Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphate transport (Pho88), putative

Species:

Leishmania major

UniProt:

Q4Q3Z5_LEIMA

TriTrypDb:

LmjF.33.1920 , LMJLV39_330028900 , LMJSD75_330028500

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	11
GO:0016020	membrane	2	10
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q3Z5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3Z5

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	11
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0033365	protein localization to organelle	5	11
GO:0045047	protein targeting to ER	6	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0070972	protein localization to endoplasmic reticulum	6	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0072594	establishment of protein localization to organelle	4	11
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	185	187	PF00675	0.693
CLV_NRD_NRD_1	25	27	PF00675	0.422
CLV_PCSK_KEX2_1	131	133	PF00082	0.548
CLV_PCSK_KEX2_1	187	189	PF00082	0.731
CLV_PCSK_KEX2_1	25	27	PF00082	0.546
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.497
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.731
CLV_PCSK_PC7_1	127	133	PF00082	0.497
CLV_PCSK_SKI1_1	25	29	PF00082	0.546
DEG_Nend_UBRbox_3	1	3	PF02207	0.306
DOC_ANK_TNKS_1	131	138	PF00023	0.297
DOC_MAPK_gen_1	25	32	PF00069	0.222
DOC_MAPK_MEF2A_6	25	34	PF00069	0.222
DOC_PP1_RVXF_1	23	30	PF00149	0.393
DOC_USP7_MATH_1	174	178	PF00917	0.514
DOC_USP7_UBL2_3	162	166	PF12436	0.482
DOC_USP7_UBL2_3	183	187	PF12436	0.579
LIG_Actin_WH2_2	88	104	PF00022	0.387
LIG_BRCT_BRCA1_1	122	126	PF00533	0.366
LIG_BRCT_BRCA1_1	95	99	PF00533	0.352
LIG_deltaCOP1_diTrp_1	151	157	PF00928	0.295
LIG_FHA_1	144	150	PF00498	0.350
LIG_FHA_1	6	12	PF00498	0.365
LIG_FHA_2	146	152	PF00498	0.373
LIG_FHA_2	17	23	PF00498	0.306
LIG_LIR_Nem_3	123	129	PF02991	0.302
LIG_LIR_Nem_3	96	101	PF02991	0.403
LIG_MLH1_MIPbox_1	95	99	PF16413	0.352
LIG_NRP_CendR_1	186	189	PF00754	0.779
LIG_PTB_Apo_2	85	92	PF02174	0.387
LIG_REV1ctd_RIR_1	96	106	PF16727	0.438
LIG_SH2_SRC	76	79	PF00017	0.522
LIG_SH2_STAP1	122	126	PF00017	0.247
LIG_SH2_STAT5	106	109	PF00017	0.373
LIG_SH2_STAT5	44	47	PF00017	0.374
LIG_SH3_3	57	63	PF00018	0.550
LIG_SUMO_SIM_anti_2	8	13	PF11976	0.357
LIG_SUMO_SIM_par_1	107	113	PF11976	0.366
LIG_SUMO_SIM_par_1	7	13	PF11976	0.333
LIG_TYR_ITIM	120	125	PF00017	0.247
LIG_UBA3_1	110	118	PF00899	0.366
LIG_UBA3_1	125	131	PF00899	0.366
LIG_WRC_WIRS_1	95	100	PF05994	0.387
MOD_CK1_1	15	21	PF00069	0.298
MOD_CK1_1	175	181	PF00069	0.492
MOD_CK1_1	182	188	PF00069	0.541
MOD_CK2_1	145	151	PF00069	0.373
MOD_CK2_1	62	68	PF00069	0.566
MOD_GlcNHglycan	170	173	PF01048	0.658
MOD_GlcNHglycan	91	94	PF01048	0.445
MOD_GSK3_1	12	19	PF00069	0.291
MOD_GSK3_1	157	164	PF00069	0.333
MOD_GSK3_1	168	175	PF00069	0.441
MOD_GSK3_1	62	69	PF00069	0.570
MOD_GSK3_1	89	96	PF00069	0.372
MOD_N-GLC_1	157	162	PF02516	0.572
MOD_NEK2_1	10	15	PF00069	0.362
MOD_NEK2_1	110	115	PF00069	0.337
MOD_NEK2_1	167	172	PF00069	0.488
MOD_NEK2_1	84	89	PF00069	0.516
MOD_NEK2_2	94	99	PF00069	0.352
MOD_PIKK_1	172	178	PF00454	0.430
MOD_Plk_1	53	59	PF00069	0.537
MOD_Plk_2-3	145	151	PF00069	0.353
MOD_Plk_2-3	62	68	PF00069	0.559
MOD_Plk_4	5	11	PF00069	0.349
MOD_Plk_4	53	59	PF00069	0.570
MOD_Plk_4	94	100	PF00069	0.455
MOD_SUMO_for_1	130	133	PF00179	0.347
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.313
TRG_ENDOCYTIC_2	106	109	PF00928	0.386
TRG_ENDOCYTIC_2	122	125	PF00928	0.247
TRG_ENDOCYTIC_2	44	47	PF00928	0.406
TRG_ER_diArg_1	186	189	PF00400	0.563
TRG_ER_diArg_1	25	27	PF00400	0.222

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP6	Leptomonas seymouri	63%	100%
A0A0S4IMC9	Bodo saltans	35%	94%
A0A3S7X6X6	Leishmania donovani	93%	100%
A0A422N623	Trypanosoma rangeli	36%	100%
A4HJX0	Leishmania braziliensis	69%	99%
A4HLQ4	Leishmania braziliensis	70%	100%
A4I954	Leishmania infantum	92%	100%
D0A6C0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B429	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%