NAD(P)-binding protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3-ketoacyl-CoA reductase, putative

Species:

Leishmania major

UniProt:

Q4Q428_LEIMA

TriTrypDb:

LmjF.33.1590 , LMJLV39_330024500 , LMJSD75_330024200

Length:

326

Annotations

LeishMANIAdb annotations

These proteins belong to short-chain dehydrogenases / reductases using NAD or NADP as cofactor. All homologs are used for very long fatty acid biosynthesis.. Expanded in multiple organisms, but especially Strigomonas. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q428

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q428

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016491	oxidoreductase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.259
CLV_NRD_NRD_1	172	174	PF00675	0.269
CLV_NRD_NRD_1	177	179	PF00675	0.262
CLV_NRD_NRD_1	315	317	PF00675	0.638
CLV_PCSK_KEX2_1	177	179	PF00082	0.230
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.193
CLV_PCSK_PC7_1	173	179	PF00082	0.193
CLV_PCSK_SKI1_1	119	123	PF00082	0.342
CLV_PCSK_SKI1_1	174	178	PF00082	0.225
CLV_PCSK_SKI1_1	206	210	PF00082	0.466
CLV_PCSK_SKI1_1	287	291	PF00082	0.594
DEG_Nend_Nbox_1	1	3	PF02207	0.409
DOC_MAPK_gen_1	104	110	PF00069	0.432
DOC_MAPK_gen_1	177	186	PF00069	0.456
DOC_MAPK_gen_1	96	103	PF00069	0.475
DOC_MAPK_MEF2A_6	96	103	PF00069	0.495
DOC_PP1_RVXF_1	289	296	PF00149	0.327
DOC_USP7_MATH_1	246	250	PF00917	0.438
DOC_USP7_MATH_1	253	257	PF00917	0.465
DOC_USP7_UBL2_3	177	181	PF12436	0.393
DOC_USP7_UBL2_3	251	255	PF12436	0.411
DOC_WW_Pin1_4	200	205	PF00397	0.271
DOC_WW_Pin1_4	230	235	PF00397	0.255
DOC_WW_Pin1_4	256	261	PF00397	0.369
LIG_14-3-3_CanoR_1	273	277	PF00244	0.298
LIG_APCC_ABBA_1	295	300	PF00400	0.371
LIG_BRCT_BRCA1_1	204	208	PF00533	0.280
LIG_Clathr_ClatBox_1	79	83	PF01394	0.455
LIG_CtBP_PxDLS_1	107	113	PF00389	0.541
LIG_DCNL_PONY_1	1	4	PF03556	0.464
LIG_eIF4E_1	139	145	PF01652	0.466
LIG_FHA_1	123	129	PF00498	0.464
LIG_FHA_1	24	30	PF00498	0.311
LIG_FHA_1	280	286	PF00498	0.338
LIG_FHA_1	288	294	PF00498	0.250
LIG_FHA_2	146	152	PF00498	0.472
LIG_FHA_2	273	279	PF00498	0.291
LIG_FHA_2	88	94	PF00498	0.455
LIG_LIR_Gen_1	114	121	PF02991	0.541
LIG_LIR_Gen_1	294	302	PF02991	0.310
LIG_LIR_Gen_1	303	313	PF02991	0.323
LIG_LIR_Gen_1	6	15	PF02991	0.261
LIG_LIR_Gen_1	89	99	PF02991	0.457
LIG_LIR_Nem_3	294	298	PF02991	0.306
LIG_LIR_Nem_3	50	55	PF02991	0.475
LIG_LIR_Nem_3	6	12	PF02991	0.322
LIG_LIR_Nem_3	89	94	PF02991	0.447
LIG_LYPXL_yS_3	98	101	PF13949	0.541
LIG_Pex14_2	208	212	PF04695	0.255
LIG_PTB_Apo_2	133	140	PF02174	0.455
LIG_PTB_Phospho_1	133	139	PF10480	0.455
LIG_SH2_SRC	193	196	PF00017	0.323
LIG_SH2_STAP1	5	9	PF00017	0.353
LIG_SH2_STAT5	139	142	PF00017	0.454
LIG_SH2_STAT5	14	17	PF00017	0.329
LIG_SH2_STAT5	193	196	PF00017	0.307
LIG_SH2_STAT5	27	30	PF00017	0.307
LIG_SH2_STAT5	3	6	PF00017	0.374
LIG_SH3_3	226	232	PF00018	0.255
LIG_SUMO_SIM_anti_2	226	231	PF11976	0.280
LIG_SUMO_SIM_par_1	20	26	PF11976	0.300
LIG_SUMO_SIM_par_1	78	84	PF11976	0.455
LIG_UBA3_1	284	291	PF00899	0.326
LIG_WRC_WIRS_1	183	188	PF05994	0.323
