Putative glycerolphosphate mutase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerolphosphate mutase, putative

Species:

Leishmania major

UniProt:

Q4Q3X7_LEIMA

TriTrypDb:

LmjF.33.2100 , LMJLV39_330031300 , LMJSD75_330030800

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q3X7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3X7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.640
CLV_MEL_PAP_1	160	166	PF00089	0.335
CLV_NRD_NRD_1	103	105	PF00675	0.335
CLV_NRD_NRD_1	23	25	PF00675	0.560
CLV_NRD_NRD_1	255	257	PF00675	0.769
CLV_NRD_NRD_1	259	261	PF00675	0.277
CLV_NRD_NRD_1	32	34	PF00675	0.398
CLV_NRD_NRD_1	419	421	PF00675	0.677
CLV_NRD_NRD_1	8	10	PF00675	0.556
CLV_PCSK_KEX2_1	103	105	PF00082	0.335
CLV_PCSK_KEX2_1	23	25	PF00082	0.584
CLV_PCSK_KEX2_1	255	257	PF00082	0.769
CLV_PCSK_KEX2_1	259	261	PF00082	0.277
CLV_PCSK_KEX2_1	32	34	PF00082	0.429
CLV_PCSK_KEX2_1	490	492	PF00082	0.583
CLV_PCSK_KEX2_1	7	9	PF00082	0.567
CLV_PCSK_KEX2_1	74	76	PF00082	0.347
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.347
CLV_PCSK_PC7_1	255	261	PF00082	0.674
CLV_PCSK_SKI1_1	141	145	PF00082	0.335
CLV_PCSK_SKI1_1	32	36	PF00082	0.341
CLV_PCSK_SKI1_1	350	354	PF00082	0.419
DEG_APCC_DBOX_1	191	199	PF00400	0.534
DEG_MDM2_SWIB_1	308	315	PF02201	0.354
DEG_Nend_Nbox_1	1	3	PF02207	0.703
DEG_SPOP_SBC_1	227	231	PF00917	0.672
DEG_SPOP_SBC_1	247	251	PF00917	0.747
DEG_SPOP_SBC_1	422	426	PF00917	0.631
DOC_CYCLIN_RxL_1	259	271	PF00134	0.262
DOC_CYCLIN_RxL_1	347	356	PF00134	0.440
DOC_MAPK_gen_1	311	319	PF00069	0.353
DOC_MAPK_MEF2A_6	173	180	PF00069	0.517
DOC_MAPK_NFAT4_5	173	181	PF00069	0.525
DOC_PP2B_LxvP_1	178	181	PF13499	0.550
DOC_PP4_FxxP_1	313	316	PF00568	0.335
DOC_USP7_MATH_1	211	215	PF00917	0.615
DOC_USP7_MATH_1	226	230	PF00917	0.541
DOC_USP7_MATH_1	247	251	PF00917	0.626
DOC_USP7_MATH_1	405	409	PF00917	0.762
DOC_USP7_MATH_1	422	426	PF00917	0.560
DOC_USP7_MATH_1	430	434	PF00917	0.665
DOC_USP7_MATH_1	436	440	PF00917	0.586
DOC_USP7_MATH_1	449	453	PF00917	0.526
DOC_WW_Pin1_4	238	243	PF00397	0.749
DOC_WW_Pin1_4	259	264	PF00397	0.358
DOC_WW_Pin1_4	428	433	PF00397	0.780
DOC_WW_Pin1_4	477	482	PF00397	0.735
DOC_WW_Pin1_4	51	56	PF00397	0.354
DOC_WW_Pin1_4	87	92	PF00397	0.354
LIG_14-3-3_CanoR_1	103	107	PF00244	0.354
LIG_14-3-3_CanoR_1	24	30	PF00244	0.563
LIG_14-3-3_CanoR_1	259	263	PF00244	0.403
LIG_14-3-3_CanoR_1	342	352	PF00244	0.440
