HEAT repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

HEAT repeat protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q425_LEIMA

TriTrypDb:

LmjF.33.1620 , LMJLV39_330024900 , LMJSD75_330024600

Length:

905

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q425

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q425

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.395
CLV_C14_Caspase3-7	803	807	PF00656	0.346
CLV_MEL_PAP_1	282	288	PF00089	0.315
CLV_NRD_NRD_1	279	281	PF00675	0.342
CLV_NRD_NRD_1	304	306	PF00675	0.463
CLV_NRD_NRD_1	375	377	PF00675	0.296
CLV_NRD_NRD_1	686	688	PF00675	0.336
CLV_NRD_NRD_1	719	721	PF00675	0.281
CLV_PCSK_KEX2_1	18	20	PF00082	0.328
CLV_PCSK_KEX2_1	304	306	PF00082	0.467
CLV_PCSK_KEX2_1	686	688	PF00082	0.383
CLV_PCSK_KEX2_1	867	869	PF00082	0.355
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.328
CLV_PCSK_PC1ET2_1	867	869	PF00082	0.355
CLV_PCSK_SKI1_1	104	108	PF00082	0.276
CLV_PCSK_SKI1_1	163	167	PF00082	0.371
CLV_PCSK_SKI1_1	174	178	PF00082	0.278
CLV_PCSK_SKI1_1	280	284	PF00082	0.317
CLV_PCSK_SKI1_1	304	308	PF00082	0.481
CLV_PCSK_SKI1_1	352	356	PF00082	0.364
CLV_PCSK_SKI1_1	360	364	PF00082	0.342
CLV_PCSK_SKI1_1	622	626	PF00082	0.250
CLV_PCSK_SKI1_1	628	632	PF00082	0.280
CLV_PCSK_SKI1_1	675	679	PF00082	0.368
CLV_PCSK_SKI1_1	843	847	PF00082	0.326
CLV_PCSK_SKI1_1	882	886	PF00082	0.481
CLV_Separin_Metazoa	206	210	PF03568	0.303
CLV_Separin_Metazoa	233	237	PF03568	0.379
CLV_Separin_Metazoa	698	702	PF03568	0.313
DEG_APCC_DBOX_1	103	111	PF00400	0.287
DEG_APCC_DBOX_1	279	287	PF00400	0.312
DEG_APCC_DBOX_1	351	359	PF00400	0.386
DEG_Nend_UBRbox_2	1	3	PF02207	0.375
DEG_SCF_FBW7_1	508	513	PF00400	0.389
DEG_SPOP_SBC_1	519	523	PF00917	0.360
DEG_SPOP_SBC_1	749	753	PF00917	0.369
DOC_CKS1_1	168	173	PF01111	0.309
DOC_MAPK_DCC_7	586	595	PF00069	0.416
DOC_MAPK_gen_1	376	383	PF00069	0.307
DOC_MAPK_gen_1	460	468	PF00069	0.482
DOC_MAPK_gen_1	570	579	PF00069	0.384
DOC_MAPK_gen_1	626	633	PF00069	0.234
DOC_MAPK_gen_1	843	849	PF00069	0.341
DOC_MAPK_HePTP_8	583	595	PF00069	0.450
DOC_MAPK_MEF2A_6	259	268	PF00069	0.285
DOC_MAPK_MEF2A_6	376	383	PF00069	0.320
DOC_MAPK_MEF2A_6	586	595	PF00069	0.463
DOC_MAPK_MEF2A_6	770	778	PF00069	0.208
DOC_PP1_RVXF_1	307	314	PF00149	0.415
DOC_PP1_RVXF_1	380	386	PF00149	0.279
DOC_PP1_RVXF_1	620	626	PF00149	0.300
DOC_PP2B_PxIxI_1	873	879	PF00149	0.467
DOC_PP4_FxxP_1	139	142	PF00568	0.440
DOC_PP4_FxxP_1	324	327	PF00568	0.393
DOC_PP4_FxxP_1	431	434	PF00568	0.272
DOC_USP7_MATH_1	510	514	PF00917	0.504
DOC_USP7_MATH_1	97	101	PF00917	0.400
DOC_USP7_MATH_2	451	457	PF00917	0.488
DOC_USP7_UBL2_3	148	152	PF12436	0.422
DOC_WW_Pin1_4	167	172	PF00397	0.326
DOC_WW_Pin1_4	506	511	PF00397	0.401
DOC_WW_Pin1_4	553	558	PF00397	0.342
