LeishMANIAdb
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Non-specific serine/threonine protein kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Non-specific serine/threonine protein kinase
Gene product:
CAMK/CAMKL family protein kinase, putative
Species:
Leishmania major
UniProt:
Q4Q416_LEIMA
TriTrypDb:
LmjF.33.1710 , LMJLV39_330026300 , LMJSD75_330025900 *
Length:
640

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 3
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q416
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q416

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0007165 signal transduction 2 2
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016310 phosphorylation 5 12
GO:0019538 protein metabolic process 3 12
GO:0035556 intracellular signal transduction 3 2
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0065007 biological regulation 1 2
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004672 protein kinase activity 3 12
GO:0004674 protein serine/threonine kinase activity 4 2
GO:0005488 binding 1 12
GO:0005509 calcium ion binding 5 12
GO:0005524 ATP binding 5 12
GO:0016301 kinase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140096 catalytic activity, acting on a protein 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 238 242 PF00656 0.337
CLV_C14_Caspase3-7 365 369 PF00656 0.318
CLV_C14_Caspase3-7 445 449 PF00656 0.513
CLV_C14_Caspase3-7 468 472 PF00656 0.450
CLV_C14_Caspase3-7 561 565 PF00656 0.594
CLV_NRD_NRD_1 244 246 PF00675 0.307
CLV_NRD_NRD_1 514 516 PF00675 0.427
CLV_NRD_NRD_1 617 619 PF00675 0.388
CLV_NRD_NRD_1 84 86 PF00675 0.303
CLV_PCSK_FUR_1 512 516 PF00082 0.457
CLV_PCSK_KEX2_1 125 127 PF00082 0.411
CLV_PCSK_KEX2_1 246 248 PF00082 0.306
CLV_PCSK_KEX2_1 514 516 PF00082 0.427
CLV_PCSK_KEX2_1 617 619 PF00082 0.530
CLV_PCSK_PC1ET2_1 125 127 PF00082 0.411
CLV_PCSK_PC1ET2_1 246 248 PF00082 0.305
CLV_PCSK_SKI1_1 154 158 PF00082 0.303
CLV_PCSK_SKI1_1 321 325 PF00082 0.670
CLV_PCSK_SKI1_1 367 371 PF00082 0.318
CLV_PCSK_SKI1_1 434 438 PF00082 0.472
CLV_PCSK_SKI1_1 441 445 PF00082 0.355
CLV_PCSK_SKI1_1 546 550 PF00082 0.487
CLV_PCSK_SKI1_1 578 582 PF00082 0.419
CLV_PCSK_SKI1_1 611 615 PF00082 0.418
CLV_PCSK_SKI1_1 618 622 PF00082 0.387
CLV_PCSK_SKI1_1 85 89 PF00082 0.345
CLV_Separin_Metazoa 623 627 PF03568 0.506
DEG_APCC_DBOX_1 366 374 PF00400 0.303
DEG_ODPH_VHL_1 111 124 PF01847 0.350
DEG_SCF_FBW7_1 322 328 PF00400 0.694
DOC_CKS1_1 306 311 PF01111 0.667
DOC_CKS1_1 322 327 PF01111 0.642
DOC_CYCLIN_RxL_1 457 469 PF00134 0.450
DOC_CYCLIN_RxL_1 542 554 PF00134 0.511
