Phosphatidylinositol N-acetylglucosaminyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-GlcNAc:PI a1-6 GlcNAc-transferase

Species:

Leishmania major

UniProt:

Q4Q420_LEIMA

TriTrypDb:

LmjF.33.1670 , LMJLV39_330025500 , LMJSD75_330025200

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0098796	membrane protein complex	2	12
GO:0140534	endoplasmic reticulum protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4Q420

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q420

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	12
GO:0006505	GPI anchor metabolic process	6	12
GO:0006506	GPI anchor biosynthetic process	6	12
GO:0006629	lipid metabolic process	3	12
GO:0006643	membrane lipid metabolic process	4	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006661	phosphatidylinositol biosynthetic process	6	12
GO:0006664	glycolipid metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009247	glycolipid biosynthetic process	5	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0019637	organophosphate metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046467	membrane lipid biosynthetic process	4	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0046488	phosphatidylinositol metabolic process	6	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901137	carbohydrate derivative biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901576	organic substance biosynthetic process	3	12
GO:1903509	liposaccharide metabolic process	4	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008194	UDP-glycosyltransferase activity	4	12
GO:0008375	acetylglucosaminyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016758	hexosyltransferase activity	4	12
GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	6	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	219	221	PF00675	0.209
CLV_NRD_NRD_1	235	237	PF00675	0.209
CLV_NRD_NRD_1	250	252	PF00675	0.184
CLV_NRD_NRD_1	33	35	PF00675	0.265
CLV_PCSK_KEX2_1	235	237	PF00082	0.193
CLV_PCSK_KEX2_1	250	252	PF00082	0.253
CLV_PCSK_KEX2_1	33	35	PF00082	0.265
CLV_PCSK_SKI1_1	279	283	PF00082	0.209
CLV_PCSK_SKI1_1	447	451	PF00082	0.653
CLV_PCSK_SKI1_1	5	9	PF00082	0.262
CLV_PCSK_SKI1_1	88	92	PF00082	0.220
DEG_APCC_DBOX_1	250	258	PF00400	0.513
DOC_CYCLIN_yClb5_NLxxxL_5	22	31	PF00134	0.472
DOC_CYCLIN_yCln2_LP_2	323	329	PF00134	0.513
DOC_MAPK_FxFP_2	12	15	PF00069	0.451
DOC_MAPK_gen_1	203	213	PF00069	0.420
DOC_MAPK_gen_1	220	227	PF00069	0.409
DOC_MAPK_gen_1	33	41	PF00069	0.435
DOC_MAPK_HePTP_8	217	229	PF00069	0.409
DOC_MAPK_HePTP_8	377	389	PF00069	0.559
DOC_MAPK_MEF2A_6	206	213	PF00069	0.434
DOC_MAPK_MEF2A_6	220	229	PF00069	0.323
DOC_MAPK_MEF2A_6	380	389	PF00069	0.566
DOC_PP1_RVXF_1	141	148	PF00149	0.459
DOC_PP2B_LxvP_1	323	326	PF13499	0.456
DOC_PP4_FxxP_1	12	15	PF00568	0.451
DOC_PP4_FxxP_1	189	192	PF00568	0.456
DOC_USP7_MATH_1	249	253	PF00917	0.405
DOC_USP7_MATH_1	333	337	PF00917	0.476
DOC_USP7_MATH_1	7	11	PF00917	0.426
DOC_USP7_UBL2_3	447	451	PF12436	0.377
DOC_WW_Pin1_4	187	192	PF00397	0.485
DOC_WW_Pin1_4	350	355	PF00397	0.460
LIG_14-3-3_CanoR_1	176	180	PF00244	0.461
LIG_14-3-3_CanoR_1	250	258	PF00244	0.395
