RNA editing complex protein MP46

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA editing complex protein MP46

Species:

Leishmania major

UniProt:

Q4Q3Z0_LEIMA

TriTrypDb:

LmjF.33.1970 , LMJLV39_330029600 , LMJSD75_330029200

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q3Z0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3Z0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	148	150	PF00675	0.565
CLV_NRD_NRD_1	347	349	PF00675	0.686
CLV_NRD_NRD_1	365	367	PF00675	0.573
CLV_NRD_NRD_1	469	471	PF00675	0.648
CLV_NRD_NRD_1	76	78	PF00675	0.507
CLV_NRD_NRD_1	82	84	PF00675	0.425
CLV_PCSK_KEX2_1	148	150	PF00082	0.527
CLV_PCSK_KEX2_1	346	348	PF00082	0.688
CLV_PCSK_KEX2_1	365	367	PF00082	0.650
CLV_PCSK_KEX2_1	471	473	PF00082	0.641
CLV_PCSK_KEX2_1	81	83	PF00082	0.443
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.688
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.716
CLV_PCSK_PC7_1	361	367	PF00082	0.568
CLV_PCSK_PC7_1	77	83	PF00082	0.539
CLV_PCSK_SKI1_1	149	153	PF00082	0.491
CLV_PCSK_SKI1_1	96	100	PF00082	0.483
DEG_SCF_FBW7_1	20	27	PF00400	0.565
DEG_SPOP_SBC_1	251	255	PF00917	0.789
DOC_CKS1_1	108	113	PF01111	0.515
DOC_CKS1_1	483	488	PF01111	0.707
DOC_CYCLIN_yClb1_LxF_4	476	481	PF00134	0.716
DOC_CYCLIN_yClb5_NLxxxL_5	315	322	PF00134	0.510
DOC_MAPK_DCC_7	100	108	PF00069	0.462
DOC_MAPK_MEF2A_6	100	108	PF00069	0.462
DOC_MAPK_RevD_3	64	78	PF00069	0.562
DOC_PP4_FxxP_1	108	111	PF00568	0.509
DOC_PP4_FxxP_1	47	50	PF00568	0.500
DOC_SPAK_OSR1_1	45	49	PF12202	0.595
DOC_USP7_MATH_1	219	223	PF00917	0.773
DOC_USP7_MATH_1	24	28	PF00917	0.527
DOC_USP7_MATH_1	251	255	PF00917	0.741
DOC_USP7_MATH_1	385	389	PF00917	0.753
DOC_USP7_MATH_1	436	440	PF00917	0.691
DOC_USP7_MATH_1	50	54	PF00917	0.660
DOC_WW_Pin1_4	107	112	PF00397	0.647
DOC_WW_Pin1_4	20	25	PF00397	0.557
DOC_WW_Pin1_4	242	247	PF00397	0.798
DOC_WW_Pin1_4	259	264	PF00397	0.672
DOC_WW_Pin1_4	388	393	PF00397	0.670
DOC_WW_Pin1_4	437	442	PF00397	0.769
DOC_WW_Pin1_4	445	450	PF00397	0.665
DOC_WW_Pin1_4	482	487	PF00397	0.782
LIG_14-3-3_CanoR_1	265	269	PF00244	0.572
LIG_14-3-3_CanoR_1	292	297	PF00244	0.544
LIG_14-3-3_CanoR_1	347	356	PF00244	0.712
LIG_14-3-3_CanoR_1	361	368	PF00244	0.715
LIG_14-3-3_CanoR_1	393	400	PF00244	0.678
LIG_14-3-3_CanoR_1	443	449	PF00244	0.731
LIG_Actin_WH2_2	53	71	PF00022	0.579