DOC_CYCLIN_yClb5_NLxxxL_5 103 111 PF00134 0.388
DOC_MAPK_gen_1 154 163 PF00069 0.303
DOC_MAPK_gen_1 457 465 PF00069 0.431
DOC_MAPK_gen_1 54 60 PF00069 0.309
DOC_MAPK_gen_1 578 585 PF00069 0.427
DOC_MAPK_gen_1 85 95 PF00069 0.303
DOC_MAPK_MEF2A_6 459 467 PF00069 0.423
DOC_MAPK_MEF2A_6 505 513 PF00069 0.533
DOC_MAPK_MEF2A_6 54 62 PF00069 0.308
DOC_MAPK_MEF2A_6 578 587 PF00069 0.387
DOC_PP1_RVXF_1 603 610 PF00149 0.476
DOC_PP2B_LxvP_1 271 274 PF13499 0.372
DOC_USP7_MATH_1 274 278 PF00917 0.443
DOC_USP7_MATH_1 325 329 PF00917 0.641
DOC_USP7_MATH_1 338 342 PF00917 0.568
DOC_USP7_MATH_1 349 353 PF00917 0.313
DOC_USP7_MATH_1 475 479 PF00917 0.421
DOC_USP7_UBL2_3 18 22 PF12436 0.490
DOC_USP7_UBL2_3 3 7 PF12436 0.763
DOC_USP7_UBL2_3 457 461 PF12436 0.423
DOC_USP7_UBL2_3 61 65 PF12436 0.307
DOC_WW_Pin1_4 20 25 PF00397 0.596
DOC_WW_Pin1_4 305 310 PF00397 0.596
DOC_WW_Pin1_4 321 326 PF00397 0.684
DOC_WW_Pin1_4 334 339 PF00397 0.676
DOC_WW_Pin1_4 5 10 PF00397 0.672
LIG_14-3-3_CanoR_1 279 289 PF00244 0.318
LIG_14-3-3_CanoR_1 398 406 PF00244 0.318
LIG_14-3-3_CanoR_1 529 533 PF00244 0.512
LIG_BIR_II_1 1 5 PF00653 0.774
LIG_BRCT_BRCA1_1 328 332 PF00533 0.664
LIG_BRCT_BRCA1_1 487 491 PF00533 0.450
LIG_BRCT_BRCA1_1 556 560 PF00533 0.391
LIG_deltaCOP1_diTrp_1 218 227 PF00928 0.303
LIG_FHA_1 280 286 PF00498 0.337
LIG_FHA_1 51 57 PF00498 0.372
LIG_FHA_1 593 599 PF00498 0.447
LIG_FHA_2 279 285 PF00498 0.399
LIG_FHA_2 378 384 PF00498 0.423
LIG_FHA_2 398 404 PF00498 0.360
LIG_FHA_2 466 472 PF00498 0.365
LIG_FHA_2 556 562 PF00498 0.402
LIG_FHA_2 6 12 PF00498 0.727
LIG_LIR_Apic_2 198 204 PF02991 0.300
LIG_LIR_Gen_1 102 113 PF02991 0.314
LIG_LIR_Gen_1 116 124 PF02991 0.272
LIG_LIR_Gen_1 189 199 PF02991 0.423
LIG_LIR_Gen_1 433 444 PF02991 0.517
LIG_LIR_Gen_1 473 482 PF02991 0.319
LIG_LIR_Nem_3 102 108 PF02991 0.314
LIG_LIR_Nem_3 116 121 PF02991 0.272
LIG_LIR_Nem_3 189 195 PF02991 0.423
LIG_LIR_Nem_3 433 439 PF02991 0.537
LIG_LIR_Nem_3 442 447 PF02991 0.505
LIG_LIR_Nem_3 488 494 PF02991 0.366
LIG_PALB2_WD40_1 608 616 PF16756 0.408
LIG_Pex14_2 387 391 PF04695 0.303
LIG_Pex14_2 404 408 PF04695 0.435
LIG_Pex14_2 609 613 PF04695 0.388
LIG_PTB_Apo_2 312 319 PF02174 0.698
LIG_Rb_LxCxE_1 622 640 PF01857 0.571
LIG_REV1ctd_RIR_1 501 507 PF16727 0.550
LIG_SH2_CRK 105 109 PF00017 0.303
LIG_SH2_CRK 594 598 PF00017 0.394
LIG_SH2_NCK_1 536 540 PF00017 0.535
LIG_SH2_STAP1 594 598 PF00017 0.429
LIG_SH2_STAT3 135 138 PF00017 0.303
LIG_SH2_STAT5 135 138 PF00017 0.301
LIG_SH2_STAT5 145 148 PF00017 0.221
LIG_SH2_STAT5 179 182 PF00017 0.303
LIG_SH2_STAT5 233 236 PF00017 0.303
LIG_SH2_STAT5 259 262 PF00017 0.318
