Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3Z1_LEIMA

TriTrypDb:

LmjF.33.1960 , LMJLV39_330029500 , LMJSD75_330029100

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3Z1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.607
CLV_C14_Caspase3-7	123	127	PF00656	0.729
CLV_C14_Caspase3-7	300	304	PF00656	0.694
CLV_C14_Caspase3-7	416	420	PF00656	0.618
CLV_C14_Caspase3-7	433	437	PF00656	0.643
CLV_C14_Caspase3-7	511	515	PF00656	0.531
CLV_C14_Caspase3-7	94	98	PF00656	0.737
CLV_NRD_NRD_1	111	113	PF00675	0.619
CLV_NRD_NRD_1	417	419	PF00675	0.582
CLV_PCSK_KEX2_1	111	113	PF00082	0.624
CLV_PCSK_KEX2_1	417	419	PF00082	0.582
CLV_PCSK_SKI1_1	130	134	PF00082	0.716
CLV_PCSK_SKI1_1	459	463	PF00082	0.665
DEG_Nend_Nbox_1	1	3	PF02207	0.694
DEG_SPOP_SBC_1	366	370	PF00917	0.786
DEG_SPOP_SBC_1	431	435	PF00917	0.681
DOC_CKS1_1	349	354	PF01111	0.849
DOC_CYCLIN_yCln2_LP_2	379	385	PF00134	0.584
DOC_MAPK_DCC_7	130	138	PF00069	0.703
DOC_MAPK_DCC_7	323	331	PF00069	0.666
DOC_MAPK_DCC_7	358	366	PF00069	0.646
DOC_MAPK_FxFP_2	138	141	PF00069	0.811
DOC_MAPK_MEF2A_6	130	138	PF00069	0.703
DOC_MAPK_MEF2A_6	323	331	PF00069	0.666
DOC_MAPK_MEF2A_6	373	380	PF00069	0.667
DOC_PP1_RVXF_1	71	77	PF00149	0.617
DOC_PP2B_LxvP_1	154	157	PF13499	0.580
DOC_PP2B_LxvP_1	523	526	PF13499	0.735
DOC_PP4_FxxP_1	138	141	PF00568	0.811
DOC_USP7_MATH_1	110	114	PF00917	0.743
DOC_USP7_MATH_1	124	128	PF00917	0.561
DOC_USP7_MATH_1	150	154	PF00917	0.771
DOC_USP7_MATH_1	21	25	PF00917	0.720
DOC_USP7_MATH_1	235	239	PF00917	0.790
DOC_USP7_MATH_1	252	256	PF00917	0.530
DOC_USP7_MATH_1	292	296	PF00917	0.805
DOC_USP7_MATH_1	301	305	PF00917	0.764
DOC_USP7_MATH_1	319	323	PF00917	0.571
DOC_USP7_MATH_1	330	334	PF00917	0.702
DOC_USP7_MATH_1	335	339	PF00917	0.667
DOC_USP7_MATH_1	431	435	PF00917	0.681
DOC_USP7_MATH_1	480	484	PF00917	0.577
DOC_USP7_MATH_1	526	530	PF00917	0.775
DOC_USP7_MATH_2	231	237	PF00917	0.831
DOC_WW_Pin1_4	171	176	PF00397	0.749
DOC_WW_Pin1_4	283	288	PF00397	0.740
DOC_WW_Pin1_4	348	353	PF00397	0.814
DOC_WW_Pin1_4	367	372	PF00397	0.535
DOC_WW_Pin1_4	427	432	PF00397	0.664
DOC_WW_Pin1_4	489	494	PF00397	0.718
LIG_14-3-3_CanoR_1	111	117	PF00244	0.609
LIG_14-3-3_CanoR_1	267	271	PF00244	0.762
LIG_14-3-3_CanoR_1	336	340	PF00244	0.773
LIG_14-3-3_CanoR_1	459	465	PF00244	0.722
LIG_BIR_III_2	314	318	PF00653	0.796
LIG_BIR_III_4	97	101	PF00653	0.785
LIG_BRCT_BRCA1_1	79	83	PF00533	0.698
LIG_eIF4E_1	489	495	PF01652	0.719
LIG_FHA_1	267	273	PF00498	0.841
LIG_FHA_1	286	292	PF00498	0.573
LIG_FHA_1	448	454	PF00498	0.558
LIG_FHA_1	466	472	PF00498	0.470
LIG_FHA_1	490	496	PF00498	0.682
LIG_FHA_2	411	417	PF00498	0.799
LIG_HP1_1	330	334	PF01393	0.626
LIG_Integrin_RGD_1	101	103	PF01839	0.741
LIG_LIR_Apic_2	170	176	PF02991	0.708
LIG_LIR_Gen_1	77	83	PF02991	0.699
LIG_LIR_Nem_3	77	81	PF02991	0.590
LIG_MLH1_MIPbox_1	79	83	PF16413	0.698
LIG_NRBOX	504	510	PF00104	0.722
LIG_Pex14_2	15	19	PF04695	0.607
LIG_Pex14_2	78	82	PF04695	0.696
LIG_Rb_LxCxE_1	408	427	PF01857	0.705
LIG_SH2_CRK	173	177	PF00017	0.861
LIG_SH2_NCK_1	173	177	PF00017	0.861
LIG_SH2_SRC	91	94	PF00017	0.749
LIG_SH2_STAT5	116	119	PF00017	0.792
LIG_SH3_3	177	183	PF00018	0.808
LIG_SH3_3	199	205	PF00018	0.835
