Dual-specificity kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dual specificity tyrosine-phosphorylation-regulated kinase 2, putative

Species:

Leishmania major

UniProt:

Q4Q405_LEIMA

TriTrypDb:

LmjF.33.1830 , LMJLV39_330027600 , LMJSD75_330027200

Length:

957

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005856	cytoskeleton	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q405

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q405

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0018105	peptidyl-serine phosphorylation	6	2
GO:0018107	peptidyl-threonine phosphorylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018209	peptidyl-serine modification	6	2
GO:0018210	peptidyl-threonine modification	6	2
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0004712	protein serine/threonine/tyrosine kinase activity	4	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.452
CLV_C14_Caspase3-7	730	734	PF00656	0.760
CLV_NRD_NRD_1	117	119	PF00675	0.530
CLV_NRD_NRD_1	315	317	PF00675	0.522
CLV_NRD_NRD_1	32	34	PF00675	0.608
CLV_NRD_NRD_1	401	403	PF00675	0.597
CLV_NRD_NRD_1	520	522	PF00675	0.737
CLV_NRD_NRD_1	532	534	PF00675	0.827
CLV_NRD_NRD_1	721	723	PF00675	0.778
CLV_NRD_NRD_1	755	757	PF00675	0.849
CLV_PCSK_FUR_1	313	317	PF00082	0.530
CLV_PCSK_FUR_1	530	534	PF00082	0.832
CLV_PCSK_KEX2_1	313	315	PF00082	0.530
CLV_PCSK_KEX2_1	369	371	PF00082	0.452
CLV_PCSK_KEX2_1	520	522	PF00082	0.737
CLV_PCSK_KEX2_1	532	534	PF00082	0.827
CLV_PCSK_KEX2_1	721	723	PF00082	0.778
CLV_PCSK_KEX2_1	755	757	PF00082	0.849
CLV_PCSK_KEX2_1	952	954	PF00082	0.777
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.452
CLV_PCSK_PC1ET2_1	952	954	PF00082	0.777
CLV_PCSK_PC7_1	528	534	PF00082	0.840
CLV_PCSK_SKI1_1	118	122	PF00082	0.436
CLV_PCSK_SKI1_1	316	320	PF00082	0.530
CLV_PCSK_SKI1_1	360	364	PF00082	0.530
CLV_PCSK_SKI1_1	921	925	PF00082	0.825
DEG_SCF_FBW7_1	420	426	PF00400	0.591
DEG_SPOP_SBC_1	800	804	PF00917	0.618
DOC_CKS1_1	420	425	PF01111	0.588
DOC_CYCLIN_yClb5_NLxxxL_5	164	173	PF00134	0.530
DOC_CYCLIN_yCln2_LP_2	556	562	PF00134	0.794
DOC_CYCLIN_yCln2_LP_2	911	914	PF00134	0.841
DOC_MAPK_FxFP_2	386	389	PF00069	0.672
DOC_MAPK_gen_1	752	762	PF00069	0.850
DOC_MAPK_gen_1	827	835	PF00069	0.779
DOC_MAPK_HePTP_8	244	256	PF00069	0.530
DOC_MAPK_MEF2A_6	192	199	PF00069	0.530
DOC_MAPK_MEF2A_6	247	256	PF00069	0.530
DOC_PP1_RVXF_1	260	267	PF00149	0.452
DOC_PP2B_LxvP_1	299	302	PF13499	0.369
