Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3Z3_LEIMA

TriTrypDb:

LmjF.33.1940 , LMJLV39_330029200 , LMJSD75_330028800

Length:

650

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

Q4Q3Z3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3Z3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.744
CLV_C14_Caspase3-7	196	200	PF00656	0.691
CLV_C14_Caspase3-7	453	457	PF00656	0.481
CLV_C14_Caspase3-7	90	94	PF00656	0.617
CLV_NRD_NRD_1	30	32	PF00675	0.417
CLV_NRD_NRD_1	338	340	PF00675	0.491
CLV_NRD_NRD_1	422	424	PF00675	0.468
CLV_NRD_NRD_1	625	627	PF00675	0.517
CLV_PCSK_FUR_1	374	378	PF00082	0.402
CLV_PCSK_KEX2_1	230	232	PF00082	0.385
CLV_PCSK_KEX2_1	30	32	PF00082	0.417
CLV_PCSK_KEX2_1	338	340	PF00082	0.407
CLV_PCSK_KEX2_1	376	378	PF00082	0.319
CLV_PCSK_KEX2_1	422	424	PF00082	0.582
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.282
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.376
CLV_PCSK_SKI1_1	168	172	PF00082	0.414
CLV_PCSK_SKI1_1	31	35	PF00082	0.499
CLV_PCSK_SKI1_1	377	381	PF00082	0.371
DEG_MDM2_SWIB_1	311	319	PF02201	0.270
DEG_SCF_TRCP1_1	638	643	PF00400	0.598
DOC_MAPK_FxFP_2	399	402	PF00069	0.270
DOC_MAPK_gen_1	371	380	PF00069	0.531
DOC_MAPK_gen_1	422	430	PF00069	0.285
DOC_MAPK_HePTP_8	534	546	PF00069	0.309
DOC_MAPK_MEF2A_6	422	430	PF00069	0.285
DOC_MAPK_MEF2A_6	510	518	PF00069	0.246
DOC_MAPK_MEF2A_6	537	546	PF00069	0.618
DOC_MAPK_RevD_3	361	377	PF00069	0.525
DOC_PP1_RVXF_1	541	547	PF00149	0.445
DOC_PP1_RVXF_1	572	579	PF00149	0.443
DOC_PP1_RVXF_1	617	623	PF00149	0.672
DOC_PP2B_LxvP_1	345	348	PF13499	0.573
DOC_PP4_FxxP_1	214	217	PF00568	0.541
DOC_PP4_FxxP_1	399	402	PF00568	0.327
DOC_PP4_FxxP_1	56	59	PF00568	0.640
DOC_USP7_MATH_1	142	146	PF00917	0.536
DOC_USP7_MATH_1	248	252	PF00917	0.520
DOC_USP7_MATH_1	47	51	PF00917	0.801
DOC_USP7_MATH_1	645	649	PF00917	0.753
DOC_USP7_MATH_1	81	85	PF00917	0.689
DOC_WW_Pin1_4	12	17	PF00397	0.640
DOC_WW_Pin1_4	127	132	PF00397	0.519
DOC_WW_Pin1_4	346	351	PF00397	0.500
LIG_14-3-3_CanoR_1	125	131	PF00244	0.492
LIG_14-3-3_CanoR_1	220	229	PF00244	0.617
LIG_14-3-3_CanoR_1	299	304	PF00244	0.396
LIG_14-3-3_CanoR_1	474	482	PF00244	0.480
LIG_14-3-3_CanoR_1	503	511	PF00244	0.304
LIG_14-3-3_CanoR_1	543	553	PF00244	0.511
LIG_14-3-3_CanoR_1	630	637	PF00244	0.542
LIG_Actin_WH2_2	214	232	PF00022	0.577
LIG_Actin_WH2_2	521	539	PF00022	0.204
LIG_BIR_II_1	1	5	PF00653	0.695
LIG_BIR_III_2	46	50	PF00653	0.642
LIG_BRCT_BRCA1_1	1	5	PF00533	0.563
LIG_Clathr_ClatBox_1	62	66	PF01394	0.628
LIG_CORNRBOX	390	398	PF00104	0.237
LIG_CtBP_PxDLS_1	59	63	PF00389	0.637
LIG_deltaCOP1_diTrp_1	420	425	PF00928	0.309
