Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q427_LEIMA

TriTrypDb:

LmjF.33.1600 , LMJLV39_330024600 , LMJSD75_330024300

Length:

899

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q427

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q427

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009451	RNA modification	5	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0009982	pseudouridine synthase activity	4	11
GO:0016853	isomerase activity	2	11
GO:0016866	intramolecular transferase activity	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.523
CLV_C14_Caspase3-7	893	897	PF00656	0.579
CLV_MEL_PAP_1	875	881	PF00089	0.341
CLV_NRD_NRD_1	217	219	PF00675	0.462
CLV_NRD_NRD_1	276	278	PF00675	0.624
CLV_NRD_NRD_1	374	376	PF00675	0.341
CLV_NRD_NRD_1	485	487	PF00675	0.276
CLV_NRD_NRD_1	546	548	PF00675	0.355
CLV_NRD_NRD_1	605	607	PF00675	0.407
CLV_NRD_NRD_1	723	725	PF00675	0.665
CLV_PCSK_FUR_1	274	278	PF00082	0.606
CLV_PCSK_KEX2_1	217	219	PF00082	0.462
CLV_PCSK_KEX2_1	274	276	PF00082	0.614
CLV_PCSK_KEX2_1	339	341	PF00082	0.710
CLV_PCSK_KEX2_1	374	376	PF00082	0.341
CLV_PCSK_KEX2_1	485	487	PF00082	0.276
CLV_PCSK_KEX2_1	545	547	PF00082	0.427
CLV_PCSK_KEX2_1	605	607	PF00082	0.490
CLV_PCSK_KEX2_1	722	724	PF00082	0.641
CLV_PCSK_KEX2_1	830	832	PF00082	0.763
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.695
CLV_PCSK_PC1ET2_1	545	547	PF00082	0.427
CLV_PCSK_PC1ET2_1	830	832	PF00082	0.763
CLV_PCSK_SKI1_1	281	285	PF00082	0.518
CLV_PCSK_SKI1_1	32	36	PF00082	0.729
CLV_PCSK_SKI1_1	420	424	PF00082	0.492
CLV_PCSK_SKI1_1	457	461	PF00082	0.529
CLV_PCSK_SKI1_1	635	639	PF00082	0.603
CLV_PCSK_SKI1_1	753	757	PF00082	0.336
CLV_PCSK_SKI1_1	786	790	PF00082	0.609
CLV_PCSK_SKI1_1	833	837	PF00082	0.539
CLV_PCSK_SKI1_1	99	103	PF00082	0.573
CLV_Separin_Metazoa	72	76	PF03568	0.588
DEG_APCC_DBOX_1	456	464	PF00400	0.506
DEG_Nend_UBRbox_1	1	4	PF02207	0.667
DEG_SCF_TRCP1_1	657	662	PF00400	0.534
DEG_SIAH_1	820	828	PF03145	0.646
DOC_CDC14_PxL_1	70	78	PF14671	0.588
DOC_CKS1_1	345	350	PF01111	0.484
DOC_CKS1_1	81	86	PF01111	0.581
DOC_CYCLIN_RxL_1	720	731	PF00134	0.554
DOC_CYCLIN_RxL_1	750	760	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	670	676	PF00134	0.405
DOC_MAPK_gen_1	485	493	PF00069	0.262
DOC_MAPK_gen_1	722	728	PF00069	0.475
DOC_MAPK_MEF2A_6	444	451	PF00069	0.331
DOC_MAPK_MEF2A_6	453	462	PF00069	0.311
DOC_PP2B_LxvP_1	670	673	PF13499	0.447
DOC_PP4_FxxP_1	345	348	PF00568	0.546
DOC_PP4_FxxP_1	773	776	PF00568	0.529
DOC_PP4_FxxP_1	782	785	PF00568	0.674
DOC_USP7_MATH_1	101	105	PF00917	0.538
DOC_USP7_MATH_1	113	117	PF00917	0.617
DOC_USP7_MATH_1	142	146	PF00917	0.500