LIG_SH2_STAT5 280 283 PF00017 0.423
LIG_SH2_STAT5 536 539 PF00017 0.506
LIG_SH2_STAT5 573 576 PF00017 0.456
LIG_SH2_STAT5 594 597 PF00017 0.388
LIG_SH2_STAT5 76 79 PF00017 0.303
LIG_SH3_3 270 276 PF00018 0.464
LIG_SH3_3 303 309 PF00018 0.600
LIG_SH3_3 319 325 PF00018 0.677
LIG_TRAF2_1 380 383 PF00917 0.337
LIG_TRAF2_1 400 403 PF00917 0.360
LIG_TRAF2_1 551 554 PF00917 0.552
LIG_TRAF2_1 559 562 PF00917 0.528
LIG_TRAF2_2 261 266 PF00917 0.450
LIG_UBA3_1 117 125 PF00899 0.411
LIG_UBA3_1 83 88 PF00899 0.366
LIG_UBA3_1 95 103 PF00899 0.384
MOD_CDK_SPK_2 20 25 PF00069 0.596
MOD_CDK_SPK_2 5 10 PF00069 0.672
MOD_CDK_SPxK_1 20 26 PF00069 0.464
MOD_CK1_1 177 183 PF00069 0.318
MOD_CK1_1 328 334 PF00069 0.688
MOD_CK1_1 337 343 PF00069 0.592
MOD_CK1_1 449 455 PF00069 0.440
MOD_CK1_1 474 480 PF00069 0.450
MOD_CK1_1 487 493 PF00069 0.185
MOD_CK1_1 531 537 PF00069 0.568
MOD_CK1_1 555 561 PF00069 0.498
MOD_CK2_1 377 383 PF00069 0.330
MOD_CK2_1 397 403 PF00069 0.318
MOD_CK2_1 5 11 PF00069 0.725
MOD_CK2_1 548 554 PF00069 0.535
MOD_CK2_1 555 561 PF00069 0.401
MOD_CK2_1 72 78 PF00069 0.353
MOD_DYRK1A_RPxSP_1 321 325 PF00069 0.641
MOD_GlcNHglycan 276 279 PF01048 0.394
MOD_GlcNHglycan 328 331 PF01048 0.659
MOD_GlcNHglycan 450 454 PF01048 0.388
MOD_GlcNHglycan 473 476 PF01048 0.372
MOD_GlcNHglycan 70 73 PF01048 0.423
MOD_GSK3_1 191 198 PF00069 0.293
MOD_GSK3_1 237 244 PF00069 0.312
MOD_GSK3_1 274 281 PF00069 0.384
MOD_GSK3_1 304 311 PF00069 0.550
MOD_GSK3_1 321 328 PF00069 0.617
MOD_GSK3_1 334 341 PF00069 0.648
MOD_GSK3_1 349 356 PF00069 0.211
MOD_GSK3_1 449 456 PF00069 0.337
MOD_GSK3_1 471 478 PF00069 0.383
MOD_GSK3_1 548 555 PF00069 0.478
MOD_GSK3_1 68 75 PF00069 0.410
MOD_N-GLC_1 253 258 PF02516 0.423
MOD_N-GLC_1 353 358 PF02516 0.354
MOD_NEK2_1 174 179 PF00069 0.377
MOD_NEK2_1 191 196 PF00069 0.317
MOD_NEK2_1 406 411 PF00069 0.558
MOD_NEK2_1 528 533 PF00069 0.571
MOD_NEK2_1 548 553 PF00069 0.441
MOD_NEK2_1 569 574 PF00069 0.412
MOD_NEK2_1 67 72 PF00069 0.423
MOD_OFUCOSY 217 222 PF10250 0.303
MOD_PIKK_1 571 577 PF00454 0.529
MOD_PKA_2 177 183 PF00069 0.303
MOD_PKA_2 278 284 PF00069 0.360
MOD_PKA_2 397 403 PF00069 0.318
MOD_PKA_2 528 534 PF00069 0.558
MOD_PKA_2 68 74 PF00069 0.413
MOD_PKB_1 245 253 PF00069 0.406
MOD_Plk_1 628 634 PF00069 0.563
MOD_Plk_4 295 301 PF00069 0.463
MOD_Plk_4 72 78 PF00069 0.326
MOD_ProDKin_1 20 26 PF00069 0.587
MOD_ProDKin_1 305 311 PF00069 0.596
MOD_ProDKin_1 321 327 PF00069 0.678
MOD_ProDKin_1 334 340 PF00069 0.671
MOD_ProDKin_1 5 11 PF00069 0.673
MOD_SUMO_for_1 156 159 PF00179 0.303
MOD_SUMO_for_1 620 623 PF00179 0.518
MOD_SUMO_for_1 633 636 PF00179 0.608
