ANAPC5 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetratricopeptide repeat, putative

Species:

Leishmania major

UniProt:

Q4Q415_LEIMA

TriTrypDb:

LmjF.33.1720 , LMJLV39_330026500 , LMJSD75_330026100

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q415

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q415

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	279	283	PF00656	0.436
CLV_C14_Caspase3-7	381	385	PF00656	0.504
CLV_C14_Caspase3-7	87	91	PF00656	0.660
CLV_NRD_NRD_1	117	119	PF00675	0.508
CLV_PCSK_KEX2_1	117	119	PF00082	0.508
CLV_PCSK_KEX2_1	40	42	PF00082	0.681
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.681
CLV_PCSK_PC7_1	36	42	PF00082	0.670
CLV_PCSK_SKI1_1	195	199	PF00082	0.318
CLV_PCSK_SKI1_1	23	27	PF00082	0.693
CLV_PCSK_SKI1_1	41	45	PF00082	0.642
CLV_PCSK_SKI1_1	5	9	PF00082	0.684
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.624
DOC_MAPK_MEF2A_6	323	332	PF00069	0.331
DOC_PP1_RVXF_1	206	213	PF00149	0.520
DOC_PP2B_LxvP_1	89	92	PF13499	0.623
DOC_PP4_FxxP_1	95	98	PF00568	0.630
DOC_USP7_MATH_1	126	130	PF00917	0.635
DOC_USP7_MATH_1	158	162	PF00917	0.556
DOC_USP7_MATH_1	369	373	PF00917	0.462
DOC_USP7_MATH_2	63	69	PF00917	0.746
DOC_WW_Pin1_4	133	138	PF00397	0.638
LIG_14-3-3_CanoR_1	157	163	PF00244	0.510
LIG_14-3-3_CanoR_1	41	48	PF00244	0.618
LIG_14-3-3_CanoR_1	5	15	PF00244	0.690
LIG_Actin_WH2_2	283	301	PF00022	0.455
LIG_BIR_II_1	1	5	PF00653	0.723
LIG_BRCT_BRCA1_1	176	180	PF00533	0.475
LIG_deltaCOP1_diTrp_1	188	194	PF00928	0.522
LIG_FHA_1	134	140	PF00498	0.623
LIG_FHA_1	285	291	PF00498	0.328
LIG_FHA_1	394	400	PF00498	0.618
LIG_FHA_2	103	109	PF00498	0.480
LIG_FHA_2	142	148	PF00498	0.618
LIG_GBD_Chelix_1	115	123	PF00786	0.535
LIG_LIR_Apic_2	132	138	PF02991	0.604
LIG_LIR_Apic_2	99	104	PF02991	0.618
LIG_LIR_Gen_1	256	265	PF02991	0.448
LIG_LIR_Gen_1	335	342	PF02991	0.327
LIG_LIR_Nem_3	256	260	PF02991	0.438
LIG_LIR_Nem_3	335	340	PF02991	0.327
LIG_NBox_RRM_1	194	204	PF00076	0.577
LIG_NRBOX	327	333	PF00104	0.450
LIG_PCNA_yPIPBox_3	117	131	PF02747	0.407
LIG_SH2_CRK	101	105	PF00017	0.674
LIG_SH2_CRK	135	139	PF00017	0.627
LIG_SH2_CRK	15	19	PF00017	0.620
LIG_SH2_CRK	257	261	PF00017	0.434
LIG_SH2_CRK	337	341	PF00017	0.352
LIG_SH2_GRB2like	47	50	PF00017	0.764
LIG_SH2_NCK_1	15	19	PF00017	0.719
LIG_SH2_SRC	47	50	PF00017	0.764
LIG_SH2_STAP1	244	248	PF00017	0.437
LIG_SH2_STAT5	135	138	PF00017	0.658
LIG_SH2_STAT5	143	146	PF00017	0.539
LIG_SH2_STAT5	47	50	PF00017	0.570
LIG_SH3_3	57	63	PF00018	0.633