DOC_WW_Pin1_4	824	829	PF00397	0.434
DOC_WW_Pin1_4	870	875	PF00397	0.378
LIG_14-3-3_CanoR_1	218	227	PF00244	0.307
LIG_14-3-3_CanoR_1	304	309	PF00244	0.436
LIG_14-3-3_CanoR_1	401	410	PF00244	0.399
LIG_14-3-3_CanoR_1	584	593	PF00244	0.334
LIG_14-3-3_CanoR_1	660	668	PF00244	0.387
LIG_14-3-3_CanoR_1	675	680	PF00244	0.240
LIG_14-3-3_CanoR_1	809	816	PF00244	0.448
LIG_Actin_WH2_2	161	179	PF00022	0.369
LIG_AP2alpha_1	139	143	PF02296	0.411
LIG_AP2alpha_2	141	143	PF02296	0.438
LIG_APCC_ABBA_1	845	850	PF00400	0.337
LIG_APCC_ABBAyCdc20_2	844	850	PF00400	0.337
LIG_BIR_III_4	473	477	PF00653	0.467
LIG_BRCT_BRCA1_1	221	225	PF00533	0.406
LIG_BRCT_BRCA1_1	320	324	PF00533	0.389
LIG_BRCT_BRCA1_1	774	778	PF00533	0.207
LIG_Clathr_ClatBox_1	132	136	PF01394	0.338
LIG_Clathr_ClatBox_1	798	802	PF01394	0.345
LIG_Clathr_ClatBox_1	846	850	PF01394	0.341
LIG_deltaCOP1_diTrp_1	366	371	PF00928	0.328
LIG_eIF4E_1	127	133	PF01652	0.351
LIG_FHA_1	193	199	PF00498	0.335
LIG_FHA_1	341	347	PF00498	0.448
LIG_FHA_1	397	403	PF00498	0.396
LIG_FHA_1	420	426	PF00498	0.445
LIG_FHA_1	482	488	PF00498	0.448
LIG_FHA_1	520	526	PF00498	0.381
LIG_FHA_1	607	613	PF00498	0.439
LIG_FHA_1	66	72	PF00498	0.367
LIG_FHA_1	669	675	PF00498	0.352
LIG_FHA_1	694	700	PF00498	0.517
LIG_FHA_1	713	719	PF00498	0.246
LIG_FHA_1	750	756	PF00498	0.394
LIG_FHA_1	815	821	PF00498	0.481
LIG_FHA_1	853	859	PF00498	0.482
LIG_FHA_2	305	311	PF00498	0.443
LIG_FHA_2	361	367	PF00498	0.341
LIG_FHA_2	467	473	PF00498	0.553
LIG_FHA_2	519	525	PF00498	0.337
LIG_FHA_2	676	682	PF00498	0.356
LIG_FHA_2	810	816	PF00498	0.370
LIG_LIR_Apic_2	136	142	PF02991	0.428
LIG_LIR_Apic_2	321	327	PF02991	0.397
LIG_LIR_Apic_2	366	370	PF02991	0.366
LIG_LIR_Apic_2	81	85	PF02991	0.293
LIG_LIR_Gen_1	129	139	PF02991	0.291
LIG_LIR_Gen_1	269	279	PF02991	0.325
LIG_LIR_Gen_1	40	50	PF02991	0.338
LIG_LIR_Gen_1	450	458	PF02991	0.516
LIG_LIR_Gen_1	634	643	PF02991	0.336
LIG_LIR_Nem_3	129	134	PF02991	0.288
LIG_LIR_Nem_3	141	146	PF02991	0.289
LIG_LIR_Nem_3	269	275	PF02991	0.318
LIG_LIR_Nem_3	40	46	PF02991	0.362
LIG_LIR_Nem_3	404	410	PF02991	0.414
LIG_LIR_Nem_3	435	440	PF02991	0.309
LIG_LIR_Nem_3	450	455	PF02991	0.483
LIG_LIR_Nem_3	634	639	PF02991	0.393
LIG_LIR_Nem_3	673	679	PF02991	0.285
LIG_LYPXL_yS_3	319	322	PF13949	0.326
LIG_NRBOX	533	539	PF00104	0.310
LIG_NRBOX	578	584	PF00104	0.356
LIG_NRBOX	679	685	PF00104	0.276
LIG_NRBOX	726	732	PF00104	0.323
LIG_NRBOX	815	821	PF00104	0.376
LIG_PCNA_TLS_4	125	132	PF02747	0.358
LIG_Pex14_1	367	371	PF04695	0.324
LIG_Pex14_1	385	389	PF04695	0.272
LIG_Pex14_2	139	143	PF04695	0.411
LIG_SH2_CRK	23	27	PF00017	0.357
LIG_SH2_CRK	580	584	PF00017	0.244
LIG_SH2_GRB2like	7	10	PF00017	0.367
LIG_SH2_NCK_1	452	456	PF00017	0.487
LIG_SH2_SRC	260	263	PF00017	0.333