LIG_Actin_WH2_2	84	102	PF00022	0.464
LIG_deltaCOP1_diTrp_1	474	481	PF00928	0.738
LIG_EVH1_1	260	264	PF00568	0.492
LIG_FHA_1	126	132	PF00498	0.611
LIG_FHA_1	381	387	PF00498	0.739
LIG_FHA_1	424	430	PF00498	0.767
LIG_FHA_1	464	470	PF00498	0.626
LIG_FHA_1	483	489	PF00498	0.800
LIG_FHA_2	1	7	PF00498	0.564
LIG_FHA_2	161	167	PF00498	0.513
LIG_FHA_2	371	377	PF00498	0.648
LIG_FHA_2	445	451	PF00498	0.769
LIG_LIR_Apic_2	105	111	PF02991	0.604
LIG_LIR_Gen_1	474	483	PF02991	0.750
LIG_LIR_Nem_3	410	415	PF02991	0.654
LIG_LIR_Nem_3	459	465	PF02991	0.581
LIG_LIR_Nem_3	474	479	PF02991	0.685
LIG_NRBOX	188	194	PF00104	0.555
LIG_NRP_CendR_1	492	495	PF00754	0.802
LIG_PTAP_UEV_1	386	391	PF05743	0.549
LIG_SH2_STAT5	173	176	PF00017	0.493
LIG_SH2_STAT5	25	28	PF00017	0.581
LIG_SH2_STAT5	275	278	PF00017	0.494
LIG_SH2_STAT5	380	383	PF00017	0.650
LIG_SH2_STAT5	412	415	PF00017	0.633
LIG_SH3_3	101	107	PF00018	0.548
LIG_SH3_3	258	264	PF00018	0.637
LIG_SH3_3	384	390	PF00018	0.763
LIG_SH3_3	477	483	PF00018	0.703
LIG_SUMO_SIM_anti_2	185	191	PF11976	0.559
LIG_SUMO_SIM_anti_2	450	459	PF11976	0.699
LIG_WW_3	262	266	PF00397	0.499
MOD_CDC14_SPxK_1	262	265	PF00782	0.595
MOD_CDC14_SPxK_1	440	443	PF00782	0.569
MOD_CDK_SPK_2	388	393	PF00069	0.719
MOD_CDK_SPxK_1	107	113	PF00069	0.623
MOD_CDK_SPxK_1	259	265	PF00069	0.612
MOD_CDK_SPxK_1	437	443	PF00069	0.630
MOD_CDK_SPxxK_3	482	489	PF00069	0.786
MOD_CK1_1	102	108	PF00069	0.523
MOD_CK1_1	12	18	PF00069	0.609
MOD_CK1_1	125	131	PF00069	0.586
MOD_CK1_1	169	175	PF00069	0.473
MOD_CK1_1	239	245	PF00069	0.741
MOD_CK1_1	259	265	PF00069	0.632
MOD_CK1_1	295	301	PF00069	0.521
MOD_CK1_1	372	378	PF00069	0.685
MOD_CK1_1	388	394	PF00069	0.646
MOD_CK1_1	396	402	PF00069	0.637
MOD_CK1_1	437	443	PF00069	0.766
MOD_CK2_1	160	166	PF00069	0.522
MOD_CK2_1	185	191	PF00069	0.505
MOD_CK2_1	194	200	PF00069	0.541
MOD_CK2_1	24	30	PF00069	0.592
MOD_CK2_1	370	376	PF00069	0.756
MOD_CK2_1	419	425	PF00069	0.737
MOD_CK2_1	444	450	PF00069	0.694
MOD_CK2_1	481	487	PF00069	0.744
MOD_Cter_Amidation	79	82	PF01082	0.510
MOD_GlcNHglycan	124	127	PF01048	0.661
MOD_GlcNHglycan	196	199	PF01048	0.441
MOD_GlcNHglycan	200	203	PF01048	0.517
MOD_GlcNHglycan	221	224	PF01048	0.775
MOD_GlcNHglycan	362	365	PF01048	0.732
MOD_GlcNHglycan	387	390	PF01048	0.657
MOD_GlcNHglycan	401	404	PF01048	0.649