LIG_EH1_1	164	172	PF00400	0.487
LIG_EH1_1	511	519	PF00400	0.165
LIG_eIF4E_1	303	309	PF01652	0.270
LIG_eIF4E_1	592	598	PF01652	0.435
LIG_FHA_1	222	228	PF00498	0.612
LIG_FHA_1	305	311	PF00498	0.295
LIG_FHA_1	513	519	PF00498	0.274
LIG_FHA_1	539	545	PF00498	0.555
LIG_FHA_1	6	12	PF00498	0.765
LIG_FHA_1	644	650	PF00498	0.553
LIG_FHA_1	67	73	PF00498	0.699
LIG_FHA_2	173	179	PF00498	0.510
LIG_FHA_2	188	194	PF00498	0.472
LIG_FHA_2	331	337	PF00498	0.602
LIG_FHA_2	88	94	PF00498	0.732
LIG_GBD_Chelix_1	478	486	PF00786	0.270
LIG_HP1_1	426	430	PF01393	0.212
LIG_LIR_Apic_2	211	217	PF02991	0.540
LIG_LIR_Apic_2	53	59	PF02991	0.799
LIG_LIR_Gen_1	224	234	PF02991	0.544
LIG_LIR_Gen_1	235	241	PF02991	0.460
LIG_LIR_Gen_1	249	257	PF02991	0.526
LIG_LIR_Gen_1	277	288	PF02991	0.417
LIG_LIR_Gen_1	341	352	PF02991	0.625
LIG_LIR_Gen_1	362	372	PF02991	0.552
LIG_LIR_Gen_1	492	502	PF02991	0.331
LIG_LIR_Gen_1	545	554	PF02991	0.448
LIG_LIR_LC3C_4	342	347	PF02991	0.439
LIG_LIR_LC3C_4	61	64	PF02991	0.634
LIG_LIR_Nem_3	132	138	PF02991	0.561
LIG_LIR_Nem_3	224	229	PF02991	0.533
LIG_LIR_Nem_3	232	237	PF02991	0.514
LIG_LIR_Nem_3	249	255	PF02991	0.560
LIG_LIR_Nem_3	277	283	PF02991	0.351
LIG_LIR_Nem_3	302	306	PF02991	0.277
LIG_LIR_Nem_3	341	347	PF02991	0.630
LIG_LIR_Nem_3	349	354	PF02991	0.597
LIG_LIR_Nem_3	362	367	PF02991	0.479
LIG_LIR_Nem_3	420	424	PF02991	0.325
LIG_LIR_Nem_3	492	498	PF02991	0.393
LIG_LIR_Nem_3	508	514	PF02991	0.297
LIG_LIR_Nem_3	545	549	PF02991	0.370
LIG_LIR_Nem_3	572	576	PF02991	0.345
LIG_LIR_Nem_3	581	587	PF02991	0.242
LIG_LIR_Nem_3	588	592	PF02991	0.252
LIG_PCNA_PIPBox_1	188	197	PF02747	0.520
LIG_PCNA_yPIPBox_3	185	195	PF02747	0.569
LIG_PCNA_yPIPBox_3	198	210	PF02747	0.552
LIG_Pex14_1	589	593	PF04695	0.414
LIG_Pex14_1	606	610	PF04695	0.522
LIG_Pex14_2	214	218	PF04695	0.540
LIG_Pex14_2	311	315	PF04695	0.459
LIG_Pex14_2	443	447	PF04695	0.414
LIG_Pex14_2	578	582	PF04695	0.411
LIG_PTB_Apo_2	264	271	PF02174	0.435
LIG_Rb_pABgroove_1	235	243	PF01858	0.466
LIG_REV1ctd_RIR_1	211	216	PF16727	0.463
LIG_SH2_CRK	306	310	PF00017	0.327
LIG_SH2_GRB2like	409	412	PF00017	0.375
LIG_SH2_GRB2like	511	514	PF00017	0.272
LIG_SH2_PTP2	226	229	PF00017	0.498
LIG_SH2_PTP2	236	239	PF00017	0.575
LIG_SH2_PTP2	351	354	PF00017	0.625
LIG_SH2_PTP2	427	430	PF00017	0.455
LIG_SH2_STAP1	306	310	PF00017	0.302
LIG_SH2_STAP1	369	373	PF00017	0.607
LIG_SH2_STAP1	445	449	PF00017	0.431
LIG_SH2_STAT3	241	244	PF00017	0.490
LIG_SH2_STAT5	116	119	PF00017	0.679
LIG_SH2_STAT5	165	168	PF00017	0.484
LIG_SH2_STAT5	209	212	PF00017	0.493
LIG_SH2_STAT5	226	229	PF00017	0.499
LIG_SH2_STAT5	236	239	PF00017	0.563
LIG_SH2_STAT5	306	309	PF00017	0.317