LIG_SH2_SRC	452	455	PF00017	0.546
LIG_SH2_SRC	900	903	PF00017	0.367
LIG_SH2_STAP1	616	620	PF00017	0.285
LIG_SH2_STAT5	127	130	PF00017	0.282
LIG_SH2_STAT5	260	263	PF00017	0.333
LIG_SH2_STAT5	345	348	PF00017	0.275
LIG_SH2_STAT5	390	393	PF00017	0.384
LIG_SH2_STAT5	437	440	PF00017	0.326
LIG_SH2_STAT5	499	502	PF00017	0.306
LIG_SH2_STAT5	676	679	PF00017	0.298
LIG_SH2_STAT5	7	10	PF00017	0.363
LIG_SH2_STAT5	735	738	PF00017	0.371
LIG_SH2_STAT5	848	851	PF00017	0.454
LIG_SH2_STAT5	893	896	PF00017	0.359
LIG_SH2_STAT5	900	903	PF00017	0.365
LIG_SH3_3	554	560	PF00018	0.369
LIG_SH3_3	700	706	PF00018	0.381
LIG_SUMO_SIM_anti_2	195	200	PF11976	0.414
LIG_SUMO_SIM_anti_2	453	459	PF11976	0.642
LIG_SUMO_SIM_anti_2	68	73	PF11976	0.370
LIG_SUMO_SIM_par_1	131	136	PF11976	0.335
LIG_SUMO_SIM_par_1	246	252	PF11976	0.312
LIG_SUMO_SIM_par_1	264	271	PF11976	0.201
LIG_SUMO_SIM_par_1	464	470	PF11976	0.403
LIG_SUMO_SIM_par_1	827	833	PF11976	0.299
LIG_SUMO_SIM_par_1	876	881	PF11976	0.445
LIG_SxIP_EBH_1	583	596	PF03271	0.281
LIG_TRAF2_1	60	63	PF00917	0.452
LIG_TYR_ITIM	578	583	PF00017	0.252
LIG_TYR_ITIM	674	679	PF00017	0.278
LIG_UBA3_1	537	543	PF00899	0.344
LIG_UBA3_1	578	586	PF00899	0.366
MOD_CDK_SPxxK_3	167	174	PF00069	0.325
MOD_CK1_1	241	247	PF00069	0.463
MOD_CK1_1	337	343	PF00069	0.409
MOD_CK1_1	57	63	PF00069	0.531
MOD_CK1_1	634	640	PF00069	0.331
MOD_CK1_1	659	665	PF00069	0.430
MOD_CK1_1	694	700	PF00069	0.358
MOD_CK1_1	86	92	PF00069	0.404
MOD_CK2_1	453	459	PF00069	0.622
MOD_CK2_1	57	63	PF00069	0.387
MOD_CK2_1	675	681	PF00069	0.324
MOD_CK2_1	809	815	PF00069	0.451
MOD_CK2_1	858	864	PF00069	0.330
MOD_CK2_1	880	886	PF00069	0.403
MOD_CK2_1	896	902	PF00069	0.312
MOD_GlcNHglycan	185	188	PF01048	0.441
MOD_GlcNHglycan	327	330	PF01048	0.537
MOD_GlcNHglycan	403	406	PF01048	0.443
MOD_GlcNHglycan	633	636	PF01048	0.323
MOD_GlcNHglycan	707	710	PF01048	0.481
MOD_GlcNHglycan	832	837	PF01048	0.497
MOD_GlcNHglycan	882	885	PF01048	0.462
MOD_GSK3_1	109	116	PF00069	0.295
MOD_GSK3_1	318	325	PF00069	0.419
MOD_GSK3_1	41	48	PF00069	0.516
MOD_GSK3_1	477	484	PF00069	0.429
MOD_GSK3_1	485	492	PF00069	0.328
MOD_GSK3_1	506	513	PF00069	0.456
MOD_GSK3_1	53	60	PF00069	0.484
MOD_GSK3_1	599	606	PF00069	0.352
MOD_GSK3_1	610	617	PF00069	0.295
MOD_GSK3_1	744	751	PF00069	0.395
MOD_GSK3_1	810	817	PF00069	0.439
MOD_N-GLC_1	216	221	PF02516	0.381
MOD_N-GLC_1	35	40	PF02516	0.440
MOD_NEK2_1	11	16	PF00069	0.437
MOD_NEK2_1	176	181	PF00069	0.349
MOD_NEK2_1	322	327	PF00069	0.348
MOD_NEK2_1	334	339	PF00069	0.337
MOD_NEK2_1	383	388	PF00069	0.301
MOD_NEK2_1	481	486	PF00069	0.419
MOD_NEK2_1	537	542	PF00069	0.292
MOD_NEK2_1	603	608	PF00069	0.481
MOD_NEK2_1	750	755	PF00069	0.343
MOD_NEK2_1	880	885	PF00069	0.387
MOD_NEK2_2	113	118	PF00069	0.300
MOD_NEK2_2	485	490	PF00069	0.380
