LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Nucleoporin NUP89
Species:
Leishmania major
UniProt:
Q4Q3Y3_LEIMA
TriTrypDb:
LmjF.33.2040 * , LMJLV39_330030700 * , LMJSD75_330030200 *
Length:
787

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005643 nuclear pore 3 7
GO:0031080 nuclear pore outer ring 3 5
GO:0032991 protein-containing complex 1 10
GO:0140513 nuclear protein-containing complex 2 10
GO:0016020 membrane 2 3
GO:0031090 organelle membrane 3 3
GO:0031965 nuclear membrane 4 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

Q4Q3Y3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3Y3

Function

Biological processes
Term Name Level Count
GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery 6 2
GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery 7 2
GO:0006355 regulation of DNA-templated transcription 6 2
GO:0006405 RNA export from nucleus 5 5
GO:0006406 mRNA export from nucleus 6 5
GO:0006606 protein import into nucleus 5 5
GO:0006810 transport 3 10
GO:0006886 intracellular protein transport 4 5
GO:0006913 nucleocytoplasmic transport 5 5
GO:0006996 organelle organization 4 2
GO:0008104 protein localization 4 10
GO:0009889 regulation of biosynthetic process 4 2
GO:0009987 cellular process 1 10
GO:0010468 regulation of gene expression 5 2
GO:0010556 regulation of macromolecule biosynthetic process 5 2
GO:0015031 protein transport 4 10
GO:0015931 nucleobase-containing compound transport 5 10
GO:0016043 cellular component organization 3 2
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 2
GO:0019222 regulation of metabolic process 3 2
GO:0031323 regulation of cellular metabolic process 4 2
GO:0031326 regulation of cellular biosynthetic process 5 2
GO:0033036 macromolecule localization 2 10
GO:0033365 protein localization to organelle 5 5
GO:0034504 protein localization to nucleus 6 5
GO:0045184 establishment of protein localization 3 10
GO:0046907 intracellular transport 3 5
GO:0050657 nucleic acid transport 6 10
GO:0050658 RNA transport 4 10
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0051028 mRNA transport 5 10
GO:0051168 nuclear export 6 5
GO:0051169 nuclear transport 4 5
GO:0051170 import into nucleus 6 5
GO:0051171 regulation of nitrogen compound metabolic process 4 2
GO:0051179 localization 1 10
GO:0051234 establishment of localization 2 10
GO:0051236 establishment of RNA localization 3 10
GO:0051252 regulation of RNA metabolic process 5 2
GO:0051276 chromosome organization 5 2
GO:0051641 cellular localization 2 10
GO:0051649 establishment of localization in cell 3 5
GO:0060255 regulation of macromolecule metabolic process 4 2
GO:0065007 biological regulation 1 2
GO:0070727 cellular macromolecule localization 3 10
GO:0071702 organic substance transport 4 10
GO:0071705 nitrogen compound transport 4 10
GO:0071840 cellular component organization or biogenesis 2 2
GO:0072594 establishment of protein localization to organelle 4 5
GO:0080090 regulation of primary metabolic process 4 2
