Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q421_LEIMA

TriTrypDb:

LmjF.33.1660 , LMJLV39_330025400 , LMJSD75_330025100

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q421

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q421

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.461
CLV_C14_Caspase3-7	190	194	PF00656	0.471
CLV_C14_Caspase3-7	46	50	PF00656	0.419
CLV_NRD_NRD_1	137	139	PF00675	0.624
CLV_NRD_NRD_1	186	188	PF00675	0.478
CLV_NRD_NRD_1	99	101	PF00675	0.436
CLV_PCSK_KEX2_1	137	139	PF00082	0.430
CLV_PCSK_KEX2_1	186	188	PF00082	0.482
CLV_PCSK_KEX2_1	99	101	PF00082	0.531
CLV_PCSK_SKI1_1	160	164	PF00082	0.371
CLV_PCSK_SKI1_1	73	77	PF00082	0.323
DEG_Nend_UBRbox_3	1	3	PF02207	0.640
DOC_PP4_FxxP_1	58	61	PF00568	0.547
DOC_USP7_MATH_1	144	148	PF00917	0.473
DOC_USP7_MATH_1	173	177	PF00917	0.455
DOC_USP7_MATH_1	78	82	PF00917	0.479
DOC_USP7_MATH_1	98	102	PF00917	0.414
LIG_14-3-3_CanoR_1	104	114	PF00244	0.449
LIG_14-3-3_CanoR_1	145	152	PF00244	0.344
LIG_14-3-3_CanoR_1	186	192	PF00244	0.459
LIG_14-3-3_CanoR_1	99	103	PF00244	0.388
LIG_APCC_ABBA_1	149	154	PF00400	0.457
LIG_DLG_GKlike_1	187	195	PF00625	0.470
LIG_FHA_1	106	112	PF00498	0.613
LIG_FHA_1	11	17	PF00498	0.412
LIG_FHA_1	37	43	PF00498	0.463
LIG_LIR_Gen_1	121	132	PF02991	0.448
LIG_LIR_Gen_1	161	170	PF02991	0.382
LIG_LIR_Gen_1	180	189	PF02991	0.547
LIG_LIR_Gen_1	32	41	PF02991	0.514
LIG_LIR_Nem_3	121	127	PF02991	0.401
LIG_LIR_Nem_3	161	165	PF02991	0.358
LIG_LIR_Nem_3	32	36	PF02991	0.365
LIG_SH2_CRK	68	72	PF00017	0.557
LIG_SH2_NCK_1	191	195	PF00017	0.480
LIG_SH2_SRC	191	194	PF00017	0.474
LIG_SH2_STAP1	107	111	PF00017	0.380
LIG_SH2_STAT5	102	105	PF00017	0.400
LIG_SH2_STAT5	107	110	PF00017	0.440
LIG_SH2_STAT5	124	127	PF00017	0.329
LIG_SH3_3	129	135	PF00018	0.412
LIG_TYR_ITIM	66	71	PF00017	0.389
LIG_WRC_WIRS_1	42	47	PF05994	0.283
MOD_CK1_1	109	115	PF00069	0.435
MOD_CK2_1	144	150	PF00069	0.525
MOD_GlcNHglycan	108	111	PF01048	0.484
MOD_GlcNHglycan	146	149	PF01048	0.484
MOD_GlcNHglycan	79	83	PF01048	0.514
MOD_GSK3_1	105	112	PF00069	0.620
MOD_GSK3_1	173	180	PF00069	0.416
MOD_GSK3_1	37	44	PF00069	0.344
MOD_NEK2_1	10	15	PF00069	0.524
MOD_NEK2_1	118	123	PF00069	0.526
MOD_NEK2_1	143	148	PF00069	0.554
MOD_NEK2_1	185	190	PF00069	0.486
MOD_NEK2_1	36	41	PF00069	0.518
MOD_PIKK_1	138	144	PF00454	0.382
MOD_PKA_2	144	150	PF00069	0.342
MOD_PKA_2	185	191	PF00069	0.436
MOD_PKA_2	98	104	PF00069	0.356
MOD_Plk_1	138	144	PF00069	0.493
MOD_Plk_1	195	201	PF00069	0.462
MOD_Plk_4	37	43	PF00069	0.543
MOD_Plk_4	51	57	PF00069	0.325
TRG_ENDOCYTIC_2	124	127	PF00928	0.446
TRG_ENDOCYTIC_2	68	71	PF00928	0.383
TRG_ER_diArg_1	185	187	PF00400	0.415
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	4	9	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEU1	Leptomonas seymouri	53%	99%
A0A3R7KFM1	Trypanosoma rangeli	24%	94%
A0A3S7X6V4	Leishmania donovani	94%	100%
A4HLM7	Leishmania braziliensis	80%	100%
A4I938	Leishmania infantum	94%	100%
C9ZIV5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B403	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%