Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q430_LEIMA

TriTrypDb:

LmjF.33.1575 , LMJLV39_330024300 , LMJSD75_330024000

Length:

511

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q430

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q430

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.516
CLV_NRD_NRD_1	410	412	PF00675	0.347
CLV_NRD_NRD_1	461	463	PF00675	0.630
CLV_NRD_NRD_1	486	488	PF00675	0.519
CLV_NRD_NRD_1	495	497	PF00675	0.436
CLV_NRD_NRD_1	8	10	PF00675	0.681
CLV_PCSK_KEX2_1	15	17	PF00082	0.672
CLV_PCSK_KEX2_1	410	412	PF00082	0.544
CLV_PCSK_KEX2_1	461	463	PF00082	0.630
CLV_PCSK_KEX2_1	495	497	PF00082	0.494
CLV_PCSK_KEX2_1	8	10	PF00082	0.697
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.644
CLV_PCSK_PC7_1	4	10	PF00082	0.555
CLV_PCSK_SKI1_1	301	305	PF00082	0.484
CLV_PCSK_SKI1_1	411	415	PF00082	0.380
CLV_PCSK_SKI1_1	42	46	PF00082	0.709
CLV_PCSK_SKI1_1	8	12	PF00082	0.689
CLV_PCSK_SKI1_1	85	89	PF00082	0.435
DEG_MDM2_SWIB_1	156	163	PF02201	0.462
DEG_Nend_UBRbox_3	1	3	PF02207	0.575
DEG_SPOP_SBC_1	166	170	PF00917	0.650
DEG_SPOP_SBC_1	44	48	PF00917	0.670
DOC_CKS1_1	206	211	PF01111	0.467
DOC_MAPK_MEF2A_6	423	431	PF00069	0.651
DOC_PP1_RVXF_1	7	14	PF00149	0.553
DOC_PP2B_LxvP_1	326	329	PF13499	0.543
DOC_USP7_MATH_1	143	147	PF00917	0.447
DOC_USP7_MATH_1	166	170	PF00917	0.546
DOC_USP7_MATH_1	254	258	PF00917	0.429
DOC_USP7_MATH_1	283	287	PF00917	0.679
DOC_USP7_MATH_1	37	41	PF00917	0.651
DOC_USP7_MATH_1	419	423	PF00917	0.474
DOC_USP7_MATH_1	44	48	PF00917	0.618
DOC_USP7_MATH_1	54	58	PF00917	0.659
DOC_USP7_MATH_1	70	74	PF00917	0.366
DOC_WW_Pin1_4	168	173	PF00397	0.642
DOC_WW_Pin1_4	198	203	PF00397	0.582
DOC_WW_Pin1_4	205	210	PF00397	0.411
DOC_WW_Pin1_4	337	342	PF00397	0.341
DOC_WW_Pin1_4	430	435	PF00397	0.539
DOC_WW_Pin1_4	466	471	PF00397	0.657
DOC_WW_Pin1_4	79	84	PF00397	0.642
LIG_14-3-3_CanoR_1	230	238	PF00244	0.627
LIG_14-3-3_CanoR_1	385	390	PF00244	0.503
LIG_14-3-3_CanoR_1	42	51	PF00244	0.703
LIG_14-3-3_CanoR_1	440	445	PF00244	0.538
LIG_14-3-3_CanoR_1	487	497	PF00244	0.498
LIG_14-3-3_CanoR_1	505	511	PF00244	0.437
LIG_14-3-3_CanoR_1	74	80	PF00244	0.473
LIG_BRCT_BRCA1_1	152	156	PF00533	0.410
LIG_BRCT_BRCA1_1	47	51	PF00533	0.610
LIG_DLG_GKlike_1	385	392	PF00625	0.464
LIG_FHA_1	211	217	PF00498	0.406
LIG_FHA_1	233	239	PF00498	0.613
