Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3Y8_LEIMA

TriTrypDb:

LmjF.33.1990 , LMJLV39_330029900 , LMJSD75_330029400

Length:

566

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3Y8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3Y8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.747
CLV_NRD_NRD_1	161	163	PF00675	0.709
CLV_NRD_NRD_1	255	257	PF00675	0.741
CLV_NRD_NRD_1	41	43	PF00675	0.691
CLV_NRD_NRD_1	547	549	PF00675	0.522
CLV_PCSK_KEX2_1	161	163	PF00082	0.709
CLV_PCSK_KEX2_1	255	257	PF00082	0.741
CLV_PCSK_KEX2_1	490	492	PF00082	0.792
CLV_PCSK_KEX2_1	547	549	PF00082	0.670
CLV_PCSK_KEX2_1	556	558	PF00082	0.623
CLV_PCSK_PC1ET2_1	490	492	PF00082	0.792
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.634
CLV_PCSK_SKI1_1	548	552	PF00082	0.663
CLV_PCSK_SKI1_1	553	557	PF00082	0.608
DEG_Nend_UBRbox_4	1	3	PF02207	0.671
DEG_SPOP_SBC_1	215	219	PF00917	0.737
DOC_CYCLIN_RxL_1	364	374	PF00134	0.542
DOC_MAPK_gen_1	553	563	PF00069	0.744
DOC_PP2B_LxvP_1	185	188	PF13499	0.729
DOC_PP4_FxxP_1	438	441	PF00568	0.540
DOC_USP7_MATH_1	169	173	PF00917	0.691
DOC_USP7_MATH_1	213	217	PF00917	0.721
DOC_USP7_MATH_1	22	26	PF00917	0.606
DOC_USP7_MATH_1	237	241	PF00917	0.728
DOC_USP7_MATH_1	333	337	PF00917	0.818
DOC_USP7_MATH_1	344	348	PF00917	0.623
DOC_USP7_MATH_1	350	354	PF00917	0.518
DOC_USP7_MATH_1	412	416	PF00917	0.731
DOC_USP7_MATH_1	421	425	PF00917	0.513
DOC_USP7_MATH_1	67	71	PF00917	0.738
DOC_USP7_MATH_2	456	462	PF00917	0.625
DOC_USP7_UBL2_3	497	501	PF12436	0.797
DOC_WW_Pin1_4	162	167	PF00397	0.824
DOC_WW_Pin1_4	204	209	PF00397	0.748
DOC_WW_Pin1_4	211	216	PF00397	0.711
DOC_WW_Pin1_4	293	298	PF00397	0.668
DOC_WW_Pin1_4	561	566	PF00397	0.675
LIG_14-3-3_CanoR_1	132	140	PF00244	0.637
LIG_14-3-3_CanoR_1	255	261	PF00244	0.754
LIG_14-3-3_CanoR_1	525	534	PF00244	0.741
LIG_BRCT_BRCA1_1	94	98	PF00533	0.711
LIG_Clathr_ClatBox_1	279	283	PF01394	0.702
LIG_eIF4E_1	391	397	PF01652	0.522
LIG_FHA_1	178	184	PF00498	0.734
LIG_FHA_1	225	231	PF00498	0.769
LIG_FHA_1	243	249	PF00498	0.537
LIG_FHA_1	379	385	PF00498	0.574
LIG_FHA_2	134	140	PF00498	0.740
LIG_FHA_2	145	151	PF00498	0.609
LIG_FHA_2	398	404	PF00498	0.624
LIG_Integrin_RGD_1	82	84	PF01839	0.829
LIG_LIR_Apic_2	437	441	PF02991	0.623
LIG_LIR_Apic_2	95	99	PF02991	0.692
LIG_LIR_Gen_1	269	276	PF02991	0.753
LIG_LIR_Nem_3	264	270	PF02991	0.798
LIG_LIR_Nem_3	31	35	PF02991	0.635
LIG_PCNA_yPIPBox_3	364	373	PF02747	0.640
LIG_Pex14_2	438	442	PF04695	0.578
LIG_SH2_NCK_1	238	242	PF00017	0.691
LIG_SH2_STAP1	124	128	PF00017	0.626
LIG_SH2_STAP1	238	242	PF00017	0.691
LIG_SH2_STAT3	113	116	PF00017	0.684
LIG_SH2_STAT5	113	116	PF00017	0.643
LIG_SH2_STAT5	260	263	PF00017	0.818
LIG_SH2_STAT5	32	35	PF00017	0.567
LIG_SH2_STAT5	391	394	PF00017	0.525
LIG_SH2_STAT5	7	10	PF00017	0.666
LIG_SH3_3	111	117	PF00018	0.595
LIG_SH3_3	181	187	PF00018	0.754
LIG_SH3_3	450	456	PF00018	0.814
LIG_SH3_3	472	478	PF00018	0.746
LIG_SH3_3	534	540	PF00018	0.568
LIG_SH3_3	61	67	PF00018	0.727
LIG_SH3_3	71	77	PF00018	0.627
LIG_SUMO_SIM_par_1	356	362	PF11976	0.610
LIG_SUMO_SIM_par_1	368	374	PF11976	0.444
LIG_SUMO_SIM_par_1	539	546	PF11976	0.751
LIG_TRAF2_1	400	403	PF00917	0.659
LIG_TYR_ITIM	36	41	PF00017	0.583
LIG_UBA3_1	551	556	PF00899	0.736
LIG_WRC_WIRS_1	140	145	PF05994	0.758
LIG_WRC_WIRS_1	226	231	PF05994	0.553
LIG_WRC_WIRS_1	405	410	PF05994	0.598
MOD_CK1_1	17	23	PF00069	0.754
MOD_CK1_1	207	213	PF00069	0.772
MOD_CK1_1	216	222	PF00069	0.684
MOD_CK1_1	225	231	PF00069	0.611
MOD_CK1_1	307	313	PF00069	0.790
MOD_CK1_1	323	329	PF00069	0.669
MOD_CK1_1	336	342	PF00069	0.727
MOD_CK1_1	407	413	PF00069	0.676
MOD_CK1_1	425	431	PF00069	0.786
MOD_CK1_1	434	440	PF00069	0.677
MOD_CK1_1	463	469	PF00069	0.779
MOD_CK2_1	133	139	PF00069	0.741
MOD_CK2_1	144	150	PF00069	0.604
MOD_CK2_1	328	334	PF00069	0.751
MOD_CK2_1	350	356	PF00069	0.553
MOD_CK2_1	380	386	PF00069	0.571
MOD_CK2_1	397	403	PF00069	0.553
MOD_CK2_1	434	440	PF00069	0.715
MOD_Cter_Amidation	159	162	PF01082	0.754
MOD_GlcNHglycan	171	174	PF01048	0.738
MOD_GlcNHglycan	199	202	PF01048	0.813
MOD_GlcNHglycan	219	222	PF01048	0.480
MOD_GlcNHglycan	239	242	PF01048	0.697
MOD_GlcNHglycan	24	27	PF01048	0.486
MOD_GlcNHglycan	245	248	PF01048	0.717
MOD_GlcNHglycan	306	309	PF01048	0.740
MOD_GlcNHglycan	330	333	PF01048	0.748
MOD_GlcNHglycan	334	338	PF01048	0.761
MOD_GlcNHglycan	346	349	PF01048	0.521
MOD_GlcNHglycan	415	418	PF01048	0.751
MOD_GlcNHglycan	424	427	PF01048	0.497
MOD_GlcNHglycan	433	436	PF01048	0.582
MOD_GlcNHglycan	465	468	PF01048	0.671
MOD_GlcNHglycan	530	533	PF01048	0.771
MOD_GlcNHglycan	9	12	PF01048	0.687
MOD_GSK3_1	167	174	PF00069	0.677
MOD_GSK3_1	207	214	PF00069	0.700
MOD_GSK3_1	215	222	PF00069	0.715
MOD_GSK3_1	224	231	PF00069	0.697
MOD_GSK3_1	289	296	PF00069	0.778
MOD_GSK3_1	303	310	PF00069	0.646
MOD_GSK3_1	319	326	PF00069	0.755
MOD_GSK3_1	404	411	PF00069	0.605
MOD_GSK3_1	421	428	PF00069	0.749
MOD_GSK3_1	430	437	PF00069	0.796
MOD_GSK3_1	506	513	PF00069	0.780
MOD_GSK3_1	524	531	PF00069	0.668
MOD_GSK3_1	557	564	PF00069	0.754
MOD_N-GLC_1	397	402	PF02516	0.573
MOD_NEK2_1	154	159	PF00069	0.816
MOD_NEK2_1	229	234	PF00069	0.704
MOD_NEK2_1	378	383	PF00069	0.594
MOD_NEK2_1	387	392	PF00069	0.520
MOD_NEK2_1	408	413	PF00069	0.596
MOD_NEK2_1	430	435	PF00069	0.681
MOD_NEK2_1	56	61	PF00069	0.572
MOD_NEK2_2	2	7	PF00069	0.601
MOD_PIKK_1	289	295	PF00454	0.719
MOD_PIKK_1	320	326	PF00454	0.828
MOD_PIKK_1	378	384	PF00454	0.588
MOD_PK_1	557	563	PF00069	0.751
MOD_PKA_2	242	248	PF00069	0.805
MOD_PKA_2	303	309	PF00069	0.698
MOD_PKA_2	524	530	PF00069	0.695
MOD_Plk_1	457	463	PF00069	0.646
MOD_Plk_1	557	563	PF00069	0.751
MOD_Plk_2-3	311	317	PF00069	0.671
MOD_Plk_2-3	371	377	PF00069	0.655
MOD_Plk_4	144	150	PF00069	0.591
MOD_Plk_4	171	177	PF00069	0.682
MOD_Plk_4	2	8	PF00069	0.593
MOD_Plk_4	225	231	PF00069	0.567
MOD_Plk_4	380	386	PF00069	0.571
MOD_Plk_4	387	393	PF00069	0.520
MOD_Plk_4	404	410	PF00069	0.411
MOD_Plk_4	557	563	PF00069	0.697
MOD_Plk_4	92	98	PF00069	0.788
MOD_ProDKin_1	162	168	PF00069	0.822
MOD_ProDKin_1	204	210	PF00069	0.749
MOD_ProDKin_1	211	217	PF00069	0.709
MOD_ProDKin_1	293	299	PF00069	0.670
TRG_DiLeu_BaEn_2	276	282	PF01217	0.601
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.507
TRG_DiLeu_BaLyEn_6	442	447	PF01217	0.689
TRG_DiLeu_BaLyEn_6	537	542	PF01217	0.689
TRG_ENDOCYTIC_2	267	270	PF00928	0.797
TRG_ENDOCYTIC_2	38	41	PF00928	0.567
TRG_ER_diArg_1	161	164	PF00400	0.711
TRG_ER_diArg_1	255	258	PF00400	0.741
TRG_ER_diArg_1	547	549	PF00400	0.522
TRG_NES_CRM1_1	277	290	PF08389	0.719

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2A9	Leptomonas seymouri	36%	94%
A0A3Q8IEY7	Leishmania donovani	88%	99%
A4HLR1	Leishmania braziliensis	69%	99%
A4I961	Leishmania infantum	89%	88%
E9B437	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	98%