GO:1903506 regulation of nucleic acid-templated transcription 7 2
GO:2001141 regulation of RNA biosynthetic process 6 2
Molecular functions
Term Name Level Count
GO:0005198 structural molecule activity 1 10
GO:0017056 structural constituent of nuclear pore 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 312 316 PF00656 0.564
CLV_C14_Caspase3-7 346 350 PF00656 0.502
CLV_C14_Caspase3-7 61 65 PF00656 0.548
CLV_NRD_NRD_1 28 30 PF00675 0.479
CLV_NRD_NRD_1 49 51 PF00675 0.330
CLV_NRD_NRD_1 544 546 PF00675 0.423
CLV_NRD_NRD_1 552 554 PF00675 0.474
CLV_PCSK_KEX2_1 28 30 PF00082 0.479
CLV_PCSK_KEX2_1 317 319 PF00082 0.535
CLV_PCSK_KEX2_1 49 51 PF00082 0.330
CLV_PCSK_KEX2_1 544 546 PF00082 0.423
CLV_PCSK_KEX2_1 552 554 PF00082 0.474
CLV_PCSK_KEX2_1 757 759 PF00082 0.524
CLV_PCSK_PC1ET2_1 317 319 PF00082 0.535
CLV_PCSK_PC1ET2_1 757 759 PF00082 0.538
CLV_PCSK_SKI1_1 224 228 PF00082 0.323
CLV_PCSK_SKI1_1 305 309 PF00082 0.362
CLV_PCSK_SKI1_1 318 322 PF00082 0.502
CLV_PCSK_SKI1_1 354 358 PF00082 0.508
CLV_PCSK_SKI1_1 408 412 PF00082 0.515
CLV_PCSK_SKI1_1 544 548 PF00082 0.428
DEG_APCC_DBOX_1 304 312 PF00400 0.359
DEG_APCC_DBOX_1 543 551 PF00400 0.462
DEG_APCC_DBOX_1 666 674 PF00400 0.487
DEG_Nend_UBRbox_3 1 3 PF02207 0.519
DOC_CKS1_1 181 186 PF01111 0.562
DOC_CYCLIN_RxL_1 78 86 PF00134 0.441
DOC_MAPK_gen_1 544 550 PF00069 0.526
DOC_MAPK_gen_1 71 80 PF00069 0.568
DOC_MAPK_MEF2A_6 224 231 PF00069 0.335
DOC_MAPK_MEF2A_6 390 397 PF00069 0.473
DOC_MAPK_MEF2A_6 408 417 PF00069 0.434
DOC_MAPK_RevD_3 530 545 PF00069 0.504
DOC_PIKK_1 149 156 PF02985 0.396
DOC_PP1_RVXF_1 493 499 PF00149 0.490
DOC_USP7_MATH_1 179 183 PF00917 0.651
DOC_USP7_MATH_1 519 523 PF00917 0.428
DOC_USP7_MATH_1 536 540 PF00917 0.449
DOC_USP7_MATH_1 570 574 PF00917 0.709
DOC_USP7_MATH_1 626 630 PF00917 0.597
DOC_USP7_MATH_1 733 737 PF00917 0.431
DOC_USP7_MATH_1 8 12 PF00917 0.580
DOC_USP7_MATH_2 345 351 PF00917 0.551
DOC_USP7_UBL2_3 491 495 PF12436 0.513
DOC_WW_Pin1_4 180 185 PF00397 0.632
DOC_WW_Pin1_4 369 374 PF00397 0.616
DOC_WW_Pin1_4 568 573 PF00397 0.730
DOC_WW_Pin1_4 577 582 PF00397 0.559
DOC_WW_Pin1_4 698 703 PF00397 0.665
LIG_14-3-3_CanoR_1 29 38 PF00244 0.424
LIG_14-3-3_CanoR_1 354 361 PF00244 0.377
LIG_14-3-3_CanoR_1 379 385 PF00244 0.505
LIG_14-3-3_CanoR_1 408 417 PF00244 0.481
LIG_14-3-3_CanoR_1 423 427 PF00244 0.298
LIG_14-3-3_CanoR_1 515 524 PF00244 0.437
LIG_14-3-3_CanoR_1 600 609 PF00244 0.448
LIG_14-3-3_CanoR_1 667 677 PF00244 0.423
LIG_14-3-3_CanoR_1 748 752 PF00244 0.523
LIG_Actin_WH2_2 35 51 PF00022 0.469
LIG_Actin_WH2_2 76 91 PF00022 0.389
LIG_BIR_III_4 17 21 PF00653 0.445
LIG_deltaCOP1_diTrp_1 270 276 PF00928 0.535
LIG_eIF4E_1 222 228 PF01652 0.442
LIG_eIF4E_1 726 732 PF01652 0.442
LIG_FHA_1 230 236 PF00498 0.392
LIG_FHA_1 330 336 PF00498 0.609
LIG_FHA_1 355 361 PF00498 0.497
LIG_FHA_1 412 418 PF00498 0.529
LIG_FHA_1 482 488 PF00498 0.495
LIG_FHA_1 541 547 PF00498 0.450
LIG_FHA_1 669 675 PF00498 0.375
LIG_FHA_1 679 685 PF00498 0.353
LIG_FHA_2 117 123 PF00498 0.401
LIG_FHA_2 201 207 PF00498 0.504
