Cilia- and flagella-associated protein 91

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1, putative

Species:

Leishmania major

UniProt:

Q4Q3W5_LEIMA

TriTrypDb:

LmjF.33.2220 , LMJLV39_330032700 , LMJSD75_330032300

Length:

754

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	12
GO:0005856	cytoskeleton	5	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10

Expansion

Sequence features

Q4Q3W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3W5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.749
CLV_C14_Caspase3-7	226	230	PF00656	0.554
CLV_C14_Caspase3-7	389	393	PF00656	0.648
CLV_C14_Caspase3-7	418	422	PF00656	0.635
CLV_C14_Caspase3-7	51	55	PF00656	0.715
CLV_C14_Caspase3-7	516	520	PF00656	0.527
CLV_C14_Caspase3-7	708	712	PF00656	0.465
CLV_NRD_NRD_1	117	119	PF00675	0.775
CLV_NRD_NRD_1	217	219	PF00675	0.260
CLV_NRD_NRD_1	261	263	PF00675	0.299
CLV_NRD_NRD_1	283	285	PF00675	0.302
CLV_NRD_NRD_1	30	32	PF00675	0.641
CLV_NRD_NRD_1	306	308	PF00675	0.323
CLV_NRD_NRD_1	453	455	PF00675	0.465
CLV_NRD_NRD_1	567	569	PF00675	0.608
CLV_NRD_NRD_1	614	616	PF00675	0.462
CLV_NRD_NRD_1	634	636	PF00675	0.520
CLV_PCSK_FUR_1	213	217	PF00082	0.261
CLV_PCSK_FUR_1	632	636	PF00082	0.598
CLV_PCSK_KEX2_1	117	119	PF00082	0.775
CLV_PCSK_KEX2_1	215	217	PF00082	0.260
CLV_PCSK_KEX2_1	261	263	PF00082	0.266
CLV_PCSK_KEX2_1	282	284	PF00082	0.325
CLV_PCSK_KEX2_1	30	32	PF00082	0.621
CLV_PCSK_KEX2_1	306	308	PF00082	0.297
CLV_PCSK_KEX2_1	312	314	PF00082	0.452
CLV_PCSK_KEX2_1	453	455	PF00082	0.456
CLV_PCSK_KEX2_1	567	569	PF00082	0.555
CLV_PCSK_KEX2_1	614	616	PF00082	0.484
CLV_PCSK_KEX2_1	634	636	PF00082	0.473
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.505
CLV_PCSK_PC1ET2_1	567	569	PF00082	0.555
CLV_PCSK_PC7_1	213	219	PF00082	0.271
CLV_PCSK_SKI1_1	124	128	PF00082	0.766
CLV_PCSK_SKI1_1	399	403	PF00082	0.635
CLV_Separin_Fungi	601	607	PF03568	0.346
CLV_Separin_Metazoa	621	625	PF03568	0.620
DEG_APCC_DBOX_1	281	289	PF00400	0.502
DEG_Nend_Nbox_1	1	3	PF02207	0.621
DEG_SPOP_SBC_1	104	108	PF00917	0.750
DOC_CKS1_1	502	507	PF01111	0.564
DOC_CYCLIN_RxL_1	485	496	PF00134	0.603
DOC_MAPK_MEF2A_6	501	509	PF00069	0.566
DOC_PP1_RVXF_1	23	29	PF00149	0.690
DOC_PP2B_LxvP_1	340	343	PF13499	0.691
DOC_PP4_FxxP_1	29	32	PF00568	0.608
DOC_PP4_FxxP_1	436	439	PF00568	0.560
DOC_PP4_FxxP_1	67	70	PF00568	0.689
DOC_PP4_FxxP_1	713	716	PF00568	0.441
DOC_USP7_MATH_1	104	108	PF00917	0.724
DOC_USP7_MATH_1	345	349	PF00917	0.634
DOC_USP7_MATH_1	361	365	PF00917	0.557
DOC_USP7_MATH_1	75	79	PF00917	0.720
DOC_WW_Pin1_4	171	176	PF00397	0.460
DOC_WW_Pin1_4	182	187	PF00397	0.460
DOC_WW_Pin1_4	429	434	PF00397	0.627
DOC_WW_Pin1_4	493	498	PF00397	0.531
DOC_WW_Pin1_4	501	506	PF00397	0.559
