Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q422_LEIMA

TriTrypDb:

LmjF.33.1650 , LMJLV39_330025300 , LMJSD75_330025000

Length:

265

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q422

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q422

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.498
CLV_NRD_NRD_1	30	32	PF00675	0.513
CLV_NRD_NRD_1	34	36	PF00675	0.525
CLV_PCSK_KEX2_1	171	173	PF00082	0.498
CLV_PCSK_KEX2_1	203	205	PF00082	0.515
CLV_PCSK_KEX2_1	30	32	PF00082	0.513
CLV_PCSK_KEX2_1	34	36	PF00082	0.525
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.412
CLV_PCSK_PC7_1	30	36	PF00082	0.389
CLV_PCSK_SKI1_1	35	39	PF00082	0.434
CLV_Separin_Metazoa	153	157	PF03568	0.291
DOC_MAPK_FxFP_2	3	6	PF00069	0.386
DOC_MAPK_gen_1	253	262	PF00069	0.454
DOC_MAPK_gen_1	30	40	PF00069	0.483
DOC_MAPK_MEF2A_6	230	237	PF00069	0.453
DOC_MAPK_NFAT4_5	230	238	PF00069	0.290
DOC_PP4_FxxP_1	3	6	PF00568	0.351
DOC_USP7_MATH_1	229	233	PF00917	0.279
DOC_USP7_MATH_1	56	60	PF00917	0.508
DOC_USP7_UBL2_3	226	230	PF12436	0.435
DOC_WW_Pin1_4	90	95	PF00397	0.328
LIG_14-3-3_CanoR_1	171	180	PF00244	0.456
LIG_14-3-3_CanoR_1	210	217	PF00244	0.419
LIG_14-3-3_CanoR_1	253	262	PF00244	0.344
LIG_14-3-3_CanoR_1	34	38	PF00244	0.367
LIG_BIR_II_1	1	5	PF00653	0.468
LIG_Clathr_ClatBox_1	18	22	PF01394	0.335
LIG_Clathr_ClatBox_1	244	248	PF01394	0.365
LIG_FHA_1	13	19	PF00498	0.418
LIG_FHA_1	182	188	PF00498	0.443
LIG_FHA_1	255	261	PF00498	0.375
LIG_FHA_1	40	46	PF00498	0.475
LIG_FHA_1	81	87	PF00498	0.470
LIG_FHA_1	94	100	PF00498	0.278
LIG_FHA_2	142	148	PF00498	0.399
LIG_FHA_2	174	180	PF00498	0.457
LIG_FHA_2	49	55	PF00498	0.407
LIG_GBD_Chelix_1	99	107	PF00786	0.504
LIG_LIR_Gen_1	10	19	PF02991	0.414
LIG_LIR_Gen_1	216	224	PF02991	0.468
LIG_LIR_Gen_1	49	56	PF02991	0.327
LIG_LIR_Nem_3	10	14	PF02991	0.410
LIG_LIR_Nem_3	216	220	PF02991	0.381
LIG_LIR_Nem_3	49	53	PF02991	0.323
LIG_LIR_Nem_3	87	92	PF02991	0.445
LIG_NRBOX	190	196	PF00104	0.481
LIG_Pex14_2	245	249	PF04695	0.302
LIG_SH2_CRK	217	221	PF00017	0.369
LIG_SH2_NCK_1	143	147	PF00017	0.405
LIG_SH2_NCK_1	50	54	PF00017	0.454
LIG_SH2_STAP1	71	75	PF00017	0.287
LIG_SH2_STAT3	17	20	PF00017	0.441
LIG_SH2_STAT5	143	146	PF00017	0.487
LIG_SH2_STAT5	17	20	PF00017	0.308
LIG_SH2_STAT5	50	53	PF00017	0.395
LIG_SH3_3	40	46	PF00018	0.415
LIG_SUMO_SIM_par_1	93	98	PF11976	0.411
MOD_CK1_1	185	191	PF00069	0.414
MOD_CK1_1	49	55	PF00069	0.529
MOD_CK1_1	84	90	PF00069	0.341
MOD_CK1_1	93	99	PF00069	0.447
MOD_CK2_1	173	179	PF00069	0.333
MOD_Cter_Amidation	32	35	PF01082	0.429
MOD_GlcNHglycan	206	210	PF01048	0.439
MOD_GlcNHglycan	89	92	PF01048	0.352
MOD_GSK3_1	181	188	PF00069	0.407
MOD_GSK3_1	205	212	PF00069	0.541
MOD_GSK3_1	248	255	PF00069	0.376
MOD_GSK3_1	80	87	PF00069	0.459
MOD_NEK2_1	12	17	PF00069	0.359
MOD_NEK2_1	182	187	PF00069	0.375
MOD_NEK2_1	205	210	PF00069	0.457
MOD_NEK2_1	21	26	PF00069	0.343
MOD_NEK2_1	38	43	PF00069	0.376
MOD_NEK2_1	48	53	PF00069	0.428
MOD_NEK2_1	81	86	PF00069	0.374
MOD_PIKK_1	12	18	PF00454	0.415
MOD_PKA_1	171	177	PF00069	0.496
MOD_PKA_2	171	177	PF00069	0.471
MOD_PKA_2	209	215	PF00069	0.465
MOD_PKA_2	222	228	PF00069	0.384
MOD_PKA_2	252	258	PF00069	0.362
MOD_PKA_2	33	39	PF00069	0.377
MOD_Plk_1	101	107	PF00069	0.370
MOD_Plk_1	21	27	PF00069	0.392
MOD_Plk_4	229	235	PF00069	0.392
MOD_Plk_4	81	87	PF00069	0.470
MOD_ProDKin_1	90	96	PF00069	0.324
TRG_ENDOCYTIC_2	217	220	PF00928	0.374
TRG_ENDOCYTIC_2	50	53	PF00928	0.360
TRG_ER_diArg_1	170	172	PF00400	0.471
TRG_ER_diArg_1	29	31	PF00400	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7K0	Leptomonas seymouri	60%	100%
A0A1X0P1S9	Trypanosomatidae	30%	100%
A0A3Q8IGM7	Leishmania donovani	96%	100%
A0A3R7MBB6	Trypanosoma rangeli	32%	98%
A4HLM6	Leishmania braziliensis	84%	100%
A4I937	Leishmania infantum	96%	100%
C9ZIV4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	98%
E9B402	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5AXA5	Trypanosoma cruzi	29%	98%