LIG_FHA_2 310 316 PF00498 0.525
LIG_FHA_2 4 10 PF00498 0.491
LIG_FHA_2 524 530 PF00498 0.507
LIG_FHA_2 581 587 PF00498 0.486
LIG_FHA_2 59 65 PF00498 0.445
LIG_FHA_2 636 642 PF00498 0.510
LIG_GBD_Chelix_1 280 288 PF00786 0.403
LIG_LIR_Apic_2 723 729 PF02991 0.531
LIG_LIR_Gen_1 188 198 PF02991 0.485
LIG_LIR_Gen_1 217 228 PF02991 0.353
LIG_LIR_Gen_1 255 265 PF02991 0.474
LIG_LIR_Gen_1 33 42 PF02991 0.465
LIG_LIR_Gen_1 339 345 PF02991 0.468
LIG_LIR_Gen_1 425 434 PF02991 0.378
LIG_LIR_Gen_1 507 517 PF02991 0.486
LIG_LIR_Gen_1 738 749 PF02991 0.413
LIG_LIR_Nem_3 188 193 PF02991 0.511
LIG_LIR_Nem_3 217 223 PF02991 0.367
LIG_LIR_Nem_3 255 261 PF02991 0.421
LIG_LIR_Nem_3 33 38 PF02991 0.467
LIG_LIR_Nem_3 339 344 PF02991 0.476
LIG_LIR_Nem_3 425 430 PF02991 0.380
LIG_LIR_Nem_3 507 512 PF02991 0.497
LIG_LIR_Nem_3 589 595 PF02991 0.408
LIG_LIR_Nem_3 738 744 PF02991 0.406
LIG_MYND_1 729 733 PF01753 0.441
LIG_Pex14_1 272 276 PF04695 0.464
LIG_SH2_CRK 478 482 PF00017 0.533
LIG_SH2_CRK 741 745 PF00017 0.517
LIG_SH2_NCK_1 5 9 PF00017 0.567
LIG_SH2_SRC 137 140 PF00017 0.529
LIG_SH2_SRC 160 163 PF00017 0.398
LIG_SH2_SRC 726 729 PF00017 0.440
LIG_SH2_STAP1 103 107 PF00017 0.439
LIG_SH2_STAP1 160 164 PF00017 0.384
LIG_SH2_STAP1 258 262 PF00017 0.446
LIG_SH2_STAP1 391 395 PF00017 0.441
LIG_SH2_STAP1 427 431 PF00017 0.352
LIG_SH2_STAT3 437 440 PF00017 0.502
LIG_SH2_STAT5 222 225 PF00017 0.442
LIG_SH2_STAT5 292 295 PF00017 0.399
LIG_SH2_STAT5 5 8 PF00017 0.579
LIG_SH2_STAT5 509 512 PF00017 0.475
LIG_SH2_STAT5 594 597 PF00017 0.535
LIG_SH2_STAT5 726 729 PF00017 0.460
LIG_SH2_STAT5 87 90 PF00017 0.424
LIG_SH3_3 117 123 PF00018 0.419
LIG_SH3_3 178 184 PF00018 0.593
LIG_SH3_3 291 297 PF00018 0.472
LIG_SH3_3 396 402 PF00018 0.463
LIG_Sin3_3 190 197 PF02671 0.463
LIG_SUMO_SIM_anti_2 507 514 PF11976 0.485
LIG_SUMO_SIM_par_1 780 785 PF11976 0.456
LIG_TRAF2_1 119 122 PF00917 0.429
LIG_TRAF2_1 297 300 PF00917 0.398
LIG_TYR_ITIM 476 481 PF00017 0.515
MOD_CK1_1 182 188 PF00069 0.589
MOD_CK1_1 319 325 PF00069 0.657
MOD_CK1_1 465 471 PF00069 0.433
MOD_CK1_1 540 546 PF00069 0.489
MOD_CK1_1 571 577 PF00069 0.757
MOD_CK1_1 580 586 PF00069 0.495
MOD_CK1_1 588 594 PF00069 0.468
MOD_CK1_1 629 635 PF00069 0.560
MOD_CK1_1 701 707 PF00069 0.643
MOD_CK2_1 116 122 PF00069 0.377
MOD_CK2_1 200 206 PF00069 0.490
MOD_CK2_1 3 9 PF00069 0.492
MOD_CK2_1 442 448 PF00069 0.480
MOD_CK2_1 523 529 PF00069 0.498
MOD_CK2_1 580 586 PF00069 0.531
MOD_CK2_1 63 69 PF00069 0.530
MOD_CK2_1 635 641 PF00069 0.517
MOD_CK2_1 692 698 PF00069 0.626
MOD_CK2_1 701 707 PF00069 0.638
MOD_Cter_Amidation 315 318 PF01082 0.541
MOD_GlcNHglycan 112 115 PF01048 0.323
MOD_GlcNHglycan 167 170 PF01048 0.633
MOD_GlcNHglycan 176 180 PF01048 0.603
MOD_GlcNHglycan 184 187 PF01048 0.382
MOD_GlcNHglycan 244 248 PF01048 0.657
MOD_GlcNHglycan 267 270 PF01048 0.547
MOD_GlcNHglycan 289 292 PF01048 0.549
MOD_GlcNHglycan 325 328 PF01048 0.698
MOD_GlcNHglycan 517 520 PF01048 0.473
MOD_GlcNHglycan 722 725 PF01048 0.503
MOD_GlcNHglycan 735 738 PF01048 0.385