LIG_FHA_1	248	254	PF00498	0.457
LIG_FHA_1	323	329	PF00498	0.600
LIG_FHA_1	395	401	PF00498	0.443
LIG_FHA_1	402	408	PF00498	0.371
LIG_FHA_1	422	428	PF00498	0.561
LIG_FHA_1	44	50	PF00498	0.549
LIG_FHA_2	118	124	PF00498	0.516
LIG_FHA_2	292	298	PF00498	0.526
LIG_FHA_2	479	485	PF00498	0.670
LIG_LIR_Apic_2	264	269	PF02991	0.462
LIG_LIR_Gen_1	342	352	PF02991	0.364
LIG_LIR_Nem_3	342	348	PF02991	0.376
LIG_LIR_Nem_3	94	99	PF02991	0.404
LIG_Pex14_1	95	99	PF04695	0.362
LIG_Pex14_2	156	160	PF04695	0.445
LIG_Pex14_2	255	259	PF04695	0.325
LIG_Pex14_2	71	75	PF04695	0.518
LIG_SH2_STAT5	402	405	PF00017	0.368
LIG_SH2_STAT5	99	102	PF00017	0.374
LIG_SH3_3	335	341	PF00018	0.377
LIG_SH3_3	378	384	PF00018	0.560
LIG_SH3_3	428	434	PF00018	0.476
LIG_SUMO_SIM_par_1	201	208	PF11976	0.444
LIG_TRAF2_1	120	123	PF00917	0.782
LIG_TRAF2_1	294	297	PF00917	0.460
LIG_TRAF2_1	341	344	PF00917	0.461
LIG_TRAF2_2	341	346	PF00917	0.436
LIG_WW_3	382	386	PF00397	0.460
MOD_CDC14_SPxK_1	82	85	PF00782	0.644
MOD_CDK_SPxK_1	79	85	PF00069	0.614
MOD_CK1_1	184	190	PF00069	0.644
MOD_CK1_1	22	28	PF00069	0.564
MOD_CK1_1	232	238	PF00069	0.630
MOD_CK1_1	366	372	PF00069	0.683
MOD_CK1_1	373	379	PF00069	0.641
MOD_CK1_1	433	439	PF00069	0.484
MOD_CK1_1	445	451	PF00069	0.502
MOD_CK1_1	47	53	PF00069	0.713
MOD_CK1_1	471	477	PF00069	0.678
MOD_CK1_1	478	484	PF00069	0.619
MOD_CK1_1	57	63	PF00069	0.601
MOD_CK1_1	73	79	PF00069	0.497
MOD_CK2_1	117	123	PF00069	0.652
MOD_CK2_1	283	289	PF00069	0.635
MOD_CK2_1	291	297	PF00069	0.446
MOD_CK2_1	445	451	PF00069	0.576
MOD_CK2_1	478	484	PF00069	0.666
MOD_CK2_1	495	501	PF00069	0.358
MOD_DYRK1A_RPxSP_1	430	434	PF00069	0.492
MOD_GlcNHglycan	117	120	PF01048	0.735
MOD_GlcNHglycan	186	189	PF01048	0.574
MOD_GlcNHglycan	232	235	PF01048	0.560
MOD_GlcNHglycan	24	27	PF01048	0.676
MOD_GlcNHglycan	263	266	PF01048	0.456
MOD_GlcNHglycan	269	272	PF01048	0.543
MOD_GlcNHglycan	279	283	PF01048	0.558
MOD_GlcNHglycan	285	288	PF01048	0.578
MOD_GlcNHglycan	366	369	PF01048	0.595
MOD_GlcNHglycan	39	42	PF01048	0.513
MOD_GlcNHglycan	414	417	PF01048	0.621
MOD_GlcNHglycan	419	422	PF01048	0.454
MOD_GlcNHglycan	470	473	PF01048	0.734
MOD_GlcNHglycan	477	480	PF01048	0.623
MOD_GlcNHglycan	52	55	PF01048	0.683
MOD_GlcNHglycan	75	78	PF01048	0.555
MOD_GSK3_1	117	124	PF00069	0.727
MOD_GSK3_1	158	165	PF00069	0.514