LIG_SUMO_SIM_anti_2	72	78	PF11976	0.643
LIG_SUMO_SIM_par_1	329	335	PF11976	0.336
LIG_SUMO_SIM_par_1	72	78	PF11976	0.633
LIG_TRAF2_1	105	108	PF00917	0.688
LIG_TRAF2_1	97	100	PF00917	0.651
LIG_TYR_ITIM	255	260	PF00017	0.401
MOD_CK1_1	129	135	PF00069	0.626
MOD_CK1_1	324	330	PF00069	0.418
MOD_CK1_1	398	404	PF00069	0.643
MOD_CK2_1	102	108	PF00069	0.486
MOD_CK2_1	141	147	PF00069	0.622
MOD_CK2_1	196	202	PF00069	0.468
MOD_CK2_1	258	264	PF00069	0.451
MOD_GlcNHglycan	176	179	PF01048	0.450
MOD_GlcNHglycan	2	5	PF01048	0.705
MOD_GlcNHglycan	322	326	PF01048	0.354
MOD_GlcNHglycan	79	82	PF01048	0.671
MOD_GlcNHglycan	86	89	PF01048	0.437
MOD_GSK3_1	125	132	PF00069	0.588
MOD_GSK3_1	17	24	PF00069	0.657
MOD_GSK3_1	280	287	PF00069	0.449
MOD_N-GLC_1	165	170	PF02516	0.544
MOD_N-GLC_1	21	26	PF02516	0.671
MOD_N-GLC_1	48	53	PF02516	0.735
MOD_NEK2_1	174	179	PF00069	0.392
MOD_NEK2_1	240	245	PF00069	0.536
MOD_NEK2_1	253	258	PF00069	0.418
MOD_NEK2_1	284	289	PF00069	0.454
MOD_NEK2_1	393	398	PF00069	0.611
MOD_NEK2_1	7	12	PF00069	0.705
MOD_NEK2_1	75	80	PF00069	0.630
MOD_NEK2_2	158	163	PF00069	0.570
MOD_NEK2_2	189	194	PF00069	0.494
MOD_NEK2_2	294	299	PF00069	0.450
MOD_PIKK_1	401	407	PF00454	0.662
MOD_PIKK_1	48	54	PF00454	0.733
MOD_PK_1	196	202	PF00069	0.513
MOD_PK_1	395	401	PF00069	0.662
MOD_PKA_2	277	283	PF00069	0.550
MOD_PKA_2	369	375	PF00069	0.431
MOD_PKA_2	84	90	PF00069	0.628
MOD_Plk_1	141	147	PF00069	0.543
MOD_Plk_1	21	27	PF00069	0.663
MOD_Plk_4	126	132	PF00069	0.682
MOD_Plk_4	21	27	PF00069	0.653
MOD_Plk_4	227	233	PF00069	0.438
MOD_Plk_4	280	286	PF00069	0.437
MOD_Plk_4	335	341	PF00069	0.336
MOD_Plk_4	382	388	PF00069	0.589
MOD_Plk_4	398	404	PF00069	0.334
MOD_Plk_4	43	49	PF00069	0.761
MOD_Plk_4	70	76	PF00069	0.617
MOD_ProDKin_1	133	139	PF00069	0.638
TRG_DiLeu_BaEn_1	335	340	PF01217	0.352
TRG_ENDOCYTIC_2	15	18	PF00928	0.620
TRG_ENDOCYTIC_2	184	187	PF00928	0.567
TRG_ENDOCYTIC_2	257	260	PF00928	0.411
TRG_ENDOCYTIC_2	337	340	PF00928	0.327
TRG_ER_diArg_1	117	119	PF00400	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P843	Leptomonas seymouri	80%	100%
A0A0S4JIY4	Bodo saltans	46%	85%
A0A0S4JLP5	Bodo saltans	24%	83%
A0A1X0P137	Trypanosomatidae	54%	94%
A0A3Q8IDU0	Leishmania donovani	97%	100%
A0A422MV93	Trypanosoma rangeli	55%	88%
A4HLN3	Leishmania braziliensis	89%	100%
A4I968	Leishmania infantum	97%	100%
C9ZIW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	87%
E9B409	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BLY0	Trypanosoma cruzi	55%	93%