Ribulose-phosphate 3-epimerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribulose-5-phosphate 3-epimerase, putative

Species:

Leishmania major

UniProt:

Q4Q431_LEIMA

TriTrypDb:

LmjF.33.1570 , LMJLV39_330024200 , LMJSD75_330023900

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	16
GO:0005829	cytosol	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

Q4Q431

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q431

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	16
GO:0006091	generation of precursor metabolites and energy	3	12
GO:0008152	metabolic process	1	16
GO:0009052	pentose-phosphate shunt, non-oxidative branch	4	2
GO:0009987	cellular process	1	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	16
GO:0044262	obsolete cellular carbohydrate metabolic process	3	2
GO:0071704	organic substance metabolic process	2	16
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:0006098	pentose-phosphate shunt	5	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006739	NADP metabolic process	7	10
GO:0006740	NADPH regeneration	4	10
GO:0006753	nucleoside phosphate metabolic process	4	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0009117	nucleotide metabolic process	5	10
GO:0019362	pyridine nucleotide metabolic process	5	10
GO:0019637	organophosphate metabolic process	3	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0044281	small molecule metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0046496	nicotinamide nucleotide metabolic process	6	10
GO:0051156	glucose 6-phosphate metabolic process	4	10
GO:0055086	nucleobase-containing small molecule metabolic process	3	10
GO:0072524	pyridine-containing compound metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0004750	D-ribulose-phosphate 3-epimerase activity	5	13
GO:0005488	binding	1	12
GO:0016853	isomerase activity	2	16
GO:0016854	racemase and epimerase activity	3	16
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	4	16
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	63	67	PF00656	0.267
CLV_NRD_NRD_1	192	194	PF00675	0.349
CLV_NRD_NRD_1	233	235	PF00675	0.408
CLV_PCSK_KEX2_1	192	194	PF00082	0.349
CLV_PCSK_SKI1_1	145	149	PF00082	0.431
DOC_MAPK_gen_1	192	200	PF00069	0.264
DOC_MAPK_gen_1	84	92	PF00069	0.390
DOC_MAPK_MEF2A_6	134	142	PF00069	0.327
DOC_MAPK_MEF2A_6	192	200	PF00069	0.267
DOC_MAPK_MEF2A_6	84	92	PF00069	0.377
DOC_PP1_RVXF_1	182	188	PF00149	0.437
DOC_PP2B_PxIxI_1	70	76	PF00149	0.300
DOC_USP7_MATH_1	111	115	PF00917	0.294
DOC_USP7_MATH_1	224	228	PF00917	0.364
DOC_WW_Pin1_4	48	53	PF00397	0.346
LIG_14-3-3_CanoR_1	184	188	PF00244	0.425
LIG_14-3-3_CanoR_1	242	249	PF00244	0.461
LIG_eIF4E_1	162	168	PF01652	0.369
LIG_FHA_1	115	121	PF00498	0.286
LIG_FHA_1	149	155	PF00498	0.396
LIG_LIR_Gen_1	38	47	PF02991	0.313
LIG_LIR_Gen_1	58	65	PF02991	0.269
LIG_LIR_Nem_3	2	7	PF02991	0.649
LIG_LIR_Nem_3	38	42	PF02991	0.313
LIG_LIR_Nem_3	58	62	PF02991	0.308
LIG_LYPXL_yS_3	195	198	PF13949	0.297
LIG_Pex14_2	87	91	PF04695	0.437
LIG_SH2_STAP1	116	120	PF00017	0.437
LIG_SH2_STAT3	162	165	PF00017	0.343
LIG_SH2_STAT5	116	119	PF00017	0.399
LIG_SH2_STAT5	162	165	PF00017	0.399
LIG_SH3_3	16	22	PF00018	0.451
LIG_SH3_3	46	52	PF00018	0.346
LIG_SH3_3	95	101	PF00018	0.286
LIG_SUMO_SIM_anti_2	164	170	PF11976	0.276
LIG_TRAF2_1	237	240	PF00917	0.399
MOD_CK1_1	114	120	PF00069	0.293
MOD_CK1_1	186	192	PF00069	0.400
MOD_CK1_1	244	250	PF00069	0.414
MOD_CK1_1	48	54	PF00069	0.369
MOD_GlcNHglycan	113	116	PF01048	0.413
MOD_GlcNHglycan	243	246	PF01048	0.544
MOD_N-GLC_1	123	128	PF02516	0.367
MOD_N-GLC_1	148	153	PF02516	0.355
MOD_N-GLC_1	71	76	PF02516	0.276
MOD_NEK2_1	241	246	PF00069	0.425
MOD_NEK2_2	224	229	PF00069	0.346
MOD_PIKK_1	148	154	PF00454	0.444
MOD_PKA_2	183	189	PF00069	0.424