DOC_PP2B_LxvP_1	556	559	PF13499	0.758
DOC_PP2B_LxvP_1	911	914	PF13499	0.841
DOC_PP4_FxxP_1	386	389	PF00568	0.672
DOC_USP7_MATH_1	20	24	PF00917	0.535
DOC_USP7_MATH_1	389	393	PF00917	0.764
DOC_USP7_MATH_1	408	412	PF00917	0.789
DOC_USP7_MATH_1	414	418	PF00917	0.725
DOC_USP7_MATH_1	428	432	PF00917	0.593
DOC_USP7_MATH_1	496	500	PF00917	0.666
DOC_USP7_MATH_1	550	554	PF00917	0.831
DOC_USP7_MATH_1	562	566	PF00917	0.630
DOC_USP7_MATH_1	584	588	PF00917	0.709
DOC_USP7_MATH_1	647	651	PF00917	0.784
DOC_USP7_MATH_1	702	706	PF00917	0.740
DOC_USP7_MATH_1	726	730	PF00917	0.764
DOC_USP7_MATH_1	740	744	PF00917	0.706
DOC_USP7_MATH_1	800	804	PF00917	0.718
DOC_USP7_MATH_1	819	823	PF00917	0.656
DOC_USP7_MATH_1	837	841	PF00917	0.596
DOC_USP7_MATH_1	846	850	PF00917	0.738
DOC_USP7_MATH_1	852	856	PF00917	0.639
DOC_USP7_MATH_1	883	887	PF00917	0.753
DOC_USP7_MATH_1	919	923	PF00917	0.656
DOC_WW_Pin1_4	419	424	PF00397	0.610
DOC_WW_Pin1_4	446	451	PF00397	0.799
DOC_WW_Pin1_4	52	57	PF00397	0.685
DOC_WW_Pin1_4	546	551	PF00397	0.759
DOC_WW_Pin1_4	580	585	PF00397	0.820
DOC_WW_Pin1_4	613	618	PF00397	0.634
DOC_WW_Pin1_4	736	741	PF00397	0.851
DOC_WW_Pin1_4	743	748	PF00397	0.748
DOC_WW_Pin1_4	801	806	PF00397	0.776
DOC_WW_Pin1_4	838	843	PF00397	0.846
DOC_WW_Pin1_4	850	855	PF00397	0.650
DOC_WW_Pin1_4	940	945	PF00397	0.831
LIG_14-3-3_CanoR_1	147	154	PF00244	0.452
LIG_14-3-3_CanoR_1	155	164	PF00244	0.351
LIG_14-3-3_CanoR_1	192	198	PF00244	0.375
LIG_14-3-3_CanoR_1	507	513	PF00244	0.747
LIG_14-3-3_CanoR_1	530	540	PF00244	0.826
LIG_14-3-3_CanoR_1	608	617	PF00244	0.739
LIG_14-3-3_CanoR_1	621	629	PF00244	0.587
LIG_14-3-3_CanoR_1	708	718	PF00244	0.825
LIG_14-3-3_CanoR_1	735	740	PF00244	0.735
LIG_14-3-3_CanoR_1	801	805	PF00244	0.725
LIG_14-3-3_CanoR_1	863	872	PF00244	0.737
LIG_14-3-3_CanoR_1	915	919	PF00244	0.829
LIG_Actin_WH2_2	607	623	PF00022	0.743
LIG_AP2alpha_2	692	694	PF02296	0.585
LIG_APCC_ABBA_1	793	798	PF00400	0.819
LIG_BRCT_BRCA1_1	231	235	PF00533	0.452
LIG_BRCT_BRCA1_1	706	710	PF00533	0.613
LIG_BRCT_BRCA1_1	90	94	PF00533	0.530
LIG_deltaCOP1_diTrp_1	265	269	PF00928	0.530
LIG_EVH1_2	302	306	PF00568	0.369
LIG_FHA_1	180	186	PF00498	0.452
LIG_FHA_1	622	628	PF00498	0.705
LIG_FHA_1	670	676	PF00498	0.643
LIG_FHA_1	767	773	PF00498	0.601
LIG_FHA_1	851	857	PF00498	0.778
LIG_FHA_1	943	949	PF00498	0.786
LIG_FHA_2	27	33	PF00498	0.595
LIG_FHA_2	388	394	PF00498	0.572
LIG_Integrin_isoDGR_2	58	60	PF01839	0.650