MOD_GlcNHglycan	421	424	PF01048	0.445
MOD_GSK3_1	102	109	PF00069	0.591
MOD_GSK3_1	169	176	PF00069	0.441
MOD_GSK3_1	194	201	PF00069	0.384
MOD_GSK3_1	20	27	PF00069	0.544
MOD_GSK3_1	207	214	PF00069	0.486
MOD_GSK3_1	236	243	PF00069	0.752
MOD_GSK3_1	252	259	PF00069	0.753
MOD_GSK3_1	419	426	PF00069	0.666
MOD_GSK3_1	437	444	PF00069	0.737
MOD_GSK3_1	450	457	PF00069	0.775
MOD_GSK3_1	5	12	PF00069	0.649
MOD_NEK2_1	174	179	PF00069	0.477
MOD_NEK2_1	192	197	PF00069	0.371
MOD_NEK2_1	228	233	PF00069	0.716
MOD_NEK2_1	256	261	PF00069	0.653
MOD_NEK2_1	408	413	PF00069	0.673
MOD_NEK2_1	488	493	PF00069	0.721
MOD_NEK2_1	99	104	PF00069	0.457
MOD_PIKK_1	12	18	PF00454	0.540
MOD_PIKK_1	393	399	PF00454	0.683
MOD_PK_1	292	298	PF00069	0.539
MOD_PK_1	52	58	PF00069	0.650
MOD_PKA_2	264	270	PF00069	0.561
MOD_PKA_2	349	355	PF00069	0.639
MOD_PKA_2	360	366	PF00069	0.715
MOD_PKA_2	99	105	PF00069	0.441
MOD_Plk_1	185	191	PF00069	0.505
MOD_Plk_1	370	376	PF00069	0.697
MOD_Plk_2-3	185	191	PF00069	0.505
MOD_Plk_2-3	221	227	PF00069	0.702
MOD_Plk_4	166	172	PF00069	0.422
MOD_Plk_4	185	191	PF00069	0.559
MOD_Plk_4	332	338	PF00069	0.580
MOD_Plk_4	408	414	PF00069	0.607
MOD_Plk_4	52	58	PF00069	0.650
MOD_ProDKin_1	107	113	PF00069	0.653
MOD_ProDKin_1	20	26	PF00069	0.565
MOD_ProDKin_1	242	248	PF00069	0.797
MOD_ProDKin_1	259	265	PF00069	0.670
MOD_ProDKin_1	388	394	PF00069	0.704
MOD_ProDKin_1	437	443	PF00069	0.770
MOD_ProDKin_1	445	451	PF00069	0.664
MOD_ProDKin_1	482	488	PF00069	0.784
MOD_SUMO_rev_2	267	274	PF00179	0.536
MOD_SUMO_rev_2	484	491	PF00179	0.791
MOD_SUMO_rev_2	61	71	PF00179	0.572
MOD_SUMO_rev_2	72	79	PF00179	0.556
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.517
TRG_ENDOCYTIC_2	412	415	PF00928	0.703
TRG_ER_diArg_1	147	149	PF00400	0.554
TRG_ER_diArg_1	347	350	PF00400	0.618
TRG_ER_diArg_1	469	472	PF00400	0.691
TRG_ER_diArg_1	81	83	PF00400	0.443
TRG_NES_CRM1_1	179	191	PF08389	0.363
TRG_NLS_MonoExtC_3	345	350	PF00514	0.612
TRG_Pf-PMV_PEXEL_1	139	144	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7J1	Leptomonas seymouri	43%	79%
A0A3S7X6X4	Leishmania donovani	90%	100%
A4HLQ9	Leishmania braziliensis	73%	100%
A4I959	Leishmania infantum	91%	100%
D0A6B3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B435	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BYM8	Trypanosoma cruzi	39%	100%