PUB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q406_LEIMA

TriTrypDb:

LmjF.33.1820 , LMJLV39_330027500 , LMJSD75_330027100

Length:

430

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q406

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q406

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.697
CLV_C14_Caspase3-7	396	400	PF00656	0.345
CLV_NRD_NRD_1	237	239	PF00675	0.418
CLV_NRD_NRD_1	296	298	PF00675	0.444
CLV_NRD_NRD_1	71	73	PF00675	0.480
CLV_PCSK_KEX2_1	212	214	PF00082	0.495
CLV_PCSK_KEX2_1	237	239	PF00082	0.419
CLV_PCSK_KEX2_1	296	298	PF00082	0.442
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.495
CLV_PCSK_SKI1_1	132	136	PF00082	0.617
CLV_PCSK_SKI1_1	242	246	PF00082	0.503
CLV_PCSK_SKI1_1	284	288	PF00082	0.491
CLV_PCSK_SKI1_1	5	9	PF00082	0.546
CLV_PCSK_SKI1_1	73	77	PF00082	0.445
DEG_APCC_DBOX_1	131	139	PF00400	0.519
DEG_Kelch_Keap1_1	318	323	PF01344	0.498
DOC_ANK_TNKS_1	107	114	PF00023	0.312
DOC_CKS1_1	287	292	PF01111	0.560
DOC_CYCLIN_RxL_1	278	291	PF00134	0.524
DOC_MAPK_gen_1	212	219	PF00069	0.525
DOC_MAPK_MEF2A_6	95	103	PF00069	0.539
DOC_PP2B_LxvP_1	109	112	PF13499	0.426
DOC_PP2B_LxvP_1	367	370	PF13499	0.473
DOC_USP7_MATH_1	174	178	PF00917	0.522
DOC_USP7_MATH_1	188	192	PF00917	0.526
DOC_USP7_MATH_1	240	244	PF00917	0.538
DOC_USP7_MATH_1	351	355	PF00917	0.486
DOC_USP7_UBL2_3	212	216	PF12436	0.501
DOC_USP7_UBL2_3	73	77	PF12436	0.437
DOC_WW_Pin1_4	286	291	PF00397	0.445
LIG_14-3-3_CanoR_1	329	338	PF00244	0.365
LIG_14-3-3_CanoR_1	373	382	PF00244	0.459
LIG_Actin_WH2_2	259	274	PF00022	0.523
LIG_Actin_WH2_2	57	74	PF00022	0.550
LIG_APCC_ABBA_1	100	105	PF00400	0.455
LIG_Clathr_ClatBox_1	392	396	PF01394	0.320
LIG_deltaCOP1_diTrp_1	405	410	PF00928	0.426
LIG_FHA_1	212	218	PF00498	0.502
LIG_FHA_1	277	283	PF00498	0.536
LIG_FHA_2	115	121	PF00498	0.612
LIG_FHA_2	287	293	PF00498	0.395
LIG_FHA_2	7	13	PF00498	0.567
LIG_FHA_2	79	85	PF00498	0.526
LIG_LIR_Apic_2	308	312	PF02991	0.485
LIG_LIR_Gen_1	335	345	PF02991	0.430
LIG_LIR_Gen_1	97	107	PF02991	0.448
LIG_LIR_Nem_3	2	7	PF02991	0.435
LIG_LIR_Nem_3	335	341	PF02991	0.457
LIG_LIR_Nem_3	97	103	PF02991	0.411
LIG_NRBOX	134	140	PF00104	0.575
LIG_NRP_CendR_1	427	430	PF00754	0.684
LIG_Pex14_1	407	411	PF04695	0.420
LIG_SH2_CRK	347	351	PF00017	0.519
LIG_SH2_CRK	4	8	PF00017	0.334
LIG_SH2_NCK_1	347	351	PF00017	0.539
LIG_SH2_STAP1	388	392	PF00017	0.434
LIG_SH2_STAT5	114	117	PF00017	0.580
LIG_SH2_STAT5	165	168	PF00017	0.527
LIG_SH2_STAT5	343	346	PF00017	0.394
LIG_SH2_STAT5	347	350	PF00017	0.462
