RNA recognition motif-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3Z9_LEIMA

TriTrypDb:

LmjF.33.1890 , LMJLV39_330028500 , LMJSD75_330028100

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q3Z9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3Z9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	549	555	PF00089	0.494
CLV_NRD_NRD_1	153	155	PF00675	0.628
CLV_NRD_NRD_1	189	191	PF00675	0.599
CLV_NRD_NRD_1	304	306	PF00675	0.641
CLV_NRD_NRD_1	426	428	PF00675	0.703
CLV_NRD_NRD_1	483	485	PF00675	0.612
CLV_NRD_NRD_1	551	553	PF00675	0.392
CLV_NRD_NRD_1	65	67	PF00675	0.691
CLV_PCSK_KEX2_1	153	155	PF00082	0.671
CLV_PCSK_KEX2_1	189	191	PF00082	0.631
CLV_PCSK_KEX2_1	304	306	PF00082	0.641
CLV_PCSK_KEX2_1	343	345	PF00082	0.657
CLV_PCSK_KEX2_1	426	428	PF00082	0.703
CLV_PCSK_KEX2_1	483	485	PF00082	0.612
CLV_PCSK_KEX2_1	551	553	PF00082	0.392
CLV_PCSK_KEX2_1	65	67	PF00082	0.691
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.657
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.703
CLV_PCSK_PC7_1	422	428	PF00082	0.750
CLV_PCSK_SKI1_1	128	132	PF00082	0.551
CLV_PCSK_SKI1_1	193	197	PF00082	0.567
CLV_PCSK_SKI1_1	483	487	PF00082	0.589
DEG_SPOP_SBC_1	332	336	PF00917	0.528
DEG_SPOP_SBC_1	75	79	PF00917	0.475
DEG_SPOP_SBC_1	88	92	PF00917	0.309
DOC_MAPK_gen_1	128	136	PF00069	0.345
DOC_MAPK_MEF2A_6	369	376	PF00069	0.490
DOC_MAPK_RevD_3	539	552	PF00069	0.325
DOC_PP2B_LxvP_1	85	88	PF13499	0.433
DOC_PP4_FxxP_1	358	361	PF00568	0.371
DOC_USP7_MATH_1	217	221	PF00917	0.511
DOC_USP7_MATH_1	244	248	PF00917	0.495
DOC_USP7_MATH_1	286	290	PF00917	0.459
DOC_USP7_MATH_1	328	332	PF00917	0.509
DOC_USP7_MATH_1	338	342	PF00917	0.496
DOC_USP7_MATH_1	390	394	PF00917	0.533
DOC_USP7_MATH_1	398	402	PF00917	0.474
DOC_USP7_MATH_1	4	8	PF00917	0.414
DOC_USP7_MATH_1	411	415	PF00917	0.411
DOC_USP7_MATH_1	444	448	PF00917	0.509
DOC_USP7_MATH_1	452	456	PF00917	0.558
DOC_USP7_MATH_1	502	506	PF00917	0.460
DOC_USP7_MATH_1	75	79	PF00917	0.496
DOC_USP7_MATH_1	88	92	PF00917	0.317
DOC_USP7_MATH_1	9	13	PF00917	0.418
DOC_USP7_UBL2_3	365	369	PF12436	0.413
DOC_USP7_UBL2_3	426	430	PF12436	0.505
DOC_USP7_UBL2_3	503	507	PF12436	0.418
DOC_USP7_UBL2_3	99	103	PF12436	0.443
DOC_WW_Pin1_4	112	117	PF00397	0.423
DOC_WW_Pin1_4	238	243	PF00397	0.575
DOC_WW_Pin1_4	313	318	PF00397	0.368
DOC_WW_Pin1_4	447	452	PF00397	0.534
DOC_WW_Pin1_4	473	478	PF00397	0.533
DOC_WW_Pin1_4	516	521	PF00397	0.426
DOC_WW_Pin1_4	97	102	PF00397	0.365
