Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q3W7_LEIMA

TriTrypDb:

LmjF.33.2200 , LMJLV39_330032300 , LMJSD75_330031900

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3W7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3W7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.754
CLV_C14_Caspase3-7	65	69	PF00656	0.840
CLV_NRD_NRD_1	129	131	PF00675	0.693
CLV_NRD_NRD_1	138	140	PF00675	0.736
CLV_NRD_NRD_1	30	32	PF00675	0.766
CLV_NRD_NRD_1	361	363	PF00675	0.548
CLV_NRD_NRD_1	385	387	PF00675	0.611
CLV_NRD_NRD_1	71	73	PF00675	0.609
CLV_PCSK_KEX2_1	129	131	PF00082	0.649
CLV_PCSK_KEX2_1	138	140	PF00082	0.631
CLV_PCSK_KEX2_1	30	32	PF00082	0.657
CLV_PCSK_KEX2_1	361	363	PF00082	0.548
CLV_PCSK_KEX2_1	387	389	PF00082	0.580
CLV_PCSK_KEX2_1	71	73	PF00082	0.623
CLV_PCSK_PC1ET2_1	387	389	PF00082	0.580
CLV_PCSK_SKI1_1	282	286	PF00082	0.610
DEG_APCC_DBOX_1	281	289	PF00400	0.617
DOC_AGCK_PIF_1	305	310	PF00069	0.654
DOC_ANK_TNKS_1	70	77	PF00023	0.772
DOC_USP7_MATH_1	165	169	PF00917	0.704
DOC_USP7_MATH_1	315	319	PF00917	0.748
DOC_USP7_MATH_1	348	352	PF00917	0.759
DOC_USP7_MATH_1	43	47	PF00917	0.755
DOC_USP7_MATH_1	50	54	PF00917	0.666
DOC_WW_Pin1_4	146	151	PF00397	0.824
DOC_WW_Pin1_4	161	166	PF00397	0.592
DOC_WW_Pin1_4	229	234	PF00397	0.677
DOC_WW_Pin1_4	386	391	PF00397	0.579
DOC_WW_Pin1_4	60	65	PF00397	0.598
LIG_14-3-3_CanoR_1	163	173	PF00244	0.585
LIG_14-3-3_CanoR_1	31	37	PF00244	0.705
LIG_14-3-3_CanoR_1	77	82	PF00244	0.761
LIG_APCC_ABBAyCdc20_2	301	307	PF00400	0.660
LIG_BRCT_BRCA1_1	140	144	PF00533	0.778
LIG_FHA_1	348	354	PF00498	0.727
LIG_FHA_1	375	381	PF00498	0.548
LIG_FHA_1	54	60	PF00498	0.607
LIG_FHA_1	76	82	PF00498	0.714
LIG_FHA_2	195	201	PF00498	0.745
LIG_LIR_Gen_1	307	316	PF02991	0.701
LIG_LIR_Nem_3	307	311	PF02991	0.711
LIG_NRBOX	177	183	PF00104	0.758
LIG_PTB_Apo_2	284	291	PF02174	0.508
LIG_PTB_Phospho_1	284	290	PF10480	0.508
LIG_REV1ctd_RIR_1	308	317	PF16727	0.753
LIG_SH2_CRK	230	234	PF00017	0.607
LIG_SH2_STAP1	308	312	PF00017	0.524
LIG_SH2_STAT3	234	237	PF00017	0.590
LIG_SH2_STAT5	234	237	PF00017	0.722
LIG_SH2_STAT5	308	311	PF00017	0.686
LIG_TRAF2_1	197	200	PF00917	0.740
LIG_TRAF2_1	93	96	PF00917	0.794
MOD_CDK_SPK_2	161	166	PF00069	0.606
MOD_CDK_SPxxK_3	229	236	PF00069	0.606
MOD_CK1_1	161	167	PF00069	0.793
MOD_CK1_1	26	32	PF00069	0.708
MOD_CK1_1	268	274	PF00069	0.773
MOD_CK1_1	4	10	PF00069	0.716
MOD_CK1_1	52	58	PF00069	0.714
MOD_CK1_1	85	91	PF00069	0.626
MOD_CK2_1	173	179	PF00069	0.598
MOD_CK2_1	194	200	PF00069	0.740
MOD_CK2_1	268	274	PF00069	0.773
