Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3Y4_LEIMA

TriTrypDb:

LmjF.33.2030 , LMJLV39_330030500 , LMJSD75_330030000

Length:

817

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q3Y4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3Y4

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0030030	cell projection organization	4	2
GO:0044782	cilium organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0120036	plasma membrane bounded cell projection organization	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	326	330	PF00656	0.631
CLV_C14_Caspase3-7	402	406	PF00656	0.527
CLV_C14_Caspase3-7	493	497	PF00656	0.684
CLV_C14_Caspase3-7	640	644	PF00656	0.511
CLV_NRD_NRD_1	303	305	PF00675	0.570
CLV_NRD_NRD_1	605	607	PF00675	0.404
CLV_NRD_NRD_1	778	780	PF00675	0.689
CLV_PCSK_KEX2_1	303	305	PF00082	0.570
CLV_PCSK_KEX2_1	778	780	PF00082	0.689
CLV_PCSK_SKI1_1	132	136	PF00082	0.428
CLV_PCSK_SKI1_1	149	153	PF00082	0.429
CLV_PCSK_SKI1_1	543	547	PF00082	0.459
CLV_PCSK_SKI1_1	592	596	PF00082	0.453
CLV_PCSK_SKI1_1	803	807	PF00082	0.611
DOC_CYCLIN_RxL_1	146	155	PF00134	0.563
DOC_CYCLIN_yCln2_LP_2	354	357	PF00134	0.632
DOC_MAPK_DCC_7	592	601	PF00069	0.556
DOC_MAPK_gen_1	606	613	PF00069	0.678
DOC_MAPK_MEF2A_6	55	64	PF00069	0.605
DOC_MAPK_MEF2A_6	592	601	PF00069	0.578
DOC_PP2B_LxvP_1	257	260	PF13499	0.678
DOC_PP2B_LxvP_1	354	357	PF13499	0.721
DOC_PP2B_LxvP_1	562	565	PF13499	0.705
DOC_PP2B_LxvP_1	7	10	PF13499	0.817
DOC_USP7_MATH_1	128	132	PF00917	0.761
DOC_USP7_MATH_1	28	32	PF00917	0.751
DOC_USP7_MATH_1	399	403	PF00917	0.660
DOC_USP7_MATH_1	406	410	PF00917	0.567
DOC_USP7_MATH_1	485	489	PF00917	0.651
DOC_USP7_MATH_1	498	502	PF00917	0.494
DOC_USP7_MATH_1	51	55	PF00917	0.705
DOC_USP7_MATH_1	518	522	PF00917	0.446
DOC_USP7_MATH_1	637	641	PF00917	0.463
DOC_WW_Pin1_4	24	29	PF00397	0.730
DOC_WW_Pin1_4	270	275	PF00397	0.725
DOC_WW_Pin1_4	332	337	PF00397	0.711
DOC_WW_Pin1_4	527	532	PF00397	0.512
DOC_WW_Pin1_4	564	569	PF00397	0.607
DOC_WW_Pin1_4	580	585	PF00397	0.621
DOC_WW_Pin1_4	592	597	PF00397	0.559
DOC_WW_Pin1_4	605	610	PF00397	0.590
DOC_WW_Pin1_4	726	731	PF00397	0.412
DOC_WW_Pin1_4	77	82	PF00397	0.658
LIG_14-3-3_CanoR_1	132	141	PF00244	0.664
LIG_14-3-3_CanoR_1	265	274	PF00244	0.803
LIG_14-3-3_CanoR_1	382	388	PF00244	0.619
LIG_14-3-3_CanoR_1	398	407	PF00244	0.538
LIG_14-3-3_CanoR_1	543	548	PF00244	0.679
LIG_14-3-3_CanoR_1	749	756	PF00244	0.490
LIG_Actin_WH2_2	698	715	PF00022	0.387
LIG_BIR_III_4	197	201	PF00653	0.548
LIG_BRCT_BRCA1_1	372	376	PF00533	0.570
