463
MOD_GSK3_1	171	178	PF00069	0.598
MOD_GSK3_1	210	217	PF00069	0.682
MOD_GSK3_1	291	298	PF00069	0.618
MOD_GSK3_1	316	323	PF00069	0.579
MOD_GSK3_1	445	452	PF00069	0.378
MOD_GSK3_1	500	507	PF00069	0.630
MOD_GSK3_1	588	595	PF00069	0.722
MOD_GSK3_1	619	626	PF00069	0.735
MOD_GSK3_1	632	639	PF00069	0.679
MOD_GSK3_1	87	94	PF00069	0.514
MOD_GSK3_1	98	105	PF00069	0.346
MOD_N-GLC_1	191	196	PF02516	0.437
MOD_N-GLC_1	361	366	PF02516	0.475
MOD_N-GLC_1	380	385	PF02516	0.556
MOD_N-GLC_1	45	50	PF02516	0.533
MOD_N-GLC_1	491	496	PF02516	0.415
MOD_N-GLC_1	51	56	PF02516	0.488
MOD_N-GLC_1	623	628	PF02516	0.514
MOD_N-GLC_2	652	654	PF02516	0.511
MOD_NEK2_1	124	129	PF00069	0.296
MOD_NEK2_1	175	180	PF00069	0.610
MOD_NEK2_1	182	187	PF00069	0.595
MOD_NEK2_1	20	25	PF00069	0.355
MOD_NEK2_1	225	230	PF00069	0.767
MOD_NEK2_1	232	237	PF00069	0.683
MOD_NEK2_1	261	266	PF00069	0.581
MOD_NEK2_1	299	304	PF00069	0.578
MOD_NEK2_1	488	493	PF00069	0.646
MOD_NEK2_1	511	516	PF00069	0.664
MOD_NEK2_2	171	176	PF00069	0.577
MOD_NEK2_2	191	196	PF00069	0.678
MOD_NEK2_2	210	215	PF00069	0.579
MOD_PIKK_1	272	278	PF00454	0.604
MOD_PIKK_1	493	499	PF00454	0.574
MOD_PKA_1	570	576	PF00069	0.721
MOD_PKA_2	232	238	PF00069	0.716
MOD_PKA_2	470	476	PF00069	0.597
MOD_PKA_2	498	504	PF00069	0.729
MOD_PKA_2	570	576	PF00069	0.736
MOD_PKB_1	537	545	PF00069	0.695
MOD_Plk_1	191	197	PF00069	0.637
MOD_Plk_1	220	226	PF00069	0.703
MOD_Plk_1	491	497	PF00069	0.640
MOD_Plk_1	539	545	PF00069	0.645
MOD_Plk_1	84	90	PF00069	0.573
MOD_Plk_2-3	553	559	PF00069	0.680
MOD_Plk_4	175	181	PF00069	0.679
MOD_Plk_4	182	188	PF00069	0.616
MOD_Plk_4	191	197	PF00069	0.705
MOD_Plk_4	20	26	PF00069	0.360
MOD_Plk_4	220	226	PF00069	0.754
MOD_Plk_4	233	239	PF00069	0.625
MOD_Plk_4	442	448	PF00069	0.351
MOD_Plk_4	5	11	PF00069	0.563
MOD_Plk_4	504	510	PF00069	0.644
MOD_Plk_4	636	642	PF00069	0.719
MOD_Plk_4	84	90	PF00069	0.573
MOD_Plk_4	91	97	PF00069	0.506
MOD_Plk_4	99	105	PF00069	0.360
MOD_ProDKin_1	214	220	PF00069	0.710
MOD_ProDKin_1	286	292	PF00069	0.648
MOD_ProDKin_1	51	57	PF00069	0.321
MOD_ProDKin_1	571	577	PF00069	0.678
MOD_ProDKin_1	588	594	PF00069	0.700
MOD_ProDKin_1	610	616	PF00069	0.700
MOD_ProDKin_1	617	623	PF00069	0.730
MOD_ProDKin_1	657	663	PF00069	0.747
MOD_ProDKin_1	73	79	PF00069	0.360
MOD_SUMO_for_1	557	560	PF00179	0.715
MOD_SUMO_rev_2	151	155	PF00179	0.582
MOD_SUMO_rev_2	553	563	PF00179	0.705
TRG_DiLeu_BaEn_4	168	174	PF01217	0.568
TRG_DiLeu_BaLyEn_6	408	413	PF01217	0.506
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.342
TRG_ENDOCYTIC_2	112	115	PF00928	0.370
TRG_ENDOCYTIC_2	12	15	PF00928	0.376
TRG_ENDOCYTIC_2	135	138	PF00928	0.300
TRG_ENDOCYTIC_2	482	485	PF00928	0.592
TRG_ENDOCYTIC_2	69	72	PF00928	0.300
TRG_ENDOCYTIC_2	81	84	PF00928	0.379
TRG_ER_diArg_1	303	306	PF00400	0.559
TRG_ER_diArg_1	498	500	PF00400	0.654
TRG_ER_diArg_1	569	571	PF00400	0.727
TRG_NLS_MonoCore_2	144	149	PF00514	0.574
TRG_NLS_MonoExtC_3	145	151	PF00514	0.577
TRG_NLS_MonoExtC_3	460	465	PF00514	0.569
TRG_NLS_MonoExtN_4	142	149	PF00514	0.561
TRG_Pf-PMV_PEXEL_1	411	416	PF00026	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P256	Leptomonas seymouri	39%	100%
A0A0N1HZC1	Leptomonas seymouri	68%	100%
A0A3Q8IU11	Leishmania donovani	95%	100%
A4HLL6	Leishmania braziliensis	80%	100%
A4I927	Leishmania infantum	95%	100%
E9B3Z2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%