LIG_14-3-3_CanoR_1	95	99	PF00244	0.462
LIG_Actin_WH2_2	137	152	PF00022	0.455
LIG_Actin_WH2_2	74	90	PF00022	0.513
LIG_BIR_III_2	332	336	PF00653	0.456
LIG_BRCT_BRCA1_1	9	13	PF00533	0.430
LIG_FHA_1	116	122	PF00498	0.463
LIG_FHA_1	208	214	PF00498	0.432
LIG_FHA_1	372	378	PF00498	0.463
LIG_FHA_1	384	390	PF00498	0.523
LIG_FHA_1	425	431	PF00498	0.349
LIG_FHA_1	53	59	PF00498	0.490
LIG_FHA_1	87	93	PF00498	0.513
LIG_FHA_2	159	165	PF00498	0.464
LIG_FHA_2	188	194	PF00498	0.487
LIG_FHA_2	354	360	PF00498	0.497
LIG_LIR_Apic_2	10	15	PF02991	0.444
LIG_LIR_Apic_2	186	192	PF02991	0.475
LIG_LIR_Apic_2	422	426	PF02991	0.274
LIG_LIR_Gen_1	224	233	PF02991	0.412
LIG_LIR_Gen_1	366	371	PF02991	0.440
LIG_LIR_Gen_1	375	385	PF02991	0.487
LIG_LIR_Gen_1	388	397	PF02991	0.482
LIG_LIR_Nem_3	11	17	PF02991	0.458
LIG_LIR_Nem_3	224	229	PF02991	0.412
LIG_LIR_Nem_3	366	370	PF02991	0.446
LIG_LIR_Nem_3	375	381	PF02991	0.475
LIG_LIR_Nem_3	388	393	PF02991	0.484
LIG_LIR_Nem_3	412	418	PF02991	0.341
LIG_MLH1_MIPbox_1	9	13	PF16413	0.430
LIG_Pex14_1	80	84	PF04695	0.434
LIG_Pex14_2	13	17	PF04695	0.467
LIG_Pex14_2	436	440	PF04695	0.376
LIG_SH2_CRK	378	382	PF00017	0.491
LIG_SH2_CRK	396	400	PF00017	0.429
LIG_SH2_GRB2like	54	57	PF00017	0.513
LIG_SH2_NCK_1	396	400	PF00017	0.470
LIG_SH2_STAP1	365	369	PF00017	0.451
LIG_SH2_STAP1	378	382	PF00017	0.447
LIG_SH2_STAP1	390	394	PF00017	0.449
LIG_SH2_STAT5	441	444	PF00017	0.328
LIG_SH2_STAT5	54	57	PF00017	0.457
LIG_SH2_STAT5	62	65	PF00017	0.432
LIG_SH3_3	319	325	PF00018	0.426
LIG_SH3_3	431	437	PF00018	0.271
LIG_SH3_3	72	78	PF00018	0.444
LIG_SUMO_SIM_anti_2	207	213	PF11976	0.409
LIG_SUMO_SIM_anti_2	94	100	PF11976	0.409
LIG_SUMO_SIM_par_1	209	215	PF11976	0.478
LIG_SUMO_SIM_par_1	326	332	PF11976	0.410
LIG_SUMO_SIM_par_1	37	42	PF11976	0.438
LIG_SUMO_SIM_par_1	385	391	PF11976	0.479
LIG_TRAF2_1	341	344	PF00917	0.420
LIG_TYR_ITAM	375	393	PF00017	0.319
LIG_UBA3_1	269	274	PF00899	0.338
MOD_CK1_1	148	154	PF00069	0.342
MOD_CK1_1	159	165	PF00069	0.334
MOD_CK1_1	187	193	PF00069	0.350
MOD_CK1_1	199	205	PF00069	0.248
MOD_CK1_1	353	359	PF00069	0.373
MOD_CK2_1	158	164	PF00069	0.316
MOD_CK2_1	249	255	PF00069	0.394
MOD_CK2_1	289	295	PF00069	0.244
MOD_CK2_1	385	391	PF00069	0.355
MOD_GlcNHglycan	185	189	PF01048	0.488
MOD_GSK3_1	159	166	PF00069	0.356
MOD_GSK3_1	183	190	PF00069	0.381
MOD_GSK3_1	273	280	PF00069	0.286
MOD_N-GLC_1	159	164	PF02516	0.338
MOD_N-GLC_1	181	186	PF02516	0.362
MOD_N-GLC_1	289	294	PF02516	0.244
MOD_N-GLC_2	107	109	PF02516	0.244
MOD_NEK2_1	145	150	PF00069	0.292
MOD_NEK2_1	289	294	PF00069	0.244
MOD_NEK2_1	310	315	PF00069	0.244
MOD_NEK2_1	86	91	PF00069	0.303
MOD_NEK2_2	120	125	PF00069	0.278
MOD_NEK2_2	385	390	PF00069	0.495
MOD_PIKK_1	249	255	PF00454	0.273
MOD_PKA_2	175	181	PF00069	0.349
MOD_PKA_2	249	255	PF00069	0.224
MOD_PKA_2	94	100	PF00069	0.266
MOD_Plk_1	126	132	PF00069	0.244
MOD_Plk_1	163	169	PF00069	0.446
MOD_Plk_1	184	190	PF00069	0.365
MOD_Plk_1	289	295	PF00069	0.244
MOD_Plk_4	126	132	PF00069	0.244
MOD_Plk_4	163	169	PF00069	0.331
MOD_Plk_4	175	181	PF00069	0.328
MOD_Plk_4	207	213	PF00069	0.308
MOD_Plk_4	277	283	PF00069	0.358