MOD_CK2_1	315	321	PF00069	0.754
MOD_CK2_1	348	354	PF00069	0.720
MOD_CK2_1	43	49	PF00069	0.770
MOD_CK2_1	90	96	PF00069	0.795
MOD_Cter_Amidation	69	72	PF01082	0.617
MOD_GlcNHglycan	146	149	PF01048	0.756
MOD_GlcNHglycan	159	163	PF01048	0.589
MOD_GlcNHglycan	167	170	PF01048	0.649
MOD_GlcNHglycan	31	34	PF01048	0.737
MOD_GlcNHglycan	317	320	PF01048	0.715
MOD_GlcNHglycan	327	330	PF01048	0.665
MOD_GlcNHglycan	335	338	PF01048	0.538
MOD_GlcNHglycan	350	353	PF01048	0.538
MOD_GlcNHglycan	374	377	PF01048	0.738
MOD_GlcNHglycan	43	46	PF01048	0.648
MOD_GlcNHglycan	64	67	PF01048	0.614
MOD_GlcNHglycan	87	90	PF01048	0.777
MOD_GSK3_1	140	147	PF00069	0.759
MOD_GSK3_1	161	168	PF00069	0.692
MOD_GSK3_1	169	176	PF00069	0.586
MOD_GSK3_1	190	197	PF00069	0.788
MOD_GSK3_1	315	322	PF00069	0.733
MOD_GSK3_1	37	44	PF00069	0.628
MOD_GSK3_1	49	56	PF00069	0.627
MOD_GSK3_1	60	67	PF00069	0.629
MOD_N-GLC_1	190	195	PF02516	0.731
MOD_N-GLC_1	219	224	PF02516	0.719
MOD_N-GLC_1	85	90	PF02516	0.663
MOD_NEK2_1	1	6	PF00069	0.797
MOD_NEK2_1	125	130	PF00069	0.598
MOD_NEK2_1	144	149	PF00069	0.657
MOD_NEK2_1	325	330	PF00069	0.561
MOD_NEK2_1	372	377	PF00069	0.774
MOD_NEK2_2	306	311	PF00069	0.689
MOD_PIKK_1	184	190	PF00454	0.653
MOD_PIKK_1	23	29	PF00454	0.607
MOD_PK_1	255	261	PF00069	0.725
MOD_PKA_1	138	144	PF00069	0.615
MOD_PKA_2	138	144	PF00069	0.732
MOD_PKA_2	165	171	PF00069	0.589
MOD_PKA_2	29	35	PF00069	0.749
MOD_PKA_2	325	331	PF00069	0.640
MOD_PKA_2	76	82	PF00069	0.761
MOD_Plk_1	139	145	PF00069	0.654
MOD_Plk_1	173	179	PF00069	0.539
MOD_Plk_1	190	196	PF00069	0.487
MOD_Plk_1	265	271	PF00069	0.786
MOD_Plk_1	306	312	PF00069	0.762
MOD_Plk_2-3	195	201	PF00069	0.642
MOD_Plk_2-3	265	271	PF00069	0.716
MOD_Plk_2-3	321	327	PF00069	0.597
MOD_Plk_2-3	364	370	PF00069	0.783
MOD_Plk_4	140	146	PF00069	0.740
MOD_Plk_4	173	179	PF00069	0.539
MOD_Plk_4	268	274	PF00069	0.773
MOD_Plk_4	306	312	PF00069	0.762
MOD_ProDKin_1	146	152	PF00069	0.823
MOD_ProDKin_1	161	167	PF00069	0.592
MOD_ProDKin_1	229	235	PF00069	0.679
MOD_ProDKin_1	386	392	PF00069	0.581
MOD_ProDKin_1	60	66	PF00069	0.598
MOD_SUMO_rev_2	247	256	PF00179	0.732
TRG_ENDOCYTIC_2	308	311	PF00928	0.709
TRG_ER_diArg_1	137	139	PF00400	0.604
TRG_ER_diArg_1	14	17	PF00400	0.565
TRG_NLS_MonoExtC_3	385	390	PF00514	0.607
TRG_NLS_MonoExtN_4	384	390	PF00514	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7U9	Leishmania donovani	83%	100%
A4HLT2	Leishmania braziliensis	54%	99%
A4I991	Leishmania infantum	83%	100%
E9B458	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%