HIT-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HIT zinc finger, putative

Species:

Leishmania major

UniProt:

Q4Q3X5_LEIMA

TriTrypDb:

LmjF.33.2120 , LMJLV39_330031500 , LMJSD75_330031000

Length:

219

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0070761	pre-snoRNP complex	3	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4Q3X5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3X5

Function

Biological processes
Term	Name	Level	Count
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	2
GO:0000470	maturation of LSU-rRNA	9	2
GO:0000491	small nucleolar ribonucleoprotein complex assembly	7	2
GO:0000492	box C/D snoRNP assembly	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006403	RNA localization	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0033036	macromolecule localization	2	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043933	protein-containing complex organization	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0048254	snoRNA localization	4	2
GO:0051179	localization	1	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.727
CLV_C14_Caspase3-7	187	191	PF00656	0.481
CLV_NRD_NRD_1	28	30	PF00675	0.334
CLV_PCSK_KEX2_1	72	74	PF00082	0.686
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.647
CLV_PCSK_SKI1_1	118	122	PF00082	0.773
CLV_PCSK_SKI1_1	167	171	PF00082	0.492
CLV_PCSK_SKI1_1	177	181	PF00082	0.490
DEG_APCC_DBOX_1	185	193	PF00400	0.559
DEG_Nend_UBRbox_1	1	4	PF02207	0.438
DEG_SPOP_SBC_1	47	51	PF00917	0.634
DOC_USP7_MATH_1	134	138	PF00917	0.683
DOC_USP7_MATH_1	143	147	PF00917	0.466
DOC_USP7_MATH_1	17	21	PF00917	0.546
DOC_USP7_MATH_1	47	51	PF00917	0.634
DOC_WW_Pin1_4	169	174	PF00397	0.561
LIG_14-3-3_CanoR_1	165	173	PF00244	0.579
LIG_14-3-3_CanoR_1	73	82	PF00244	0.626
LIG_BIR_III_2	103	107	PF00653	0.666
LIG_DLG_GKlike_1	171	178	PF00625	0.537
LIG_FHA_2	74	80	PF00498	0.627
LIG_LIR_Gen_1	49	60	PF02991	0.569
LIG_LIR_Gen_1	81	91	PF02991	0.664
LIG_LIR_Nem_3	201	205	PF02991	0.418
LIG_LIR_Nem_3	49	55	PF02991	0.571
LIG_LIR_Nem_3	81	86	PF02991	0.656
LIG_PTB_Apo_2	196	203	PF02174	0.495
LIG_SH2_NCK_1	197	201	PF00017	0.558
LIG_SH2_STAT3	150	153	PF00017	0.568
LIG_SH2_STAT5	150	153	PF00017	0.568
LIG_SH2_STAT5	22	25	PF00017	0.483
LIG_TRAF2_1	34	37	PF00917	0.579
MOD_CK1_1	124	130	PF00069	0.773
MOD_CK1_1	137	143	PF00069	0.573
MOD_CK1_1	184	190	PF00069	0.500
MOD_CK1_1	84	90	PF00069	0.665
MOD_CK2_1	31	37	PF00069	0.494
MOD_CK2_1	73	79	PF00069	0.610
MOD_GlcNHglycan	125	129	PF01048	0.660
MOD_GlcNHglycan	136	139	PF01048	0.707
MOD_GlcNHglycan	167	170	PF01048	0.543
MOD_GlcNHglycan	19	22	PF01048	0.325
MOD_GSK3_1	112	119	PF00069	0.627
MOD_GSK3_1	165	172	PF00069	0.532
MOD_GSK3_1	17	24	PF00069	0.560
MOD_GSK3_1	178	185	PF00069	0.527
MOD_NEK2_1	55	60	PF00069	0.582
MOD_PIKK_1	22	28	PF00454	0.542
MOD_PKA_2	31	37	PF00069	0.453
MOD_Plk_4	55	61	PF00069	0.605
MOD_ProDKin_1	169	175	PF00069	0.553
TRG_ER_diArg_1	13	16	PF00400	0.488
TRG_ER_diArg_1	164	167	PF00400	0.621
TRG_ER_diArg_1	186	189	PF00400	0.477
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTG1	Leptomonas seymouri	51%	79%
A0A3S7X700	Leishmania donovani	89%	100%
A0A422NI17	Trypanosoma rangeli	34%	100%
A4HLS4	Leishmania braziliensis	72%	100%
A4I983	Leishmania infantum	89%	100%
D0A6A4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B450	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%