LIG_14-3-3_CanoR_1	466	470	PF00244	0.668
LIG_14-3-3_CanoR_1	94	100	PF00244	0.354
LIG_Actin_WH2_2	157	175	PF00022	0.453
LIG_BRCT_BRCA1_1	164	168	PF00533	0.335
LIG_deltaCOP1_diTrp_1	135	144	PF00928	0.313
LIG_deltaCOP1_diTrp_1	368	377	PF00928	0.514
LIG_FHA_1	275	281	PF00498	0.272
LIG_FHA_2	203	209	PF00498	0.663
LIG_FHA_2	229	235	PF00498	0.679
LIG_FHA_2	96	102	PF00498	0.335
LIG_GBD_Chelix_1	299	307	PF00786	0.335
LIG_LIR_Apic_2	54	60	PF02991	0.354
LIG_LIR_Gen_1	165	176	PF02991	0.335
LIG_LIR_Gen_1	318	327	PF02991	0.354
LIG_LIR_Nem_3	165	171	PF02991	0.335
LIG_LIR_Nem_3	375	380	PF02991	0.684
LIG_LIR_Nem_3	484	488	PF02991	0.693
LIG_LIR_Nem_3	83	89	PF02991	0.354
LIG_MLH1_MIPbox_1	164	168	PF16413	0.335
LIG_NRP_CendR_1	490	492	PF00754	0.583
LIG_Pex14_1	240	244	PF04695	0.578
LIG_Pex14_2	308	312	PF04695	0.354
LIG_PTB_Apo_2	11	18	PF02174	0.546
LIG_SH2_CRK	128	132	PF00017	0.453
LIG_SH2_CRK	149	153	PF00017	0.354
LIG_SH2_GRB2like	51	54	PF00017	0.453
LIG_SH2_STAT3	12	15	PF00017	0.634
LIG_SH2_STAT5	86	89	PF00017	0.354
LIG_SH3_1	260	266	PF00018	0.358
LIG_SH3_2	413	418	PF14604	0.779
LIG_SH3_3	260	266	PF00018	0.360
LIG_SH3_3	407	413	PF00018	0.656
LIG_SH3_3	467	473	PF00018	0.597
LIG_SH3_5	481	485	PF00018	0.689
LIG_SH3_CIN85_PxpxPR_1	413	418	PF14604	0.779
LIG_SUMO_SIM_par_1	330	335	PF11976	0.335
LIG_TRAF2_1	290	293	PF00917	0.262
LIG_TRAF2_1	386	389	PF00917	0.719
LIG_TRAF2_2	130	135	PF00917	0.389
LIG_WRC_WIRS_1	485	490	PF05994	0.569
LIG_WW_3	415	419	PF00397	0.779
MOD_CDC14_SPxK_1	262	265	PF00782	0.262
MOD_CDK_SPxK_1	259	265	PF00069	0.262
MOD_CDK_SPxK_1	477	483	PF00069	0.690
MOD_CDK_SPxxK_3	51	58	PF00069	0.354
MOD_CDK_SPxxK_3	87	94	PF00069	0.354
MOD_CK1_1	218	224	PF00069	0.698
MOD_CK1_1	230	236	PF00069	0.584
MOD_CK1_1	423	429	PF00069	0.776
MOD_CK1_1	431	437	PF00069	0.681
MOD_CK1_1	439	445	PF00069	0.572
MOD_CK1_1	452	458	PF00069	0.584
MOD_CK2_1	102	108	PF00069	0.335
MOD_CK2_1	228	234	PF00069	0.820
MOD_CK2_1	286	292	PF00069	0.313
MOD_CK2_1	441	447	PF00069	0.770
MOD_CK2_1	451	457	PF00069	0.624
MOD_CK2_1	95	101	PF00069	0.335
MOD_Cter_Amidation	72	75	PF01082	0.347
MOD_GlcNHglycan	155	158	PF01048	0.354
MOD_GlcNHglycan	164	167	PF01048	0.354
MOD_GlcNHglycan	234	237	PF01048	0.780
MOD_GlcNHglycan	250	253	PF01048	0.522
MOD_GlcNHglycan	288	291	PF01048	0.267
MOD_GlcNHglycan	407	410	PF01048	0.677
MOD_GlcNHglycan	434	437	PF01048	0.729
MOD_GlcNHglycan	438	441	PF01048	0.674
