Protein HGH1 homolog

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3Y2_LEIMA

TriTrypDb:

LmjF.33.2050 , LMJLV39_330030800 , LMJSD75_330030300

Length:

397

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q3Y2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3Y2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	383	387	PF00656	0.524
CLV_C14_Caspase3-7	70	74	PF00656	0.520
CLV_NRD_NRD_1	109	111	PF00675	0.440
CLV_NRD_NRD_1	113	115	PF00675	0.391
CLV_NRD_NRD_1	40	42	PF00675	0.415
CLV_PCSK_SKI1_1	210	214	PF00082	0.379
CLV_PCSK_SKI1_1	321	325	PF00082	0.470
CLV_PCSK_SKI1_1	84	88	PF00082	0.501
DEG_APCC_DBOX_1	209	217	PF00400	0.414
DEG_APCC_KENBOX_2	52	56	PF00400	0.561
DEG_SCF_FBW7_1	357	364	PF00400	0.508
DOC_MAPK_gen_1	110	119	PF00069	0.424
DOC_MAPK_MEF2A_6	134	143	PF00069	0.393
DOC_MAPK_MEF2A_6	210	219	PF00069	0.355
DOC_PP1_RVXF_1	54	61	PF00149	0.318
DOC_USP7_MATH_1	16	20	PF00917	0.618
DOC_USP7_MATH_1	199	203	PF00917	0.723
DOC_USP7_MATH_1	49	53	PF00917	0.409
DOC_USP7_MATH_1	99	103	PF00917	0.487
DOC_USP7_UBL2_3	111	115	PF12436	0.439
DOC_WW_Pin1_4	242	247	PF00397	0.510
DOC_WW_Pin1_4	261	266	PF00397	0.289
DOC_WW_Pin1_4	357	362	PF00397	0.543
DOC_WW_Pin1_4	61	66	PF00397	0.403
LIG_14-3-3_CanoR_1	236	246	PF00244	0.529
LIG_APCC_ABBA_1	174	179	PF00400	0.487
LIG_APCC_ABBA_1	377	382	PF00400	0.432
LIG_APCC_ABBAyCdc20_2	173	179	PF00400	0.490
LIG_CtBP_PxDLS_1	193	198	PF00389	0.498
LIG_FHA_1	138	144	PF00498	0.379
LIG_FHA_1	218	224	PF00498	0.495
LIG_FHA_1	358	364	PF00498	0.632
LIG_FHA_1	90	96	PF00498	0.348
LIG_FHA_2	151	157	PF00498	0.468
LIG_FHA_2	183	189	PF00498	0.412
LIG_FHA_2	278	284	PF00498	0.521
LIG_GBD_Chelix_1	298	306	PF00786	0.423
LIG_LIR_Apic_2	386	391	PF02991	0.612
LIG_LIR_Gen_1	28	36	PF02991	0.466
LIG_LIR_Nem_3	28	33	PF02991	0.435
LIG_LIR_Nem_3	57	62	PF02991	0.437
LIG_MYND_3	378	382	PF01753	0.438
LIG_NRBOX	212	218	PF00104	0.366
LIG_NRBOX	57	63	PF00104	0.433
LIG_PCNA_yPIPBox_3	288	302	PF02747	0.506
LIG_Rb_LxCxE_1	280	300	PF01857	0.535
LIG_SH2_CRK	269	273	PF00017	0.501
LIG_SH2_PTP2	388	391	PF00017	0.645
LIG_SH2_SRC	78	81	PF00017	0.490
LIG_SH2_STAP1	178	182	PF00017	0.505
LIG_SH2_STAT5	132	135	PF00017	0.534
LIG_SH2_STAT5	170	173	PF00017	0.383
LIG_SH2_STAT5	252	255	PF00017	0.477
LIG_SH2_STAT5	380	383	PF00017	0.481
LIG_SH2_STAT5	388	391	PF00017	0.535
LIG_SH2_STAT5	78	81	PF00017	0.483
LIG_SUMO_SIM_anti_2	138	143	PF11976	0.374
LIG_SUMO_SIM_anti_2	345	353	PF11976	0.655