LIG_LIR_Apic_2	246	252	PF02991	0.530
LIG_LIR_Apic_2	297	301	PF02991	0.501
LIG_LIR_Apic_2	385	389	PF02991	0.659
LIG_LIR_Apic_2	786	790	PF02991	0.752
LIG_LIR_Apic_2	898	902	PF02991	0.761
LIG_LIR_Gen_1	161	170	PF02991	0.530
LIG_LIR_Gen_1	305	312	PF02991	0.427
LIG_LIR_Gen_1	352	363	PF02991	0.487
LIG_LIR_Nem_3	161	165	PF02991	0.530
LIG_LIR_Nem_3	167	173	PF02991	0.333
LIG_LIR_Nem_3	265	269	PF02991	0.374
LIG_LIR_Nem_3	305	309	PF02991	0.427
LIG_LIR_Nem_3	352	358	PF02991	0.487
LIG_LIR_Nem_3	91	97	PF02991	0.413
LIG_MYND_1	854	858	PF01753	0.845
LIG_Pex14_2	358	362	PF04695	0.394
LIG_Pex14_2	94	98	PF04695	0.407
LIG_REV1ctd_RIR_1	316	324	PF16727	0.452
LIG_SH2_CRK	143	147	PF00017	0.530
LIG_SH2_CRK	241	245	PF00017	0.413
LIG_SH2_CRK	787	791	PF00017	0.747
LIG_SH2_SRC	555	558	PF00017	0.611
LIG_SH2_SRC	681	684	PF00017	0.703
LIG_SH2_SRC	773	776	PF00017	0.759
LIG_SH2_STAP1	260	264	PF00017	0.452
LIG_SH2_STAP1	758	762	PF00017	0.775
LIG_SH2_STAT3	44	47	PF00017	0.584
LIG_SH2_STAT5	241	244	PF00017	0.378
LIG_SH2_STAT5	298	301	PF00017	0.369
LIG_SH2_STAT5	44	47	PF00017	0.506
LIG_SH2_STAT5	555	558	PF00017	0.771
LIG_SH2_STAT5	71	74	PF00017	0.594
LIG_SH3_2	420	425	PF14604	0.783
LIG_SH3_2	910	915	PF14604	0.765
LIG_SH3_3	278	284	PF00018	0.530
LIG_SH3_3	417	423	PF00018	0.761
LIG_SH3_3	431	437	PF00018	0.577
LIG_SH3_3	454	460	PF00018	0.695
LIG_SH3_3	461	467	PF00018	0.595
LIG_SH3_3	510	516	PF00018	0.857
LIG_SH3_3	537	543	PF00018	0.826
LIG_SH3_3	611	617	PF00018	0.623
LIG_SH3_3	769	775	PF00018	0.759
LIG_SH3_3	818	824	PF00018	0.631
LIG_SH3_3	840	846	PF00018	0.774
LIG_SH3_3	907	913	PF00018	0.756
LIG_SH3_3	943	949	PF00018	0.720
LIG_SUMO_SIM_anti_2	182	188	PF11976	0.452
LIG_SUMO_SIM_par_1	13	19	PF11976	0.411
LIG_SUMO_SIM_par_1	193	198	PF11976	0.530
LIG_SUMO_SIM_par_1	226	232	PF11976	0.452
LIG_SUMO_SIM_par_1	622	631	PF11976	0.686
LIG_SxIP_EBH_1	901	915	PF03271	0.607
LIG_TRAF2_1	124	127	PF00917	0.530
LIG_TYR_ITIM	160	165	PF00017	0.530
LIG_TYR_ITIM	37	42	PF00017	0.624
LIG_WRC_WIRS_1	21	26	PF05994	0.551
LIG_WRC_WIRS_1	355	360	PF05994	0.530
LIG_WW_3	371	375	PF00397	0.452
LIG_WW_3	912	916	PF00397	0.842
MOD_CDK_SPK_2	743	748	PF00069	0.786
MOD_CDK_SPxK_1	419	425	PF00069	0.591
MOD_CDK_SPxxK_3	850	857	PF00069	0.840
MOD_CK1_1	404	410	PF00069	0.738
MOD_CK1_1	499	505	PF00069	0.645
MOD_CK1_1	582	588	PF00069	0.813
MOD_CK1_1	650	656	PF00069	0.729
MOD_CK1_1	743	749	PF00069	0.845
MOD_CK1_1	828	834	PF00069	0.831
MOD_CK1_1	841	847	PF00069	0.651