LIG_BRCT_BRCA1_1	487	491	PF00533	0.607
LIG_BRCT_BRCA1_1	625	629	PF00533	0.410
LIG_CtBP_PxDLS_1	426	430	PF00389	0.588
LIG_EH1_1	160	168	PF00400	0.675
LIG_eIF4E_1	146	152	PF01652	0.544
LIG_eIF4E_1	655	661	PF01652	0.379
LIG_EVH1_1	562	566	PF00568	0.638
LIG_FHA_1	153	159	PF00498	0.494
LIG_FHA_1	162	168	PF00498	0.552
LIG_FHA_1	194	200	PF00498	0.548
LIG_FHA_1	228	234	PF00498	0.576
LIG_FHA_1	283	289	PF00498	0.769
LIG_FHA_1	437	443	PF00498	0.640
LIG_FHA_1	474	480	PF00498	0.629
LIG_FHA_1	540	546	PF00498	0.595
LIG_FHA_1	593	599	PF00498	0.570
LIG_FHA_1	676	682	PF00498	0.377
LIG_FHA_1	78	84	PF00498	0.650
LIG_FHA_1	91	97	PF00498	0.479
LIG_FHA_2	12	18	PF00498	0.642
LIG_FHA_2	180	186	PF00498	0.472
LIG_FHA_2	357	363	PF00498	0.695
LIG_FHA_2	461	467	PF00498	0.663
LIG_FHA_2	491	497	PF00498	0.671
LIG_FHA_2	749	755	PF00498	0.423
LIG_FHA_2	758	764	PF00498	0.425
LIG_GBD_Chelix_1	506	514	PF00786	0.361
LIG_LIR_Gen_1	40	48	PF02991	0.598
LIG_LIR_Gen_1	542	551	PF02991	0.695
LIG_LIR_Gen_1	614	625	PF02991	0.410
LIG_LIR_Gen_1	652	663	PF02991	0.448
LIG_LIR_Nem_3	40	44	PF02991	0.619
LIG_LIR_Nem_3	416	421	PF02991	0.565
LIG_LIR_Nem_3	542	547	PF02991	0.661
LIG_LIR_Nem_3	626	632	PF02991	0.410
LIG_LIR_Nem_3	652	658	PF02991	0.449
LIG_MLH1_MIPbox_1	625	629	PF16413	0.410
LIG_PCNA_yPIPBox_3	606	617	PF02747	0.629
LIG_PDZ_Class_1	812	817	PF00595	0.519
LIG_Pex14_2	628	632	PF04695	0.410
LIG_Pex14_2	98	102	PF04695	0.589
LIG_PTB_Apo_2	321	328	PF02174	0.748
LIG_PTB_Apo_2	621	628	PF02174	0.410
LIG_PTB_Apo_2	680	687	PF02174	0.384
LIG_PTB_Phospho_1	621	627	PF10480	0.410
LIG_PTB_Phospho_1	680	686	PF10480	0.386
LIG_SH2_CRK	655	659	PF00017	0.445
LIG_SH2_GRB2like	686	689	PF00017	0.411
LIG_SH2_NCK_1	686	690	PF00017	0.404
LIG_SH2_PTP2	544	547	PF00017	0.660
LIG_SH2_STAP1	146	150	PF00017	0.538
LIG_SH2_STAP1	646	650	PF00017	0.438
LIG_SH2_STAP1	746	750	PF00017	0.399
LIG_SH2_STAT3	750	753	PF00017	0.487
LIG_SH2_STAT5	114	117	PF00017	0.713
LIG_SH2_STAT5	370	373	PF00017	0.466
LIG_SH2_STAT5	464	467	PF00017	0.553
LIG_SH2_STAT5	527	530	PF00017	0.658
LIG_SH2_STAT5	544	547	PF00017	0.482
LIG_SH2_STAT5	617	620	PF00017	0.410
LIG_SH2_STAT5	627	630	PF00017	0.410
LIG_SH2_STAT5	665	668	PF00017	0.387
LIG_SH2_STAT5	686	689	PF00017	0.411
LIG_SH2_STAT5	746	749	PF00017	0.369
LIG_SH2_STAT5	750	753	PF00017	0.368
LIG_SH3_3	164	170	PF00018	0.619
LIG_SH3_3	256	262	PF00018	0.673
LIG_SH3_3	526	532	PF00018	0.618
LIG_SH3_3	544	550	PF00018	0.659
LIG_SH3_3	560	566	PF00018	0.606
LIG_SH3_3	581	587	PF00018	0.656
LIG_SH3_3	591	597	PF00018	0.648
