Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q3W8_LEIMA

TriTrypDb:

LmjF.33.2190 , LMJLV39_330032200 , LMJSD75_330031800

Length:

762

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3W8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3W8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.496
CLV_C14_Caspase3-7	364	368	PF00656	0.654
CLV_C14_Caspase3-7	540	544	PF00656	0.674
CLV_NRD_NRD_1	293	295	PF00675	0.640
CLV_NRD_NRD_1	344	346	PF00675	0.675
CLV_NRD_NRD_1	4	6	PF00675	0.690
CLV_NRD_NRD_1	597	599	PF00675	0.664
CLV_NRD_NRD_1	613	615	PF00675	0.516
CLV_NRD_NRD_1	722	724	PF00675	0.643
CLV_NRD_NRD_1	87	89	PF00675	0.665
CLV_PCSK_FUR_1	2	6	PF00082	0.658
CLV_PCSK_FUR_1	342	346	PF00082	0.679
CLV_PCSK_KEX2_1	293	295	PF00082	0.640
CLV_PCSK_KEX2_1	342	344	PF00082	0.680
CLV_PCSK_KEX2_1	37	39	PF00082	0.686
CLV_PCSK_KEX2_1	4	6	PF00082	0.690
CLV_PCSK_KEX2_1	509	511	PF00082	0.563
CLV_PCSK_KEX2_1	597	599	PF00082	0.664
CLV_PCSK_KEX2_1	613	615	PF00082	0.516
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.659
CLV_PCSK_PC1ET2_1	509	511	PF00082	0.563
CLV_PCSK_SKI1_1	242	246	PF00082	0.473
CLV_PCSK_SKI1_1	284	288	PF00082	0.553
CLV_PCSK_SKI1_1	344	348	PF00082	0.641
CLV_PCSK_SKI1_1	352	356	PF00082	0.678
CLV_PCSK_SKI1_1	485	489	PF00082	0.626
CLV_PCSK_SKI1_1	527	531	PF00082	0.665
CLV_PCSK_SKI1_1	713	717	PF00082	0.660
DEG_Nend_UBRbox_1	1	4	PF02207	0.629
DEG_ODPH_VHL_1	547	560	PF01847	0.546
DEG_SPOP_SBC_1	685	689	PF00917	0.682
DOC_CKS1_1	103	108	PF01111	0.695
DOC_CKS1_1	127	132	PF01111	0.611
DOC_PP1_RVXF_1	507	514	PF00149	0.575
DOC_PP1_RVXF_1	702	708	PF00149	0.574
DOC_PP4_FxxP_1	43	46	PF00568	0.712
DOC_PP4_FxxP_1	678	681	PF00568	0.704
DOC_USP7_MATH_1	174	178	PF00917	0.715
DOC_USP7_MATH_1	199	203	PF00917	0.718
DOC_USP7_MATH_1	296	300	PF00917	0.659
DOC_USP7_MATH_1	357	361	PF00917	0.626
DOC_USP7_MATH_1	414	418	PF00917	0.590
DOC_USP7_MATH_1	437	441	PF00917	0.656
DOC_USP7_MATH_1	44	48	PF00917	0.592
DOC_USP7_MATH_1	459	463	PF00917	0.639
DOC_USP7_MATH_1	562	566	PF00917	0.674
DOC_USP7_MATH_1	601	605	PF00917	0.628
DOC_USP7_MATH_1	643	647	PF00917	0.708
DOC_USP7_MATH_1	668	672	PF00917	0.752
DOC_USP7_MATH_1	684	688	PF00917	0.562
DOC_USP7_MATH_1	717	721	PF00917	0.550
DOC_USP7_MATH_1	736	740	PF00917	0.656
DOC_WW_Pin1_4	102	107	PF00397	0.576
DOC_WW_Pin1_4	126	131	PF00397	0.651
DOC_WW_Pin1_4	139	144	PF00397	0.599
DOC_WW_Pin1_4	178	183	PF00397	0.677
DOC_WW_Pin1_4	187	192	PF00397	0.578
DOC_WW_Pin1_4	197	202	PF00397	0.759
DOC_WW_Pin1_4	204	209	PF00397	0.642