LIG_SUMO_SIM_anti_2	89	95	PF11976	0.398
LIG_TRAF2_1	135	138	PF00917	0.419
LIG_UBA3_1	75	84	PF00899	0.505
MOD_CDK_SPK_2	261	266	PF00069	0.509
MOD_CDK_SPxxK_3	242	249	PF00069	0.511
MOD_CK1_1	150	156	PF00069	0.418
MOD_CK1_1	19	25	PF00069	0.577
MOD_CK1_1	241	247	PF00069	0.523
MOD_CK1_1	3	9	PF00069	0.719
MOD_CK2_1	132	138	PF00069	0.465
MOD_CK2_1	182	188	PF00069	0.488
MOD_CK2_1	294	300	PF00069	0.474
MOD_CK2_1	301	307	PF00069	0.501
MOD_CK2_1	342	348	PF00069	0.608
MOD_CK2_1	365	371	PF00069	0.537
MOD_CK2_1	99	105	PF00069	0.454
MOD_GlcNHglycan	18	21	PF01048	0.567
MOD_GlcNHglycan	6	9	PF01048	0.750
MOD_GlcNHglycan	97	100	PF01048	0.460
MOD_GSK3_1	146	153	PF00069	0.546
MOD_GSK3_1	235	242	PF00069	0.447
MOD_GSK3_1	301	308	PF00069	0.501
MOD_GSK3_1	357	364	PF00069	0.638
MOD_GSK3_1	67	74	PF00069	0.535
MOD_GSK3_1	95	102	PF00069	0.503
MOD_N-GLC_1	145	150	PF02516	0.374
MOD_N-GLC_1	217	222	PF02516	0.376
MOD_N-GLC_1	95	100	PF02516	0.405
MOD_NEK2_1	147	152	PF00069	0.395
MOD_NEK2_1	217	222	PF00069	0.347
MOD_NEK2_1	239	244	PF00069	0.460
MOD_NEK2_1	301	306	PF00069	0.449
MOD_NEK2_1	328	333	PF00069	0.512
MOD_NEK2_1	373	378	PF00069	0.527
MOD_OFUCOSY	97	103	PF10250	0.449
MOD_PIKK_1	328	334	PF00454	0.476
MOD_PK_1	314	320	PF00069	0.534
MOD_PKA_2	182	188	PF00069	0.501
MOD_PKA_2	235	241	PF00069	0.549
MOD_Plk_1	137	143	PF00069	0.383
MOD_Plk_1	206	212	PF00069	0.500
MOD_Plk_4	137	143	PF00069	0.382
MOD_Plk_4	301	307	PF00069	0.482
MOD_Plk_4	365	371	PF00069	0.454
MOD_Plk_4	373	379	PF00069	0.466
MOD_Plk_4	71	77	PF00069	0.505
MOD_Plk_4	89	95	PF00069	0.276
MOD_ProDKin_1	242	248	PF00069	0.510
MOD_ProDKin_1	261	267	PF00069	0.290
MOD_ProDKin_1	357	363	PF00069	0.524
MOD_ProDKin_1	61	67	PF00069	0.404
TRG_DiLeu_BaEn_2	27	33	PF01217	0.421
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.391
TRG_ENDOCYTIC_2	177	180	PF00928	0.412
TRG_ENDOCYTIC_2	269	272	PF00928	0.540
TRG_ER_diArg_1	248	251	PF00400	0.423
TRG_Pf-PMV_PEXEL_1	221	226	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	251	256	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMC4	Leptomonas seymouri	65%	91%
A0A0S4J7H7	Bodo saltans	36%	100%
A0A1X0P3N1	Trypanosomatidae	47%	100%
A0A3Q8IGP7	Leishmania donovani	88%	97%
A0A422N467	Trypanosoma rangeli	47%	100%
A4HLR7	Leishmania braziliensis	77%	94%
A4I943	Leishmania infantum	88%	97%
D0A6A8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B443	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	98%
V5BTV3	Trypanosoma cruzi	46%	89%