DOC_WW_Pin1_4	690	695	PF00397	0.611
LIG_14-3-3_CanoR_1	102	110	PF00244	0.743
LIG_14-3-3_CanoR_1	154	160	PF00244	0.727
LIG_14-3-3_CanoR_1	458	464	PF00244	0.591
LIG_14-3-3_CanoR_1	654	660	PF00244	0.528
LIG_14-3-3_CanoR_1	695	705	PF00244	0.474
LIG_14-3-3_CanoR_1	92	99	PF00244	0.741
LIG_BIR_III_4	138	142	PF00653	0.698
LIG_BIR_III_4	720	724	PF00653	0.509
LIG_CaM_IQ_9	156	171	PF13499	0.415
LIG_CaM_IQ_9	521	536	PF13499	0.417
LIG_FHA_1	183	189	PF00498	0.554
LIG_FHA_1	337	343	PF00498	0.726
LIG_FHA_1	415	421	PF00498	0.561
LIG_FHA_1	433	439	PF00498	0.572
LIG_FHA_1	494	500	PF00498	0.566
LIG_FHA_1	502	508	PF00498	0.560
LIG_FHA_1	673	679	PF00498	0.542
LIG_FHA_2	224	230	PF00498	0.521
LIG_FHA_2	299	305	PF00498	0.544
LIG_FHA_2	36	42	PF00498	0.692
LIG_FHA_2	49	55	PF00498	0.708
LIG_Integrin_RGD_1	136	138	PF01839	0.652
LIG_LIR_Apic_2	174	180	PF02991	0.471
LIG_LIR_Apic_2	435	439	PF02991	0.602
LIG_LIR_Apic_2	66	70	PF02991	0.685
LIG_LIR_Apic_2	711	716	PF02991	0.444
LIG_LIR_Gen_1	234	243	PF02991	0.555
LIG_LIR_Gen_1	464	472	PF02991	0.629
LIG_LIR_Nem_3	234	240	PF02991	0.531
LIG_LIR_Nem_3	367	371	PF02991	0.552
LIG_LIR_Nem_3	464	470	PF02991	0.658
LIG_LIR_Nem_3	646	652	PF02991	0.525
LIG_MYND_3	131	135	PF01753	0.681
LIG_NRBOX	523	529	PF00104	0.422
LIG_PTB_Apo_2	532	539	PF02174	0.418
LIG_REV1ctd_RIR_1	26	31	PF16727	0.664
LIG_REV1ctd_RIR_1	535	545	PF16727	0.444
LIG_SH2_CRK	237	241	PF00017	0.510
LIG_SH2_CRK	467	471	PF00017	0.638
LIG_SH2_GRB2like	196	199	PF00017	0.557
LIG_SH2_PTP2	177	180	PF00017	0.507
LIG_SH2_SRC	177	180	PF00017	0.507
LIG_SH2_SRC	196	199	PF00017	0.345
LIG_SH2_SRC	292	295	PF00017	0.554
LIG_SH2_STAP1	649	653	PF00017	0.421
LIG_SH2_STAT3	2	5	PF00017	0.676
LIG_SH2_STAT5	177	180	PF00017	0.472
LIG_SH2_STAT5	237	240	PF00017	0.562
LIG_SH2_STAT5	292	295	PF00017	0.554
LIG_SH3_3	169	175	PF00018	0.467
LIG_SH3_3	29	35	PF00018	0.693
LIG_SH3_3	499	505	PF00018	0.554
LIG_SH3_3	691	697	PF00018	0.621
LIG_SUMO_SIM_anti_2	206	212	PF11976	0.467
LIG_SUMO_SIM_par_1	677	682	PF11976	0.576
LIG_TRAF2_1	671	674	PF00917	0.454
LIG_TRAF2_1	698	701	PF00917	0.635
MOD_CDK_SPK_2	429	434	PF00069	0.603
MOD_CDK_SPK_2	493	498	PF00069	0.535
MOD_CDK_SPK_2	690	695	PF00069	0.681
MOD_CDK_SPxxK_3	501	508	PF00069	0.667
MOD_CK1_1	155	161	PF00069	0.694
MOD_CK1_1	223	229	PF00069	0.442
MOD_CK1_1	348	354	PF00069	0.760
MOD_CK1_1	364	370	PF00069	0.675
MOD_CK1_1	383	389	PF00069	0.470
MOD_CK1_1	432	438	PF00069	0.650
MOD_CK1_1	48	54	PF00069	0.677
MOD_CK1_1	63	69	PF00069	0.699
MOD_CK2_1	142	148	PF00069	0.770
MOD_CK2_1	200	206	PF00069	0.372
MOD_CK2_1	298	304	PF00069	0.423
MOD_CK2_1	35	41	PF00069	0.644
MOD_CK2_1	667	673	PF00069	0.424
MOD_DYRK1A_RPxSP_1	501	505	PF00069	0.552
MOD_GlcNHglycan	144	147	PF01048	0.729
MOD_GlcNHglycan	202	205	PF01048	0.372