DOC_USP7_MATH_1	150	154	PF00917	0.429
DOC_USP7_MATH_1	247	251	PF00917	0.471
DOC_USP7_MATH_1	252	256	PF00917	0.347
DOC_USP7_MATH_1	329	333	PF00917	0.672
DOC_USP7_MATH_1	39	43	PF00917	0.628
DOC_USP7_MATH_1	564	568	PF00917	0.464
DOC_USP7_MATH_1	655	659	PF00917	0.707
DOC_USP7_MATH_1	734	738	PF00917	0.553
DOC_USP7_MATH_1	774	778	PF00917	0.498
DOC_USP7_MATH_1	788	792	PF00917	0.519
DOC_USP7_MATH_1	815	819	PF00917	0.562
DOC_USP7_MATH_1	849	853	PF00917	0.616
DOC_USP7_MATH_1	877	881	PF00917	0.438
DOC_USP7_MATH_2	310	316	PF00917	0.458
DOC_WW_Pin1_4	239	244	PF00397	0.724
DOC_WW_Pin1_4	315	320	PF00397	0.576
DOC_WW_Pin1_4	338	343	PF00397	0.561
DOC_WW_Pin1_4	344	349	PF00397	0.707
DOC_WW_Pin1_4	359	364	PF00397	0.431
DOC_WW_Pin1_4	41	46	PF00397	0.605
DOC_WW_Pin1_4	452	457	PF00397	0.408
DOC_WW_Pin1_4	480	485	PF00397	0.652
DOC_WW_Pin1_4	519	524	PF00397	0.356
DOC_WW_Pin1_4	80	85	PF00397	0.761
LIG_14-3-3_CanoR_1	235	243	PF00244	0.473
LIG_14-3-3_CanoR_1	26	30	PF00244	0.620
LIG_14-3-3_CanoR_1	285	292	PF00244	0.336
LIG_14-3-3_CanoR_1	374	380	PF00244	0.379
LIG_14-3-3_CanoR_1	685	689	PF00244	0.461
LIG_14-3-3_CanoR_1	723	729	PF00244	0.578
LIG_14-3-3_CanoR_1	733	742	PF00244	0.690
LIG_14-3-3_CanoR_1	833	840	PF00244	0.526
LIG_14-3-3_CanoR_1	878	882	PF00244	0.373
LIG_Actin_WH2_2	881	897	PF00022	0.400
LIG_BIR_III_4	468	472	PF00653	0.393
LIG_BRCT_BRCA1_1	699	703	PF00533	0.494
LIG_deltaCOP1_diTrp_1	588	595	PF00928	0.423
LIG_DLG_GKlike_1	375	383	PF00625	0.342
LIG_EVH1_1	131	135	PF00568	0.575
LIG_FHA_1	173	179	PF00498	0.417
LIG_FHA_1	285	291	PF00498	0.458
LIG_FHA_1	363	369	PF00498	0.352
LIG_FHA_1	453	459	PF00498	0.546
LIG_FHA_1	534	540	PF00498	0.464
LIG_FHA_1	8	14	PF00498	0.628
LIG_FHA_1	834	840	PF00498	0.606
LIG_FHA_2	306	312	PF00498	0.450
LIG_FHA_2	33	39	PF00498	0.572
LIG_FHA_2	560	566	PF00498	0.472
LIG_FHA_2	798	804	PF00498	0.337
LIG_FHA_2	98	104	PF00498	0.659
LIG_GBD_Chelix_1	162	170	PF00786	0.409
LIG_GBD_Chelix_1	178	186	PF00786	0.370
LIG_HP1_1	456	460	PF01393	0.362
LIG_LIR_Apic_2	44	50	PF02991	0.656
LIG_LIR_Apic_2	772	776	PF02991	0.528
LIG_LIR_Gen_1	613	624	PF02991	0.369
LIG_LIR_Nem_3	613	619	PF02991	0.369
LIG_LIR_Nem_3	749	755	PF02991	0.439
LIG_PDZ_Class_1	894	899	PF00595	0.504
LIG_Pex14_1	769	773	PF04695	0.501
LIG_REV1ctd_RIR_1	531	539	PF16727	0.438
LIG_RPA_C_Fungi	175	187	PF08784	0.397
LIG_RPA_C_Fungi	370	382	PF08784	0.270
LIG_RPA_C_Fungi	680	692	PF08784	0.362
LIG_SH2_CRK	489	493	PF00017	0.317
LIG_SH2_NCK_1	548	552	PF00017	0.428
LIG_SH2_NCK_1	678	682	PF00017	0.391
LIG_SH2_SRC	47	50	PF00017	0.560
LIG_SH2_SRC	548	551	PF00017	0.424
LIG_SH2_STAP1	286	290	PF00017	0.415