DOC_WW_Pin1_4	319	324	PF00397	0.675
DOC_WW_Pin1_4	333	338	PF00397	0.557
DOC_WW_Pin1_4	449	454	PF00397	0.797
DOC_WW_Pin1_4	528	533	PF00397	0.661
DOC_WW_Pin1_4	541	546	PF00397	0.575
DOC_WW_Pin1_4	578	583	PF00397	0.659
DOC_WW_Pin1_4	639	644	PF00397	0.707
DOC_WW_Pin1_4	676	681	PF00397	0.603
DOC_WW_Pin1_4	87	92	PF00397	0.674
LIG_14-3-3_CanoR_1	204	208	PF00244	0.685
LIG_14-3-3_CanoR_1	315	323	PF00244	0.671
LIG_14-3-3_CanoR_1	344	354	PF00244	0.607
LIG_14-3-3_CanoR_1	438	442	PF00244	0.635
LIG_14-3-3_CanoR_1	5	15	PF00244	0.618
LIG_14-3-3_CanoR_1	607	616	PF00244	0.654
LIG_14-3-3_CanoR_1	69	75	PF00244	0.645
LIG_14-3-3_CanoR_1	76	81	PF00244	0.702
LIG_14-3-3_CanoR_1	99	104	PF00244	0.601
LIG_BIR_III_2	28	32	PF00653	0.642
LIG_BIR_III_4	307	311	PF00653	0.622
LIG_deltaCOP1_diTrp_1	742	751	PF00928	0.557
LIG_EVH1_1	457	461	PF00568	0.580
LIG_EVH1_2	494	498	PF00568	0.574
LIG_EVH1_2	674	678	PF00568	0.565
LIG_FHA_1	103	109	PF00498	0.604
LIG_FHA_1	173	179	PF00498	0.636
LIG_FHA_1	187	193	PF00498	0.638
LIG_FHA_1	691	697	PF00498	0.702
LIG_FHA_1	70	76	PF00498	0.610
LIG_FHA_2	127	133	PF00498	0.682
LIG_FHA_2	218	224	PF00498	0.506
LIG_FHA_2	23	29	PF00498	0.686
LIG_FHA_2	692	698	PF00498	0.679
LIG_Integrin_RGD_1	38	40	PF01839	0.578
LIG_LIR_Apic_2	40	46	PF02991	0.712
LIG_LIR_Apic_2	676	681	PF02991	0.698
LIG_LIR_Apic_2	730	736	PF02991	0.682
LIG_LIR_Gen_1	223	233	PF02991	0.497
LIG_LIR_Gen_1	299	309	PF02991	0.552
LIG_LIR_Gen_1	405	414	PF02991	0.673
LIG_LIR_Gen_1	59	68	PF02991	0.641
LIG_LIR_Gen_1	602	611	PF02991	0.621
LIG_LIR_Gen_1	742	752	PF02991	0.553
LIG_LIR_Nem_3	223	229	PF02991	0.587
LIG_LIR_Nem_3	262	266	PF02991	0.589
LIG_LIR_Nem_3	299	304	PF02991	0.552
LIG_LIR_Nem_3	405	409	PF02991	0.674
LIG_LIR_Nem_3	59	64	PF02991	0.639
LIG_LIR_Nem_3	602	608	PF02991	0.628
LIG_LIR_Nem_3	625	631	PF02991	0.624
LIG_LIR_Nem_3	742	747	PF02991	0.569
LIG_NRBOX	350	356	PF00104	0.545
LIG_PCNA_yPIPBox_3	741	752	PF02747	0.600
LIG_Pex14_1	501	505	PF04695	0.561
LIG_RPA_C_Fungi	602	614	PF08784	0.620
LIG_SH2_CRK	283	287	PF00017	0.450
LIG_SH2_CRK	301	305	PF00017	0.507
LIG_SH2_GRB2like	628	631	PF00017	0.631
LIG_SH2_NCK_1	301	305	PF00017	0.600
LIG_SH2_STAT3	185	188	PF00017	0.546
LIG_SH2_STAT5	185	188	PF00017	0.546
LIG_SH2_STAT5	22	25	PF00017	0.574
LIG_SH2_STAT5	505	508	PF00017	0.621
LIG_SH2_STAT5	733	736	PF00017	0.599
LIG_SH3_1	455	461	PF00018	0.611
LIG_SH3_3	100	106	PF00018	0.732
LIG_SH3_3	124	130	PF00018	0.637
LIG_SH3_3	176	182	PF00018	0.679
LIG_SH3_3	195	201	PF00018	0.723
LIG_SH3_3	455	461	PF00018	0.797