MOD_CK2_1	13	19	PF00069	0.644
MOD_CK2_1	26	32	PF00069	0.387
MOD_CK2_1	302	308	PF00069	0.452
MOD_CK2_1	345	351	PF00069	0.300
MOD_CK2_1	387	393	PF00069	0.521
MOD_CK2_1	562	568	PF00069	0.818
MOD_CK2_1	748	754	PF00069	0.671
MOD_Cter_Amidation	719	722	PF01082	0.737
MOD_DYRK1A_RPxSP_1	801	805	PF00069	0.725
MOD_GlcNHglycan	231	234	PF01048	0.530
MOD_GlcNHglycan	310	313	PF01048	0.530
MOD_GlcNHglycan	406	409	PF01048	0.805
MOD_GlcNHglycan	430	433	PF01048	0.606
MOD_GlcNHglycan	450	453	PF01048	0.728
MOD_GlcNHglycan	479	482	PF01048	0.688
MOD_GlcNHglycan	495	499	PF01048	0.549
MOD_GlcNHglycan	522	525	PF01048	0.799
MOD_GlcNHglycan	552	555	PF01048	0.712
MOD_GlcNHglycan	563	568	PF01048	0.765
MOD_GlcNHglycan	586	589	PF01048	0.689
MOD_GlcNHglycan	637	640	PF01048	0.699
MOD_GlcNHglycan	665	668	PF01048	0.748
MOD_GlcNHglycan	695	699	PF01048	0.776
MOD_GlcNHglycan	718	721	PF01048	0.777
MOD_GlcNHglycan	724	727	PF01048	0.821
MOD_GlcNHglycan	848	851	PF01048	0.834
MOD_GlcNHglycan	9	12	PF01048	0.749
MOD_GlcNHglycan	90	93	PF01048	0.530
MOD_GlcNHglycan	954	957	PF01048	0.758
MOD_GSK3_1	181	188	PF00069	0.452
MOD_GSK3_1	239	246	PF00069	0.452
MOD_GSK3_1	397	404	PF00069	0.726
MOD_GSK3_1	419	426	PF00069	0.617
MOD_GSK3_1	546	553	PF00069	0.761
MOD_GSK3_1	579	586	PF00069	0.793
MOD_GSK3_1	609	616	PF00069	0.758
MOD_GSK3_1	641	648	PF00069	0.841
MOD_GSK3_1	683	690	PF00069	0.709
MOD_GSK3_1	722	729	PF00069	0.680
MOD_GSK3_1	731	738	PF00069	0.755
MOD_GSK3_1	763	770	PF00069	0.752
MOD_GSK3_1	837	844	PF00069	0.771
MOD_GSK3_1	846	853	PF00069	0.665
MOD_GSK3_1	863	870	PF00069	0.541
MOD_GSK3_1	938	945	PF00069	0.796
MOD_N-GLC_1	404	409	PF02516	0.709
MOD_N-GLC_1	550	555	PF02516	0.834
MOD_N-GLC_1	645	650	PF02516	0.770
MOD_NEK2_1	104	109	PF00069	0.530
MOD_NEK2_1	164	169	PF00069	0.335
MOD_NEK2_1	181	186	PF00069	0.416
MOD_NEK2_1	193	198	PF00069	0.375
MOD_NEK2_1	401	406	PF00069	0.659
MOD_NEK2_1	486	491	PF00069	0.576
MOD_NEK2_1	620	625	PF00069	0.825
MOD_NEK2_1	694	699	PF00069	0.615
MOD_NEK2_2	327	332	PF00069	0.413
MOD_NEK2_2	408	413	PF00069	0.787
MOD_PIKK_1	387	393	PF00454	0.621
MOD_PIKK_1	414	420	PF00454	0.639
MOD_PIKK_1	828	834	PF00454	0.777
MOD_PIKK_1	864	870	PF00454	0.756
MOD_PIKK_1	883	889	PF00454	0.510
MOD_PK_1	345	351	PF00069	0.296
MOD_PK_1	756	762	PF00069	0.775
MOD_PKA_1	520	526	PF00069	0.800
MOD_PKA_1	532	538	PF00069	0.823
MOD_PKA_2	146	152	PF00069	0.452
MOD_PKA_2	327	333	PF00069	0.452
MOD_PKA_2	401	407	PF00069	0.747
