Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q429_LEIMA

TriTrypDb:

LmjF.33.1580 , LMJLV39_330024400 , LMJSD75_330024100

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q429

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q429

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	277	281	PF00656	0.551
CLV_MEL_PAP_1	221	227	PF00089	0.732
CLV_NRD_NRD_1	29	31	PF00675	0.657
CLV_PCSK_KEX2_1	274	276	PF00082	0.823
CLV_PCSK_KEX2_1	29	31	PF00082	0.657
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.823
CLV_PCSK_SKI1_1	219	223	PF00082	0.576
CLV_PCSK_SKI1_1	22	26	PF00082	0.654
CLV_PCSK_SKI1_1	34	38	PF00082	0.445
CLV_PCSK_SKI1_1	40	44	PF00082	0.387
DEG_APCC_DBOX_1	124	132	PF00400	0.734
DEG_Nend_Nbox_1	1	3	PF02207	0.684
DEG_SCF_FBW7_1	4	11	PF00400	0.711
DEG_SPOP_SBC_1	310	314	PF00917	0.756
DOC_CYCLIN_RxL_1	104	115	PF00134	0.654
DOC_CYCLIN_RxL_1	19	28	PF00134	0.669
DOC_MAPK_gen_1	29	35	PF00069	0.626
DOC_MAPK_MEF2A_6	241	249	PF00069	0.513
DOC_PP1_RVXF_1	105	112	PF00149	0.650
DOC_PP1_RVXF_1	32	39	PF00149	0.629
DOC_PP2B_LxvP_1	324	327	PF13499	0.751
DOC_USP7_MATH_1	172	176	PF00917	0.780
DOC_WW_Pin1_4	4	9	PF00397	0.708
DOC_WW_Pin1_4	59	64	PF00397	0.805
LIG_14-3-3_CanoR_1	120	124	PF00244	0.722
LIG_14-3-3_CanoR_1	34	39	PF00244	0.639
LIG_Actin_WH2_2	71	87	PF00022	0.663
LIG_DCNL_PONY_1	1	4	PF03556	0.714
LIG_FHA_1	116	122	PF00498	0.582
LIG_FHA_1	132	138	PF00498	0.728
LIG_FHA_1	184	190	PF00498	0.712
LIG_FHA_1	199	205	PF00498	0.449
LIG_FHA_1	254	260	PF00498	0.777
LIG_FHA_1	280	286	PF00498	0.793
LIG_FHA_1	5	11	PF00498	0.562
LIG_FHA_1	55	61	PF00498	0.620
LIG_FHA_2	96	102	PF00498	0.682
LIG_LIR_Gen_1	179	189	PF02991	0.728
LIG_LIR_Gen_1	313	324	PF02991	0.486
LIG_LIR_Nem_3	179	185	PF02991	0.742
LIG_LIR_Nem_3	288	292	PF02991	0.775
LIG_LIR_Nem_3	313	319	PF02991	0.535
LIG_SH2_CRK	316	320	PF00017	0.485
LIG_SH2_STAP1	229	233	PF00017	0.710
LIG_SH2_STAP1	316	320	PF00017	0.485
LIG_SH2_STAP1	56	60	PF00017	0.739
LIG_SH2_STAT5	158	161	PF00017	0.818
LIG_SH2_STAT5	261	264	PF00017	0.795
LIG_SH2_STAT5	268	271	PF00017	0.690
LIG_SH2_STAT5	316	319	PF00017	0.491
LIG_SH2_STAT5	56	59	PF00017	0.547
LIG_SH3_3	137	143	PF00018	0.735
LIG_SH3_3	222	228	PF00018	0.733
LIG_SH3_3	230	236	PF00018	0.629
LIG_SUMO_SIM_anti_2	136	141	PF11976	0.736
LIG_TRAF2_1	47	50	PF00917	0.762
LIG_WRC_WIRS_1	35	40	PF05994	0.650
MOD_CDC14_SPxK_1	62	65	PF00782	0.736
MOD_CDK_SPxK_1	59	65	PF00069	0.804
MOD_CK1_1	198	204	PF00069	0.695
MOD_CK1_1	217	223	PF00069	0.486
MOD_CK1_1	252	258	PF00069	0.764
MOD_CK1_1	314	320	PF00069	0.739
MOD_CK1_1	41	47	PF00069	0.700
MOD_CK1_1	95	101	PF00069	0.661
MOD_CK2_1	44	50	PF00069	0.744
MOD_CK2_1	95	101	PF00069	0.674
MOD_Cter_Amidation	272	275	PF01082	0.810
MOD_GlcNHglycan	198	201	PF01048	0.582
MOD_GlcNHglycan	256	259	PF01048	0.776
MOD_GlcNHglycan	324	327	PF01048	0.667
MOD_GlcNHglycan	94	97	PF01048	0.675
MOD_GSK3_1	115	122	PF00069	0.675
MOD_GSK3_1	172	179	PF00069	0.697
MOD_GSK3_1	194	201	PF00069	0.605
MOD_GSK3_1	249	256	PF00069	0.674
MOD_GSK3_1	275	282	PF00069	0.789
MOD_GSK3_1	310	317	PF00069	0.752
MOD_GSK3_1	34	41	PF00069	0.628
MOD_GSK3_1	4	11	PF00069	0.711
MOD_LATS_1	160	166	PF00433	0.813
MOD_NEK2_1	196	201	PF00069	0.587
MOD_NEK2_1	322	327	PF00069	0.723
MOD_NEK2_1	38	43	PF00069	0.672
MOD_NEK2_2	243	248	PF00069	0.768
MOD_PKA_1	274	280	PF00069	0.622
MOD_PKA_2	119	125	PF00069	0.711
MOD_PKA_2	274	280	PF00069	0.622
MOD_Plk_1	217	223	PF00069	0.723
MOD_Plk_4	217	223	PF00069	0.705
MOD_Plk_4	243	249	PF00069	0.769
MOD_Plk_4	314	320	PF00069	0.726
MOD_Plk_4	38	44	PF00069	0.673
MOD_ProDKin_1	4	10	PF00069	0.712
MOD_ProDKin_1	59	65	PF00069	0.804
MOD_SUMO_rev_2	110	118	PF00179	0.341
MOD_SUMO_rev_2	91	95	PF00179	0.703
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.723
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.613
TRG_ENDOCYTIC_2	182	185	PF00928	0.735
TRG_ENDOCYTIC_2	316	319	PF00928	0.491
TRG_ER_diArg_1	104	107	PF00400	0.670
TRG_ER_diArg_1	20	23	PF00400	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IHI6	Leishmania donovani	94%	100%
A4I930	Leishmania infantum	94%	100%
E9B3Z5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%