CAF1C_H4-bd domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosome assembly protein RRB1, putative

Species:

Leishmania major

UniProt:

Q4Q3Z6_LEIMA

TriTrypDb:

LmjF.33.1910 , LMJLV39_330028800 , LMJSD75_330028400

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q3Z6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3Z6

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0022613	ribonucleoprotein complex biogenesis	4	2
GO:0042254	ribosome biogenesis	5	2
GO:0044085	cellular component biogenesis	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.532
CLV_C14_Caspase3-7	220	224	PF00656	0.602
CLV_C14_Caspase3-7	246	250	PF00656	0.652
CLV_C14_Caspase3-7	57	61	PF00656	0.733
CLV_C14_Caspase3-7	65	69	PF00656	0.674
CLV_C14_Caspase3-7	8	12	PF00656	0.770
CLV_NRD_NRD_1	28	30	PF00675	0.548
CLV_NRD_NRD_1	34	36	PF00675	0.559
CLV_NRD_NRD_1	467	469	PF00675	0.435
CLV_PCSK_KEX2_1	2	4	PF00082	0.647
CLV_PCSK_KEX2_1	34	36	PF00082	0.588
CLV_PCSK_KEX2_1	43	45	PF00082	0.561
CLV_PCSK_KEX2_1	467	469	PF00082	0.532
CLV_PCSK_KEX2_1	6	8	PF00082	0.614
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.644
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.596
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.626
CLV_PCSK_SKI1_1	257	261	PF00082	0.476
CLV_PCSK_SKI1_1	3	7	PF00082	0.645
CLV_PCSK_SKI1_1	468	472	PF00082	0.530
CLV_PCSK_SKI1_1	477	481	PF00082	0.460
CLV_PCSK_SKI1_1	483	487	PF00082	0.379
DEG_APCC_DBOX_1	199	207	PF00400	0.537
DEG_APCC_DBOX_1	505	513	PF00400	0.471
DEG_Nend_UBRbox_1	1	4	PF02207	0.652
DEG_SPOP_SBC_1	382	386	PF00917	0.446
DOC_CKS1_1	335	340	PF01111	0.440
DOC_CKS1_1	469	474	PF01111	0.565
DOC_MAPK_gen_1	328	335	PF00069	0.485
DOC_MAPK_gen_1	421	430	PF00069	0.522
DOC_MAPK_gen_1	444	453	PF00069	0.405
DOC_MAPK_gen_1	482	490	PF00069	0.456
DOC_MAPK_MEF2A_6	162	170	PF00069	0.454
DOC_MAPK_MEF2A_6	200	208	PF00069	0.532
DOC_PP1_RVXF_1	425	431	PF00149	0.417
DOC_PP1_RVXF_1	99	106	PF00149	0.569
DOC_PP4_FxxP_1	335	338	PF00568	0.422
DOC_USP7_MATH_1	123	127	PF00917	0.720
DOC_USP7_MATH_1	277	281	PF00917	0.563
DOC_USP7_MATH_1	338	342	PF00917	0.455
DOC_USP7_MATH_1	382	386	PF00917	0.405
DOC_USP7_MATH_1	432	436	PF00917	0.532
DOC_USP7_MATH_1	484	488	PF00917	0.476
DOC_USP7_MATH_1	5	9	PF00917	0.732
DOC_USP7_UBL2_3	2	6	PF12436	0.673
DOC_WW_Pin1_4	334	339	PF00397	0.433
DOC_WW_Pin1_4	349	354	PF00397	0.332
DOC_WW_Pin1_4	396	401	PF00397	0.382
DOC_WW_Pin1_4	468	473	PF00397	0.491
LIG_14-3-3_CanoR_1	446	453	PF00244	0.422
LIG_14-3-3_CanoR_1	506	510	PF00244	0.451
LIG_APCC_ABBA_1	490	495	PF00400	0.400
LIG_BRCT_BRCA1_1	101	105	PF00533	0.686
LIG_BRCT_BRCA1_1	486	490	PF00533	0.356
LIG_CaM_NSCaTE_8	128	135	PF13499	0.704
LIG_eIF4E_1	568	574	PF01652	0.363
