Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q400_LEIMA

TriTrypDb:

LmjF.33.1880 , LMJLV39_330028400 , LMJSD75_330028000

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q400

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q400

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.590
CLV_C14_Caspase3-7	175	179	PF00656	0.562
CLV_NRD_NRD_1	101	103	PF00675	0.559
CLV_NRD_NRD_1	111	113	PF00675	0.499
CLV_NRD_NRD_1	142	144	PF00675	0.357
CLV_PCSK_KEX2_1	101	103	PF00082	0.565
CLV_PCSK_KEX2_1	111	113	PF00082	0.499
CLV_PCSK_SKI1_1	101	105	PF00082	0.647
CLV_PCSK_SKI1_1	111	115	PF00082	0.504
CLV_PCSK_SKI1_1	2	6	PF00082	0.542
CLV_PCSK_SKI1_1	225	229	PF00082	0.641
CLV_PCSK_SKI1_1	285	289	PF00082	0.580
DEG_Nend_UBRbox_1	1	4	PF02207	0.480
DOC_CDC14_PxL_1	270	278	PF14671	0.592
DOC_CYCLIN_RxL_1	222	231	PF00134	0.505
DOC_PP1_RVXF_1	169	175	PF00149	0.573
DOC_PP2B_LxvP_1	28	31	PF13499	0.445
DOC_USP7_MATH_1	176	180	PF00917	0.568
DOC_USP7_MATH_1	198	202	PF00917	0.712
DOC_USP7_MATH_1	223	227	PF00917	0.479
DOC_USP7_MATH_1	263	267	PF00917	0.548
DOC_WW_Pin1_4	29	34	PF00397	0.558
LIG_14-3-3_CanoR_1	169	175	PF00244	0.620
LIG_14-3-3_CanoR_1	260	270	PF00244	0.640
LIG_14-3-3_CanoR_1	294	302	PF00244	0.538
LIG_14-3-3_CanoR_1	38	47	PF00244	0.498
LIG_14-3-3_CanoR_1	93	100	PF00244	0.538
LIG_14-3-3_CterR_2	308	311	PF00244	0.608
LIG_Actin_WH2_2	13	29	PF00022	0.484
LIG_BRCT_BRCA1_1	255	259	PF00533	0.488
LIG_CaM_IQ_9	292	307	PF13499	0.463
LIG_eIF4E_1	47	53	PF01652	0.386
LIG_FHA_1	156	162	PF00498	0.574
LIG_FHA_2	77	83	PF00498	0.585
LIG_LIR_Gen_1	154	164	PF02991	0.604
LIG_LIR_Gen_1	173	182	PF02991	0.540
LIG_LIR_LC3C_4	136	139	PF02991	0.459
LIG_LIR_Nem_3	120	126	PF02991	0.534
LIG_LIR_Nem_3	154	160	PF02991	0.542
LIG_LIR_Nem_3	16	21	PF02991	0.413
LIG_LIR_Nem_3	173	177	PF02991	0.538
LIG_LIR_Nem_3	256	262	PF02991	0.572
LIG_LIR_Nem_3	297	302	PF02991	0.543
LIG_LIR_Nem_3	45	50	PF02991	0.588
LIG_LIR_Nem_3	79	84	PF02991	0.619
LIG_PTB_Apo_2	125	132	PF02174	0.372
LIG_SH2_CRK	18	22	PF00017	0.424
LIG_SH2_STAP1	153	157	PF00017	0.526
LIG_SH2_STAT5	153	156	PF00017	0.491
LIG_SH2_STAT5	205	208	PF00017	0.625
LIG_SH2_STAT5	77	80	PF00017	0.433
LIG_SH3_3	6	12	PF00018	0.443
LIG_Sin3_3	247	254	PF02671	0.481
LIG_SUMO_SIM_par_1	249	257	PF11976	0.567
LIG_SxIP_EBH_1	199	208	PF03271	0.523
LIG_UBA3_1	250	258	PF00899	0.582
LIG_WRC_WIRS_1	259	264	PF05994	0.536
MOD_CK1_1	261	267	PF00069	0.678
MOD_CK2_1	153	159	PF00069	0.584
MOD_CK2_1	76	82	PF00069	0.581
MOD_GlcNHglycan	13	16	PF01048	0.480
MOD_GlcNHglycan	213	216	PF01048	0.680
MOD_GlcNHglycan	263	266	PF01048	0.669
MOD_GlcNHglycan	289	293	PF01048	0.418
MOD_GlcNHglycan	296	299	PF01048	0.343
MOD_GlcNHglycan	55	58	PF01048	0.608
MOD_GSK3_1	151	158	PF00069	0.586
MOD_GSK3_1	203	210	PF00069	0.660
MOD_GSK3_1	290	297	PF00069	0.546
MOD_GSK3_1	7	14	PF00069	0.559
MOD_LATS_1	36	42	PF00433	0.478
MOD_N-GLC_1	127	132	PF02516	0.366
MOD_NEK2_1	197	202	PF00069	0.655
MOD_NEK2_1	26	31	PF00069	0.620
MOD_NEK2_1	280	285	PF00069	0.566
MOD_NEK2_1	288	293	PF00069	0.347
MOD_NEK2_1	53	58	PF00069	0.604
MOD_PKA_2	170	176	PF00069	0.571
MOD_PKA_2	198	204	PF00069	0.665
MOD_PKA_2	26	32	PF00069	0.576
MOD_PKA_2	92	98	PF00069	0.504
MOD_Plk_1	127	133	PF00069	0.456
MOD_Plk_1	7	13	PF00069	0.436
MOD_Plk_2-3	76	82	PF00069	0.553
MOD_ProDKin_1	29	35	PF00069	0.560
MOD_SUMO_rev_2	136	145	PF00179	0.455
TRG_DiLeu_BaEn_1	99	104	PF01217	0.638
TRG_DiLeu_BaEn_2	108	114	PF01217	0.593
TRG_DiLeu_BaEn_4	109	115	PF01217	0.501
TRG_DiLeu_LyEn_5	99	104	PF01217	0.519
TRG_ENDOCYTIC_2	164	167	PF00928	0.612
TRG_ENDOCYTIC_2	18	21	PF00928	0.424
TRG_ENDOCYTIC_2	50	53	PF00928	0.514
TRG_ENDOCYTIC_2	81	84	PF00928	0.560
TRG_ER_diArg_1	100	102	PF00400	0.550
TRG_ER_diArg_1	111	113	PF00400	0.489
TRG_ER_diArg_1	169	172	PF00400	0.627
TRG_ER_diArg_1	25	28	PF00400	0.454
TRG_ER_diArg_1	302	305	PF00400	0.470
TRG_ER_diArg_1	307	310	PF00400	0.544
TRG_Pf-PMV_PEXEL_1	101	106	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P3M6	Trypanosomatidae	26%	100%
A0A3R7ME57	Trypanosoma rangeli	29%	100%
A0A3S7X6V8	Leishmania donovani	93%	100%
A4HLP9	Leishmania braziliensis	71%	100%
D0A6C5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AHN7	Leishmania infantum	93%	100%
E9B424	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BTW6	Trypanosoma cruzi	31%	100%