MOD_PKA_2	241	247	PF00069	0.451
MOD_Plk_1	10	16	PF00069	0.415
MOD_Plk_1	71	77	PF00069	0.276
MOD_Plk_4	11	17	PF00069	0.418
MOD_Plk_4	176	182	PF00069	0.313
MOD_Plk_4	183	189	PF00069	0.306
MOD_Plk_4	224	230	PF00069	0.340
MOD_Plk_4	30	36	PF00069	0.316
MOD_Plk_4	45	51	PF00069	0.374
MOD_ProDKin_1	48	54	PF00069	0.346
MOD_SUMO_rev_2	121	129	PF00179	0.425
MOD_SUMO_rev_2	227	237	PF00179	0.423
TRG_DiLeu_BaEn_1	153	158	PF01217	0.437
TRG_DiLeu_BaEn_2	182	188	PF01217	0.343
TRG_ENDOCYTIC_2	195	198	PF00928	0.297
TRG_ER_diArg_1	191	193	PF00400	0.287
TRG_ER_diArg_1	83	86	PF00400	0.372
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P388	Leptomonas seymouri	76%	100%
A0A0N0P4Y1	Leptomonas seymouri	44%	100%
A0A0S4JIP2	Bodo saltans	58%	100%
A0A1X0P1B6	Trypanosomatidae	55%	100%
A0A1X0P628	Trypanosomatidae	47%	100%
A0A3Q8IDT1	Leishmania donovani	97%	100%
A0A3R7KMA2	Trypanosoma rangeli	55%	100%
A0A3R7LEK7	Trypanosoma rangeli	47%	100%
A0A3S7X9N8	Leishmania donovani	43%	100%
A4HLL7	Leishmania braziliensis	90%	100%
A4HN39	Leishmania braziliensis	44%	100%
A4I928	Leishmania infantum	97%	100%
A4IBQ7	Leishmania infantum	43%	100%
C9ZN91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
D0A531	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AFJ2	Leishmania major	43%	100%
E9B3Z3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O14105	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	100%
O34557	Bacillus subtilis (strain 168)	42%	100%
O66107	Treponema pallidum (strain Nichols)	39%	100%
O67098	Aquifex aeolicus (strain VF5)	34%	100%
O84123	Chlamydia trachomatis (strain D/UW-3/Cx)	39%	100%
P0AG07	Escherichia coli (strain K12)	39%	100%
P0AG08	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	39%	100%
P0AG09	Escherichia coli O157:H7	39%	100%
P0AG10	Shigella flexneri	39%	100%
P32719	Escherichia coli (strain K12)	35%	100%
P39362	Escherichia coli (strain K12)	28%	100%
P40117	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	40%	100%
P44756	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	38%	100%
P45455	Serratia marcescens	39%	100%
P46969	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	100%
P51012	Rhodobacter capsulatus	41%	100%
P51013	Rhodospirillum rubrum	38%	100%
P56188	Helicobacter pylori (strain ATCC 700392 / 26695)	34%	100%
P57603	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	39%	100%
P65761	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	46%	100%
P74061	Synechocystis sp. (strain PCC 6803 / Kazusa)	41%	100%
P9WI50	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	46%	100%
P9WI51	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	46%	100%
Q04539	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	37%	100%
Q2QD12	Homo sapiens	41%	100%
Q43157	Spinacia oleracea	42%	92%
Q43843	Solanum tuberosum	43%	94%
Q58093	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	37%	100%
Q5R5Y2	Pongo abelii	42%	100%
Q6FL81	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	44%	100%
Q755M2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	41%	100%
Q89A59	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	31%	100%
Q8K940	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	37%	100%
Q8SRP6	Encephalitozoon cuniculi (strain GB-M1)	35%	100%
Q8VEE0	Mus musculus	43%	100%
Q96AT9	Homo sapiens	42%	100%
Q9CCP9	Mycobacterium leprae (strain TN)	46%	100%
Q9L0Z5	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	41%	100%
Q9PKR7	Chlamydia muridarum (strain MoPn / Nigg)	37%	100%
Q9SAU2	Arabidopsis thaliana	42%	93%
Q9SE42	Oryza sativa subsp. japonica	46%	100%
Q9Z8Z9	Chlamydia pneumoniae	36%	100%
Q9ZJ75	Helicobacter pylori (strain J99 / ATCC 700824)	34%	100%
Q9ZTP5	Oryza sativa subsp. japonica	43%	96%
V5BCV0	Trypanosoma cruzi	52%	100%
V5BHA6	Trypanosoma cruzi	56%	100%