LIG_SH2_STAT5	344	347	PF00017	0.498
LIG_SH2_STAT5	351	354	PF00017	0.594
LIG_SH2_STAT5	409	412	PF00017	0.290
LIG_SH2_STAT5	427	430	PF00017	0.431
LIG_SH2_STAT5	484	487	PF00017	0.344
LIG_SH2_STAT5	526	529	PF00017	0.439
LIG_SH2_STAT5	577	580	PF00017	0.351
LIG_SH2_STAT5	586	589	PF00017	0.260
LIG_SH2_STAT5	592	595	PF00017	0.217
LIG_SH3_3	128	134	PF00018	0.504
LIG_SH3_3	13	19	PF00018	0.652
LIG_SH3_3	30	36	PF00018	0.727
LIG_SH3_3	344	350	PF00018	0.535
LIG_SH3_3	353	359	PF00018	0.522
LIG_SH3_3	61	67	PF00018	0.632
LIG_SUMO_SIM_anti_2	515	520	PF11976	0.425
LIG_SUMO_SIM_anti_2	61	66	PF11976	0.631
LIG_SUMO_SIM_par_1	116	122	PF11976	0.637
LIG_SUMO_SIM_par_1	514	520	PF11976	0.388
LIG_SUMO_SIM_par_1	532	538	PF11976	0.299
LIG_SUMO_SIM_par_1	556	563	PF11976	0.394
LIG_SUMO_SIM_par_1	61	66	PF11976	0.631
LIG_UBA3_1	532	537	PF00899	0.358
LIG_UBA3_1	620	627	PF00899	0.583
LIG_WRC_WIRS_1	210	215	PF05994	0.462
MOD_CDK_SPK_2	12	17	PF00069	0.669
MOD_CK1_1	129	135	PF00069	0.535
MOD_CK1_1	23	29	PF00069	0.681
MOD_CK1_1	251	257	PF00069	0.586
MOD_CK1_1	388	394	PF00069	0.270
MOD_CK1_1	505	511	PF00069	0.354
MOD_CK1_1	52	58	PF00069	0.790
MOD_CK1_1	520	526	PF00069	0.280
MOD_CK2_1	127	133	PF00069	0.560
MOD_CK2_1	172	178	PF00069	0.504
MOD_CK2_1	187	193	PF00069	0.425
MOD_CK2_1	229	235	PF00069	0.459
MOD_CK2_1	330	336	PF00069	0.481
MOD_CK2_1	47	53	PF00069	0.732
MOD_CK2_1	485	491	PF00069	0.439
MOD_CK2_1	636	642	PF00069	0.747
MOD_GlcNHglycan	101	104	PF01048	0.581
MOD_GlcNHglycan	121	124	PF01048	0.370
MOD_GlcNHglycan	172	175	PF01048	0.326
MOD_GlcNHglycan	2	5	PF01048	0.542
MOD_GlcNHglycan	231	234	PF01048	0.322
MOD_GlcNHglycan	390	393	PF01048	0.237
MOD_GlcNHglycan	49	52	PF01048	0.489
MOD_GlcNHglycan	519	522	PF01048	0.307
MOD_GlcNHglycan	631	634	PF01048	0.369
MOD_GlcNHglycan	638	641	PF01048	0.568
MOD_GSK3_1	172	179	PF00069	0.630
MOD_GSK3_1	18	25	PF00069	0.695
MOD_GSK3_1	194	201	PF00069	0.616
MOD_GSK3_1	274	281	PF00069	0.410
MOD_GSK3_1	485	492	PF00069	0.451
MOD_GSK3_1	498	505	PF00069	0.450
MOD_GSK3_1	538	545	PF00069	0.563
MOD_GSK3_1	636	643	PF00069	0.598
MOD_GSK3_1	87	94	PF00069	0.745
MOD_GSK3_1	97	104	PF00069	0.645
MOD_N-GLC_1	257	262	PF02516	0.392
MOD_N-GLC_1	37	42	PF02516	0.536
MOD_N-GLC_1	512	517	PF02516	0.564
MOD_N-GLC_1	74	79	PF02516	0.477
MOD_N-GLC_1	91	96	PF02516	0.442
MOD_N-GLC_2	12	14	PF02516	0.379
MOD_NEK2_1	22	27	PF00069	0.743
MOD_NEK2_1	221	226	PF00069	0.560
MOD_NEK2_1	229	234	PF00069	0.524
MOD_NEK2_1	504	509	PF00069	0.342
MOD_NEK2_1	578	583	PF00069	0.381
MOD_NEK2_1	631	636	PF00069	0.701
MOD_NEK2_1	91	96	PF00069	0.642
MOD_NEK2_2	209	214	PF00069	0.492
MOD_NEK2_2	248	253	PF00069	0.453
MOD_NEK2_2	591	596	PF00069	0.447
MOD_PIKK_1	221	227	PF00454	0.589
MOD_PIKK_1	330	336	PF00454	0.481
MOD_PIKK_1	403	409	PF00454	0.489
MOD_PIKK_1	433	439	PF00454	0.464
MOD_PKA_1	626	632	PF00069	0.599
MOD_PKA_2	219	225	PF00069	0.614
MOD_PKA_2	388	394	PF00069	0.424
MOD_PKA_2	466	472	PF00069	0.648
MOD_PKA_2	473	479	PF00069	0.560
MOD_PKA_2	502	508	PF00069	0.441
MOD_PKA_2	542	548	PF00069	0.518
MOD_PKA_2	578	584	PF00069	0.295
MOD_PKA_2	629	635	PF00069	0.538
MOD_Plk_1	248	254	PF00069	0.587
MOD_Plk_1	330	336	PF00069	0.572
MOD_Plk_1	37	43	PF00069	0.793
MOD_Plk_1	413	419	PF00069	0.437
MOD_Plk_1	512	518	PF00069	0.337
MOD_Plk_1	537	543	PF00069	0.596
MOD_Plk_1	640	646	PF00069	0.598
MOD_Plk_1	91	97	PF00069	0.741
MOD_Plk_2-3	172	178	PF00069	0.660
MOD_Plk_4	209	215	PF00069	0.478
MOD_Plk_4	251	257	PF00069	0.559
MOD_Plk_4	274	280	PF00069	0.270
MOD_Plk_4	304	310	PF00069	0.386
MOD_Plk_4	485	491	PF00069	0.346
MOD_Plk_4	578	584	PF00069	0.354
MOD_Plk_4	91	97	PF00069	0.777
MOD_ProDKin_1	12	18	PF00069	0.638
MOD_ProDKin_1	127	133	PF00069	0.523
MOD_ProDKin_1	346	352	PF00069	0.500
MOD_SUMO_rev_2	336	345	PF00179	0.582
TRG_DiLeu_BaEn_1	235	240	PF01217	0.459
TRG_DiLeu_BaEn_2	490	496	PF01217	0.414
TRG_DiLeu_BaLyEn_6	165	170	PF01217	0.451
TRG_DiLeu_BaLyEn_6	616	621	PF01217	0.566
TRG_ENDOCYTIC_2	207	210	PF00928	0.478
TRG_ENDOCYTIC_2	226	229	PF00928	0.541
TRG_ENDOCYTIC_2	236	239	PF00928	0.527
TRG_ENDOCYTIC_2	306	309	PF00928	0.338
TRG_ENDOCYTIC_2	344	347	PF00928	0.562
TRG_ENDOCYTIC_2	351	354	PF00928	0.572
TRG_ENDOCYTIC_2	427	430	PF00928	0.371
TRG_ENDOCYTIC_2	445	448	PF00928	0.313
TRG_ENDOCYTIC_2	511	514	PF00928	0.364
TRG_ENDOCYTIC_2	592	595	PF00928	0.280
TRG_ER_diArg_1	326	329	PF00400	0.596
TRG_ER_diArg_1	337	339	PF00400	0.663
TRG_ER_diArg_1	421	423	PF00400	0.342
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.309
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.285

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IIV3	Bodo saltans	25%	85%
A0A0S4IZJ9	Bodo saltans	27%	68%
A0A1X0NUP0	Trypanosomatidae	21%	100%
A0A1X0P3P0	Trypanosomatidae	33%	95%
A0A3Q8IDV0	Leishmania donovani	91%	100%
A0A3R7R847	Trypanosoma rangeli	32%	98%
A0A3S7X5M8	Leishmania donovani	22%	100%
A0A422MY34	Trypanosoma rangeli	23%	100%
A4HKK2	Leishmania braziliensis	22%	100%
A4HLQ6	Leishmania braziliensis	76%	100%
A4I834	Leishmania infantum	22%	100%
A4I956	Leishmania infantum	92%	100%
D0A6B6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	98%
E9B2Z2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4Q564	Leishmania major	23%	100%
V5B8R5	Trypanosoma cruzi	33%	98%
V5BBK9	Trypanosoma cruzi	23%	100%