LIG_FHA_1	185	191	PF00498	0.540
LIG_FHA_1	95	101	PF00498	0.610
LIG_FHA_2	191	197	PF00498	0.540
LIG_FHA_2	212	218	PF00498	0.470
LIG_FHA_2	399	405	PF00498	0.416
LIG_FHA_2	452	458	PF00498	0.357
LIG_FHA_2	484	490	PF00498	0.355
LIG_FHA_2	506	512	PF00498	0.376
LIG_FHA_2	564	570	PF00498	0.484
LIG_Integrin_RGD_1	129	131	PF01839	0.663
LIG_LIR_Gen_1	169	175	PF02991	0.458
LIG_LIR_Gen_1	82	93	PF02991	0.555
LIG_LIR_Nem_3	156	161	PF02991	0.454
LIG_LIR_Nem_3	163	168	PF02991	0.454
LIG_LIR_Nem_3	169	173	PF02991	0.454
LIG_LIR_Nem_3	350	354	PF02991	0.385
LIG_LIR_Nem_3	565	571	PF02991	0.364
LIG_LIR_Nem_3	82	88	PF02991	0.532
LIG_LYPXL_yS_3	165	168	PF13949	0.454
LIG_PCNA_PIPBox_1	522	531	PF02747	0.602
LIG_PCNA_yPIPBox_3	494	506	PF02747	0.469
LIG_PCNA_yPIPBox_3	516	529	PF02747	0.587
LIG_PTB_Apo_2	149	156	PF02174	0.454
LIG_PTB_Phospho_1	149	155	PF10480	0.454
LIG_REV1ctd_RIR_1	156	165	PF16727	0.454
LIG_SH2_NCK_1	216	220	PF00017	0.667
LIG_SH2_STAP1	155	159	PF00017	0.469
LIG_SH2_STAT3	536	539	PF00017	0.536
LIG_SH2_STAT5	207	210	PF00017	0.475
LIG_SH2_STAT5	228	231	PF00017	0.624
LIG_SH3_3	367	373	PF00018	0.361
LIG_SUMO_SIM_anti_2	202	207	PF11976	0.520
LIG_SUMO_SIM_anti_2	495	504	PF11976	0.444
LIG_SUMO_SIM_par_1	144	149	PF11976	0.462
LIG_SUMO_SIM_par_1	280	288	PF11976	0.391
LIG_SUMO_SIM_par_1	413	420	PF11976	0.347
LIG_SUMO_SIM_par_1	495	504	PF11976	0.375
LIG_TRAF2_1	392	395	PF00917	0.373
LIG_UBA3_1	573	580	PF00899	0.486
MOD_CK1_1	308	314	PF00069	0.626
MOD_CK1_1	341	347	PF00069	0.435
MOD_CK1_1	496	502	PF00069	0.393
MOD_CK1_1	99	105	PF00069	0.646
MOD_CK2_1	101	107	PF00069	0.708
MOD_CK2_1	389	395	PF00069	0.397
MOD_CK2_1	451	457	PF00069	0.475
MOD_CK2_1	483	489	PF00069	0.365
MOD_CK2_1	563	569	PF00069	0.484
MOD_GlcNHglycan	277	280	PF01048	0.556
MOD_GlcNHglycan	321	324	PF01048	0.616
MOD_GlcNHglycan	360	363	PF01048	0.327
MOD_GlcNHglycan	457	460	PF01048	0.372
MOD_GlcNHglycan	529	532	PF01048	0.606
MOD_GSK3_1	144	151	PF00069	0.612
MOD_GSK3_1	15	22	PF00069	0.748
MOD_GSK3_1	217	224	PF00069	0.573
MOD_GSK3_1	334	341	PF00069	0.440
MOD_GSK3_1	354	361	PF00069	0.179
MOD_GSK3_1	451	458	PF00069	0.359
MOD_LATS_1	481	487	PF00433	0.463
MOD_N-GLC_1	178	183	PF02516	0.266
MOD_N-GLC_1	221	226	PF02516	0.713
MOD_N-GLC_1	308	313	PF02516	0.590
MOD_N-GLC_1	493	498	PF02516	0.392
MOD_N-GLC_2	210	212	PF02516	0.254
MOD_NEK2_1	148	153	PF00069	0.454
MOD_NEK2_1	206	211	PF00069	0.466
MOD_NEK2_1	451	456	PF00069	0.351
MOD_NEK2_2	364	369	PF00069	0.503
MOD_PIKK_1	190	196	PF00454	0.454
MOD_PIKK_1	277	283	PF00454	0.543
MOD_PIKK_1	398	404	PF00454	0.427
MOD_PIKK_1	554	560	PF00454	0.404
MOD_PKA_1	6	12	PF00069	0.718
MOD_PKA_2	505	511	PF00069	0.455
MOD_PKA_2	6	12	PF00069	0.720
MOD_PKB_1	444	452	PF00069	0.451
