Charged multivesicular body protein 1a

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vesicular protein trafficking mediator, putative

Species:

Leishmania major

UniProt:

Q4Q3Z7_LEIMA

TriTrypDb:

LmjF.33.1900 , LMJLV39_330028700 , LMJSD75_330028300

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0000815	ESCRT III complex	3	8
GO:0005768	endosome	7	2
GO:0005770	late endosome	8	2
GO:0005771	multivesicular body	9	2
GO:0016363	nuclear matrix	2	8
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0032991	protein-containing complex	1	8
GO:0036452	ESCRT complex	2	8
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0098796	membrane protein complex	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q3Z7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3Z7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	14
GO:0006996	organelle organization	4	8
GO:0007034	vacuolar transport	4	14
GO:0007076	mitotic chromosome condensation	4	8
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	14
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	8
GO:0016192	vesicle-mediated transport	4	8
GO:0016197	endosomal transport	4	2
GO:0022402	cell cycle process	2	8
GO:0030261	chromosome condensation	6	8
GO:0032509	endosome transport via multivesicular body sorting pathway	5	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0045324	late endosome to vacuole transport	5	2
GO:0046907	intracellular transport	3	14
GO:0051179	localization	1	14
GO:0051234	establishment of localization	2	14
GO:0051276	chromosome organization	5	8
GO:0051641	cellular localization	2	14
GO:0051649	establishment of localization in cell	3	14
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	8
GO:0071985	multivesicular body sorting pathway	5	2
GO:1903047	mitotic cell cycle process	3	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	184	186	PF00675	0.716
CLV_NRD_NRD_1	59	61	PF00675	0.305
CLV_PCSK_KEX2_1	40	42	PF00082	0.368
CLV_PCSK_KEX2_1	61	63	PF00082	0.321
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.368
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.321
CLV_PCSK_SKI1_1	104	108	PF00082	0.267
CLV_PCSK_SKI1_1	113	117	PF00082	0.396
CLV_PCSK_SKI1_1	40	44	PF00082	0.313
CLV_PCSK_SKI1_1	89	93	PF00082	0.386
DOC_MAPK_gen_1	3	12	PF00069	0.387
DOC_USP7_MATH_1	138	142	PF00917	0.342
DOC_USP7_MATH_1	175	179	PF00917	0.643
DOC_USP7_MATH_1	25	29	PF00917	0.328
DOC_USP7_UBL2_3	100	104	PF12436	0.362
DOC_USP7_UBL2_3	15	19	PF12436	0.347
DOC_USP7_UBL2_3	36	40	PF12436	0.322
DOC_USP7_UBL2_3	89	93	PF12436	0.453
LIG_14-3-3_CanoR_1	81	90	PF00244	0.375
LIG_FAT_LD_1	152	160	PF03623	0.267
LIG_FHA_1	144	150	PF00498	0.309
LIG_FHA_2	105	111	PF00498	0.375
LIG_FHA_2	135	141	PF00498	0.389
LIG_LIR_Gen_1	5	16	PF02991	0.436
LIG_LIR_Nem_3	5	11	PF02991	0.437
LIG_Pex14_2	12	16	PF04695	0.351
LIG_PTB_Apo_2	10	17	PF02174	0.461
LIG_SH2_CRK	8	12	PF00017	0.370
LIG_SH2_STAP1	54	58	PF00017	0.321
LIG_SH2_STAP1	8	12	PF00017	0.492
LIG_SH2_STAT5	68	71	PF00017	0.321
LIG_TYR_ITIM	66	71	PF00017	0.355
LIG_UBA3_1	10	19	PF00899	0.325
MOD_CK1_1	143	149	PF00069	0.323
MOD_CK2_1	134	140	PF00069	0.404
MOD_CK2_1	151	157	PF00069	0.351
MOD_GlcNHglycan	125	128	PF01048	0.383
MOD_GlcNHglycan	142	145	PF01048	0.329
MOD_GlcNHglycan	166	170	PF01048	0.289
MOD_GlcNHglycan	23	26	PF01048	0.297
MOD_GSK3_1	134	141	PF00069	0.327
MOD_GSK3_1	15	22	PF00069	0.325
MOD_GSK3_1	77	84	PF00069	0.322
MOD_GSK3_1	89	96	PF00069	0.273
MOD_NEK2_1	139	144	PF00069	0.330
MOD_NEK2_1	176	181	PF00069	0.753
MOD_NEK2_1	21	26	PF00069	0.357
MOD_NEK2_1	95	100	PF00069	0.286
MOD_Plk_4	151	157	PF00069	0.321
TRG_ENDOCYTIC_2	68	71	PF00928	0.321
TRG_ENDOCYTIC_2	8	11	PF00928	0.485
TRG_ER_diArg_1	59	62	PF00400	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2G2	Leptomonas seymouri	49%	100%
A0A0N1IMC7	Leptomonas seymouri	78%	100%
A0A0S4IQI9	Bodo saltans	56%	96%
A0A0S4JPB9	Bodo saltans	46%	100%
A0A1X0P5A2	Trypanosomatidae	45%	99%
A0A3Q8IGX6	Leishmania donovani	96%	100%
A0A3R7NNK8	Trypanosoma rangeli	44%	99%
A0A3S7X9V9	Leishmania donovani	44%	99%
A0A422N603	Trypanosoma rangeli	62%	97%
A4HLQ2	Leishmania braziliensis	84%	100%
A4HNA9	Leishmania braziliensis	46%	100%
A4I952	Leishmania infantum	95%	100%
A4IBY0	Leishmania infantum	44%	99%
C9ZYM6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	99%
D0A6C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	82%
E9AFR7	Leishmania major	44%	100%
E9B427	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B6X0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	99%
O60074	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	100%
O96552	Dictyostelium discoideum	41%	100%
P69771	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	100%
Q3SX42	Bos taurus	27%	96%
Q54DB1	Dictyostelium discoideum	26%	100%
Q5E994	Bos taurus	40%	100%
Q5F3A2	Gallus gallus	26%	95%
Q5R605	Pongo abelii	46%	100%
Q5RAV2	Pongo abelii	26%	96%
Q5ZKX1	Gallus gallus	39%	100%
Q66IV6	Xenopus laevis	25%	95%
Q6DF27	Xenopus tropicalis	41%	100%
Q6NUD8	Xenopus laevis	45%	100%
Q6NVL7	Xenopus tropicalis	24%	95%
Q6NXD2	Danio rerio	25%	95%
Q6PHF0	Danio rerio	45%	100%
Q7LBR1	Homo sapiens	41%	100%
Q7SYR0	Xenopus laevis	23%	95%
Q7SZB5	Xenopus laevis	41%	100%
Q7ZVB1	Danio rerio	41%	100%
Q84VG1	Oryza sativa subsp. japonica	39%	100%
Q8BJF9	Mus musculus	27%	96%
Q8LE58	Arabidopsis thaliana	42%	100%
Q921W0	Mus musculus	46%	100%
Q941D5	Arabidopsis thaliana	28%	97%
Q99LU0	Mus musculus	41%	100%
Q9CQD4	Mus musculus	41%	100%
Q9HD42	Homo sapiens	46%	100%
Q9SKI2	Arabidopsis thaliana	28%	91%
Q9SSM4	Arabidopsis thaliana	41%	100%
Q9UQN3	Homo sapiens	26%	96%