MOD_GSK3_1 102 109 PF00069 0.386
MOD_GSK3_1 175 182 PF00069 0.622
MOD_GSK3_1 307 314 PF00069 0.494
MOD_GSK3_1 316 323 PF00069 0.594
MOD_GSK3_1 380 387 PF00069 0.498
MOD_GSK3_1 481 488 PF00069 0.535
MOD_GSK3_1 515 522 PF00069 0.483
MOD_GSK3_1 536 543 PF00069 0.458
MOD_GSK3_1 571 578 PF00069 0.689
MOD_GSK3_1 601 608 PF00069 0.507
MOD_GSK3_1 678 685 PF00069 0.436
MOD_N-GLC_1 154 159 PF02516 0.386
MOD_N-GLC_1 200 205 PF02516 0.521
MOD_N-GLC_1 211 216 PF02516 0.326
MOD_N-GLC_1 442 447 PF02516 0.565
MOD_N-GLC_1 629 634 PF02516 0.570
MOD_NEK2_1 125 130 PF00069 0.528
MOD_NEK2_1 320 325 PF00069 0.700
MOD_NEK2_1 384 389 PF00069 0.408
MOD_NEK2_1 575 580 PF00069 0.724
MOD_NEK2_1 58 63 PF00069 0.402
MOD_NEK2_1 747 752 PF00069 0.518
MOD_NEK2_1 83 88 PF00069 0.442
MOD_NEK2_2 160 165 PF00069 0.516
MOD_PIKK_1 123 129 PF00454 0.524
MOD_PIKK_1 154 160 PF00454 0.382
MOD_PIKK_1 274 280 PF00454 0.464
MOD_PIKK_1 573 579 PF00454 0.694
MOD_PIKK_1 635 641 PF00454 0.522
MOD_PIKK_1 649 655 PF00454 0.410
MOD_PKA_2 422 428 PF00069 0.383
MOD_PKA_2 747 753 PF00069 0.507
MOD_Plk_1 154 160 PF00069 0.393
MOD_Plk_1 200 206 PF00069 0.461
MOD_Plk_1 254 260 PF00069 0.517
MOD_Plk_1 465 471 PF00069 0.388
MOD_Plk_1 536 542 PF00069 0.420
MOD_Plk_1 58 64 PF00069 0.432
MOD_Plk_1 588 594 PF00069 0.485
MOD_Plk_1 629 635 PF00069 0.462
MOD_Plk_1 706 712 PF00069 0.541
MOD_Plk_2-3 3 9 PF00069 0.492
MOD_Plk_4 200 206 PF00069 0.532
MOD_Plk_4 422 428 PF00069 0.354
MOD_Plk_4 519 525 PF00069 0.399
MOD_Plk_4 537 543 PF00069 0.386
MOD_Plk_4 588 594 PF00069 0.485
MOD_Plk_4 684 690 PF00069 0.437
MOD_Plk_4 83 89 PF00069 0.431
MOD_ProDKin_1 180 186 PF00069 0.624
MOD_ProDKin_1 369 375 PF00069 0.607
MOD_ProDKin_1 568 574 PF00069 0.730
MOD_ProDKin_1 577 583 PF00069 0.548
MOD_ProDKin_1 698 704 PF00069 0.662
TRG_DiLeu_BaEn_1 472 477 PF01217 0.398
TRG_DiLeu_BaEn_4 75 81 PF01217 0.452
TRG_DiLeu_BaLyEn_6 351 356 PF01217 0.407
TRG_ENDOCYTIC_2 258 261 PF00928 0.409
TRG_ENDOCYTIC_2 35 38 PF00928 0.442
TRG_ENDOCYTIC_2 391 394 PF00928 0.471
TRG_ENDOCYTIC_2 427 430 PF00928 0.353
TRG_ENDOCYTIC_2 478 481 PF00928 0.534
TRG_ENDOCYTIC_2 509 512 PF00928 0.475
TRG_ENDOCYTIC_2 715 718 PF00928 0.503
TRG_ENDOCYTIC_2 741 744 PF00928 0.510
TRG_ER_diArg_1 28 30 PF00400 0.479
TRG_ER_diArg_1 415 418 PF00400 0.443
TRG_ER_diArg_1 48 50 PF00400 0.330
TRG_ER_diArg_1 544 546 PF00400 0.426
TRG_ER_diArg_1 70 73 PF00400 0.628
TRG_ER_diArg_1 764 767 PF00400 0.580
TRG_NES_CRM1_1 405 419 PF08389 0.406
TRG_Pf-PMV_PEXEL_1 305 309 PF00026 0.407
TRG_Pf-PMV_PEXEL_1 545 549 PF00026 0.494
TRG_Pf-PMV_PEXEL_1 631 636 PF00026 0.471

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IAQ9 Leptomonas seymouri 74% 88%
A0A0S4J8I7 Bodo saltans 30% 100%
A0A1X0P3M8 Trypanosomatidae 44% 100%
A0A3Q8IMG5 Leishmania donovani 96% 100%
A0A422N462 Trypanosoma rangeli 44% 99%
A4HLR6 Leishmania braziliensis 89% 100%
A4I942 Leishmania infantum 96% 100%
D0A6A9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 99%
E9B442 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS