Putative serine/threonine-protein kinase a

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NEK family Serine/threonine-protein kinase, putative

Species:

Leishmania major

UniProt:

Q4Q3Y9_LEIMA

TriTrypDb:

LmjF.33.1980 , LMJLV39_330029700 , LMJSD75_330029300

Length:

448

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 6
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 10

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 81
NetGPI	no	yes: 0, no: 81

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

Q4Q3Y9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3Y9

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	82
GO:0006793	phosphorus metabolic process	3	82
GO:0006796	phosphate-containing compound metabolic process	4	82
GO:0006807	nitrogen compound metabolic process	2	82
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	82
GO:0009987	cellular process	1	82
GO:0016310	phosphorylation	5	82
GO:0019538	protein metabolic process	3	82
GO:0035556	intracellular signal transduction	3	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	82
GO:0003824	catalytic activity	1	82
GO:0004672	protein kinase activity	3	82
GO:0004674	protein serine/threonine kinase activity	4	54
GO:0005488	binding	1	82
GO:0005524	ATP binding	5	82
GO:0016301	kinase activity	4	82
GO:0016740	transferase activity	2	82
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	82
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	82

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.275
CLV_C14_Caspase3-7	305	309	PF00656	0.572
CLV_MEL_PAP_1	52	58	PF00089	0.390
CLV_NRD_NRD_1	157	159	PF00675	0.327
CLV_NRD_NRD_1	237	239	PF00675	0.329
CLV_NRD_NRD_1	256	258	PF00675	0.202
CLV_NRD_NRD_1	358	360	PF00675	0.285
CLV_NRD_NRD_1	54	56	PF00675	0.369
CLV_PCSK_KEX2_1	156	158	PF00082	0.356
CLV_PCSK_KEX2_1	237	239	PF00082	0.317

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2D3	Leptomonas seymouri	25%	85%
A0A0N0P3N5	Leptomonas seymouri	46%	100%
A0A0N0P953	Leptomonas seymouri	37%	94%
A0A0N1I9A0	Leptomonas seymouri	33%	69%
A0A0N1IM47	Leptomonas seymouri	39%	100%
A0A0N1PD05	Leptomonas seymouri	85%	100%
A0A0S4IMB7	Bodo saltans	65%	100%
A0A0S4IQ75	Bodo saltans	34%	89%
A0A0S4IRZ7	Bodo saltans	41%	91%
A0A0S4IVW1	Bodo saltans	28%	72%

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