MOD_CDC14_SPxK_1	203	206	PF00782	0.280
MOD_CDK_SPxK_1	200	206	PF00069	0.280
MOD_CK1_1	23	29	PF00069	0.340
MOD_CK1_1	249	255	PF00069	0.424
MOD_CK1_1	256	262	PF00069	0.386
MOD_CK2_1	145	151	PF00069	0.481
MOD_CK2_1	320	326	PF00069	0.515
MOD_CK2_1	87	93	PF00069	0.455
MOD_Cter_Amidation	44	47	PF01082	0.232
MOD_GlcNHglycan	110	113	PF01048	0.304
MOD_GlcNHglycan	188	191	PF01048	0.272
MOD_GlcNHglycan	255	258	PF01048	0.612
MOD_GlcNHglycan	269	272	PF01048	0.410
MOD_GlcNHglycan	59	62	PF01048	0.245
MOD_GSK3_1	182	189	PF00069	0.323
MOD_GSK3_1	207	214	PF00069	0.299
MOD_GSK3_1	230	237	PF00069	0.247
MOD_GSK3_1	249	256	PF00069	0.394
MOD_GSK3_1	316	323	PF00069	0.472
MOD_GSK3_1	53	60	PF00069	0.455
MOD_NEK2_1	186	191	PF00069	0.307
MOD_NEK2_1	212	217	PF00069	0.247
MOD_NEK2_1	87	92	PF00069	0.467
MOD_NEK2_2	197	202	PF00069	0.307
MOD_NEK2_2	246	251	PF00069	0.450
MOD_PIKK_1	120	126	PF00454	0.535
MOD_PIKK_1	69	75	PF00454	0.554
MOD_PKA_1	177	183	PF00069	0.393
MOD_PKA_1	316	322	PF00069	0.441
MOD_PKA_2	177	183	PF00069	0.544
MOD_PKA_2	272	278	PF00069	0.296
MOD_PKB_1	314	322	PF00069	0.404
MOD_Plk_4	197	203	PF00069	0.299
MOD_Plk_4	20	26	PF00069	0.344
MOD_Plk_4	272	278	PF00069	0.302
MOD_Plk_4	3	9	PF00069	0.415
MOD_ProDKin_1	200	206	PF00069	0.271
MOD_ProDKin_1	230	236	PF00069	0.255
MOD_ProDKin_1	256	262	PF00069	0.365
TRG_ENDOCYTIC_2	115	118	PF00928	0.541
TRG_ENDOCYTIC_2	5	8	PF00928	0.381
TRG_ENDOCYTIC_2	98	101	PF00928	0.541
TRG_ER_diArg_1	313	316	PF00400	0.414
TRG_NLS_MonoExtC_3	176	181	PF00514	0.393
TRG_NLS_MonoExtN_4	174	181	PF00514	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTS4	Leptomonas seymouri	81%	100%
A0A0S4IWL0	Bodo saltans	30%	100%
A0A0S4JBE7	Bodo saltans	30%	100%
A0A0S4JNE8	Bodo saltans	63%	100%
A0A0S4JSF1	Bodo saltans	25%	81%
A0A1X0NKR7	Trypanosomatidae	28%	88%
A0A1X0NWL8	Trypanosomatidae	28%	100%
A0A1X0P1C4	Trypanosomatidae	63%	100%
A0A3Q8IE20	Leishmania donovani	32%	100%
A0A3Q8IHN8	Leishmania donovani	26%	96%
A0A3Q8IIU6	Leishmania donovani	26%	100%
A0A3S7X6T1	Leishmania donovani	95%	100%
A0A422NG64	Trypanosoma rangeli	63%	100%
A0A422NJG3	Trypanosoma rangeli	31%	100%
A3LXZ3	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	28%	94%
A4ECA9	Collinsella aerofaciens (strain ATCC 25986 / DSM 3979 / JCM 10188 / KCTC 3647 / NCTC 11838 / VPI 1003)	26%	100%
A4HLM0	Leishmania braziliensis	89%	100%
A4HM71	Leishmania braziliensis	29%	96%
A4HME4	Leishmania braziliensis	26%	100%
A4I931	Leishmania infantum	95%	100%
A4IAT4	Leishmania infantum	26%	96%
A4IB16	Leishmania infantum	26%	100%
A5DND6	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	28%	96%
A5E0R1	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	27%	93%
A6SG70	Botryotinia fuckeliana (strain B05.10)	32%	98%
A7B4V1	Ruminococcus gnavus (strain ATCC 29149 / VPI C7-9)	25%	100%
A7TMJ2	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	28%	94%
A8N6B4	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	30%	96%
A8Q1U2	Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)	23%	100%
C9ZNQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D0A2C4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	94%