MOD_SUMO_rev_2 119 127 PF00179 0.355
MOD_SUMO_rev_2 381 387 PF00179 0.433
MOD_SUMO_rev_2 477 486 PF00179 0.341
TRG_DiLeu_BaEn_1 442 447 PF01217 0.415
TRG_DiLeu_BaEn_2 382 388 PF01217 0.423
TRG_DiLeu_BaLyEn_6 583 588 PF01217 0.398
TRG_DiLeu_BaLyEn_6 91 96 PF01217 0.388
TRG_ENDOCYTIC_2 105 108 PF00928 0.303
TRG_ENDOCYTIC_2 233 236 PF00928 0.303
TRG_ENDOCYTIC_2 501 504 PF00928 0.459
TRG_ENDOCYTIC_2 594 597 PF00928 0.396
TRG_ER_diArg_1 245 248 PF00400 0.299
TRG_ER_diArg_1 511 514 PF00400 0.407
TRG_ER_diArg_1 616 618 PF00400 0.521
TRG_NES_CRM1_1 435 450 PF08389 0.508
TRG_Pf-PMV_PEXEL_1 154 159 PF00026 0.318
TRG_Pf-PMV_PEXEL_1 258 262 PF00026 0.343
TRG_Pf-PMV_PEXEL_1 617 622 PF00026 0.431

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMD1 Leptomonas seymouri 81% 100%
A0A0S4IPB3 Bodo saltans 30% 95%
A0A0S4JIY0 Bodo saltans 52% 99%
A0A1X0NJJ7 Trypanosomatidae 29% 85%
A0A1X0P150 Trypanosomatidae 56% 100%
A0A2I0BVG8 Plasmodium falciparum (isolate NF54) 27% 100%
A0A3Q8IIY5 Leishmania donovani 24% 100%
A0A3Q8IU22 Leishmania donovani 98% 100%
A0A3S5H5G0 Leishmania donovani 25% 100%
A0A3S5H5U5 Leishmania donovani 26% 100%
A0A3S5IQS7 Trypanosoma rangeli 30% 87%
A0A422N215 Trypanosoma rangeli 54% 100%
A0A509AHB6 Plasmodium berghei (strain Anka) 28% 100%
A0A509AQE6 Plasmodium berghei (strain Anka) 28% 100%
A0A5K1K8H0 Plasmodium falciparum (isolate 3D7) 27% 100%
A0AAR7 Lotus japonicus 26% 100%
A2ZVI7 Oryza sativa subsp. japonica 30% 100%
A4H459 Leishmania braziliensis 25% 100%
A4H4S9 Leishmania braziliensis 26% 100%
A4HCD7 Leishmania braziliensis 29% 100%
A4HFF3 Leishmania braziliensis 27% 100%
A4HLN2 Leishmania braziliensis 91% 99%
A4HSE2 Leishmania infantum 25% 100%
A4I967 Leishmania infantum 98% 100%
A5A7I7 Solanum tuberosum 28% 100%
A5A7I8 Solanum tuberosum 28% 100%
B9FKW9 Oryza sativa subsp. japonica 30% 100%
C9ZIW2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
D0A2A6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 86%
E9AE77 Leishmania major 24% 100%
E9AG71 Leishmania infantum 26% 100%
E9AKB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AKZ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B408 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
O49717 Arabidopsis thaliana 30% 100%
O80673 Arabidopsis thaliana 28% 100%
P28582 Daucus carota 29% 100%
P28583 Glycine max 29% 100%
P49101 Zea mays 30% 100%
P53681 Daucus carota 28% 100%
P53683 Oryza sativa subsp. japonica 30% 100%
P53684 Oryza sativa subsp. japonica 28% 100%
P62343 Plasmodium falciparum (isolate K1 / Thailand) 27% 100%
P62344 Plasmodium falciparum (isolate 3D7) 27% 100%
P93759 Arabidopsis thaliana 31% 100%