MOD_GSK3_1	168	175	PF00069	0.687
MOD_GSK3_1	229	236	PF00069	0.552
MOD_GSK3_1	243	250	PF00069	0.554
MOD_GSK3_1	278	285	PF00069	0.775
MOD_GSK3_1	287	294	PF00069	0.602
MOD_GSK3_1	363	370	PF00069	0.692
MOD_GSK3_1	417	424	PF00069	0.515
MOD_GSK3_1	43	50	PF00069	0.659
MOD_GSK3_1	440	447	PF00069	0.552
MOD_GSK3_1	471	478	PF00069	0.654
MOD_GSK3_1	54	61	PF00069	0.520
MOD_LATS_1	438	444	PF00433	0.509
MOD_N-GLC_1	287	292	PF02516	0.673
MOD_N-GLC_1	322	327	PF02516	0.449
MOD_N-GLC_1	370	375	PF02516	0.557
MOD_N-GLC_1	417	422	PF02516	0.612
MOD_NEK2_1	150	155	PF00069	0.381
MOD_NEK2_1	19	24	PF00069	0.731
MOD_NEK2_1	32	37	PF00069	0.587
MOD_NEK2_1	444	449	PF00069	0.600
MOD_NEK2_1	455	460	PF00069	0.634
MOD_NEK2_1	58	63	PF00069	0.602
MOD_PIKK_1	137	143	PF00454	0.472
MOD_PIKK_1	339	345	PF00454	0.459
MOD_PIKK_1	59	65	PF00454	0.491
MOD_PK_1	442	448	PF00069	0.495
MOD_PKA_1	495	501	PF00069	0.485
MOD_PKA_2	181	187	PF00069	0.563
MOD_PKA_2	229	235	PF00069	0.564
MOD_PKA_2	267	273	PF00069	0.591
MOD_PKA_2	32	38	PF00069	0.702
MOD_PKA_2	495	501	PF00069	0.485
MOD_PKA_2	504	510	PF00069	0.517
MOD_PKA_2	73	79	PF00069	0.494
MOD_PKB_1	440	448	PF00069	0.408
MOD_Plk_1	121	127	PF00069	0.644
MOD_Plk_1	243	249	PF00069	0.530
MOD_Plk_1	287	293	PF00069	0.587
MOD_Plk_1	450	456	PF00069	0.620
MOD_Plk_1	85	91	PF00069	0.458
MOD_Plk_2-3	122	128	PF00069	0.513
MOD_Plk_4	151	157	PF00069	0.354
MOD_Plk_4	181	187	PF00069	0.650
MOD_Plk_4	254	260	PF00069	0.359
MOD_ProDKin_1	168	174	PF00069	0.633
MOD_ProDKin_1	198	204	PF00069	0.564
MOD_ProDKin_1	205	211	PF00069	0.407
MOD_ProDKin_1	337	343	PF00069	0.343
MOD_ProDKin_1	430	436	PF00069	0.542
MOD_ProDKin_1	466	472	PF00069	0.656
MOD_ProDKin_1	79	85	PF00069	0.650
TRG_DiLeu_BaLyEn_6	212	217	PF01217	0.422
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.611
TRG_ER_diArg_1	409	411	PF00400	0.326
TRG_ER_diArg_1	494	496	PF00400	0.473
TRG_ER_diArg_1	8	10	PF00400	0.695
TRG_NES_CRM1_1	302	317	PF08389	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U7	Leptomonas seymouri	50%	100%
A0A3Q8IHT9	Leishmania donovani	92%	100%
A0A3R7LW25	Trypanosoma rangeli	30%	100%
A4HLL8	Leishmania braziliensis	77%	100%
A4I929	Leishmania infantum	92%	100%
D0A532	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B3Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5DDH0	Trypanosoma cruzi	28%	100%