D0A534	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
D3U1D9	Klebsiella oxytoca	27%	100%
D4A1J4	Rattus norvegicus	25%	100%
E9AEL0	Leishmania major	28%	100%
E9AEU5	Leishmania major	26%	100%
E9B3Z6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B5S1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	96%
E9B601	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
F4J2Z7	Arabidopsis thaliana	25%	100%
F4JZN6	Arabidopsis thaliana	26%	98%
G4N286	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	25%	100%
G9FRD6	Clostridium sardiniense	23%	100%
M2ZIX7	Pseudocercospora fijiensis (strain CIRAD86)	31%	100%
O54939	Rattus norvegicus	30%	100%
O57314	Anas platyrhynchos	31%	100%
P37440	Escherichia coli (strain K12)	25%	100%
P37694	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	25%	100%
P39071	Bacillus subtilis (strain 168)	24%	100%
P9WGR4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	26%	100%
P9WGR5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	100%
Q06136	Homo sapiens	27%	98%
Q09517	Caenorhabditis elegans	28%	100%
Q0IH28	Xenopus laevis	25%	100%
Q0VFE7	Xenopus tropicalis	24%	100%
Q10130	Caenorhabditis elegans	24%	86%
Q17703	Caenorhabditis elegans	26%	100%
Q1R183	Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11)	26%	100%
Q28IU1	Xenopus tropicalis	31%	100%
Q2KIJ5	Bos taurus	27%	98%
Q2UET3	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	26%	94%
Q3SXM5	Homo sapiens	30%	99%
Q3T0R4	Bos taurus	26%	100%
Q4JK73	Macaca fascicularis	29%	100%
Q4P622	Ustilago maydis (strain 521 / FGSC 9021)	25%	93%
Q4R5G7	Macaca fascicularis	31%	100%
Q53GQ0	Homo sapiens	33%	100%
Q556J2	Dictyostelium discoideum	26%	98%
Q566S6	Danio rerio	26%	100%
Q59V93	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	93%
Q5E9H7	Bos taurus	30%	100%
Q5HLD8	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	24%	100%
Q5NVG2	Pongo abelii	28%	100%
Q5R6U1	Pongo abelii	28%	100%
Q5RJY4	Rattus norvegicus	28%	100%
Q5XG41	Xenopus laevis	31%	100%
Q60V51	Caenorhabditis briggsae	27%	100%
Q6AYS8	Rattus norvegicus	27%	100%
Q6BIG0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	29%	94%
Q6BQK1	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	21%	99%
Q6GV12	Mus musculus	27%	98%
Q6IAN0	Homo sapiens	28%	100%
Q6P3L6	Danio rerio	31%	100%
Q6P7R8	Rattus norvegicus	32%	100%
Q6QA32	Danio rerio	27%	100%
Q75A60	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	28%	93%
Q8AVY8	Xenopus laevis	31%	100%
Q8CN40	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	24%	100%
Q8JZV9	Mus musculus	24%	100%
Q8L9C4	Arabidopsis thaliana	28%	100%
Q8NBQ5	Homo sapiens	28%	100%
Q8T197	Dictyostelium discoideum	25%	100%
Q8XBJ4	Escherichia coli O157:H7	25%	100%
Q99J47	Mus musculus	27%	100%
Q9EQ06	Mus musculus	28%	100%
Q9FYL6	Arabidopsis thaliana	27%	100%
Q9L9F8	Streptomyces niveus	26%	100%
Q9Y140	Drosophila melanogaster	24%	100%
R9UAM1	Ruminococcus gnavus	25%	100%
V5B376	Trypanosoma cruzi	31%	96%
V5B6S6	Trypanosoma cruzi	32%	100%
V5BCN8	Trypanosoma cruzi	60%	100%