LIG_TRAF2_1	114	117	PF00917	0.708
LIG_TRAF2_1	405	408	PF00917	0.784
LIG_TRAF2_1	429	432	PF00917	0.697
LIG_TRAF2_1	591	594	PF00917	0.653
LIG_TRAF2_1	647	650	PF00917	0.537
LIG_WW_2	458	461	PF00397	0.579
LIG_WW_3	452	456	PF00397	0.665
MOD_CDC14_SPxK_1	452	455	PF00782	0.693
MOD_CDK_SPxK_1	449	455	PF00069	0.695
MOD_CDK_SPxxK_3	197	204	PF00069	0.714
MOD_CK1_1	102	108	PF00069	0.659
MOD_CK1_1	138	144	PF00069	0.663
MOD_CK1_1	177	183	PF00069	0.788
MOD_CK1_1	187	193	PF00069	0.676
MOD_CK1_1	200	206	PF00069	0.754
MOD_CK1_1	299	305	PF00069	0.638
MOD_CK1_1	350	356	PF00069	0.646
MOD_CK1_1	379	385	PF00069	0.710
MOD_CK1_1	440	446	PF00069	0.676
MOD_CK1_1	47	53	PF00069	0.546
MOD_CK1_1	515	521	PF00069	0.571
MOD_CK1_1	636	642	PF00069	0.642
MOD_CK1_1	676	682	PF00069	0.656
MOD_CK1_1	79	85	PF00069	0.719
MOD_CK1_1	9	15	PF00069	0.693
MOD_CK2_1	402	408	PF00069	0.783
MOD_CK2_1	414	420	PF00069	0.635
MOD_CK2_1	643	649	PF00069	0.594
MOD_CK2_1	691	697	PF00069	0.744
MOD_CK2_1	736	742	PF00069	0.612
MOD_DYRK1A_RPxSP_1	321	325	PF00069	0.640
MOD_DYRK1A_RPxSP_1	541	545	PF00069	0.713
MOD_DYRK1A_RPxSP_1	578	582	PF00069	0.546
MOD_GlcNHglycan	116	120	PF01048	0.668
MOD_GlcNHglycan	208	211	PF01048	0.735
MOD_GlcNHglycan	297	301	PF01048	0.655
MOD_GlcNHglycan	317	320	PF01048	0.516
MOD_GlcNHglycan	338	341	PF01048	0.685
MOD_GlcNHglycan	347	350	PF01048	0.641
MOD_GlcNHglycan	363	366	PF01048	0.561
MOD_GlcNHglycan	514	517	PF01048	0.614
MOD_GlcNHglycan	523	526	PF01048	0.589
MOD_GlcNHglycan	564	567	PF01048	0.677
MOD_GlcNHglycan	584	587	PF01048	0.586
MOD_GlcNHglycan	601	604	PF01048	0.624
MOD_GlcNHglycan	635	638	PF01048	0.697
MOD_GlcNHglycan	64	67	PF01048	0.645
MOD_GlcNHglycan	655	658	PF01048	0.580
MOD_GlcNHglycan	670	673	PF01048	0.561
MOD_GlcNHglycan	675	678	PF01048	0.681
MOD_GlcNHglycan	697	700	PF01048	0.711
MOD_GSK3_1	135	142	PF00069	0.663
MOD_GSK3_1	174	181	PF00069	0.709
MOD_GSK3_1	199	206	PF00069	0.717
MOD_GSK3_1	213	220	PF00069	0.541
MOD_GSK3_1	311	318	PF00069	0.640
MOD_GSK3_1	357	364	PF00069	0.692
MOD_GSK3_1	376	383	PF00069	0.556
MOD_GSK3_1	4	11	PF00069	0.648
MOD_GSK3_1	410	417	PF00069	0.632
MOD_GSK3_1	436	443	PF00069	0.832
MOD_GSK3_1	511	518	PF00069	0.588
MOD_GSK3_1	537	544	PF00069	0.659
MOD_GSK3_1	578	585	PF00069	0.665
MOD_GSK3_1	639	646	PF00069	0.711
MOD_GSK3_1	686	693	PF00069	0.697
MOD_GSK3_1	713	720	PF00069	0.664
MOD_GSK3_1	76	83	PF00069	0.696
MOD_GSK3_1	95	102	PF00069	0.523
MOD_N-GLC_1	653	658	PF02516	0.687
MOD_N-GLC_1	99	104	PF02516	0.647
MOD_NEK2_1	186	191	PF00069	0.694