LIG_SH3_3	731	737	PF00018	0.400
LIG_SUMO_SIM_anti_2	500	508	PF11976	0.675
LIG_SUMO_SIM_anti_2	700	706	PF11976	0.383
LIG_SUMO_SIM_par_1	154	160	PF11976	0.568
LIG_SUMO_SIM_par_1	169	175	PF11976	0.494
LIG_TRAF2_1	360	363	PF00917	0.808
LIG_TRAF2_1	497	500	PF00917	0.743
LIG_TRAF2_1	761	764	PF00917	0.500
LIG_TRFH_1	352	356	PF08558	0.713
LIG_TYR_ITSM	540	547	PF00017	0.590
LIG_UBA3_1	601	607	PF00899	0.655
LIG_UBA3_1	62	67	PF00899	0.592
LIG_WW_3	355	359	PF00397	0.726
MOD_CDC14_SPxK_1	729	732	PF00782	0.416
MOD_CDK_SPxK_1	726	732	PF00069	0.409
MOD_CK1_1	172	178	PF00069	0.499
MOD_CK1_1	269	275	PF00069	0.831
MOD_CK1_1	330	336	PF00069	0.719
MOD_CK1_1	623	629	PF00069	0.477
MOD_CK1_1	73	79	PF00069	0.723
MOD_CK1_1	745	751	PF00069	0.478
MOD_CK1_1	788	794	PF00069	0.434
MOD_CK2_1	11	17	PF00069	0.638
MOD_CK2_1	179	185	PF00069	0.471
MOD_CK2_1	356	362	PF00069	0.768
MOD_CK2_1	421	427	PF00069	0.589
MOD_CK2_1	460	466	PF00069	0.484
MOD_CK2_1	498	504	PF00069	0.601
MOD_CK2_1	51	57	PF00069	0.670
MOD_CK2_1	757	763	PF00069	0.451
MOD_CMANNOS	223	226	PF00535	0.381
MOD_DYRK1A_RPxSP_1	592	596	PF00069	0.581
MOD_GlcNHglycan	126	129	PF01048	0.566
MOD_GlcNHglycan	2	5	PF01048	0.554
MOD_GlcNHglycan	213	217	PF01048	0.420
MOD_GlcNHglycan	268	271	PF01048	0.644
MOD_GlcNHglycan	279	282	PF01048	0.502
MOD_GlcNHglycan	290	293	PF01048	0.510
MOD_GlcNHglycan	332	335	PF01048	0.499
MOD_GlcNHglycan	401	404	PF01048	0.533
MOD_GlcNHglycan	547	550	PF01048	0.467
MOD_GlcNHglycan	814	817	PF01048	0.664
MOD_GSK3_1	124	131	PF00069	0.763
MOD_GSK3_1	132	139	PF00069	0.768
MOD_GSK3_1	157	164	PF00069	0.570
MOD_GSK3_1	172	179	PF00069	0.627
MOD_GSK3_1	238	245	PF00069	0.663
MOD_GSK3_1	24	31	PF00069	0.729
MOD_GSK3_1	265	272	PF00069	0.844
MOD_GSK3_1	273	280	PF00069	0.729
MOD_GSK3_1	323	330	PF00069	0.730
MOD_GSK3_1	335	342	PF00069	0.714
MOD_GSK3_1	539	546	PF00069	0.631
MOD_GSK3_1	645	652	PF00069	0.451
MOD_GSK3_1	671	678	PF00069	0.375
MOD_GSK3_1	69	76	PF00069	0.666
MOD_GSK3_1	744	751	PF00069	0.410
MOD_GSK3_1	785	792	PF00069	0.454
MOD_LATS_1	309	315	PF00433	0.737
MOD_N-GLC_1	323	328	PF02516	0.456
MOD_N-GLC_1	623	628	PF02516	0.410
MOD_N-GLC_1	682	687	PF02516	0.588
MOD_N-GLC_1	723	728	PF02516	0.587
MOD_N-GLC_2	366	368	PF02516	0.377
MOD_N-GLC_2	443	445	PF02516	0.465
MOD_N-GLC_2	697	699	PF02516	0.606
MOD_N-GLC_2	717	719	PF02516	0.397
MOD_NEK2_1	152	157	PF00069	0.635
MOD_NEK2_1	176	181	PF00069	0.662
MOD_NEK2_1	266	271	PF00069	0.844
MOD_NEK2_1	310	315	PF00069	0.711
MOD_NEK2_1	327	332	PF00069	0.772
MOD_NEK2_1	376	381	PF00069	0.494
MOD_NEK2_1	421	426	PF00069	0.596
MOD_NEK2_1	490	495	PF00069	0.666
MOD_NEK2_1	505	510	PF00069	0.571
MOD_NEK2_1	558	563	PF00069	0.762
MOD_NEK2_1	590	595	PF00069	0.570
MOD_NEK2_1	611	616	PF00069	0.557
MOD_NEK2_1	620	625	PF00069	0.325
MOD_NEK2_1	654	659	PF00069	0.443
MOD_NEK2_1	70	75	PF00069	0.625
MOD_NEK2_1	723	728	PF00069	0.387
MOD_NEK2_1	739	744	PF00069	0.400
MOD_NEK2_1	812	817	PF00069	0.450
MOD_NEK2_1	91	96	PF00069	0.581
MOD_NEK2_2	650	655	PF00069	0.329
MOD_PIKK_1	39	45	PF00454	0.618
MOD_PIKK_1	485	491	PF00454	0.595
MOD_PKA_1	304	310	PF00069	0.772
MOD_PKA_2	288	294	PF00069	0.808
MOD_PKA_2	381	387	PF00069	0.586
MOD_PKA_2	748	754	PF00069	0.420
MOD_PKB_1	263	271	PF00069	0.772
MOD_Plk_1	255	261	PF00069	0.845
MOD_Plk_1	323	329	PF00069	0.654
MOD_Plk_1	39	45	PF00069	0.643
MOD_Plk_1	499	505	PF00069	0.702
MOD_Plk_1	623	629	PF00069	0.403
MOD_Plk_1	671	677	PF00069	0.376
MOD_Plk_1	682	688	PF00069	0.394
MOD_Plk_1	700	706	PF00069	0.383
MOD_Plk_2-3	169	175	PF00069	0.686
MOD_Plk_2-3	448	454	PF00069	0.587
MOD_Plk_4	152	158	PF00069	0.551
MOD_Plk_4	172	178	PF00069	0.428
MOD_Plk_4	335	341	PF00069	0.665
MOD_Plk_4	406	412	PF00069	0.588
MOD_Plk_4	413	419	PF00069	0.561
MOD_Plk_4	437	443	PF00069	0.580
MOD_Plk_4	460	466	PF00069	0.661
MOD_Plk_4	623	629	PF00069	0.410
MOD_Plk_4	650	656	PF00069	0.456
MOD_Plk_4	700	706	PF00069	0.352
MOD_Plk_4	739	745	PF00069	0.403
MOD_Plk_4	91	97	PF00069	0.583
MOD_ProDKin_1	24	30	PF00069	0.728
MOD_ProDKin_1	270	276	PF00069	0.724
MOD_ProDKin_1	332	338	PF00069	0.711
MOD_ProDKin_1	527	533	PF00069	0.507
MOD_ProDKin_1	564	570	PF00069	0.601
MOD_ProDKin_1	580	586	PF00069	0.531
MOD_ProDKin_1	592	598	PF00069	0.555
MOD_ProDKin_1	605	611	PF00069	0.585
MOD_ProDKin_1	726	732	PF00069	0.409
MOD_ProDKin_1	77	83	PF00069	0.650
TRG_DiLeu_BaEn_1	204	209	PF01217	0.666
TRG_DiLeu_BaEn_4	362	368	PF01217	0.707
TRG_DiLeu_BaEn_4	427	433	PF01217	0.635
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.668
TRG_DiLeu_BaLyEn_6	597	602	PF01217	0.568
TRG_DiLeu_LyEn_5	204	209	PF01217	0.666
TRG_ENDOCYTIC_2	418	421	PF00928	0.566
TRG_ENDOCYTIC_2	544	547	PF00928	0.660
TRG_ENDOCYTIC_2	617	620	PF00928	0.410
TRG_ENDOCYTIC_2	655	658	PF00928	0.447
TRG_ER_diArg_1	260	263	PF00400	0.831
TRG_ER_diArg_1	302	304	PF00400	0.766

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8G1	Leptomonas seymouri	47%	75%
A0A3S7X6Z4	Leishmania donovani	92%	100%
A4HLR5	Leishmania braziliensis	71%	74%
A4I941	Leishmania infantum	92%	100%
E9B441	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%