LIG_SH3_3	324	330	PF00018	0.788
LIG_SH3_3	346	352	PF00018	0.855
LIG_SH3_3	354	360	PF00018	0.724
LIG_SH3_3	368	374	PF00018	0.587
LIG_SH3_3	492	498	PF00018	0.715
LIG_SUMO_SIM_par_1	362	370	PF11976	0.628
LIG_SUMO_SIM_par_1	500	506	PF11976	0.695
LIG_TRAF2_1	261	264	PF00917	0.752
LIG_TRAF2_1	6	9	PF00917	0.731
LIG_WRC_WIRS_1	481	486	PF05994	0.488
LIG_WRC_WIRS_1	78	83	PF05994	0.698
LIG_WW_3	325	329	PF00397	0.785
MOD_CDK_SPK_2	353	358	PF00069	0.790
MOD_CDK_SPxK_1	283	289	PF00069	0.624
MOD_CDK_SPxK_1	367	373	PF00069	0.749
MOD_CK1_1	214	220	PF00069	0.678
MOD_CK1_1	265	271	PF00069	0.862
MOD_CK1_1	273	279	PF00069	0.729
MOD_CK1_1	31	37	PF00069	0.763
MOD_CK1_1	367	373	PF00069	0.784
MOD_CK1_1	427	433	PF00069	0.619
MOD_CK1_1	457	463	PF00069	0.688
MOD_CK1_1	535	541	PF00069	0.590
MOD_CK2_1	258	264	PF00069	0.706
MOD_CK2_1	273	279	PF00069	0.707
MOD_CK2_1	292	298	PF00069	0.542
MOD_CK2_1	302	308	PF00069	0.602
MOD_CK2_1	410	416	PF00069	0.803
MOD_GlcNHglycan	103	108	PF01048	0.569
MOD_GlcNHglycan	120	123	PF01048	0.697
MOD_GlcNHglycan	164	167	PF01048	0.818
MOD_GlcNHglycan	19	22	PF01048	0.726
MOD_GlcNHglycan	237	240	PF01048	0.770
MOD_GlcNHglycan	30	33	PF01048	0.572
MOD_GlcNHglycan	426	429	PF01048	0.667
MOD_GlcNHglycan	455	459	PF01048	0.729
MOD_GlcNHglycan	534	537	PF01048	0.809
MOD_GlcNHglycan	55	58	PF01048	0.614
MOD_GlcNHglycan	87	90	PF01048	0.733
MOD_GlcNHglycan	92	96	PF01048	0.707
MOD_GSK3_1	17	24	PF00069	0.723
MOD_GSK3_1	207	214	PF00069	0.682
MOD_GSK3_1	258	265	PF00069	0.824
MOD_GSK3_1	266	273	PF00069	0.759
MOD_GSK3_1	27	34	PF00069	0.621
MOD_GSK3_1	330	337	PF00069	0.806
MOD_GSK3_1	362	369	PF00069	0.856
MOD_GSK3_1	386	393	PF00069	0.618
MOD_GSK3_1	427	434	PF00069	0.628
MOD_GSK3_1	447	454	PF00069	0.513
MOD_N-GLC_1	36	41	PF02516	0.772
MOD_N-GLC_1	63	68	PF02516	0.712
MOD_N-GLC_2	294	296	PF02516	0.799
MOD_NEK2_1	17	22	PF00069	0.616
MOD_NEK2_1	27	32	PF00069	0.627
MOD_NEK2_1	364	369	PF00069	0.629
MOD_NEK2_1	422	427	PF00069	0.681
MOD_PIKK_1	262	268	PF00454	0.856
MOD_PK_1	302	308	PF00069	0.610
MOD_PKA_2	110	116	PF00069	0.741
MOD_PKA_2	118	124	PF00069	0.652
MOD_PKA_2	186	192	PF00069	0.630
MOD_PKA_2	266	272	PF00069	0.829
MOD_PKA_2	273	279	PF00069	0.782
MOD_PKA_2	301	307	PF00069	0.630
MOD_PKA_2	335	341	PF00069	0.775
MOD_PKA_2	451	457	PF00069	0.726
MOD_PKA_2	526	532	PF00069	0.658
MOD_Plk_1	222	228	PF00069	0.611
MOD_Plk_1	242	248	PF00069	0.645
MOD_Plk_1	302	308	PF00069	0.788
MOD_Plk_1	385	391	PF00069	0.780
MOD_Plk_4	150	156	PF00069	0.812
MOD_Plk_4	207	213	PF00069	0.842
MOD_Plk_4	222	228	PF00069	0.590
MOD_Plk_4	77	83	PF00069	0.699
MOD_ProDKin_1	171	177	PF00069	0.752
MOD_ProDKin_1	283	289	PF00069	0.741
MOD_ProDKin_1	348	354	PF00069	0.812
MOD_ProDKin_1	367	373	PF00069	0.533
MOD_ProDKin_1	427	433	PF00069	0.658
MOD_ProDKin_1	489	495	PF00069	0.719
MOD_SUMO_rev_2	511	519	PF00179	0.667
TRG_DiLeu_BaEn_1	375	380	PF01217	0.772
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.607
TRG_ENDOCYTIC_2	2	5	PF00928	0.752

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6Z0	Leishmania donovani	86%	100%
A4HLQ8	Leishmania braziliensis	64%	100%
A4I958	Leishmania infantum	86%	100%
E9B434	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%