MOD_NEK2_2	614	619	PF00069	0.419
MOD_PKA_1	304	310	PF00069	0.430
MOD_PKA_2	304	310	PF00069	0.430
MOD_PKA_2	337	343	PF00069	0.336
MOD_PKA_2	65	71	PF00069	0.351
MOD_PKA_2	659	665	PF00069	0.398
MOD_PKA_2	685	691	PF00069	0.442
MOD_PKA_2	810	816	PF00069	0.450
MOD_PKA_2	858	864	PF00069	0.374
MOD_Plk_1	216	222	PF00069	0.496
MOD_Plk_1	360	366	PF00069	0.334
MOD_Plk_1	391	397	PF00069	0.324
MOD_Plk_1	41	47	PF00069	0.419
MOD_Plk_1	419	425	PF00069	0.333
MOD_Plk_1	453	459	PF00069	0.501
MOD_Plk_1	75	81	PF00069	0.374
MOD_Plk_1	814	820	PF00069	0.478
MOD_Plk_1	852	858	PF00069	0.418
MOD_Plk_2-3	453	459	PF00069	0.461
MOD_Plk_2-3	896	902	PF00069	0.252
MOD_Plk_4	238	244	PF00069	0.475
MOD_Plk_4	384	390	PF00069	0.300
MOD_Plk_4	453	459	PF00069	0.476
MOD_Plk_4	477	483	PF00069	0.502
MOD_Plk_4	489	495	PF00069	0.284
MOD_Plk_4	573	579	PF00069	0.291
MOD_Plk_4	603	609	PF00069	0.302
MOD_Plk_4	75	81	PF00069	0.306
MOD_Plk_4	750	756	PF00069	0.448
MOD_Plk_4	772	778	PF00069	0.365
MOD_Plk_4	793	799	PF00069	0.334
MOD_Plk_4	83	89	PF00069	0.278
MOD_Plk_4	896	902	PF00069	0.252
MOD_ProDKin_1	167	173	PF00069	0.320
MOD_ProDKin_1	506	512	PF00069	0.397
MOD_ProDKin_1	553	559	PF00069	0.350
MOD_ProDKin_1	824	830	PF00069	0.422
MOD_ProDKin_1	870	876	PF00069	0.380
MOD_SUMO_for_1	146	149	PF00179	0.282
MOD_SUMO_rev_2	159	165	PF00179	0.458
TRG_DiLeu_BaEn_1	101	106	PF01217	0.299
TRG_DiLeu_BaEn_1	529	534	PF01217	0.467
TRG_DiLeu_BaEn_1	695	700	PF01217	0.384
TRG_DiLeu_BaEn_1	815	820	PF01217	0.370
TRG_DiLeu_BaLyEn_6	619	624	PF01217	0.300
TRG_DiLeu_BaLyEn_6	825	830	PF01217	0.458
TRG_DiLeu_LyEn_5	101	106	PF01217	0.299
TRG_DiLeu_LyEn_5	815	820	PF01217	0.370
TRG_ENDOCYTIC_2	127	130	PF00928	0.292
TRG_ENDOCYTIC_2	23	26	PF00928	0.316
TRG_ENDOCYTIC_2	319	322	PF00928	0.326
TRG_ENDOCYTIC_2	407	410	PF00928	0.338
TRG_ENDOCYTIC_2	437	440	PF00928	0.303
TRG_ENDOCYTIC_2	452	455	PF00928	0.481
TRG_ENDOCYTIC_2	580	583	PF00928	0.240
TRG_ENDOCYTIC_2	676	679	PF00928	0.264
TRG_ER_diArg_1	304	306	PF00400	0.436
TRG_ER_diArg_1	685	687	PF00400	0.389
TRG_ER_diArg_1	808	811	PF00400	0.380
TRG_Pf-PMV_PEXEL_1	280	284	PF00026	0.317
TRG_Pf-PMV_PEXEL_1	6	10	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	818	822	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2B9	Leptomonas seymouri	75%	100%
A0A0S4KNI8	Bodo saltans	45%	99%
A0A1X0NM76	Trypanosomatidae	54%	100%
A0A3S7X6Q1	Leishmania donovani	95%	100%
A0A422N6C6	Trypanosoma rangeli	50%	100%
A0JMW2	Xenopus laevis	23%	100%
A4HLM3	Leishmania braziliensis	87%	100%
A4I934	Leishmania infantum	95%	100%
B9EJR8	Mus musculus	23%	100%
C9ZQE2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B3Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q86Y56	Homo sapiens	24%	100%
V5BDB2	Trypanosoma cruzi	52%	100%