LIG_SH2_STAP1	489	493	PF00017	0.326
LIG_SH2_STAP1	548	552	PF00017	0.421
LIG_SH2_STAP1	77	81	PF00017	0.568
LIG_SH2_STAT5	185	188	PF00017	0.506
LIG_SH2_STAT5	227	230	PF00017	0.519
LIG_SH2_STAT5	286	289	PF00017	0.397
LIG_SH2_STAT5	47	50	PF00017	0.679
LIG_SH2_STAT5	520	523	PF00017	0.500
LIG_SH2_STAT5	55	58	PF00017	0.624
LIG_SH3_1	129	135	PF00018	0.579
LIG_SH3_3	129	135	PF00018	0.579
LIG_SH3_3	237	243	PF00018	0.575
LIG_SH3_3	418	424	PF00018	0.365
LIG_SH3_3	748	754	PF00018	0.418
LIG_Sin3_3	212	219	PF02671	0.346
LIG_SUMO_SIM_anti_2	707	713	PF11976	0.353
LIG_SUMO_SIM_par_1	666	671	PF11976	0.502
LIG_SUMO_SIM_par_1	693	698	PF11976	0.414
LIG_SUMO_SIM_par_1	753	758	PF11976	0.361
LIG_TYR_ITIM	487	492	PF00017	0.448
LIG_WRC_WIRS_1	106	111	PF05994	0.586
LIG_WRC_WIRS_1	301	306	PF05994	0.392
MOD_CDC14_SPxK_1	483	486	PF00782	0.440
MOD_CDK_SPK_2	239	244	PF00069	0.513
MOD_CDK_SPK_2	41	46	PF00069	0.595
MOD_CDK_SPK_2	452	457	PF00069	0.408
MOD_CDK_SPK_2	480	485	PF00069	0.388
MOD_CDK_SPxK_1	480	486	PF00069	0.483
MOD_CK1_1	105	111	PF00069	0.599
MOD_CK1_1	231	237	PF00069	0.502
MOD_CK1_1	238	244	PF00069	0.494
MOD_CK1_1	315	321	PF00069	0.558
MOD_CK1_1	354	360	PF00069	0.497
MOD_CK1_1	361	367	PF00069	0.509
MOD_CK1_1	658	664	PF00069	0.472
MOD_CK1_1	737	743	PF00069	0.680
MOD_CK1_1	791	797	PF00069	0.503
MOD_CK2_1	140	146	PF00069	0.571
MOD_CK2_1	305	311	PF00069	0.448
MOD_CK2_1	315	321	PF00069	0.460
MOD_CK2_1	32	38	PF00069	0.666
MOD_CK2_1	347	353	PF00069	0.600
MOD_CK2_1	559	565	PF00069	0.461
MOD_CK2_1	66	72	PF00069	0.729
MOD_CK2_1	698	704	PF00069	0.549
MOD_CK2_1	769	775	PF00069	0.456
MOD_CK2_1	97	103	PF00069	0.616
MOD_CMANNOS	591	594	PF00535	0.462
MOD_DYRK1A_RPxSP_1	239	243	PF00069	0.547
MOD_GlcNHglycan	117	120	PF01048	0.689
MOD_GlcNHglycan	188	191	PF01048	0.567
MOD_GlcNHglycan	230	233	PF01048	0.654
MOD_GlcNHglycan	249	252	PF01048	0.413
MOD_GlcNHglycan	254	257	PF01048	0.449
MOD_GlcNHglycan	263	266	PF01048	0.573
MOD_GlcNHglycan	330	334	PF01048	0.706
MOD_GlcNHglycan	394	397	PF01048	0.530
MOD_GlcNHglycan	656	660	PF01048	0.661
MOD_GlcNHglycan	661	664	PF01048	0.683
MOD_GlcNHglycan	670	673	PF01048	0.478
MOD_GlcNHglycan	847	850	PF01048	0.585
MOD_GSK3_1	136	143	PF00069	0.593
MOD_GSK3_1	150	157	PF00069	0.390
MOD_GSK3_1	231	238	PF00069	0.545
MOD_GSK3_1	28	35	PF00069	0.552
MOD_GSK3_1	343	350	PF00069	0.650
MOD_GSK3_1	354	361	PF00069	0.529
MOD_GSK3_1	533	540	PF00069	0.370
MOD_GSK3_1	655	662	PF00069	0.734
MOD_GSK3_1	668	675	PF00069	0.468
MOD_GSK3_1	724	731	PF00069	0.679
MOD_GSK3_1	845	852	PF00069	0.484
MOD_GSK3_1	97	104	PF00069	0.601
MOD_N-GLC_1	124	129	PF02516	0.755
MOD_N-GLC_1	747	752	PF02516	0.479
MOD_N-GLC_1	791	796	PF02516	0.619