MOD_Plk_4	334	340	PF00069	0.335
MOD_Plk_4	385	391	PF00069	0.358
MOD_Plk_4	436	442	PF00069	0.497
MOD_Plk_4	76	82	PF00069	0.247
MOD_ProDKin_1	187	193	PF00069	0.357
MOD_ProDKin_1	350	356	PF00069	0.318
MOD_SUMO_rev_2	276	281	PF00179	0.338
TRG_DiLeu_BaEn_1	259	264	PF01217	0.259
TRG_ENDOCYTIC_2	378	381	PF00928	0.337
TRG_ENDOCYTIC_2	390	393	PF00928	0.344
TRG_ENDOCYTIC_2	396	399	PF00928	0.343
TRG_ENDOCYTIC_2	418	421	PF00928	0.338
TRG_ENDOCYTIC_2	62	65	PF00928	0.292
TRG_ER_diArg_1	168	171	PF00400	0.386
TRG_ER_diArg_1	249	251	PF00400	0.303
TRG_ER_diArg_1	32	34	PF00400	0.305
TRG_ER_diLys_1	450	454	PF00400	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0S1	Leptomonas seymouri	93%	100%
A0A0S4JIR0	Bodo saltans	71%	100%
A0A1X0P1G6	Trypanosomatidae	81%	100%
A0A3Q8IK70	Leishmania donovani	99%	100%
A0A422N220	Trypanosoma rangeli	79%	100%
A0PVZ1	Mycobacterium ulcerans (strain Agy99)	25%	98%
A0R2E2	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	24%	100%
A4HLM8	Leishmania braziliensis	94%	100%
A4I939	Leishmania infantum	99%	100%
A5U3B9	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	22%	100%
A6ZW78	Saccharomyces cerevisiae (strain YJM789)	42%	100%
B1VEI4	Corynebacterium urealyticum (strain ATCC 43042 / DSM 7109)	22%	100%
B2HQV2	Mycobacterium marinum (strain ATCC BAA-535 / M)	24%	97%
B3LKQ3	Saccharomyces cerevisiae (strain RM11-1a)	42%	100%
B5VSZ6	Saccharomyces cerevisiae (strain AWRI1631)	42%	100%
C3PK12	Corynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CIP 107346 / CN-1)	24%	100%
C7R101	Jonesia denitrificans (strain ATCC 14870 / DSM 20603 / BCRC 15368 / CIP 55.134 / JCM 11481 / NBRC 15587 / NCTC 10816 / Prevot 55134)	24%	100%
C9ZIV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
D3Q051	Stackebrandtia nassauensis (strain DSM 44728 / CIP 108903 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)	25%	100%
D6Z995	Segniliparus rotundus (strain ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM 44985 / JCM 13578)	24%	100%
E9B404	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
P0CF99	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	22%	100%
P32363	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	100%
P37287	Homo sapiens	50%	94%
P42982	Bacillus subtilis (strain 168)	25%	100%
P87172	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	100%
P9WMY8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	22%	100%
P9WMY9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	22%	100%
P9WMZ4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	23%	100%
P9WMZ5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	23%	100%
Q4JSW2	Corynebacterium jeikeium (strain K411)	23%	100%
Q53U18	Streptomyces fradiae	24%	100%
Q58577	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	23%	100%
Q59002	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	25%	100%
Q64323	Mus musculus	49%	94%
Q6NJL3	Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)	25%	100%
Q7TY88	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	23%	100%
Q81ST7	Bacillus anthracis	24%	100%
Q94BX4	Arabidopsis thaliana	55%	100%
V5DDG0	Trypanosoma cruzi	78%	100%