MOD_PKA_2	506	512	PF00069	0.782
MOD_PKA_2	520	526	PF00069	0.623
MOD_PKA_2	531	537	PF00069	0.815
MOD_PKA_2	568	574	PF00069	0.594
MOD_PKA_2	593	599	PF00069	0.762
MOD_PKA_2	620	626	PF00069	0.714
MOD_PKA_2	800	806	PF00069	0.727
MOD_PKA_2	837	843	PF00069	0.768
MOD_PKA_2	864	870	PF00069	0.756
MOD_PKA_2	904	910	PF00069	0.708
MOD_PKA_2	914	920	PF00069	0.777
MOD_PKB_1	530	538	PF00069	0.826
MOD_Plk_1	104	110	PF00069	0.530
MOD_Plk_1	396	402	PF00069	0.705
MOD_Plk_1	550	556	PF00069	0.648
MOD_Plk_1	756	762	PF00069	0.775
MOD_Plk_1	828	834	PF00069	0.812
MOD_Plk_4	104	110	PF00069	0.530
MOD_Plk_4	181	187	PF00069	0.452
MOD_Plk_4	195	201	PF00069	0.530
MOD_Plk_4	220	226	PF00069	0.468
MOD_Plk_4	239	245	PF00069	0.278
MOD_Plk_4	302	308	PF00069	0.452
MOD_Plk_4	354	360	PF00069	0.530
MOD_Plk_4	867	873	PF00069	0.707
MOD_ProDKin_1	419	425	PF00069	0.614
MOD_ProDKin_1	446	452	PF00069	0.800
MOD_ProDKin_1	52	58	PF00069	0.696
MOD_ProDKin_1	546	552	PF00069	0.761
MOD_ProDKin_1	580	586	PF00069	0.821
MOD_ProDKin_1	613	619	PF00069	0.636
MOD_ProDKin_1	736	742	PF00069	0.853
MOD_ProDKin_1	743	749	PF00069	0.748
MOD_ProDKin_1	801	807	PF00069	0.775
MOD_ProDKin_1	838	844	PF00069	0.849
MOD_ProDKin_1	850	856	PF00069	0.652
MOD_ProDKin_1	940	946	PF00069	0.825
MOD_SUMO_for_1	210	213	PF00179	0.530
MOD_SUMO_for_1	424	427	PF00179	0.770
MOD_SUMO_rev_2	136	142	PF00179	0.530
MOD_SUMO_rev_2	203	212	PF00179	0.530
MOD_SUMO_rev_2	232	240	PF00179	0.530
MOD_SUMO_rev_2	392	396	PF00179	0.795
MOD_SUMO_rev_2	638	644	PF00179	0.697
TRG_DiLeu_BaEn_2	350	356	PF01217	0.530
TRG_DiLeu_BaEn_4	393	399	PF01217	0.732
TRG_DiLeu_BaLyEn_6	812	817	PF01217	0.712
TRG_ENDOCYTIC_2	143	146	PF00928	0.530
TRG_ENDOCYTIC_2	162	165	PF00928	0.216
TRG_ENDOCYTIC_2	170	173	PF00928	0.530
TRG_ENDOCYTIC_2	241	244	PF00928	0.491
TRG_ENDOCYTIC_2	39	42	PF00928	0.616
TRG_ENDOCYTIC_2	83	86	PF00928	0.530
TRG_ER_diArg_1	313	316	PF00400	0.530
TRG_ER_diArg_1	325	328	PF00400	0.199
TRG_ER_diArg_1	530	533	PF00400	0.820
TRG_ER_diArg_1	706	709	PF00400	0.594
TRG_ER_diArg_1	862	865	PF00400	0.757
TRG_NES_CRM1_1	102	117	PF08389	0.452
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.333
TRG_Pf-PMV_PEXEL_1	608	613	PF00026	0.740
TRG_Pf-PMV_PEXEL_1	921	926	PF00026	0.772

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6S4	Leishmania donovani	92%	100%
A4HLP3	Leishmania braziliensis	68%	100%
A4I978	Leishmania infantum	92%	100%
E9B419	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%