LIG_14-3-3_CanoR_1	189	193	PF00244	0.382
LIG_14-3-3_CanoR_1	262	271	PF00244	0.440
LIG_14-3-3_CanoR_1	28	33	PF00244	0.392
LIG_14-3-3_CanoR_1	551	556	PF00244	0.599
LIG_14-3-3_CanoR_1	65	71	PF00244	0.490
LIG_Actin_WH2_2	142	158	PF00022	0.384
LIG_Actin_WH2_2	90	107	PF00022	0.417
LIG_BRCT_BRCA1_1	132	136	PF00533	0.350
LIG_deltaCOP1_diTrp_1	179	185	PF00928	0.323
LIG_eIF4E_1	528	534	PF01652	0.470
LIG_FHA_1	265	271	PF00498	0.451
LIG_FHA_1	75	81	PF00498	0.431
LIG_FHA_1	88	94	PF00498	0.348
LIG_FHA_2	31	37	PF00498	0.387
LIG_FHA_2	368	374	PF00498	0.409
LIG_FHA_2	459	465	PF00498	0.537
LIG_Integrin_RGD_1	19	21	PF01839	0.671
LIG_LIR_Gen_1	169	176	PF02991	0.355
LIG_LIR_Gen_1	291	302	PF02991	0.405
LIG_LIR_Nem_3	133	139	PF02991	0.350
LIG_LIR_Nem_3	169	175	PF02991	0.356
LIG_LIR_Nem_3	291	297	PF02991	0.412
LIG_LIR_Nem_3	354	360	PF02991	0.376
LIG_LIR_Nem_3	495	501	PF02991	0.375
LIG_PDZ_Class_1	551	556	PF00595	0.599
LIG_Pex14_2	497	501	PF04695	0.416
LIG_SH2_NCK_1	325	329	PF00017	0.427
LIG_SH2_STAP1	528	532	PF00017	0.475
LIG_SH2_STAT3	106	109	PF00017	0.435
LIG_SH2_STAT5	106	109	PF00017	0.435
LIG_SH2_STAT5	357	360	PF00017	0.370
LIG_SH3_3	236	242	PF00018	0.529
LIG_SH3_3	373	379	PF00018	0.482
LIG_SUMO_SIM_anti_2	115	122	PF11976	0.362
LIG_SUMO_SIM_par_1	90	98	PF11976	0.394
LIG_TRAF2_1	219	222	PF00917	0.448
LIG_TYR_ITIM	355	360	PF00017	0.517
LIG_WRC_WIRS_1	29	34	PF05994	0.433
LIG_WRC_WIRS_1	498	503	PF05994	0.462
MOD_CDK_SPK_2	313	318	PF00069	0.443
MOD_CDK_SPxK_1	97	103	PF00069	0.432
MOD_CDK_SPxxK_3	473	480	PF00069	0.579
MOD_CDK_SPxxK_3	516	523	PF00069	0.528
MOD_CK1_1	115	121	PF00069	0.481
MOD_CK1_1	188	194	PF00069	0.472
MOD_CK1_1	331	337	PF00069	0.675
MOD_CK1_1	348	354	PF00069	0.436
MOD_CK1_1	388	394	PF00069	0.640
MOD_CK1_1	418	424	PF00069	0.650
MOD_CK1_1	447	453	PF00069	0.676
MOD_CK1_1	473	479	PF00069	0.505
MOD_CK1_1	78	84	PF00069	0.590
MOD_CK2_1	188	194	PF00069	0.494
MOD_CK2_1	197	203	PF00069	0.398
MOD_CK2_1	286	292	PF00069	0.499
MOD_CK2_1	30	36	PF00069	0.445
MOD_CK2_1	367	373	PF00069	0.513
MOD_CK2_1	418	424	PF00069	0.740
MOD_CK2_1	458	464	PF00069	0.658
MOD_CK2_1	516	522	PF00069	0.527
MOD_Cter_Amidation	424	427	PF01082	0.629
MOD_GlcNHglycan	11	14	PF01048	0.549
MOD_GlcNHglycan	247	250	PF01048	0.598
MOD_GlcNHglycan	329	333	PF01048	0.635
MOD_GlcNHglycan	347	350	PF01048	0.500
MOD_GlcNHglycan	387	390	PF01048	0.769
MOD_GlcNHglycan	392	396	PF01048	0.719
MOD_GlcNHglycan	431	434	PF01048	0.673
MOD_GlcNHglycan	443	447	PF01048	0.567
MOD_GlcNHglycan	454	457	PF01048	0.647
MOD_GlcNHglycan	472	475	PF01048	0.600
MOD_GlcNHglycan	504	507	PF01048	0.593
MOD_GlcNHglycan	528	531	PF01048	0.668
MOD_GlcNHglycan	534	537	PF01048	0.289
MOD_GlcNHglycan	6	9	PF01048	0.533
MOD_GlcNHglycan	85	88	PF01048	0.599
MOD_GSK3_1	115	122	PF00069	0.478
MOD_GSK3_1	197	204	PF00069	0.454
MOD_GSK3_1	217	224	PF00069	0.733
MOD_GSK3_1	328	335	PF00069	0.653
MOD_GSK3_1	338	345	PF00069	0.600
MOD_GSK3_1	364	371	PF00069	0.598
MOD_GSK3_1	407	414	PF00069	0.613
MOD_GSK3_1	442	449	PF00069	0.647
MOD_GSK3_1	454	461	PF00069	0.595
MOD_GSK3_1	466	473	PF00069	0.692
MOD_GSK3_1	70	77	PF00069	0.656
MOD_GSK3_1	79	86	PF00069	0.513
MOD_NEK2_1	185	190	PF00069	0.441
MOD_NEK2_1	273	278	PF00069	0.431
MOD_NEK2_1	30	35	PF00069	0.503
MOD_NEK2_1	364	369	PF00069	0.553
MOD_NEK2_1	497	502	PF00069	0.500
MOD_NEK2_1	80	85	PF00069	0.520
MOD_PIKK_1	197	203	PF00454	0.446
MOD_PIKK_1	264	270	PF00454	0.446
MOD_PIKK_1	348	354	PF00454	0.463
MOD_PKA_1	429	435	PF00069	0.612
MOD_PKA_1	65	71	PF00069	0.649
MOD_PKA_2	188	194	PF00069	0.455
MOD_PKA_2	398	404	PF00069	0.628
MOD_PKA_2	64	70	PF00069	0.611
MOD_PKB_1	427	435	PF00069	0.553
MOD_Plk_1	178	184	PF00069	0.388
MOD_Plk_1	292	298	PF00069	0.489
MOD_Plk_4	115	121	PF00069	0.431
MOD_Plk_4	22	28	PF00069	0.500
MOD_Plk_4	275	281	PF00069	0.385
MOD_Plk_4	80	86	PF00069	0.629
MOD_Plk_4	89	95	PF00069	0.407
MOD_ProDKin_1	112	118	PF00069	0.511
MOD_ProDKin_1	238	244	PF00069	0.733
MOD_ProDKin_1	313	319	PF00069	0.437
MOD_ProDKin_1	447	453	PF00069	0.676
MOD_ProDKin_1	473	479	PF00069	0.668
MOD_ProDKin_1	516	522	PF00069	0.527
MOD_ProDKin_1	97	103	PF00069	0.439
MOD_SUMO_rev_2	188	198	PF00179	0.453
TRG_DiLeu_BaEn_1	36	41	PF01217	0.435
TRG_DiLeu_BaLyEn_6	481	486	PF01217	0.481
TRG_ENDOCYTIC_2	357	360	PF00928	0.445
TRG_ENDOCYTIC_2	498	501	PF00928	0.452
TRG_ER_diArg_1	153	156	PF00400	0.594
TRG_ER_diArg_1	256	259	PF00400	0.507
TRG_ER_diArg_1	303	305	PF00400	0.549
TRG_ER_diArg_1	482	484	PF00400	0.501
TRG_ER_diArg_1	550	552	PF00400	0.473
TRG_ER_diArg_1	64	66	PF00400	0.558
TRG_NLS_MonoCore_2	425	430	PF00514	0.625
TRG_NLS_MonoExtC_3	425	430	PF00514	0.634
TRG_NLS_MonoExtN_4	426	433	PF00514	0.631
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I907	Leptomonas seymouri	40%	90%
A0A3S7X6X8	Leishmania donovani	90%	100%
A4HLQ0	Leishmania braziliensis	69%	89%
A4I950	Leishmania infantum	89%	100%
E9B425	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%