LIG_SH3_3	120	126	PF00018	0.657
LIG_SUMO_SIM_anti_2	204	210	PF11976	0.505
LIG_SUMO_SIM_anti_2	353	361	PF11976	0.557
LIG_TYR_ITIM	345	350	PF00017	0.508
MOD_CK1_1	264	270	PF00069	0.481
MOD_CK1_1	36	42	PF00069	0.728
MOD_CK1_1	419	425	PF00069	0.477
MOD_CK2_1	114	120	PF00069	0.531
MOD_CK2_1	121	127	PF00069	0.602
MOD_CK2_1	285	291	PF00069	0.459
MOD_CK2_1	329	335	PF00069	0.379
MOD_CMANNOS	407	410	PF00535	0.417
MOD_GlcNHglycan	150	154	PF01048	0.582
MOD_GlcNHglycan	314	317	PF01048	0.517
MOD_GlcNHglycan	331	334	PF01048	0.337
MOD_GlcNHglycan	35	38	PF01048	0.692
MOD_GlcNHglycan	375	378	PF01048	0.469
MOD_GSK3_1	250	257	PF00069	0.477
MOD_GSK3_1	36	43	PF00069	0.637
MOD_GSK3_1	6	13	PF00069	0.496
MOD_N-GLC_1	33	38	PF02516	0.688
MOD_N-GLC_1	351	356	PF02516	0.590
MOD_NEK2_1	10	15	PF00069	0.516
MOD_NEK2_1	149	154	PF00069	0.554
MOD_NEK2_1	261	266	PF00069	0.471
MOD_NEK2_1	271	276	PF00069	0.476
MOD_NEK2_1	55	60	PF00069	0.412
MOD_PIKK_1	188	194	PF00454	0.568
MOD_PKA_1	5	11	PF00069	0.534
MOD_PKA_2	217	223	PF00069	0.458
MOD_PKA_2	271	277	PF00069	0.526
MOD_PKA_2	345	351	PF00069	0.555
MOD_PKA_2	78	84	PF00069	0.613
MOD_Plk_1	121	127	PF00069	0.675
MOD_Plk_1	16	22	PF00069	0.437
MOD_Plk_1	240	246	PF00069	0.551
MOD_Plk_1	351	357	PF00069	0.568
MOD_Plk_2-3	116	122	PF00069	0.636
MOD_Plk_4	363	369	PF00069	0.535
MOD_Plk_4	416	422	PF00069	0.540
MOD_ProDKin_1	286	292	PF00069	0.445
MOD_SUMO_for_1	170	173	PF00179	0.559
MOD_SUMO_for_1	94	97	PF00179	0.545
MOD_SUMO_rev_2	204	214	PF00179	0.503
MOD_SUMO_rev_2	356	364	PF00179	0.510
TRG_DiLeu_BaEn_1	105	110	PF01217	0.355
TRG_DiLeu_BaEn_1	241	246	PF01217	0.348
TRG_DiLeu_BaEn_1	51	56	PF01217	0.505
TRG_DiLeu_BaEn_1	97	102	PF01217	0.460
TRG_DiLeu_BaEn_4	150	156	PF01217	0.552
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.478
TRG_DiLeu_LyEn_5	105	110	PF01217	0.378
TRG_ENDOCYTIC_2	347	350	PF00928	0.507
TRG_ENDOCYTIC_2	380	383	PF00928	0.530
TRG_ENDOCYTIC_2	4	7	PF00928	0.336
TRG_ENDOCYTIC_2	411	414	PF00928	0.389
TRG_ER_diArg_1	295	297	PF00400	0.447
TRG_ER_diArg_1	69	72	PF00400	0.468
TRG_NES_CRM1_1	90	105	PF08389	0.549
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0R4	Leptomonas seymouri	51%	100%
A0A0S4JD21	Bodo saltans	28%	100%
A0A1X0P4D8	Trypanosomatidae	39%	100%
A0A3Q8IGN6	Leishmania donovani	90%	100%
A0A422N3D5	Trypanosoma rangeli	38%	100%
A4HLP2	Leishmania braziliensis	77%	100%
A4I977	Leishmania infantum	90%	100%
D0A6D1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B418	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5DQF0	Trypanosoma cruzi	37%	100%