MOD_GlcNHglycan	343	346	PF01048	0.734
MOD_GlcNHglycan	357	360	PF01048	0.747
MOD_GlcNHglycan	586	589	PF01048	0.557
MOD_GlcNHglycan	669	672	PF01048	0.482
MOD_GlcNHglycan	94	97	PF01048	0.797
MOD_GSK3_1	167	174	PF00069	0.308
MOD_GSK3_1	225	232	PF00069	0.341
MOD_GSK3_1	341	348	PF00069	0.745
MOD_GSK3_1	349	356	PF00069	0.783
MOD_GSK3_1	366	373	PF00069	0.435
MOD_GSK3_1	383	390	PF00069	0.464
MOD_GSK3_1	552	559	PF00069	0.572
MOD_GSK3_1	87	94	PF00069	0.698
MOD_N-GLC_1	104	109	PF02516	0.601
MOD_N-GLC_1	45	50	PF02516	0.621
MOD_NEK2_1	266	271	PF00069	0.416
MOD_NEK2_1	308	313	PF00069	0.436
MOD_NEK2_1	349	354	PF00069	0.715
MOD_NEK2_1	60	65	PF00069	0.640
MOD_NEK2_1	76	81	PF00069	0.698
MOD_NEK2_2	345	350	PF00069	0.669
MOD_PIKK_1	287	293	PF00454	0.442
MOD_PKA_2	266	272	PF00069	0.438
MOD_PKA_2	623	629	PF00069	0.509
MOD_PKA_2	653	659	PF00069	0.558
MOD_PKA_2	87	93	PF00069	0.736
MOD_Plk_1	220	226	PF00069	0.341
MOD_Plk_1	35	41	PF00069	0.720
MOD_Plk_1	656	662	PF00069	0.489
MOD_Plk_1	672	678	PF00069	0.461
MOD_Plk_2-3	229	235	PF00069	0.442
MOD_Plk_4	158	164	PF00069	0.321
MOD_Plk_4	266	272	PF00069	0.438
MOD_Plk_4	35	41	PF00069	0.674
MOD_Plk_4	432	438	PF00069	0.599
MOD_Plk_4	446	452	PF00069	0.442
MOD_ProDKin_1	171	177	PF00069	0.306
MOD_ProDKin_1	182	188	PF00069	0.306
MOD_ProDKin_1	429	435	PF00069	0.625
MOD_ProDKin_1	493	499	PF00069	0.533
MOD_ProDKin_1	501	507	PF00069	0.561
MOD_ProDKin_1	690	696	PF00069	0.613
MOD_SUMO_rev_2	229	238	PF00179	0.330
MOD_SUMO_rev_2	473	481	PF00179	0.564
MOD_SUMO_rev_2	728	734	PF00179	0.531
TRG_DiLeu_BaEn_1	206	211	PF01217	0.321
TRG_DiLeu_BaLyEn_6	523	528	PF01217	0.423
TRG_ENDOCYTIC_2	237	240	PF00928	0.399
TRG_ENDOCYTIC_2	467	470	PF00928	0.636
TRG_ER_diArg_1	116	118	PF00400	0.721
TRG_ER_diArg_1	213	216	PF00400	0.308
TRG_ER_diArg_1	261	263	PF00400	0.328
TRG_ER_diArg_1	282	284	PF00400	0.325
TRG_ER_diArg_1	29	31	PF00400	0.642
TRG_ER_diArg_1	305	307	PF00400	0.482
TRG_ER_diArg_1	528	531	PF00400	0.405
TRG_ER_diArg_1	613	615	PF00400	0.486
TRG_ER_diArg_1	632	635	PF00400	0.566
TRG_ER_diArg_1	99	102	PF00400	0.777
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	545	549	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	614	618	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8T7	Leptomonas seymouri	64%	99%
A0A0S4J7Y8	Bodo saltans	33%	100%
A0A1X0P3Q9	Trypanosomatidae	41%	100%
A0A3Q8IGQ6	Leishmania donovani	94%	100%
A0A422NI23	Trypanosoma rangeli	41%	100%
A4HLT5	Leishmania braziliensis	81%	100%
D0A691	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AHP1	Leishmania infantum	94%	100%
E9B461	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q386N1	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	40%	100%
V5BP91	Trypanosoma cruzi	41%	100%