MOD_NEK2_1	1	6	PF00069	0.587
MOD_NEK2_1	102	107	PF00069	0.542
MOD_NEK2_1	186	191	PF00069	0.423
MOD_NEK2_1	506	511	PF00069	0.388
MOD_NEK2_1	533	538	PF00069	0.335
MOD_NEK2_1	894	899	PF00069	0.531
MOD_NEK2_2	684	689	PF00069	0.423
MOD_PIKK_1	113	119	PF00454	0.575
MOD_PIKK_1	424	430	PF00454	0.553
MOD_PIKK_1	474	480	PF00454	0.587
MOD_PIKK_1	600	606	PF00454	0.413
MOD_PIKK_1	676	682	PF00454	0.428
MOD_PIKK_1	728	734	PF00454	0.689
MOD_PIKK_1	803	809	PF00454	0.395
MOD_PKA_2	234	240	PF00069	0.666
MOD_PKA_2	25	31	PF00069	0.569
MOD_PKA_2	252	258	PF00069	0.402
MOD_PKA_2	284	290	PF00069	0.443
MOD_PKA_2	351	357	PF00069	0.482
MOD_PKA_2	53	59	PF00069	0.719
MOD_PKA_2	684	690	PF00069	0.459
MOD_PKA_2	763	769	PF00069	0.449
MOD_PKA_2	877	883	PF00069	0.483
MOD_PKB_1	722	730	PF00069	0.540
MOD_PKB_1	831	839	PF00069	0.627
MOD_Plk_1	102	108	PF00069	0.617
MOD_Plk_1	397	403	PF00069	0.410
MOD_Plk_1	506	512	PF00069	0.347
MOD_Plk_1	747	753	PF00069	0.466
MOD_Plk_1	77	83	PF00069	0.502
MOD_Plk_1	791	797	PF00069	0.611
MOD_Plk_2-3	559	565	PF00069	0.389
MOD_Plk_2-3	698	704	PF00069	0.487
MOD_Plk_4	25	31	PF00069	0.551
MOD_Plk_4	747	753	PF00069	0.435
MOD_Plk_4	791	797	PF00069	0.540
MOD_Plk_4	850	856	PF00069	0.611
MOD_ProDKin_1	239	245	PF00069	0.718
MOD_ProDKin_1	315	321	PF00069	0.583
MOD_ProDKin_1	338	344	PF00069	0.560
MOD_ProDKin_1	359	365	PF00069	0.477
MOD_ProDKin_1	41	47	PF00069	0.599
MOD_ProDKin_1	452	458	PF00069	0.394
MOD_ProDKin_1	480	486	PF00069	0.634
MOD_ProDKin_1	519	525	PF00069	0.362
MOD_ProDKin_1	80	86	PF00069	0.759
MOD_SUMO_rev_2	315	325	PF00179	0.633
TRG_DiLeu_BaLyEn_6	751	756	PF01217	0.478
TRG_ENDOCYTIC_2	489	492	PF00928	0.319
TRG_ER_diArg_1	216	218	PF00400	0.459
TRG_ER_diArg_1	274	277	PF00400	0.605
TRG_ER_diArg_1	373	375	PF00400	0.326
TRG_ER_diArg_1	484	486	PF00400	0.315
TRG_ER_diArg_1	546	548	PF00400	0.355
TRG_ER_diArg_1	605	607	PF00400	0.488
TRG_ER_diArg_1	722	724	PF00400	0.630
TRG_NLS_MonoExtC_3	544	550	PF00514	0.357
TRG_NLS_MonoExtN_4	827	834	PF00514	0.645
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	444	448	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	753	758	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	833	837	PF00026	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0E0	Leptomonas seymouri	47%	99%
A0A1X0P134	Trypanosomatidae	24%	100%
A0A3Q8IEW6	Leishmania donovani	93%	100%
A0A3R7KAP3	Trypanosoma rangeli	29%	100%
A4HLM1	Leishmania braziliensis	78%	100%
A4I932	Leishmania infantum	93%	100%
D0A535	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B3Z7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BLS1	Trypanosoma cruzi	29%	100%