MOD_GlcNHglycan	444	447	PF01048	0.587
MOD_GlcNHglycan	450	454	PF01048	0.546
MOD_GSK3_1	102	109	PF00069	0.335
MOD_GSK3_1	172	179	PF00069	0.555
MOD_GSK3_1	211	218	PF00069	0.651
MOD_GSK3_1	226	233	PF00069	0.651
MOD_GSK3_1	236	243	PF00069	0.682
MOD_GSK3_1	254	261	PF00069	0.537
MOD_GSK3_1	348	355	PF00069	0.456
MOD_GSK3_1	421	428	PF00069	0.787
MOD_GSK3_1	430	437	PF00069	0.656
MOD_GSK3_1	438	445	PF00069	0.545
MOD_N-GLC_1	25	30	PF02516	0.405
MOD_N-GLC_2	184	186	PF02516	0.700
MOD_NEK2_1	1	6	PF00069	0.723
MOD_NEK2_1	106	111	PF00069	0.335
MOD_NEK2_1	134	139	PF00069	0.326
MOD_NEK2_1	153	158	PF00069	0.483
MOD_NEK2_1	167	172	PF00069	0.354
MOD_NEK2_1	254	259	PF00069	0.652
MOD_NEK2_1	348	353	PF00069	0.350
MOD_NEK2_1	486	491	PF00069	0.571
MOD_PIKK_1	106	112	PF00454	0.347
MOD_PIKK_1	219	225	PF00454	0.746
MOD_PIKK_1	465	471	PF00454	0.732
MOD_PKA_1	420	426	PF00069	0.791
MOD_PKA_2	102	108	PF00069	0.354
MOD_PKA_2	162	168	PF00069	0.354
MOD_PKA_2	172	178	PF00069	0.354
MOD_PKA_2	254	260	PF00069	0.652
MOD_PKA_2	465	471	PF00069	0.669
MOD_PKA_2	95	101	PF00069	0.354
MOD_PKB_1	418	426	PF00069	0.790
MOD_Plk_1	106	112	PF00069	0.335
MOD_Plk_1	134	140	PF00069	0.335
MOD_Plk_1	25	31	PF00069	0.427
MOD_Plk_1	367	373	PF00069	0.501
MOD_Plk_4	167	173	PF00069	0.370
MOD_Plk_4	25	31	PF00069	0.589
MOD_Plk_4	348	354	PF00069	0.447
MOD_ProDKin_1	238	244	PF00069	0.750
MOD_ProDKin_1	259	265	PF00069	0.358
MOD_ProDKin_1	428	434	PF00069	0.779
MOD_ProDKin_1	477	483	PF00069	0.735
MOD_ProDKin_1	51	57	PF00069	0.354
MOD_ProDKin_1	87	93	PF00069	0.354
MOD_SUMO_rev_2	52	60	PF00179	0.335
TRG_DiLeu_BaEn_1	293	298	PF01217	0.294
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.397
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.455
TRG_ENDOCYTIC_2	128	131	PF00928	0.354
TRG_ENDOCYTIC_2	148	151	PF00928	0.183
TRG_ENDOCYTIC_2	485	488	PF00928	0.696
TRG_ER_diArg_1	102	104	PF00400	0.346
TRG_ER_diArg_1	23	25	PF00400	0.541
TRG_ER_diArg_1	254	256	PF00400	0.769
TRG_ER_diArg_1	258	260	PF00400	0.277
TRG_ER_diArg_1	31	33	PF00400	0.414
TRG_ER_diArg_1	417	420	PF00400	0.679
TRG_ER_diArg_1	490	492	PF00400	0.583
TRG_ER_diArg_1	7	9	PF00400	0.567
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHK5	Leptomonas seymouri	67%	100%
A0A3Q8IU44	Leishmania donovani	93%	98%
A4HLS2	Leishmania braziliensis	81%	98%
A4I981	Leishmania infantum	93%	98%
E9B448	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	98%