Ribonuclease P

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Ribonuclease P

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3Z2_LEIMA

TriTrypDb:

LmjF.33.1950 , LMJLV39_330029300 , LMJSD75_330028900

Length:

694

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q3Z2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3Z2

Function

Biological processes
Term	Name	Level	Count
GO:0000966	RNA 5'-end processing	7	2
GO:0001682	tRNA 5'-leader removal	9	2
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006396	RNA processing	6	9
GO:0006399	tRNA metabolic process	7	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008033	tRNA processing	8	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016070	RNA metabolic process	5	9
GO:0034470	ncRNA processing	7	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0034660	ncRNA metabolic process	6	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0046483	heterocycle metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:0099116	tRNA 5'-end processing	8	2
GO:1901360	organic cyclic compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004518	nuclease activity	4	9
GO:0004519	endonuclease activity	5	8
GO:0004521	RNA endonuclease activity	5	8
GO:0004526	ribonuclease P activity	6	8
GO:0004540	RNA nuclease activity	4	8
GO:0004549	tRNA-specific ribonuclease activity	5	8
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	8
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	8
GO:0140098	catalytic activity, acting on RNA	3	8
GO:0140101	catalytic activity, acting on a tRNA	4	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.760
CLV_C14_Caspase3-7	410	414	PF00656	0.450
CLV_NRD_NRD_1	153	155	PF00675	0.315
CLV_NRD_NRD_1	2	4	PF00675	0.423
CLV_NRD_NRD_1	326	328	PF00675	0.420
CLV_NRD_NRD_1	87	89	PF00675	0.340
CLV_PCSK_FUR_1	324	328	PF00082	0.500
CLV_PCSK_KEX2_1	153	155	PF00082	0.289
CLV_PCSK_KEX2_1	2	4	PF00082	0.433
CLV_PCSK_KEX2_1	326	328	PF00082	0.414
CLV_PCSK_KEX2_1	336	338	PF00082	0.327
CLV_PCSK_KEX2_1	87	89	PF00082	0.359
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.479
CLV_PCSK_PC7_1	149	155	PF00082	0.239
CLV_PCSK_SKI1_1	154	158	PF00082	0.305
CLV_PCSK_SKI1_1	21	25	PF00082	0.485
CLV_PCSK_SKI1_1	212	216	PF00082	0.406
CLV_PCSK_SKI1_1	312	316	PF00082	0.403
CLV_PCSK_SKI1_1	326	330	PF00082	0.419
CLV_PCSK_SKI1_1	440	444	PF00082	0.300
CLV_PCSK_SKI1_1	519	523	PF00082	0.380
CLV_PCSK_SKI1_1	529	533	PF00082	0.257
CLV_PCSK_SKI1_1	55	59	PF00082	0.494
DEG_APCC_DBOX_1	425	433	PF00400	0.335
DEG_Nend_UBRbox_1	1	4	PF02207	0.491
DEG_SCF_TRCP1_1	39	45	PF00400	0.506
DOC_CDC14_PxL_1	247	255	PF14671	0.536
DOC_CKS1_1	572	577	PF01111	0.733
DOC_MAPK_gen_1	149	157	PF00069	0.314
DOC_MAPK_gen_1	231	239	PF00069	0.514
DOC_MAPK_gen_1	324	332	PF00069	0.475
DOC_MAPK_gen_1	523	532	PF00069	0.284
DOC_MAPK_MEF2A_6	212	221	PF00069	0.443
DOC_MAPK_MEF2A_6	233	241	PF00069	0.501
DOC_MAPK_MEF2A_6	401	409	PF00069	0.391
DOC_PP1_RVXF_1	151	158	PF00149	0.399
DOC_PP1_RVXF_1	527	533	PF00149	0.300
DOC_PP2B_LxvP_1	317	320	PF13499	0.471
DOC_PP2B_LxvP_1	547	550	PF13499	0.358
DOC_USP7_MATH_1	204	208	PF00917	0.406
DOC_USP7_MATH_1	260	264	PF00917	0.515
DOC_USP7_MATH_1	272	276	PF00917	0.698
DOC_USP7_MATH_1	305	309	PF00917	0.548
DOC_USP7_MATH_1	322	326	PF00917	0.316
DOC_USP7_MATH_1	491	495	PF00917	0.342
DOC_USP7_MATH_1	590	594	PF00917	0.763
DOC_USP7_MATH_1	597	601	PF00917	0.548
DOC_USP7_MATH_1	604	608	PF00917	0.469
DOC_USP7_MATH_1	612	616	PF00917	0.571
DOC_USP7_MATH_1	628	632	PF00917	0.459
DOC_WW_Pin1_4	254	259	PF00397	0.723
DOC_WW_Pin1_4	268	273	PF00397	0.641
DOC_WW_Pin1_4	424	429	PF00397	0.335
DOC_WW_Pin1_4	459	464	PF00397	0.303
DOC_WW_Pin1_4	483	488	PF00397	0.332
DOC_WW_Pin1_4	493	498	PF00397	0.280
DOC_WW_Pin1_4	514	519	PF00397	0.280
DOC_WW_Pin1_4	571	576	PF00397	0.757
DOC_WW_Pin1_4	586	591	PF00397	0.630
LIG_14-3-3_CanoR_1	135	140	PF00244	0.282
LIG_14-3-3_CanoR_1	2	8	PF00244	0.480
LIG_14-3-3_CanoR_1	384	392	PF00244	0.505
LIG_14-3-3_CanoR_1	55	63	PF00244	0.408
LIG_14-3-3_CanoR_1	87	94	PF00244	0.415
LIG_Actin_WH2_2	121	139	PF00022	0.280
LIG_APCC_ABBA_1	349	354	PF00400	0.429
LIG_APCC_ABBA_1	686	691	PF00400	0.481
LIG_APCC_ABBAyCdc20_2	348	354	PF00400	0.423
LIG_APCC_ABBAyCdc20_2	540	546	PF00400	0.349
LIG_BIR_III_2	484	488	PF00653	0.314
LIG_Clathr_ClatBox_1	329	333	PF01394	0.452
LIG_FHA_1	120	126	PF00498	0.455
LIG_FHA_1	445	451	PF00498	0.415
LIG_FHA_1	593	599	PF00498	0.604
LIG_FHA_1	89	95	PF00498	0.351
LIG_FHA_1	99	105	PF00498	0.442
LIG_FHA_2	169	175	PF00498	0.399
LIG_FHA_2	384	390	PF00498	0.526
LIG_FHA_2	664	670	PF00498	0.748
LIG_FHA_2	685	691	PF00498	0.506
LIG_HP1_1	217	221	PF01393	0.335
LIG_HP1_1	428	432	PF01393	0.358
LIG_LIR_Apic_2	542	548	PF02991	0.406
LIG_LIR_Apic_2	599	604	PF02991	0.444
LIG_LIR_Gen_1	172	183	PF02991	0.287
LIG_LIR_Gen_1	216	226	PF02991	0.488
LIG_LIR_Nem_3	140	145	PF02991	0.298
LIG_LIR_Nem_3	172	178	PF02991	0.336
LIG_LIR_Nem_3	191	196	PF02991	0.263
LIG_LIR_Nem_3	333	338	PF02991	0.346
LIG_LIR_Nem_3	364	369	PF02991	0.445
LIG_LIR_Nem_3	510	516	PF02991	0.281
LIG_Pex14_1	601	605	PF04695	0.471
LIG_SH2_CRK	460	464	PF00017	0.280
LIG_SH2_CRK	474	478	PF00017	0.128
LIG_SH2_SRC	338	341	PF00017	0.449
LIG_SH2_STAP1	160	164	PF00017	0.280
LIG_SH2_STAP1	551	555	PF00017	0.280
LIG_SH2_STAT3	127	130	PF00017	0.399
LIG_SH2_STAT5	127	130	PF00017	0.410
LIG_SH2_STAT5	145	148	PF00017	0.449
LIG_SH2_STAT5	175	178	PF00017	0.280
LIG_SH2_STAT5	338	341	PF00017	0.449
LIG_SH2_STAT5	460	463	PF00017	0.280
LIG_SH3_3	182	188	PF00018	0.358
LIG_SH3_3	211	217	PF00018	0.300
LIG_SH3_3	252	258	PF00018	0.719
LIG_SUMO_SIM_anti_2	78	85	PF11976	0.406
LIG_SUMO_SIM_par_1	427	434	PF11976	0.273
LIG_TYR_ITIM	358	363	PF00017	0.321
LIG_UBA3_1	310	315	PF00899	0.432
LIG_WRC_WIRS_1	139	144	PF05994	0.288
MOD_CDC14_SPxK_1	496	499	PF00782	0.450
MOD_CDK_SPK_2	514	519	PF00069	0.280
MOD_CDK_SPxK_1	493	499	PF00069	0.450
MOD_CK1_1	138	144	PF00069	0.463
MOD_CK1_1	254	260	PF00069	0.677
MOD_CK1_1	383	389	PF00069	0.520
MOD_CK1_1	399	405	PF00069	0.301
MOD_CK1_1	40	46	PF00069	0.742
MOD_CK1_1	444	450	PF00069	0.271
MOD_CK1_1	489	495	PF00069	0.443
MOD_CK1_1	56	62	PF00069	0.147
MOD_CK1_1	562	568	PF00069	0.712
MOD_CK1_1	78	84	PF00069	0.453
MOD_CK1_1	92	98	PF00069	0.286
MOD_CK2_1	562	568	PF00069	0.615
MOD_CK2_1	628	634	PF00069	0.714
MOD_CK2_1	663	669	PF00069	0.758
MOD_CK2_1	684	690	PF00069	0.488
MOD_GlcNHglycan	260	263	PF01048	0.736
MOD_GlcNHglycan	264	267	PF01048	0.727
MOD_GlcNHglycan	274	277	PF01048	0.705
MOD_GlcNHglycan	281	284	PF01048	0.669
MOD_GlcNHglycan	296	300	PF01048	0.472
MOD_GlcNHglycan	39	42	PF01048	0.753
MOD_GlcNHglycan	398	401	PF01048	0.549
MOD_GlcNHglycan	47	50	PF01048	0.700
MOD_GlcNHglycan	493	496	PF01048	0.335
MOD_GlcNHglycan	561	564	PF01048	0.609
MOD_GlcNHglycan	592	595	PF01048	0.674
MOD_GlcNHglycan	606	609	PF01048	0.573
MOD_GlcNHglycan	610	613	PF01048	0.585
MOD_GlcNHglycan	614	617	PF01048	0.683
MOD_GlcNHglycan	630	633	PF01048	0.475
MOD_GlcNHglycan	645	648	PF01048	0.605
MOD_GlcNHglycan	651	654	PF01048	0.709
MOD_GlcNHglycan	77	80	PF01048	0.359
MOD_GlcNHglycan	91	94	PF01048	0.322
MOD_GSK3_1	25	32	PF00069	0.662
MOD_GSK3_1	254	261	PF00069	0.702
MOD_GSK3_1	268	275	PF00069	0.764
MOD_GSK3_1	395	402	PF00069	0.389
MOD_GSK3_1	440	447	PF00069	0.343
MOD_GSK3_1	485	492	PF00069	0.307
MOD_GSK3_1	493	500	PF00069	0.301
MOD_GSK3_1	53	60	PF00069	0.582
MOD_GSK3_1	586	593	PF00069	0.615
MOD_GSK3_1	604	611	PF00069	0.480
MOD_GSK3_1	88	95	PF00069	0.398
MOD_N-GLC_1	618	623	PF02516	0.555
MOD_NEK2_1	441	446	PF00069	0.392
MOD_NEK2_1	532	537	PF00069	0.302
MOD_NEK2_2	188	193	PF00069	0.280
MOD_PIKK_1	441	447	PF00454	0.271
MOD_PK_1	135	141	PF00069	0.279
MOD_PKA_1	87	93	PF00069	0.398
MOD_PKA_2	383	389	PF00069	0.581
MOD_PKA_2	532	538	PF00069	0.370
MOD_PKA_2	87	93	PF00069	0.411
MOD_PKB_1	135	143	PF00069	0.300
MOD_Plk_1	618	624	PF00069	0.737
MOD_Plk_4	103	109	PF00069	0.314
MOD_Plk_4	138	144	PF00069	0.249
MOD_Plk_4	188	194	PF00069	0.390
MOD_Plk_4	3	9	PF00069	0.473
MOD_Plk_4	362	368	PF00069	0.333
MOD_Plk_4	78	84	PF00069	0.417
MOD_ProDKin_1	254	260	PF00069	0.725
MOD_ProDKin_1	268	274	PF00069	0.641
MOD_ProDKin_1	424	430	PF00069	0.335
MOD_ProDKin_1	459	465	PF00069	0.303
MOD_ProDKin_1	483	489	PF00069	0.332
MOD_ProDKin_1	493	499	PF00069	0.280
MOD_ProDKin_1	514	520	PF00069	0.280
MOD_ProDKin_1	571	577	PF00069	0.757
MOD_ProDKin_1	586	592	PF00069	0.629
MOD_SUMO_rev_2	308	317	PF00179	0.373
MOD_SUMO_rev_2	434	442	PF00179	0.325
MOD_SUMO_rev_2	617	627	PF00179	0.714
TRG_DiLeu_BaEn_1	129	134	PF01217	0.406
TRG_DiLeu_BaEn_1	313	318	PF01217	0.469
TRG_DiLeu_BaLyEn_6	511	516	PF01217	0.358
TRG_ENDOCYTIC_2	175	178	PF00928	0.280
TRG_ENDOCYTIC_2	360	363	PF00928	0.336
TRG_ENDOCYTIC_2	474	477	PF00928	0.296
TRG_ER_diArg_1	1	3	PF00400	0.470
TRG_ER_diArg_1	134	137	PF00400	0.299
TRG_ER_diArg_1	153	155	PF00400	0.176
TRG_ER_diArg_1	324	327	PF00400	0.446
TRG_ER_diArg_1	527	530	PF00400	0.295
TRG_ER_diArg_1	86	88	PF00400	0.389
TRG_NES_CRM1_1	468	481	PF08389	0.406
TRG_Pf-PMV_PEXEL_1	312	316	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	553	557	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	567	572	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM55	Leptomonas seymouri	54%	92%
A0A1X0P3X4	Trypanosomatidae	46%	100%
A0A3Q8IHV9	Leishmania donovani	92%	100%
A0A422MWI6	Trypanosoma rangeli	47%	100%
A4HLQ7	Leishmania braziliensis	80%	98%
A4I957	Leishmania infantum	92%	100%
D0A6B5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B432	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
F4JKB6	Arabidopsis thaliana	22%	100%
Q680B9	Arabidopsis thaliana	21%	100%
V5BPA7	Trypanosoma cruzi	47%	100%