MOD_Plk_1	493	499	PF00069	0.406
MOD_Plk_1	50	56	PF00069	0.689
MOD_Plk_1	510	516	PF00069	0.290
MOD_Plk_2-3	144	150	PF00069	0.488
MOD_Plk_2-3	217	223	PF00069	0.570
MOD_Plk_2-3	232	238	PF00069	0.628
MOD_Plk_2-3	50	56	PF00069	0.647
MOD_Plk_4	123	129	PF00069	0.582
MOD_Plk_4	184	190	PF00069	0.457
MOD_Plk_4	354	360	PF00069	0.475
MOD_Plk_4	364	370	PF00069	0.375
MOD_Plk_4	493	499	PF00069	0.374
MOD_Plk_4	505	511	PF00069	0.347
MOD_Plk_4	578	584	PF00069	0.510
MOD_ProDKin_1	334	340	PF00069	0.440
MOD_ProDKin_1	349	355	PF00069	0.335
MOD_ProDKin_1	396	402	PF00069	0.389
MOD_ProDKin_1	468	474	PF00069	0.484
TRG_DiLeu_BaEn_1	300	305	PF01217	0.310
TRG_ENDOCYTIC_2	155	158	PF00928	0.454
TRG_ENDOCYTIC_2	165	168	PF00928	0.454
TRG_ENDOCYTIC_2	568	571	PF00928	0.381
TRG_ENDOCYTIC_2	85	88	PF00928	0.514
TRG_ER_diArg_1	34	37	PF00400	0.620
TRG_ER_diArg_1	466	468	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	302	306	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P833	Leptomonas seymouri	82%	100%
A0A0N0P8W9	Leptomonas seymouri	23%	87%
A0A0S4IIU6	Bodo saltans	62%	97%
A0A1X0P3N3	Trypanosomatidae	63%	100%
A0A3S7X390	Leishmania donovani	22%	90%
A0A3S7X6T4	Leishmania donovani	97%	100%
A0A422N600	Trypanosoma rangeli	61%	100%
A4HLQ3	Leishmania braziliensis	89%	100%
A4I5C6	Leishmania infantum	22%	90%
A4I953	Leishmania infantum	97%	100%
D0A6C1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9B0M4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	90%
E9B428	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O22466	Solanum lycopersicum	23%	100%
O22467	Arabidopsis thaliana	22%	100%
O22468	Arabidopsis thaliana	23%	100%
O22469	Arabidopsis thaliana	23%	100%
P0CS36	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	23%	100%
P0CS37	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	23%	100%
P90916	Caenorhabditis elegans	24%	100%
Q04225	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
Q10G81	Oryza sativa subsp. japonica	23%	100%
Q1JQD2	Bos taurus	31%	100%
Q2UA71	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	24%	100%
Q4P553	Ustilago maydis (strain 521 / FGSC 9021)	26%	100%
Q4WEI5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	100%
Q54ED4	Dictyostelium discoideum	32%	100%
Q54SD4	Dictyostelium discoideum	24%	100%
Q5XI13	Rattus norvegicus	31%	100%
Q61Y48	Caenorhabditis briggsae	23%	100%
Q6CSI1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	23%	100%
Q7S7N3	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	21%	100%
Q810D6	Mus musculus	32%	100%
Q9BQ67	Homo sapiens	33%	100%
Q9I8G9	Gallus gallus	24%	100%
Q9P783	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q9ZUN8	Arabidopsis thaliana	34%	100%
V5BPB2	Trypanosoma cruzi	56%	94%