Q06850 Arabidopsis thaliana 28% 100%
Q0D715 Oryza sativa subsp. japonica 29% 100%
Q0DYK7 Oryza sativa subsp. japonica 29% 100%
Q10KY3 Oryza sativa subsp. japonica 29% 100%
Q1PE17 Arabidopsis thaliana 31% 100%
Q1PFH8 Arabidopsis thaliana 29% 100%
Q2QQR2 Oryza sativa subsp. japonica 28% 100%
Q2QVG8 Oryza sativa subsp. japonica 31% 100%
Q2QX45 Oryza sativa subsp. japonica 28% 100%
Q2QY37 Oryza sativa subsp. japonica 31% 100%
Q2RAV0 Oryza sativa subsp. japonica 31% 100%
Q38868 Arabidopsis thaliana 31% 100%
Q38869 Arabidopsis thaliana 29% 100%
Q38870 Arabidopsis thaliana 28% 99%
Q38871 Arabidopsis thaliana 28% 100%
Q38872 Arabidopsis thaliana 28% 100%
Q38873 Arabidopsis thaliana 29% 100%
Q39016 Arabidopsis thaliana 28% 100%
Q3E9C0 Arabidopsis thaliana 31% 100%
Q42396 Arabidopsis thaliana 28% 100%
Q42438 Arabidopsis thaliana 29% 100%
Q42479 Arabidopsis thaliana 32% 100%
Q4QIV8 Leishmania major 26% 100%
Q4QJJ0 Leishmania major 25% 100%
Q53P85 Oryza sativa subsp. japonica 29% 100%
Q5VQQ5 Oryza sativa subsp. japonica 30% 100%
Q69IM9 Oryza sativa subsp. japonica 30% 100%
Q6AVI8 Oryza sativa subsp. japonica 29% 100%
Q6F3A6 Oryza sativa subsp. japonica 30% 100%
Q6I587 Oryza sativa subsp. japonica 29% 100%
Q6I5I8 Oryza sativa subsp. japonica 29% 100%
Q6K968 Oryza sativa subsp. japonica 29% 100%
Q6NLQ6 Arabidopsis thaliana 30% 100%
Q6Z2M9 Oryza sativa subsp. japonica 30% 100%
Q6ZIU9 Oryza sativa subsp. japonica 30% 100%
Q75GE8 Oryza sativa subsp. japonica 30% 100%
Q7RAH3 Plasmodium yoelii yoelii 28% 100%
Q7XIM0 Oryza sativa subsp. japonica 28% 100%
Q7XJR9 Arabidopsis thaliana 30% 100%
Q7XSQ5 Oryza sativa subsp. japonica 30% 100%
Q84SL0 Oryza sativa subsp. japonica 29% 100%
Q852N6 Oryza sativa subsp. japonica 28% 100%
Q8IBS5 Plasmodium falciparum (isolate 3D7) 27% 100%
Q8LPZ7 Oryza sativa subsp. japonica 30% 100%
Q8RWL2 Arabidopsis thaliana 31% 100%
Q8W4I7 Arabidopsis thaliana 29% 100%
Q9C6P3 Arabidopsis thaliana 30% 100%
Q9FKW4 Arabidopsis thaliana 29% 100%
Q9FMP5 Arabidopsis thaliana 30% 100%
Q9FX86 Arabidopsis thaliana 28% 100%
Q9FXQ3 Oryza sativa subsp. japonica 30% 100%
Q9LET1 Arabidopsis thaliana 27% 100%
Q9M101 Arabidopsis thaliana 28% 100%
Q9S9V0 Arabidopsis thaliana 28% 100%
Q9SIQ7 Arabidopsis thaliana 31% 100%
Q9SSF8 Arabidopsis thaliana 30% 100%
Q9SZM3 Arabidopsis thaliana 28% 100%
Q9ZSA2 Arabidopsis thaliana 30% 100%
Q9ZSA3 Arabidopsis thaliana 30% 100%
Q9ZSA4 Arabidopsis thaliana 28% 100%
Q9ZV15 Arabidopsis thaliana 27% 100%
V5BCN4 Trypanosoma cruzi 60% 100%
V5BN97 Trypanosoma cruzi 30% 87%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS