LisH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LisH domain-containing protein FOPNL, putative

Species:

Leishmania major

UniProt:

Q4Q3Z8_LEIMA

TriTrypDb:

LmjF.33.1895 , LMJLV39_330028600 , LMJSD75_330028200

Length:

127

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	9
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q3Z8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3Z8

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	9
GO:0006996	organelle organization	4	9
GO:0007010	cytoskeleton organization	5	9
GO:0007017	microtubule-based process	2	9
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0034453	microtubule anchoring	4	9
GO:0071840	cellular component organization or biogenesis	2	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	93	95	PF00675	0.287
CLV_PCSK_KEX2_1	93	95	PF00082	0.287
CLV_PCSK_SKI1_1	93	97	PF00082	0.210
DOC_PIKK_1	56	63	PF02985	0.262
DOC_WW_Pin1_4	83	88	PF00397	0.487
LIG_14-3-3_CanoR_1	94	102	PF00244	0.489
LIG_CtBP_PxDLS_1	55	59	PF00389	0.456
LIG_FHA_1	74	80	PF00498	0.446
LIG_FHA_2	39	45	PF00498	0.574
LIG_LIR_Gen_1	66	73	PF02991	0.414
LIG_LIR_Nem_3	66	70	PF02991	0.435
LIG_PCNA_yPIPBox_3	57	65	PF02747	0.355
LIG_SH2_CRK	113	117	PF00017	0.403
LIG_SH2_STAT5	67	70	PF00017	0.446
LIG_SH3_3	45	51	PF00018	0.535
LIG_TRAF2_1	2	5	PF00917	0.481
LIG_TYR_ITIM	111	116	PF00017	0.403
LIG_WRC_WIRS_1	67	72	PF05994	0.446
MOD_CK1_1	104	110	PF00069	0.356
MOD_CK1_1	37	43	PF00069	0.606
MOD_CK1_1	86	92	PF00069	0.512
MOD_GlcNHglycan	103	106	PF01048	0.250
MOD_GSK3_1	101	108	PF00069	0.356
MOD_GSK3_1	34	41	PF00069	0.514
MOD_N-GLC_1	17	22	PF02516	0.494
MOD_NEK2_1	73	78	PF00069	0.421
MOD_PIKK_1	86	92	PF00454	0.544
MOD_PKA_2	11	17	PF00069	0.449
MOD_PKA_2	119	125	PF00069	0.490
MOD_PKA_2	34	40	PF00069	0.549
MOD_Plk_1	73	79	PF00069	0.404
MOD_ProDKin_1	83	89	PF00069	0.487
MOD_SUMO_for_1	24	27	PF00179	0.396
TRG_DiLeu_BaLyEn_6	107	112	PF01217	0.403
TRG_ENDOCYTIC_2	113	116	PF00928	0.403
TRG_ENDOCYTIC_2	67	70	PF00928	0.438
TRG_ER_diArg_1	92	94	PF00400	0.487
TRG_Pf-PMV_PEXEL_1	94	99	PF00026	0.287

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAR5	Leptomonas seymouri	82%	100%
A0A0S4IMB6	Bodo saltans	49%	100%
A0A3S7X6W5	Leishmania donovani	95%	100%
A0A422N5Z6	Trypanosoma rangeli	55%	99%
A4HLQ1	Leishmania braziliensis	92%	100%
A4I951	Leishmania infantum	95%	100%
D0A6C3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	84%
E9B426	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4V7R8	Xenopus laevis	42%	75%
Q5ZJ24	Gallus gallus	40%	73%
Q96NB1	Homo sapiens	39%	73%
Q9CZS3	Mus musculus	38%	73%