MOD_NEK2_1	266	271	PF00069	0.564
MOD_NEK2_1	285	290	PF00069	0.433
MOD_NEK2_1	347	352	PF00069	0.548
MOD_NEK2_1	378	383	PF00069	0.718
MOD_NEK2_1	653	658	PF00069	0.656
MOD_NEK2_2	437	442	PF00069	0.700
MOD_PIKK_1	180	186	PF00454	0.684
MOD_PIKK_1	217	223	PF00454	0.559
MOD_PIKK_1	285	291	PF00454	0.592
MOD_PIKK_1	6	12	PF00454	0.687
MOD_PIKK_1	705	711	PF00454	0.603
MOD_PK_1	76	82	PF00069	0.721
MOD_PK_1	99	105	PF00069	0.583
MOD_PKA_1	4	10	PF00069	0.693
MOD_PKA_2	203	209	PF00069	0.617
MOD_PKA_2	213	219	PF00069	0.711
MOD_PKA_2	4	10	PF00069	0.679
MOD_PKA_2	437	443	PF00069	0.721
MOD_PKA_2	499	505	PF00069	0.431
MOD_PKB_1	2	10	PF00069	0.662
MOD_PKB_1	343	351	PF00069	0.640
MOD_Plk_1	266	272	PF00069	0.561
MOD_Plk_1	296	302	PF00069	0.635
MOD_Plk_1	392	398	PF00069	0.610
MOD_Plk_1	717	723	PF00069	0.664
MOD_Plk_1	729	735	PF00069	0.517
MOD_Plk_1	99	105	PF00069	0.648
MOD_Plk_4	174	180	PF00069	0.680
MOD_Plk_4	299	305	PF00069	0.547
MOD_Plk_4	70	76	PF00069	0.549
MOD_Plk_4	717	723	PF00069	0.687
MOD_Plk_4	729	735	PF00069	0.490
MOD_Plk_4	99	105	PF00069	0.648
MOD_ProDKin_1	102	108	PF00069	0.578
MOD_ProDKin_1	126	132	PF00069	0.652
MOD_ProDKin_1	139	145	PF00069	0.598
MOD_ProDKin_1	178	184	PF00069	0.675
MOD_ProDKin_1	187	193	PF00069	0.579
MOD_ProDKin_1	197	203	PF00069	0.756
MOD_ProDKin_1	204	210	PF00069	0.640
MOD_ProDKin_1	319	325	PF00069	0.671
MOD_ProDKin_1	333	339	PF00069	0.558
MOD_ProDKin_1	449	455	PF00069	0.798
MOD_ProDKin_1	528	534	PF00069	0.660
MOD_ProDKin_1	541	547	PF00069	0.576
MOD_ProDKin_1	578	584	PF00069	0.660
MOD_ProDKin_1	639	645	PF00069	0.704
MOD_ProDKin_1	676	682	PF00069	0.602
MOD_ProDKin_1	87	93	PF00069	0.675
TRG_DiLeu_BaEn_3	481	487	PF01217	0.594
TRG_DiLeu_BaEn_4	328	334	PF01217	0.663
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.561
TRG_DiLeu_BaLyEn_6	225	230	PF01217	0.503
TRG_DiLeu_BaLyEn_6	579	584	PF01217	0.702
TRG_ENDOCYTIC_2	283	286	PF00928	0.490
TRG_ENDOCYTIC_2	301	304	PF00928	0.470
TRG_ER_diArg_1	1	4	PF00400	0.661
TRG_ER_diArg_1	211	214	PF00400	0.685
TRG_ER_diArg_1	293	295	PF00400	0.640
TRG_ER_diArg_1	342	345	PF00400	0.679
TRG_ER_diArg_1	596	598	PF00400	0.677
TRG_ER_diArg_1	85	88	PF00400	0.727
TRG_ER_FFAT_2	16	27	PF00635	0.569
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.648
TRG_Pf-PMV_PEXEL_1	475	480	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEZ5	Leishmania donovani	83%	99%
A4HLT1	Leishmania braziliensis	55%	67%
A4I990	Leishmania infantum	83%	99%
E9B457	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	68%